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7863047 |
Intracorporeal medicaments for photodynamic treatment of disease
New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a...
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7820144 |
Receptor selective cannabimimetic aminoalkylindoles
Disclosed are cannabimimetic aminoalkylindole compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. The disclosed compounds may...
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7715901 |
Sensitized online BOLD-MRI imaging method
An online Blood Oxygenation Level-Dependent (BOLD)-magnetic resonance imaging (MRI) method for functional clinical guidance or monitoring a therapeutic modality involving treatment by a sensitizer...
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7648695 |
Medicaments for chemotherapeutic treatment of disease
New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a...
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7402299 |
Intracorporeal medicaments for photodynamic treatment of disease
New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a...
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7396681 |
Application of Hsp70 proteins
The invention relates to the use of Hsp70 protein or fragments thereof for the activation of NK-cells, pharmaceutical preparations, medical product or medical adjuvants containing a Hsp70 protein...
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7384623 |
High energy phototherapeutic agents
High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive...
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7172749 |
Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and...
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6818202 |
Enhancement of NMR and MRI in the presence of hyperpolarized noble gases
The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which...
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6652833 |
Functionalized active-nucleus complex sensor
A functionalized active-nucleus complex sensor that selectively associates with one or more target species, and a method for assaying and screening for one or a plurality of target species...
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6596258 |
Method of obtaining extracellular and intracellular pH images and spectra by magnetic resonance using extrinsic indicators containing 1H or 19F
The present invention refers to the use of a selection of imidazole compounds in a method of obtaining extracellular or intracellular pH images in biological systems, by magnetic resonance,...
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6593144 |
Magnetic resonance imaging using hyperpolarized noble gases
A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and...
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6586592 |
Bis-arylsulfones
The present invention provides pharmaceutically active compounds useful for the treatment of diseases or disorders of the central nervous system.
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6562319 |
Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and...
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6493570 |
Method for improved imaging and photodynamic therapy
The present invention is directed to an apparatus and method of imaging and treatment using at least one photodynamic therapy (“PDT”) agent. In particular, the apparatus and method is for ima...
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6420436 |
Imaging contrast media and methods of use
This invention relates to a non-aqueous fluorocarbon composition for use in magnetic resonance imaging (MRI) or radiographic imaging (X-ray or computed tomography), particularly imaging of the...
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6417384 |
Radioiodinated phospholipid ether analogs and methods of using the same
The present invention provides improved radioiodinated phospholipid ether analogs which demonstrate significant tumor avidity and longer plasma half-life than shorter-chain analogs. The...
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6315981 |
Gas filled microspheres as magnetic resonance imaging contrast agents
Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.
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6177059 |
GPIb-lipid complex and uses thereof
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6042809 |
Administrable compositions and methods for magnetic resonance imaging
The invention relates to the application of hyperpolarized gases to magnetic resonance imaging (MRI) of living subjects. The invention also concerns administrable compositions, formulations,...
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5922304 |
Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.
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5827502 |
Microparticulate microbubble-generating contrast agents
The present invention relates to contrast agents comprising microbubble-generating carbohydrate particles having a surfactant admixed within the microparticulate structure, wherein the microbubbles...
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5811581 |
Process for the purification of opacifying contrast agents
A process for the purification of opacifying contrastographic agents, comprising chromatographic and nanofiltration techniques combined together, the subsequent chromatographic separation of the...
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5785950 |
Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of making and using them
This invention relates to compositions comprising highly fluorinated, chloro-substituted, non-cyclic organic compounds having 7 to 9 carbon atoms and to processes of making and using them. More...
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5770181 |
Composition and method for delivering active agents
This invention relates to a non-aqueous fluorocarbon composition for use in magnetic resonance imaging (MRI) or radiographic imaging (X-ray or computed tomography), particularly imaging of the...
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5660815 |
Water soluble fluorinated fatty acid sulfonate derivatives useful as magnetic resonance imaging agents
The present invention relates to improved imaging agents useful for 19 F magnetic resonance imaging (MRI). More particularly, the present invention relates to fluorinated fatty acid sulfonate...
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5639444 |
Method of electrical impedance imaging using a triiodophenyl compound or gas encapsulated microbubbles
Agents for use in improving tissue/tissue contrast in electrical impedance tomography are described. In particular triiodophenyl compounds, metal chelates, magnetic particles, conducting particles...
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5622687 |
Calixarene conjugates useful as MRI and CT diagnostic imaging agents
Calixarene conjugates useful for imaging, particularly magnetic resonance imaging (MRI) and computed tomography (CT) are described. Said calixarene conjugates comprise (i) a calixarene backbone,...
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5603917 |
Methods for the in vivo measurement of the concentration of NMR-detectable xenobiotic compounds
Methods wherein the concentration of NMR-detectable xenobiotic compounds may be determined in living subjects by in vivo measurement of one or more magnetic resonance signals. In preferred...
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5558856 |
Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging
The present invention relates to contrast agents comprising microbubble-generating carbohydrate particles having a surfactant admixed within the microparticulate structure, with the proviso that...
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5540908 |
Detection of hypoxia with reagents containing 2-nitroimidazole compounds and methods of making such reagents
Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly...
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5536491 |
19 F poly aza macrocyclic MRI contrast medium
A 19 F-MRI contrast medium for MRI using 19 F as a detectable nucleus, comprising a metal complex compound in which a macro-cyclic polyamine ligand containing not less than one fluorine atoms is...
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5516977 |
Xenogeneic tissue implant in ear pinna
Immunocompromised hosts comprising xenogeneic fetal lymph node tissue implanted in the ear pinna are provided. The chimeric hosts are prepared by inserting the xenogeneic lymph node tissue into the...
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5505932 |
Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging
In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents...
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5498421 |
Composition useful for in vivo delivery of biologics and methods employing same
In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a...
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5496536 |
Percutaneous lymphography
Injectable contrast agents of great clinical importance for lymphography, characterized by non-water soluble particle sizes between about 5 or 10 nm and about 500 or 900 nm, which have selective...
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5496535 |
Fluorocarbon contrast media for use with MRI and radiographic imaging
This invention relates to a non-aqueous fluorocarbon composition for use in magnetic resonance imaging (MRI) or radiographic imaging (X-ray or computed tomography), particularly imaging of the...
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5439669 |
Biological imaging emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
Oil and water emulsions containing alkylphosphoryl choline or alkylglycerophosphoryl choline surfactants are disclosed. The surfactants have the following general structures: ##STR1## In the above...
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5401493 |
Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same
Organic compounds for diagnostic imaging which contain at least one aryl group which has been derivatized to contain at least one perfluoro-1H,1H-neopentyl moiety are provided. The...
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5397563 |
Perfluoro-t-butyl-containing steroids for use in fluorine-19 NMR and/or MRI
Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The...
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5397562 |
Use of 19 F magnetic resonance to non-invasively assess pO2 and temperature in vivo
Oxygen tension of tissue in a living subject may be determined non-invasively by a method which involves: administering to a living mammalian subject a biologically compatible perfluorocarbon...
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5393513 |
Stable, highly concentrated fluoro carbon emulsions
A non-toxic, brominated perfluorocarbon emulsion for internal and intravenous use in animals (including humans) is disclosed, for use as an oxygen transport medium and as a contrast enhancement...
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5385724 |
Trifluoromethyl analogs of X-ray contrast media for magnetic resonance imaging
Methods and compositions are disclosed for enhancing 19 F magnetic resonance imaging which utilize trifluoromethyl derivatives of iodinated X-ray contrast media. Typical magnetic resonance contrast...
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5358704 |
Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
Novel compounds of the formula ##STR1## and metal chelates of the compounds are useful particularly for MRI of the hepatobiliary system.
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5324504 |
Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI
Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The...
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5324503 |
Iodo-phenylated chelates for x-ray contrast
Hybrid agents for enhancing in vivo diagnostic imaging of body organs and tissues, and methods of preparing and using the same.
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5284645 |
Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems
Disclosed are fluorocarbon emulsions comprising amino acids and substances related to amino acids, such as substituted amino acids or amphoteric groups of amino acid side chains, for example, the...
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5236694 |
19F labelled dextrans and antibodies as NMR imaging and spectroscopy agents
19 F labelled compounds are disclosed which are useful in methods of NMR imaging and spectroscopy. The compounds comprise a 19 F-containing sensor moiety, and a transport polymer or substrate, and...
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5234680 |
Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI
The present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl...
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5130119 |
Method of using fluorosubstituted benzene derivatives in F-NMR imaging
Fluorosubstituted benzene derivatives of Formula I ##STR1## wherein Y, R2, R3 and R4 are defined herein, are NMR diagnostic agents.
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