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8182790 |
Contrast agents
A contrast agent of the general formula (I): Z1-L-V-Z2 (I) wherein at least one of Z1 and Z2 is present and are equal or different reporter moieties detectable in in vivo imaging of the human or...
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8147805 |
Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y c...
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8147804 |
Method and device for isolating a chemically and radiochemically cleaned 68Ga-radionuclide and for marking a marking precursor with the 68Ga-radionuclide
The invention relates to initial 68Ge/Ga-generator elute which is guided directly to a cation exchanger, whereon 68Ga is quantitatively absorbed and is cleaned simultaneously in a chemical and...
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8147800 |
Methods and compositions for F-18 labeling of proteins, peptides and other molecules
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or...
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8133472 |
Cyclopeptides containing RGD mimetics as imaging markers for integrins
Radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used...
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8128906 |
Stabilized uncoated particles of reversed liquid crystalline phase materials
Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to...
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8105622 |
Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate...
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8097252 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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8097282 |
Methods of administering liquid droplet aerosols of nanoparticulate drugs
There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface...
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8084018 |
Methods for imaging dopamine transporter level
Presented is a method for assessing dopamine transporter levels in a selected area of a subject's central nervous system by SPECT imaging comprising administering an injection of a labeled dopamine...
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8048407 |
In situ gelling self-reactive materials for embolization
A method and composition for treating arteriovenous malformations (AVMs), or abnormal vasculature in the body are provided. The method comprises introducing into the region of an AVM a composition...
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8003079 |
Core and core-shell nanoparticles containing iodine for X-ray imaging
Nanoparticles having an average particle size of less than 2000 nm, wherein said nanoparticles comprise a polymer having pendant cleavable iodine substituted groups are provided. Processes for...
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7981400 |
Shiga toxin B-subunit as a vector for tumor diagnosis and drug delivery to GB3 expressing tumors
The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs...
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7947253 |
Perturbed membrane-binding compounds and methods of using the same
The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis...
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7920735 |
Method and device for automatically differentiating bones or other calcium-containing materials and contrast agent in soft tissue
In at least one embodiment, two image data records of two computed tomography pictures of the object are provided that have been recorded in the context of a different spectral distribution of the...
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7914787 |
Production and use of novel peptide-based agents with bispecific antibodies
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a...
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7894880 |
Measurement of renal extraction fraction using contrast enhanced computed tomography
Renal extraction fraction (EF) is determined through use of computed tomography (CT) measurements of arterial blood before and after injection of a radiographic contrast agent into the blood and CT...
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7892547 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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7862800 |
Radiopaque cyanoacrylate compositions
This invention relates to sterilized cyanoacrylate adhesive compositions with x-ray imagining capabilities, methods of making such compositions, and methods of using such compositions.
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7863047 |
Intracorporeal medicaments for photodynamic treatment of disease
New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a...
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7837982 |
Imaging agents
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged...
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7820164 |
Chimeric, human and humanized anti-CSAP monoclonal antibodies
The present invention provides humanized, chimeric and human anti-CSAp antibodies and anti-CSAp antibody fusion proteins that are useful for the treatment and diagnosis of various cancers,...
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7815894 |
Compounds, compositions and methods for medical imaging of neuropsychiatric disorders
Compounds, compositions and methods for the diagnosis of Alzheimer's disease. Synthesized Glycerophosphocholine (GPC) may be used as a diagnostic aid to measure progression of Alzheimer's disease....
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7811551 |
Imaging agents
The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy...
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7811549 |
Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects
Methods are presented that comprise the administration of a pharmaceutical composition comprising adenosine and dipyridamole, as well methods comprising the combined administration of dipyridamole...
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7803352 |
Method for continuous visualization of a blood clot or plaque in body lumen
A method for visualizing a blood clot or plaque disposed within a body lumen comprising: binding a contrasting complex comprising a contrast material and a thrombolytic material or a clot...
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7790860 |
Targeting and imaging tumor vasculature using conjugates that bind to aminophospholipids
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidyserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor...
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7790141 |
Radio-opaque compounds, compositions containing same and methods of their synthesis and use
Radio-opaque biodegradable compositions are formed by modifying terminal groups of synthetic and natural biodegradable polymers such as polylactones with iodinated moieties. The biodegradable...
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7785568 |
Compositions and methods for enhancing contrast in imaging
Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided....
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7771705 |
Radiographic contrasting agents and radio-opaque polymeric materials for medical devices
The present invention discloses a radiographic contrasting agent containing multiple aromatic groups, each of which is substituted with at least three halogen atoms. The radiographic contrasting...
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7763234 |
Pharmaceutical compounds
A pharmaceutical of the general formula Z—(L)n-V, wherein V denotes an amino acid sequence X1-X2-Val-Tyr-Ile-His-Pro-X8-X9-X10; L denotes a bond or a linker; Z denotes a group that optionally can c...
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7731940 |
Compositions and methods related to serotonin 5-HT1A receptors
Contemplated substituted arylpiperazinyl compounds, and most preferably 18F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous...
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7713516 |
Method for determining suitability of various contrast agents for the imaging examination of the patient and uses of the ligand contained in a selected contrast agent
A method is for determining suitability of various contrast agents for the imaging examination of the. In this case, a tissue sample is taken from the patient, it is divided into a plurality of...
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7715901 |
Sensitized online BOLD-MRI imaging method
An online Blood Oxygenation Level-Dependent (BOLD)-magnetic resonance imaging (MRI) method for functional clinical guidance or monitoring a therapeutic modality involving treatment by a sensitizer...
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7713517 |
Compositions and methods for enhancing contrast in imaging
Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided....
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7708979 |
Thermogelling polymer blends for biomaterial applications
Thermogelling polymers are described containing poly (n-isopropyl acrylamide). Solutions of this polymer, copolymers or mixtures of the polymer with a second polymer such as poly(ethylene glycol),...
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7704488 |
Dendritic and star-shaped contrast agents for medical devices and bioabsorbable radiopaque bulk material and method for producing same
In accordance with the present invention, a high intensity radiopaque contrast agent is disclosed. The agent may be coated on or incorporated within bulk materials, which may then be subsequently...
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7700075 |
Virtual colonoscopy with radiolabeled phospholipid ether analogs
The present invention provides agents and methods for dual modality virtual colonoscopy that gives both anatomical and functional information using hybrid CT/PET scanning. In preferred embodiments,...
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7684852 |
System, formulation, kit and method for tagging colonic residue in an individual
This invention relates to a colonic residue tagging system, formulation, kit and method for use in preparing an individual for a predetermined activity which requires tagging at least some colonic...
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7670590 |
Perturbed membrane-binding compounds and methods of using the same
The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis...
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7666392 |
Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins
The present application is directed to radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic...
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7666390 |
DTPA derivatives and metal complexes thereof, and radiation source and contrast agent including the metal complexes
The present invention relates to diethylenetriamine pentaacetic acid (DTPA) derivates and metal complexes thereof, and radiation sources and contrast agents including the metal complexes. More...
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7658913 |
Compositions useful for reducing nephrotoxicity and methods of use thereof
The present invention provides compositions and methods to reduce renal damage caused by nephrotoxic drugs. The invention provides compositions comprising a substituted cyclodextrin, a nephrotoxic...
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7648713 |
Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate...
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7635464 |
Selective targeting of apoptotic cells
The invention relates to a method of selectively targeting an active agent (or agent capable of becoming an active agent) to apoptotic cells in a vertebrate, comprising administering to said...
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7608407 |
Fluorescence polarization assay for determining histidine decarboxylase activity
The present invention relates to fluorescence polarization assays for determining the HDC modulating activity of a candidate compound including providing a reaction mixture comprising a HDC,...
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7601333 |
Use of a tetrapeptide AcSDKP (SEQ ID No. 1) analog resistant to the angiotensin I converting enzyme for measuring glomerular filtration rate in a human or an animal and kit containing same
The invention concerns the use of ACE-resistant N-acétyl-Ser-Asp-Lys-Pro analogues for preparing a reagent or marker adapted to measure a glomerular filtration rate.
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7597876 |
Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled...
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7591998 |
Stool marker
A stool marker formulation for oral administration and suitable for use in CT Colography including a material adapted to provide marked stool which has a modified response to radiation relative to...
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7570411 |
Optical limiter having trimetallic nitride endohedral metallofullerence films
An exemplary optical limiter device (100) has an optically transmissive substrate (102) and a layer (104) on a first surface (106) of the substrate, the layer having a trimetallic nitride...
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