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7608249 |
Enhanced substrate imaging by reversible binding to a paramagnetic complex
The invention relates to a method for the Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Imaging of a substrate molecule different from water wherein the NMR signal is enhanced by a...
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7438893 |
Polybiotin compounds for magnetic resonance imaging and drug delivery
The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds...
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7368100 |
Backbone-substituted bifunctional DOTA ligands, complexes and compositions thereof, and methods of using same
Backbone-substituted 1,4,7,10-tetraaza cyclododecane-N,N′,N″,N′″-tetraacetic acid compounds, metal complexes thereof, compositions thereof, conjugates thereof, and methods of use in...
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7354568 |
Magnetic resonance imaging agents for the detection of physiological agents
The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
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7351389 |
Aminocarboxylate ligands having substituted aromatic amide moieties
Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula
wherein R 13 , A 1 , R 1 and R 2 are as...
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7344704 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
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7341711 |
Porphyrin compounds and their use in high-field MRI
A new use in magnetic resonance imaging employing a field greater than 1.5 Tesla, of a porphyrin compound of the following general formula I is provided:
in which R 0 and R′ 0 are such that...
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7338651 |
Multi-use multimodal imaging chelates
Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10...
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7306785 |
Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety...
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7226578 |
Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the...
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7211241 |
Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography...
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7208140 |
Trimeric macrocyclic substituted benzene derivatives
The metal complexes of general formula I
in which Hal stands for bromine or iodine and A 1 and A 2 have different meanings, are suitable as contrast media.
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7198776 |
Metal complex compounds
The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination...
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7163935 |
Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging...
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7125965 |
MRI probes of membrane potential
The invention provides methods and compositions for molecular resonance imaging of membrane potential. The compositions comprise an indicator moiety attached through an optional linker to a...
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7081452 |
Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging...
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7078013 |
Pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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7029655 |
Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic...
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7012140 |
Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
The present invention is directed, in general, to a contrast agent comprising a tetraazacyclododecane ligand and comprising a macrocyclic ring and a paramagnetic metal ion coordinated to the...
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6951639 |
1,4,7,10-tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them
1,4,7,10-Tetraazacyclodedecane butyltriols of general formula I A
in which
R 1 means hydrogen or a metal ion equivalent independent of one another and R 2 means a butyltriol radical...
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6875419 |
Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use
The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism....
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6869589 |
Cryptate compounds and methods for diagnosis and therapy
The present invention relates to cryptate compounds useful as chelating agents. In particular, the present invention relates to functionalized derivatives of certain cryptate compounds. These...
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6827927 |
Gadolinium complex tetramides and use in medical imaging
The invention concerns a racemic compound of the pair of enantiomers of formula (III) wherein R represents an alkyl group or a phenyl group optionally substituted.
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6825317 |
Cyclic tetrapeptide derivatives and pharmaceutical uses thereof
The present invention provides a cyclic tetrapeptide derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: wherein each of R 21 and R 22 ...
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6818203 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
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6774228 |
Tetra-aza macrocycles and metal complexes thereof
1,4,7,10-Tetrazacyclododecanes carrying a side chain terminating in a group capable of reacting with an antibody, and their complexes with a di- or tripositive metal having a coordination number of...
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6746662 |
pH sensitive MRI contrast agents
A composition and method is disclosed for providing a magnetic resonance imaging contrast agent that is sensitive to pH, the compound and salts thereof including, a tetraaza base having a spacer at...
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6719958 |
Polychelants, their complexes with metal ions, their preparation and their uses
A new class of polychelants, their chelates with metal ions and their physiologically acceptable salts, useful, either as they are or in association or formulation with other components, for...
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6713046 |
Magnetic resonance imaging agents for the delivery of therapeutic agents
The invention relates to novel magnetic resonance imaging contrast agents and methods of delivering therapeutically active agents.
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6709646 |
Bioactivated diagnostic imaging contrast agents
The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow...
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6676928 |
Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with polar radicals of general formula I (K) 1 -G-(Z-R f ) m (R) p (I) in which R means the polar radical, R f means a perfluorinated carbon chain, K is a...
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6673333 |
Functional MRI agents for cancer imaging
The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.
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6656450 |
Macrocyclic magnetic resonance imaging contrast agents
The invention relates to novel magnetic resonance imaging contrast agents.
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6652835 |
Targeting multimeric imaging agents through multilocus binding
The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon...
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RE38329 |
Chelated complexes of paramagnetic metals with low toxicity
Compounds of formula (I) and (II) wherein the R, R 1 , R 2 , R 3 and R 4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I)...
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6641797 |
Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH...
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6589506 |
Method for magnetic resonance imaging of the lung
A method for the assessment of pulmonary ventilation and lung perfusion through Magnetic Resonance Imaging (MRI), comprising the steps of: positioning a human subject in an MRI apparatus,...
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6521209 |
Bifunctional detection agents
The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
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6468502 |
Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the...
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6358490 |
Three-step pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, three-step pretargeting methods are described.
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6312664 |
Biodegradable contrast media for MR imaging
A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone...
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6241968 |
Compositions for increasing the MRI contrast in visualizing the digestive tract of patients
The invention provides, as contrast signal generators in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R 1 R 2 )CR 3 --CO--Z--Z (1)...
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6187285 |
Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging
Chelates of the compounds of formula I ##STR1## in which R is a hydrophilic group containing 3 or 4 successive phenyl rings and m is 1 or 2, with metal ions, for use in diagnostic imaging.
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6180113 |
Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes
Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes are useful in tumor therapy and interventional radiology.
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6143274 |
Method for imaging and radiopharmaceutical therapy using 1-substituted-4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
A method for imaging mammalian tissue utilizing a non-ionic complex of a paramagnetic ion of lanthanide element and a macrocyclic chelating agent.
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6123921 |
Bifunctional detection agents having an optical dye linked to an MRI contrast agent
The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker,...
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6113880 |
Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging
The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.
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6083479 |
Contrast media for infarction and necrosis imaging
The invention relates to new compounds that are suitable as contrast media especially for infarction and necrosis imaging, process for their production and pharmaceutical agents that contain these...
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6068831 |
Pseudopolyrotaxanes
The invention relates to new metal complex-containing or iodine-containing benzene derivatives that contain pseudopolyrotaxanes. They are valuable compounds for diagnosis. The pseudopolyrotaxane...
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6057419 |
Cascade polymer complexes, process for producing the same and pharmaceuticals containing the same
Cascade polymer complexes that contain a) complexing ligands of general formula (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of...
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