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7384624 |
Oral contrast and method of producing the oral contrast
Oral contrast compositions are used as an aid for CAT scans and are ideally fast-flowing and good tasting for assisting in quick preparation of a patient in today's extremely active and busy...
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7384623 |
High energy phototherapeutic agents
High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive...
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7385041 |
Dual functioning excipient for metal chelate contrast agents
A novel dual functioning excipient for metal chelate contrast agents is disclosed. The present excipient,
X m [X′(L′)] n...
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7378081 |
Composition and method for direct visualization of the human appendix
A positive contrast agent composition containing meglumine diatrizoate, sodium diatrizoate, simethicone, famotidine and aspartame in predetermined amounts that is orally administered to a patient...
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7344705 |
Composition comprising low density microspheres
Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected...
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7338652 |
Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents
New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such...
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7320784 |
Immobilized labeling compounds and methods
The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to the...
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7306786 |
Calcium phosphate cements comprising a water-soluble contrast agent
Methods are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products and include a contrast agent. In the subject methods, dry reactants that include a...
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7306785 |
Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety...
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7288244 |
Determining vulnerable plaque in blood vessels
The invention is based on the realisation that inflamed plaques in blood vessel walls, which are potentially vulnerable to rupture, can be detected at elevated temperatures which are lower than...
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7270799 |
Perturbed membrane-binding compounds and methods of using the same
The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis...
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7270800 |
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7261876 |
Multivalent constructs for therapeutic and diagnostic applications
The invention provides compositions and methods for therapeutic and diagnostic applications.
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7226578 |
Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the...
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7220402 |
Alpha-fetoprotein peptides and uses for imaging
The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include...
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7211241 |
Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography...
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7203350 |
Display for computer-aided diagnosis of mammograms
A method for displaying a computer-generated determination of the likelihood of malignancy in a mammogram lesion. The method requires providing a digitized image of a mammogram, displaying the...
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7198777 |
Optical contrast agents for optically modifying incident radiation
A method of enhancing the contrast of an image of a sample, comprises forming an image of a mixture, by exposing the mixture to electromagnetic radiation. The mixture comprises the sample and...
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7191109 |
Positron emission tomograph apparatus
In a PET apparatus 1, in a calculation processing unit 50, for each frame, radiation data for a region of interest K of a measurement-subjected part H is extracted, and then the optimum...
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7189383 |
Radioactively labelled amino acid analogues, their preparation and use
The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula (I) wherein: R is (C 1 –C 6 ) alkyl optionally substituted with...
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7175830 |
Imaging of drug accumulation as a guide to antitumor therapy
The use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labeled anticancer drug to a patient and imaging at least a part of the patient...
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7155046 |
Method of determining physical parameters of bodily structures
A method is disclosed to accurately determine spatial parameters (for example, the diameter, cross-sectional area and segment length) of bodily structures like human arteries. This is done by...
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7151117 |
Concentrated X-ray contrast media can act as universal antigens and can inhibit or prevent allergic reactions
The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to...
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7141234 |
Imaging of drug accumulation as a guide to antitumor therapy
The present invention describes the use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labelled anticancer drug to a patient and imaging at...
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7138103 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
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7122172 |
Methods and compositions for targeted drug delivery
Disclosed are Drug Delivery Molecules (DDMs) which both facilitate functional imaging, as by PET or SPECT, and create a biological effect and methods of their use. These DDMs are variously designed...
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7122133 |
Finely particulate functional metal and finely particulate functional semiconductor each with dispersion stability and process for producing the same
A stabilized dispersion of metal fine particles comprising, fine particles of metal which is obtained by reducing at least one metallic acid or salt thereof selected from the group consisting of...
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7118730 |
Quinoline derivative as diagnostic probe for disease with tau protein accumulation
The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits...
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7101532 |
Liposome containing hydrophobic iodine compound
A liposome containing a hydrophobic iodine compound such as a 1,3,5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an...
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7091325 |
Fibrin/fibrinogen-binding conjugate
A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding...
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7087722 |
Fibrin binding domain polypeptides and uses and methods of producing same
This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding...
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7067276 |
Method of using metaloporphyrins for treatment of arteriosclerotic lesions
A method for treating arteriosclerotic lesions is provided wherein the method is characterized by administering a chemical compound to the patient, the compound being a porphyrin complexed with a...
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7060251 |
Imaging agents for early detection and monitoring of cardiovascular plaque
The invention provides imaging agents comprising a label in association with a plaque specific targeting molecule. Methods for using the imaging agents to diagnose or monitor plaque formation and...
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7056493 |
Radio-opaque polymer biomaterials
Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy...
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7011816 |
Labeling targeting agents with gallium-68 and gallium-67
A method and compositions are described for labeling a targeting agent with Ga-68, in which eluate from an acid-eluted Ge-68/Ga-68 generator is combined with a macrocycle-containing targetable...
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7003144 |
Vessel delineation in magnetic resonance angiographic images
Delineating vessels in an angiogram involves two methods: graph generation and skeletonization. Generating a graph includes obtaining a digital image of an angiogram, recognizing a first growth...
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6974567 |
Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque
Detectably labeled macrophage scavenger receptor antagonists useful for the diagnosis and monitoring of various cardiovascular diseases including but not limited to atherosclerosis, vulnerable...
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6953567 |
Fluorination of proteins and peptides for F-18 positron emission tomography
Thiol-containing peptides can be radiolabeled with fluorine-18 (F-18) by reacting a peptide comprising a free thiol group with an F-18-bound labelling reagent which also has a group that is...
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6951641 |
Concentrated X-ray contrast media can act as universal antigens and can inhibit or prevent allergic reactions
The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to...
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6926884 |
GPIb-lipid bond construct and use thereof
The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing...
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6893625 |
Chimeric antibody with specificity to human B cell surface antigen
A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production,...
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6872381 |
Radiopharmaceuticals for diagnosing Alzheimer's disease
This invention is directed to the use of radiopharmaceuticals in diagnosing Alzheimer's disease. In particular the radiopharmaceuticals of the invention are able to pass through the blood-brain...
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6818199 |
Media and methods for enhanced medical imaging
Metal nanoparticles are described that are useful for enhancing the contrast of x-rays or other radiation sources. A method is disclosed whereby the agents are administered intravenously or...
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6808698 |
Method for localization of blood clots
A method wherein a radiolabelled compound is localized at a thrombus. Two-dimensional images, representing a physical property associated with the radiolabelled thrombus, are acquired and assembled...
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6776977 |
Polypodal chelants for metallopharmaceuticals
Tripodal polyaminophosphonate chelants are disclosed, as well as chelates of the chelants with metal ions to form radiopharmaceutical and radioactive, MRI and X-ray or CT imaging compounds and...
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6777387 |
Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
The present invention is directed to polymeric prodrug transport forms and methods of making and using the same. In one preferred aspect, the prodrugs are of the formula: wherein G is a...
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6773696 |
Contrast agent comprising low density microspheres
Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total...
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6773695 |
Modulation of allergic response
The modulation or elimination of an allergic condition according to the invention can be achieved by injecting small amounts of allergen directly into a lymph node, which greatly reduces the...
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6743925 |
Nitroimidazole derivative and diagnostic imaging agent containing the same
A nitroimidazole derivative represented by the following formula (1): [wherein R 1 represents a hydrogen atom or a C1-C4 alkanoyl group; and X represents a fluorine atom or an isotope thereof],...
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6737039 |
Methods for detecting lesions in dense breast tissue using LHRH antagonists
Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a...
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