Patents in Class 424/9.350

Matches 1 - 50 out of 83

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Match	Document	Document Title
1	7326404	Konjac-mannan and ginseng compositions and methods and uses thereof The present invention relates to a number of compositions namely a konjac -mannan mixture, a ginseng composition and a composition comprising konjac -mannan and American ginseng. Methods of use...
2	7005517	Paramagnetic metal-phthalocyanine complex compounds and contrast agent using the same The present invention provides a novel paramagnetic metal-phthalocyanine complexes and pharmaceutically acceptable salts thereof, which are useful as contrast agents for MRI(Magnetic Resonance...
3	6790942	Biologically active conjugates having a detectable reporter moiety and method of identification of the derivative Biologically active drug polymer derivatives, namely peptides or protein derivatives, are useful medicaments and are represented by the generic formula: RO—(CH 2 —CH 2 O) n...
4	6713045	Targeted magnetic resonance imaging agents for the detection of physiological processes The invention relates to novel targeted magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
5	6673333	Functional MRI agents for cancer imaging The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.
6	6649591	Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
7	6630121	Supercritical fluid-assisted nebulization and bubble drying A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure...
8	6559330	CALCIUM COMPLEX OF &lsqb &lsqb (4R)-4-&lsqb BIS&lcub CARBOXY-.KAPPA.O)METHYL&rsqb AMINO-.KAPPA.N&rsqb -6,9-BIS&lsqb (CARBOXY.KAPPA.O)METHYL&rsqb -1-&lsqb (4,4-DIPHENYLCYCLOHEXYL)OXY&rsqb -1-HYDROXY-2-OXA-6,9-DIAZA-1-PHOSPHAUNDECAN-11-YLIC-ACID-.KAPPA.N6,.KAPPA.N9,.KAPPA.011&rsqb 1-OXIDATO(6-)&rsqb -, HEXAHYDROGEN, ITS SALTS, PHARMACEUTICAL AGENTS THAT CONTAIN THESE COMPLEXES, THEIR USE IN TREATMENT AND AS ADDITIVES IN DIAGNOSIS, AS WELL AS PROCESSES FOR THE PRODUCTION OF THE COMPLEXES AND AGENTS The invention relates to the calcium complex of...
9	6482429	Stable powder inhalation dosage formulation An insufflation for the administration of a drug into a body cavity is described where the carrier for the drug is a finely divided powder selected from the group consisting of myoinositol,...
10	6451980	Signal enhancement of bispecific antibody-polymer probe for immunoassay use An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a...
11	6429297	Modified avidin and streptavidin and methods of use thereof The present invention relates to a compound of the formula These modified streptavidin compounds have are useful as part of a delivery system to deliver a molecule to a target site for use in...
12	6423314	Tumor derived carbohydrate binding protein The active, galactose binding site of proteins associated with metastatic tumor cells has been identified and sequenced. The polypeptide comprising the active site may be used as an...
13	6409990	Macromolecular carrier for drug and diagnostic agent delivery New macromolecular carriers for drugs and diagnostic agents are described that make use of the chemical attachment of new leashes to oligomeric backbone structures. The synthesis of these leashes...
14	6369043	Sodium ion absorption inhibitors, sodium ion excretion accelerators, and preventive and therapeutic agents for diseases resulting from excessive intake of common salt An sodium ion absorption inhibitor, a sodium ion excretion accelerator and an agent for preventing and treating a disease caused by excessive common salt ingestion, each of which comprising a metal...
15	6329208	Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling Simple equations that relate glucose, glutamate, glucuronate, and phenylacetylglutamine 13 C NMR multiplet areas to gluconeogenesis and pyruvate recycling during metabolism of [1,2,3- 13 C 3 ...
16	6312664	Biodegradable contrast media for MR imaging A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone...
17	6268351	Methods for inducing proliferation in auditory receptor epithelium The present invention provides novel methods for stimulating proliferation in auditory receptor epithelium. Administration of agents that activate cAMP production result in demonstrable...
18	6214621	Conjugates of a particle vector and oligonucleotides, process for their preparation, and pharmaceutical compositions containing them The invention relates to an ionic conjugate, which is stable in a biological medium, and which is comprised of a particle vector with at least one cationic, nonliquid, hydrophilic nucleus and of...
19	6113880	Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.
20	6107459	Technetium-99m labeled peptides for diagnostic imaging This invention relates to reagents, radiolabeled reagents and methods for producing such reagents and radiolabeled reagents. Specifically, the invention relates to technetium-99m (Tc-99m) labeled...
21	6068831	Pseudopolyrotaxanes The invention relates to new metal complex-containing or iodine-containing benzene derivatives that contain pseudopolyrotaxanes. They are valuable compounds for diagnosis. The pseudopolyrotaxane...
22	6033644	Biomodulators as universal imaging agents Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue...
23	6022865	Stable aqueous solution having high concentrations of calcium and phosphate ions and solid complex A stable aqueous solution having high concentrations of both biologically available calcium and biologically available phosphate is provided by combining phosphate and calcium ions in the aqueous...
24	6017901	Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions Hyaluronic acid or hyaluronic acid ester derivatives, wherein one or more hydroxy functions of its 1,4β-D-glucuronic acid and 1,3-β-N-acetyl-D-glucosamine alternating repeating units are...
25	6010681	Biodegradable blood-pool contrast agents The invention provides a blood pool contrast agent having an overall molecular weight of at least 10KD comprising a macrostructure which has bound thereto a plurality of opsonization inhibiting...
26	5985244	Polymers with a gas magnetic resonance imaging Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents...
27	5985245	Contrast agents for MRI using a manganese compound and kojic acid There is provided a contrast medium composition comprising: (a) a first contrast agent comprising a physiologically tolerable manganese compound, a physiologically tolerable reducing compound...
28	5968477	Radiolabeled annexin conjugates with hexose and a chelator Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.
29	5965131	Delivery of diagnostic and therapeutic agents to a target site An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the...
30	5928958	Superparamagnetic particles, process for their manufacture and usage Superparamagnetic particles consist of superparamagnetic one-domain particles and aggregates of superparamagnetic one-domain particles to whose surfaces are bound organic substances optionally...
31	5928626	Contrast agents, consisting of carbohydrate particles The present invention relates to contrast agents comprising water-soluble microbubble-generating carbohydrate microparticles in admixture with at least 10% w/w relative to the overall composition...
32	5871710	Graft co-polymer adducts of platinum (II) compounds A biocompatible graft co-polymer adduct including a polymeric carrier, a protective chain linked to the polymeric carrier, a reporter group linked to the carrier or to the carrier and the...
33	5846516	Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications Perfluoroalkylated amphiphilic phosphorus compounds, corresponding to the formulae: ##STR1## wherein V is O or S; R 1 , R 2 and R 3 are H or substituted or unsubstituted perfluoroalkylated or...
34	5811076	Macromolecular contrast media for MR imaging A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone...
35	5811581	Process for the purification of opacifying contrast agents A process for the purification of opacifying contrastographic agents, comprising chromatographic and nanofiltration techniques combined together, the subsequent chromatographic separation of the...
36	5804163	Contrast agents for magnetic resonance imaging aminosaccharide A contrast enhancing agent for magnetic resonance images having a chelating agent, which can be bound to metals having at least one unpaired electron. Examples of such chelating agents include...
37	5756069	Amphipathic polychelating compounds and method of use An amphipathic polychelating compound including a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of the...
38	5739121	Fluorocyclosaccharide drug delivery systems Novel fluorine-containing cyclic saccharide compounds, in particular fluorocyclodextrin compounds, and drug inclusion complexes of these compounds, as well as methods for preparation of the novel...
39	5707604	Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles This application concerns novel agents comprising cationic or chemically basic metal chelators in association with hydrophilic carriers of anionic or chemically acidic saccharides, sulfatoids and...
40	5703056	Non-invasive imaging of gene transfer The subject invention provides a method of detecting gene transfer to and expression in a target tissue of a host subject comprising: (a) administering to the host subject a transfer vector...
41	5681543	Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic...
42	5643549	Leukostimulatory agent for in vivo leukocyte tagging Methods and reagents for the in vivo tagging of leukocytes, and in particular lymphocytes, with a leukostimulatory agent and a linked medically useful metal ion, including a radioisotope, and...
43	5624661	Hypoosmotic compositions comprising a polymer and a complexed contrast agent for MRI Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents...
44	5620675	Radioactive peptides This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing label radiodiagnostic agents. Specifically, the invention relates to...
45	5601799	Partially delipidated D25 polysaccaride composition for imaging and diagnosis The present invention relates to a D 25 polysaccharide compound whose lipid has been partially removed and to its derivatives, wherein at least 85% by weight, preferably 90% of the compound, exists...
46	5597548	.sup.13 C Isotopomer analyses in intact tissue using (.sup.13 C) homonuclear decoupling Entry of 13 C-enriched acetyl-CoA into the citric acid cycle results in scrambling of 13 C into the various carbon positions of all intermediate pools. The eventual result is that the 13 C...
47	5593658	Medical compositions A biocompatible medical composition including a polymeric carrier, a protective chain linked to the polymeric carrier, and a reporter group linked to the carrier or to the carrier and the...
48	5580543	Method of magnetic resonance image enhancement Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced...
49	5580568	Cellulose diacetate compositions for use in embolizing blood vessels Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a cellulose diacetate polymer, a biocompatible solvent and a water insoluble contrasting agent...
50	5567411	Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group Dendritic derivatives of 3,5-bis(aminomethyl)benzene and aminomethyl benzene core groups are disclosed. In each derivative, termed an "amplifier" because the dendritic structure on each molecule...

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