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7005517 Paramagnetic metal-phthalocyanine complex compounds and contrast agent using the same  
The present invention provides a novel paramagnetic metal-phthalocyanine complexes and pharmaceutically acceptable salts thereof, which are useful as contrast agents for MRI(Magnetic Resonance...
6790942 Biologically active conjugates having a detectable reporter moiety and method of identification of the derivative  
Biologically active drug polymer derivatives, namely peptides or protein derivatives, are useful medicaments and are represented by the generic formula: RO—(CH 2 —CH 2 O) n...
6713045 Targeted magnetic resonance imaging agents for the detection of physiological processes  
The invention relates to novel targeted magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
6673333 Functional MRI agents for cancer imaging  
The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.
6649591 Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications  
In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
6630121 Supercritical fluid-assisted nebulization and bubble drying  
A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure...
6599498 Heat stable colloidal iron oxides coated with reduced carbohydrates and carbohdrate derivatives  
Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising...
6559330 CALCIUM COMPLEX OF &lsqb &lsqb (4R)-4-&lsqb BIS&lcub CARBOXY-.KAPPA.O)METHYL&rsqb AMINO-.KAPPA.N&rsqb -6,9-BIS&lsqb (CARBOXY.KAPPA.O)METHYL&rsqb -1-&lsqb (4,4-DIPHENYLCYCLOHEXYL)OXY&rsqb -1-HYDROXY-2-OXA-6,9-DIAZA-1-PHOSPHAUNDECAN-11-YLIC-ACID-.KAPPA.N6,.KAPPA.N9,.KAPPA.011&rsqb 1-OXIDATO(6-)&rsqb -, HEXAHYDROGEN, ITS SALTS, PHARMACEUTICAL AGENTS THAT CONTAIN THESE COMPLEXES, THEIR USE IN TREATMENT AND AS ADDITIVES IN DIAGNOSIS, AS WELL AS PROCESSES FOR THE PRODUCTION OF THE COMPLEXES AND AGENTS  
The invention relates to the calcium complex of...
6482429 Stable powder inhalation dosage formulation  
An insufflation for the administration of a drug into a body cavity is described where the carrier for the drug is a finely divided powder selected from the group consisting of myoinositol,...
6451980 Signal enhancement of bispecific antibody-polymer probe for immunoassay use  
An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a...
6429297 Modified avidin and streptavidin and methods of use thereof  
The present invention relates to a compound of the formula These modified streptavidin compounds have are useful as part of a delivery system to deliver a molecule to a target site for use in...
6423314 Tumor derived carbohydrate binding protein  
The active, galactose binding site of proteins associated with metastatic tumor cells has been identified and sequenced. The polypeptide comprising the active site may be used as an...
6409990 Macromolecular carrier for drug and diagnostic agent delivery  
New macromolecular carriers for drugs and diagnostic agents are described that make use of the chemical attachment of new leashes to oligomeric backbone structures. The synthesis of these leashes...
6369043 Sodium ion absorption inhibitors, sodium ion excretion accelerators, and preventive and therapeutic agents for diseases resulting from excessive intake of common salt  
An sodium ion absorption inhibitor, a sodium ion excretion accelerator and an agent for preventing and treating a disease caused by excessive common salt ingestion, each of which comprising a metal...
6329208 Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling  
Simple equations that relate glucose, glutamate, glucuronate, and phenylacetylglutamine 13 C NMR multiplet areas to gluconeogenesis and pyruvate recycling during metabolism of [1,2,3- 13 C 3 ...
6312664 Biodegradable contrast media for MR imaging  
A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone...
6287538 DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production  
Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z 1 ,...
6268351 Methods for inducing proliferation in auditory receptor epithelium  
The present invention provides novel methods for stimulating proliferation in auditory receptor epithelium. Administration of agents that activate cAMP production result in demonstrable...
6214621 Conjugates of a particle vector and oligonucleotides, process for their preparation, and pharmaceutical compositions containing them  
The invention relates to an ionic conjugate, which is stable in a biological medium, and which is comprised of a particle vector with at least one cationic, nonliquid, hydrophilic nucleus and of...
6113880 Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging  
The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.
6107459 Technetium-99m labeled peptides for diagnostic imaging  
This invention relates to reagents, radiolabeled reagents and methods for producing such reagents and radiolabeled reagents. Specifically, the invention relates to technetium-99m (Tc-99m) labeled...
6068831 Pseudopolyrotaxanes  
The invention relates to new metal complex-containing or iodine-containing benzene derivatives that contain pseudopolyrotaxanes. They are valuable compounds for diagnosis. The pseudopolyrotaxane...
6033644 Biomodulators as universal imaging agents  
Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue...
6022865 Stable aqueous solution having high concentrations of calcium and phosphate ions and solid complex  
A stable aqueous solution having high concentrations of both biologically available calcium and biologically available phosphate is provided by combining phosphate and calcium ions in the aqueous...
6017901 Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions  
Hyaluronic acid or hyaluronic acid ester derivatives, wherein one or more hydroxy functions of its 1,4β-D-glucuronic acid and 1,3-β-N-acetyl-D-glucosamine alternating repeating units are...
6010681 Biodegradable blood-pool contrast agents  
The invention provides a blood pool contrast agent having an overall molecular weight of at least 10KD comprising a macrostructure which has bound thereto a plurality of opsonization inhibiting...
5985245 Contrast agents for MRI using a manganese compound and kojic acid  
There is provided a contrast medium composition comprising: (a) a first contrast agent comprising a physiologically tolerable manganese compound, a physiologically tolerable reducing compound...
5985244 Polymers with a gas magnetic resonance imaging  
Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents...
5980862 Magnetic resonance imaging agents for the detection of physiological agents  
The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
5968477 Radiolabeled annexin conjugates with hexose and a chelator  
Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.
5965131 Delivery of diagnostic and therapeutic agents to a target site  
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the...
5958408 Delivery of diagnostic and therapeutic agents to a target site  
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the...
5928958 Superparamagnetic particles, process for their manufacture and usage  
Superparamagnetic particles consist of superparamagnetic one-domain particles and aggregates of superparamagnetic one-domain particles to whose surfaces are bound organic substances optionally...
5928626 Contrast agents, consisting of carbohydrate particles  
The present invention relates to contrast agents comprising water-soluble microbubble-generating carbohydrate microparticles in admixture with at least 10% w/w relative to the overall composition...
5871710 Graft co-polymer adducts of platinum (II) compounds  
A biocompatible graft co-polymer adduct including a polymeric carrier, a protective chain linked to the polymeric carrier, a reporter group linked to the carrier or to the carrier and the...
5859214 DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production  
Compounds of general formula I ##STR1## wherein Z 1 , Z 2 , X, R 2 and R 3 are as herein defined, are valuable pharmaceutical agents. In particular, the compounds are useful as contrast agents in...
5846537 Modified avidin and streptavidin and methods of use thereof  
The present invention provides modified avidin and streptavidin compounds that have suitable blood clearance kinetics for use in a two-step approach to deliver a molecule to a target site. In...
5846516 Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications  
Perfluoroalkylated amphiphilic phosphorus compounds, corresponding to the formulae: ##STR1## wherein V is O or S; R 1 , R 2 and R 3 are H or substituted or unsubstituted perfluoroalkylated or...
5811581 Process for the purification of opacifying contrast agents  
A process for the purification of opacifying contrastographic agents, comprising chromatographic and nanofiltration techniques combined together, the subsequent chromatographic separation of the...
5811076 Macromolecular contrast media for MR imaging  
A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone...
5804163 Contrast agents for magnetic resonance imaging aminosaccharide  
A contrast enhancing agent for magnetic resonance images having a chelating agent, which can be bound to metals having at least one unpaired electron. Examples of such chelating agents include...
5756069 Amphipathic polychelating compounds and method of use  
An amphipathic polychelating compound including a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of the...
5739121 Fluorocyclosaccharide drug delivery systems  
Novel fluorine-containing cyclic saccharide compounds, in particular fluorocyclodextrin compounds, and drug inclusion complexes of these compounds, as well as methods for preparation of the novel...
5712389 Polyaminated ligands and metal complexes thereof  
Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formula CH (R 1...
5707605 Magnetic resonance imaging agents for the detection of physiological agents  
The invention relates to magnetic resonance imaging agents comprising a paramagnetic metal ion bound to a complex wherein said complex comprises a chelator and a blocking moiety convalently...
5707604 Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles  
This application concerns novel agents comprising cationic or chemically basic metal chelators in association with hydrophilic carriers of anionic or chemically acidic saccharides, sulfatoids and...
5703056 Non-invasive imaging of gene transfer  
The subject invention provides a method of detecting gene transfer to and expression in a target tissue of a host subject comprising: (a) administering to the host subject a transfer vector...
5681543 Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI  
Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic...
5643549 Leukostimulatory agent for in vivo leukocyte tagging  
Methods and reagents for the in vivo tagging of leukocytes, and in particular lymphocytes, with a leukostimulatory agent and a linked medically useful metal ion, including a radioisotope, and...
5637289 Contrast agents, consisting of galactose particles  
The present invention relates to contrast agents comprising water-soluble microbubble-generating carbohydrate microparticles in admixture with at least 10% w/w relative to the overall composition...
Matches 1 - 50 out of 101 1 2 3 >