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7608249 |
Enhanced substrate imaging by reversible binding to a paramagnetic complex
The invention relates to a method for the Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Imaging of a substrate molecule different from water wherein the NMR signal is enhanced by a...
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7582280 |
Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications
The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such...
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7557577 |
Water-soluble paramagnetic substance reducing the relaxation time of the coolant in an MRI system
The invention relates to the use of a water-soluble paramagnetic substance, in particular a magnetic resonance contrast medium, to reduce the magnetic resonance relaxation time of a coolant for...
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7524483 |
Responsive paramagnetic MRI contrast agents
A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
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7438893 |
Polybiotin compounds for magnetic resonance imaging and drug delivery
The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds...
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7229606 |
Diagnostic imaging contrast agents with extended blood retention
The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
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7226578 |
Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the...
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7211241 |
Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography...
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7208139 |
Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic...
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7074387 |
DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production
Compounds of formula I
wherein Z 1 , Z 2 , X, R 2 and R 3 are as defined herein, are suitable as NMR shift reagents.
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6818203 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
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6803030 |
Bile acids conjugates with metal ion chelates and the use thereof
Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.).
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6676928 |
Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with polar radicals of general formula I (K) 1 -G-(Z-R f ) m (R) p (I) in which R means the polar radical, R f means a perfluorinated carbon chain, K is a...
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6641797 |
Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH...
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6548044 |
Imaging sexual response
The present invention relates to methods for contrast-enhanced imaging of sexual response. In particular, the present invention relates to methods of magnetic resonance imaging (MRI), computerized...
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6521209 |
Bifunctional detection agents
The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
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6468502 |
Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the...
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6461588 |
Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics
Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance...
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6337064 |
Manganese chelates with high relaxivity in serum
Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging.
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6254850 |
Metal complexes, suitable for use in diagnosis and therapy
The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents...
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6232295 |
Cell-specific contrast agent and gene delivery vehicles
A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the...
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6123921 |
Bifunctional detection agents having an optical dye linked to an MRI contrast agent
The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
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6045776 |
Process for the production of metal-complex carboxylic acid amides
The invention relates to a process for the production of metal-complex carboxylic acid amides, characterized in that a metal-complex carboxylic acid mixture that consists of the metal-complex...
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6040432 |
Metal complexes, of DTPA derivatives suitable for use in diagnosis and therapy
The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents...
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5932707 |
Thioether-containing metal chelating compounds
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have the formula (a) and (b), where A, A'=--SZ or...
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5919433 |
Macrocyclic metal complex carboxylic acids, their use as well as process for their production
The invention relates to new macrocyclic metal complex carboxylic acids of formula II ##STR1## whereby Z o stands for a metal ion equivalent of atomic numbers 58-71 and R stands for a CHX 1 ...
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5919432 |
Polyaminated ligands and metal complexes thereof
Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formula CH(R 1...
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5914097 |
Amino-acyl-type and catecholamine-type contrast agents for MRI
The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate...
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5914095 |
Polychelants containg amide bonds
There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA...
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5900228 |
Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
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5885548 |
Multiply substituted DTPA derivatives and their metal complexes, and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents
The invention relates to new, multiply substituted diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or...
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5843399 |
DTPA monoamides for MRI
Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z 1 , Z 2...
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5804164 |
Water-soluble lipophilic contrast agents
The present invention relates to water-soluble, lipophilic contrast-enhancing agents, pharmaceutical compositions thereof and methods for diagnostic analysis, particularly NMR or MRI analysis using...
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5801228 |
Polymeric contrast agents for medical imaging
The invention provides polymeric polychelants containing polymer repeat units of formula L--Ch--L--B! (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic...
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5759518 |
Metal complexes of dendrimeric macromolecules, diagnostics agents that contain the latter as well as process for the production of the complexes and agents
The invention relates to new metal complexes of dendrimeric macromolecules that contain 8 to 64 ions of an element of atomic numbers 21-129, 39, 42-44, or 57-83 and a polymeric, complexing ligand...
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5733528 |
Paramagnetic chelates for nuclear magnetic resonance diagnosis
New compounds endowed with a chelating property for paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging...
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5730956 |
DTPA di-alkyl monoamides for x-ray and MRI
The invention relates to diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing gadolinium, dysprosium, iron or manganese, pharmaceutical agents...
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5693310 |
Amide complexes
Compounds of general Formula I ##STR1## wherein R 3 is a saturated, unsaturated, straight- or branched-chain or cyclic aliphatic hydrocarbon residue of up to 16 carbon atoms or, if R 4 is a...
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5676923 |
Substituted DTPA monoamides of the central carboxylic acid group and their metal complexes
Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents...
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5672335 |
Use of metal complexes as liver and gallbladder X-ray diagnostic agents
Metal complexes containing a metal of atomic numbers 39-42, 44-51 or 56-83 and a complexing agent can be used for the production of contrast media for use in the contrast-enhanced computer...
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5651955 |
Method of electrical impedance imaging using ionic metal chelates
A method of electrical impedance imaging (EII) of a subject comprising administering an EII sensitive contrast agent and generating an electrical impedance image of at least part of the subject.
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5635158 |
Peptides modified by the phosphine group for marking with 99M TC and 186-188 RE or paramagnetic agents
The peptides described are modified with the phosphine group and are useful for marking with 99m Tc and 186 -188 Re or paramagnetic agents for use in diagnosis and radiotherapy; in particular...
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5616312 |
Thiol ligands and complexes for X-ray imaging
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein R 1 , R 2 , R 3 , R 4 , and R 5 are the same or different and...
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5614170 |
Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an...
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5571498 |
Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an...
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5554357 |
Magnetic resonance imaging agents containing hydrazide moieties
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized...
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5531978 |
Aminopolycarboxylic acids and derivatives thereof
There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and...
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5494655 |
Methods for detecting blood perfusion variations by magnetic resonance imaging
The invention provides a method of monitoring the vasodilatory or vasoconstrictive effects of a physiologically active substance administered to a human or non-human animal body, said method...
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5476644 |
Cyclic triamine chelating agents
The present invention provides compounds of the formula ##STR1## chelated with a paramagnetic metal ion wherein Z1 and Z2 each represent the atoms necessary to complete a monocyclic or polycyclic...
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5466439 |
Polymeric contrast enhancing agents for magnetic resonance images
A polymeric contrast enhancing agent for magnetic resonance images having a chelating agent, which can be bound to metal ions having at least one unpaired electron, such as gadolinium. Examples of...
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