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7608249 |
Enhanced substrate imaging by reversible binding to a paramagnetic complex
The invention relates to a method for the Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Imaging of a substrate molecule different from water wherein the NMR signal is enhanced by a...
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7557577 |
Water-soluble paramagnetic substance reducing the relaxation time of the coolant in an MRI system
The invention relates to the use of a water-soluble paramagnetic substance, in particular a magnetic resonance contrast medium, to reduce the magnetic resonance relaxation time of a coolant for...
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7438893 |
Polybiotin compounds for magnetic resonance imaging and drug delivery
The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds...
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7279150 |
Chelating agents with lipophilic carriers
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
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7270799 |
Perturbed membrane-binding compounds and methods of using the same
The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis...
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7229606 |
Diagnostic imaging contrast agents with extended blood retention
The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
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7211241 |
Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography...
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7208139 |
Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic...
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7198776 |
Metal complex compounds
The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination...
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7175829 |
Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an...
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7132513 |
Bifunctional chelating agent
The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO 2 , —NH 2 , —NCS, —NHCOCH 2 -Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH 2 -Q, or...
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7074387 |
DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production
Compounds of formula I
wherein Z 1 , Z 2 , X, R 2 and R 3 are as defined herein, are suitable as NMR shift reagents.
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7060250 |
Diagnostic imaging contrast agents with extended blood retention
The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
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7045606 |
Bifunctional chelating agent for actinium
The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z,...
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7029655 |
Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic...
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6818203 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
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6803030 |
Bile acids conjugates with metal ion chelates and the use thereof
Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.).
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6709646 |
Bioactivated diagnostic imaging contrast agents
The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow...
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6676928 |
Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with polar radicals of general formula I (K) 1 -G-(Z-R f ) m (R) p (I) in which R means the polar radical, R f means a perfluorinated carbon chain, K is a...
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6652835 |
Targeting multimeric imaging agents through multilocus binding
The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon...
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6641797 |
Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH...
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6589506 |
Method for magnetic resonance imaging of the lung
A method for the assessment of pulmonary ventilation and lung perfusion through Magnetic Resonance Imaging (MRI), comprising the steps of: positioning a human subject in an MRI apparatus,...
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6521209 |
Bifunctional detection agents
The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
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6468502 |
Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the...
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6403055 |
Diagnostic imaging contrast agent with improved in serum relaxivity
Compounds of formula (I): are used as their paramagnetic chelates as contrast agents in magnetic resonance imaging. These compounds have high affinity to plasma proteins and exhibit extremely...
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6337064 |
Manganese chelates with high relaxivity in serum
Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging.
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6312664 |
Biodegradable contrast media for MR imaging
A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone...
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6303761 |
Triaminepentaacetic acid compound and paramagnetic metal complex prepared from using the compound as ligand
The present invention provides a triaminepentaacetic acid compound which can be used as a ligand to coordinate to a metal ion to form a paramagnetic metal complex. The paramagnetic metal complex of...
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6254850 |
Metal complexes, suitable for use in diagnosis and therapy
The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents...
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6232295 |
Cell-specific contrast agent and gene delivery vehicles
A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the...
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6165378 |
Polysaccharide derivative/magnetic metal oxide composite
The present invention provides a polysaccharide-magnetic metal oxide complex consisting of a polysaccharide derivative obtained by carboxyalkyl-etherifying and unsubstituted or substituted...
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6123921 |
Bifunctional detection agents having an optical dye linked to an MRI contrast agent
The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
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6113880 |
Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging
The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.
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6099824 |
Benzyloxy derivatives of DTPA for MRI
Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having...
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6068831 |
Pseudopolyrotaxanes
The invention relates to new metal complex-containing or iodine-containing benzene derivatives that contain pseudopolyrotaxanes. They are valuable compounds for diagnosis. The pseudopolyrotaxane...
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6060040 |
Cross-linked polymeric compositions for increasing the MRI contrast in visualising the digestive tract of patients
The invention provides, as contrast signal generators in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R 1 R 2 )CR 3 --CO--Z--A (1)...
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6057419 |
Cascade polymer complexes, process for producing the same and pharmaceuticals containing the same
Cascade polymer complexes that contain a) complexing ligands of general formula (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of...
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6045775 |
Parenteral administration of positive and negative contrast agents for MRI
This invention relates to improvements in and relating to magnetic resonance imaging of the human or non-human body. The invention particularly relates to a method in which positive and negative...
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6040432 |
Metal complexes, of DTPA derivatives suitable for use in diagnosis and therapy
The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents...
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6039931 |
Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
Compounds of general Formula I ##STR1## wherein Z 1 and Z 2 in each case independently mean the residue --(CH 2 ) m --(C 6 H 4 ) q --(O) k --(CH 2 ) n --(C 6 H 4 ) l --(O) r --R, ...
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6022524 |
Process for the conjugation of chelants with molecules containing amino groups
A process for the preparation of macromolecular chelants characterized by a high content in chelant groups per macromolecule.
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6010681 |
Biodegradable blood-pool contrast agents
The invention provides a blood pool contrast agent having an overall molecular weight of at least 10KD comprising a macrostructure which has bound thereto a plurality of opsonization inhibiting...
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5961953 |
Magnetic resonance blood pool agents
The present invention provides compositions comprising contrast agents capable of binding non-covalently to blood proteins. The compositions of the invention provide increased residence time of...
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5900228 |
Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
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5885548 |
Multiply substituted DTPA derivatives and their metal complexes, and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents
The invention relates to new, multiply substituted diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or...
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5876695 |
Metal complex-containing pharmaceutical agents
Improved metal complex-containing pharmaceutical agents are described which, as an additive, contain one or more complexing agents and/or one or more weak metal complex(es) or mixtures thereof.
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5871710 |
Graft co-polymer adducts of platinum (II) compounds
A biocompatible graft co-polymer adduct including a polymeric carrier, a protective chain linked to the polymeric carrier, a reporter group linked to the carrier or to the carrier and the...
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5869023 |
Composition for MRI comprising both a positive and a negative contrast agent
This invention relates to improvements in and relating to magnetic resonance imaging of the human or non-human body. The invention particularly relates to a method in which positive and negative...
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5833947 |
Magnetic resonance imaging
The invention provides a method of monitoring the vasodilatory or vasoconstrictive effects of a physiologically active substance administered to a human or non-human animal body, said method...
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5817292 |
MR imaging compositions and methods
This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer...
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