Patents in Class 424/9.365

Matches 1 - 50 out of 81

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Match	Document	Document Title
1	8092782	Polybiotin compounds of magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds...
2	8017105	Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
3	8003078	Targeted MR imaging agents MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient...
4	7988950	Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (MRI) which contain a chelating moiety with polyhydroxylated substituents The present invention relates to a novel class of paramagnetic ion-based contrast i agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or...
5	7917188	Method for using CEST contrast agents in MRI A method for mapping a physico-chemical parameter using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging is used with agents having only one exchangeable entity...
6	7897140	Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in...
7	7807140	Magnetic resonance imaging contrast agents synthesized using ring-opening metathesis polymerization Polymeric chelating agents and metal chelates, particularly those of lanthanide metals and more specifically those of Gd(III), useful as contrast agents in magnetic resonance imaging (MRI) for...
8	7727512	Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
9	7666390	DTPA derivatives and metal complexes thereof, and radiation source and contrast agent including the metal complexes The present invention relates to diethylenetriamine pentaacetic acid (DTPA) derivates and metal complexes thereof, and radiation sources and contrast agents including the metal complexes. More...
10	7608249	Enhanced substrate imaging by reversible binding to a paramagnetic complex The invention relates to a method for the Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Imaging of a substrate molecule different from water wherein the NMR signal is enhanced by a...
11	7557577	Water-soluble paramagnetic substance reducing the relaxation time of the coolant in an MRI system The invention relates to the use of a water-soluble paramagnetic substance, in particular a magnetic resonance contrast medium, to reduce the magnetic resonance relaxation time of a coolant for...
12	7524483	Responsive paramagnetic MRI contrast agents A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
13	7438893	Polybiotin compounds for magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds...
14	7229606	Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
15	7226578	Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention...
16	7211241	Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography...
17	7208139	Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic and...
18	7074387	DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as NMR shift reagents.
19	6818203	Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a p...
20	6803030	Bile acids conjugates with metal ion chelates and the use thereof Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.).
21	6676928	Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use Perfluoroalkyl-containing complexes with polar radicals of general formula I (K)1-G-(Z-Rf)m(R)p (I) in which R means the polar radical, Rf means a perfluorinated carbon chain, K is a metal complex,...
22	6641797	Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH position,...
23	6521209	Bifunctional detection agents The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
24	6468502	Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention...
25	6461588	Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance...
26	6337064	Manganese chelates with high relaxivity in serum Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging.
27	6254850	Metal complexes, suitable for use in diagnosis and therapy The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents...
28	6232295	Cell-specific contrast agent and gene delivery vehicles A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the...
29	6123921	Bifunctional detection agents having an optical dye linked to an MRI contrast agent The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
30	6045776	Process for the production of metal-complex carboxylic acid amides The invention relates to a process for the production of metal-complex carboxylic acid amides, characterized in that a metal-complex carboxylic acid mixture that consists of the metal-complex...
31	6040432	Metal complexes, of DTPA derivatives suitable for use in diagnosis and therapy The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents...
32	5932707	Thioether-containing metal chelating compounds Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have the formula (a) and (b), where A, A'=--SZ or...
33	5919433	Macrocyclic metal complex carboxylic acids, their use as well as process for their production The invention relates to new macrocyclic metal complex carboxylic acids of formula II ##STR1## whereby Zo stands for a metal ion equivalent of atomic numbers 58-71 and R stands for a CHX1...
34	5919432	Polyaminated ligands and metal complexes thereof Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formula...
35	5914097	Amino-acyl-type and catecholamine-type contrast agents for MRI The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate...
36	5914095	Polychelants containg amide bonds There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA...
37	5900228	Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
38	5885548	Multiply substituted DTPA derivatives and their metal complexes, and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents The invention relates to new, multiply substituted diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or...
39	5843399	DTPA monoamides for MRI Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z1, Z2, R1,...
40	5804164	Water-soluble lipophilic contrast agents The present invention relates to water-soluble, lipophilic contrast-enhancing agents, pharmaceutical compositions thereof and methods for diagnostic analysis, particularly NMR or MRI analysis using...
41	5801228	Polymeric contrast agents for medical imaging The invention provides polymeric polychelants containing polymer repeat units of formula L--Ch--L--B! (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic...
42	5759518	Metal complexes of dendrimeric macromolecules, diagnostics agents that contain the latter as well as process for the production of the complexes and agents The invention relates to new metal complexes of dendrimeric macromolecules that contain 8 to 64 ions of an element of atomic numbers 21-129, 39, 42-44, or 57-83 and a polymeric, complexing ligand...
43	5733528	Paramagnetic chelates for nuclear magnetic resonance diagnosis New compounds endowed with a chelating property for paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging...
44	5730956	DTPA di-alkyl monoamides for x-ray and MRI The invention relates to diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing gadolinium, dysprosium, iron or manganese, pharmaceutical agents...
45	5693310	Amide complexes Compounds of general Formula I ##STR1## wherein R3 is a saturated, unsaturated, straight- or branched-chain or cyclic aliphatic hydrocarbon residue of up to 16 carbon atoms or, if R4 is a hydrogen...
46	5676923	Substituted DTPA monoamides of the central carboxylic acid group and their metal complexes Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents...
47	5672335	Use of metal complexes as liver and gallbladder X-ray diagnostic agents Metal complexes containing a metal of atomic numbers 39-42, 44-51 or 56-83 and a complexing agent can be used for the production of contrast media for use in the contrast-enhanced computer...
48	5651955	Method of electrical impedance imaging using ionic metal chelates A method of electrical impedance imaging (EII) of a subject comprising administering an EII sensitive contrast agent and generating an electrical impedance image of at least part of the subject.
49	5635158	Peptides modified by the phosphine group for marking with 99M TC and 186-188 RE or paramagnetic agents The peptides described are modified with the phosphine group and are useful for marking with 99m Tc and 186-188 Re or paramagnetic agents for use in diagnosis and radiotherapy; in particular...
50	5616312	Thiol ligands and complexes for X-ray imaging The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein R1, R2, R3, R4, and R5 are the same or different and are...

Matches 1 - 50 out of 81

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