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Document Title |
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7368099 |
MRI contrast agents
An MRI contrast agent enables direct detection and imaging of exfoliated vascular endothelial sites. The MRI contrast agent includes an imaging unit which contains an unpaired electron-carrying...
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7354568 |
Magnetic resonance imaging agents for the detection of physiological agents
The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
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7344704 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
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7341711 |
Porphyrin compounds and their use in high-field MRI
A new use in magnetic resonance imaging employing a field greater than 1.5 Tesla, of a porphyrin compound of the following general formula I is provided:
in which R 0 and R′ 0 are such that...
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7338651 |
Multi-use multimodal imaging chelates
Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10...
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7303741 |
Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional...
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7279150 |
Chelating agents with lipophilic carriers
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
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7244413 |
Functionalized encapsulated fluorescent nanocrystals
Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated...
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7238341 |
Peptide-based multimeric targeted contrast agents
Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
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7229606 |
Diagnostic imaging contrast agents with extended blood retention
The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
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7226578 |
Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the...
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7211241 |
Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography...
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7208139 |
Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic...
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7198776 |
Metal complex compounds
The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination...
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7186400 |
Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
Compounds of general formula (I): in which: R 1 is hydrogen, C 1 –C 20 alkyl, C 3 –C 10 cycloalkyl, C 4 –C 20 cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight...
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7179450 |
Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129 Xe in a selected structure, environment, or system. The signal data...
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7175829 |
Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an...
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7138105 |
Compositions for delivery of therapeutics and other materials, and methods of making and using the same
In part, the present invention is directed to compositions comprising a carrier with a metal binding domain, a metal ion, and an active agent.
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7132513 |
Bifunctional chelating agent
The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO 2 , —NH 2 , —NCS, —NHCOCH 2 -Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH 2 -Q, or...
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7128895 |
Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability
The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the...
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7110806 |
Method for imaging an artery using a magnetic resonance contrast agent
The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides...
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7074387 |
DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production
Compounds of formula I
wherein Z 1 , Z 2 , X, R 2 and R 3 are as defined herein, are suitable as NMR shift reagents.
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7045606 |
Bifunctional chelating agent for actinium
The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z,...
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7029655 |
Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic...
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7020578 |
Method for evaluating novel, stroke treatments using a tissue risk map
A method of evaluating novel stroke treatments includes generating a risk map indicative of the probability of tissue infarction on voxel-by-voxel basis and selecting a probability range for...
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6994841 |
Relating to magnetic resonance imaging
The invention shows a method for obtaining temporally spaced images of tissues, including blood vessels, to reveal blood flow abnormalities within those tissues and vessels.
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6982324 |
Degradable macromolecular magnetic resonance imaging contrast agents and methods thereof
Novel degradable macromolecular magnetic resonance imaging contrast agents for use in various diagnostic procedures, and methods for synthesizing, using and degrading these agents, are disclosed....
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6926883 |
Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as imaging agents for diagnostic purposes. In accordance with the...
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6911457 |
Diabetes imaging probes
The present invention relates to novel imaging probes and methods for using the probes in diagnostic imaging processes and other imaging processes to determine physiological functions.
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6899864 |
Morpholino imaging and therapy
The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate...
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6896874 |
MR-signal emitting coatings
The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer...
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6875419 |
Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use
The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism....
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6852842 |
Methods for functional kidney imaging using small dendrimer contrast agents
Small dendrimer-based MRI contrast agents are disclosed to accumulate in renal tubules. The accumulation enables visualization of renal structure and function, permitting assessment of structural...
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6818203 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
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6808699 |
Methods for imaging pulmonary and cardiac vasculature and evaluating blood flow using dissolved polarized 129Xe
MR spectroscopy and imaging methods for imaging pulmonary and cardiac vasculature and the cardiac region and evaluating blood flow or circulatory deficits use dissolved phase polarized 129 Xe gas...
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6797255 |
Methods and compositions for enhancing magnetic resonance imaging
Substantially nontoxic manganese complexes of compounds of the formula: wherein n=0, 1 or 2, R 1 and R 2 are hydrogen or alkyl groups of 1 to 4 carbon atoms, and R 3 and R 4 are hydrogen,...
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6776977 |
Polypodal chelants for metallopharmaceuticals
Tripodal polyaminophosphonate chelants are disclosed, as well as chelates of the chelants with metal ions to form radiopharmaceutical and radioactive, MRI and X-ray or CT imaging compounds and...
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6770020 |
Method of using gadolinium neutron capture to treat cancers
Described is a method of using gadolinium-containing compounds as agents for neutron capture therapy to treat neoplastic cell growth. The subject is exposed to a gadolinium-containing compound for...
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6709646 |
Bioactivated diagnostic imaging contrast agents
The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow...
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6685915 |
Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
Linear extended polymeric paramagnetic chelates for use as MRI contrast agents are synthesized by conjugating DTPA chelator moieties to higher than 90% of the monomer residues of the polyamino acid...
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6680211 |
Fluorescent nanocrystal-embedded microspheres for fluorescence analysis
Provided are a fluorescent microsphere comprised of a plurality of fluorescent nanocrystals embedded in a polymeric microsphere; a kit prepared from the fluorescent microspheres; and a method of...
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6676928 |
Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with polar radicals of general formula I (K) 1 -G-(Z-R f ) m (R) p (I) in which R means the polar radical, R f means a perfluorinated carbon chain, K is a...
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6656448 |
Matrix metalloproteinase inhibitors
Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties;a chelator; and 0-1 linking groups...
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6652835 |
Targeting multimeric imaging agents through multilocus binding
The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon...
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6641797 |
Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH...
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6589506 |
Method for magnetic resonance imaging of the lung
A method for the assessment of pulmonary ventilation and lung perfusion through Magnetic Resonance Imaging (MRI), comprising the steps of: positioning a human subject in an MRI apparatus,...
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6576220 |
Non-invasive methods for surgery in the vasculature
Novel methods of non-invasive intravascular surgery are disclosed, which include the intravascular administration of a composition comprising gas or gaseous precursor filled vesicles, followed by...
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6548044 |
Imaging sexual response
The present invention relates to methods for contrast-enhanced imaging of sexual response. In particular, the present invention relates to methods of magnetic resonance imaging (MRI), computerized...
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6534039 |
Extended organic cobalt and nickel magnetic complexes
Disclosed is a method for in vivo imaging tissue of a individual, by performing magnetic resonance imaging utilizing an extended cobalt complex as a contrast enhancement agent. The extended cobalt...
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6479033 |
Antitumor cystostatic and contrast agent
The invention concerns a composition for the treatment of tumors, of (i) at least one cytostatic drug component which is unencapsulated or is encapsulated in a PEG-, immuno-, or immuno/PEG...
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