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7384794 |
Micro-devices and analytical procedures for investigation of biological systems
Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the...
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7371738 |
Method of transdermal drug delivery using hyaluronic acid nanoparticles
The present invention relates to the development of a hyaluronic acid and hyaluronic acid hybrid nanoparticle systems for the administration of active molecules, peptides, DNA and/or other...
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7371365 |
Methods for detecting parenchymal plaques in vivo
Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity...
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7335771 |
Quinacridone derivatives as labelling reagents for fluorescence detection of biological materials
Disclosed are new quinacridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the quinacridone dyes and...
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7312461 |
Laparoscopic tumor therapy using high energy electron irradiation
A laparoscopic tumor therapy method and an articulated electron beam transport system are provided for use with a high power, long focus electron source for tumor therapy. The high power, long...
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7306807 |
Hemorrhagic feline calicivirus, calicivirus vaccine and method for preventing calicivirus infection or disease
The present invention relates to a novel, isolated and purified hemorrhagic feline calicivirus FCV-DD1. The invention further embraces monovalent and multivalent vaccines containing the new FCV-DD1...
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7285289 |
Nanoparticle vaccines
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
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7279150 |
Chelating agents with lipophilic carriers
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
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7252959 |
Assays for diagnosis of thrombophilic disease
The present invention provides methods for diagnosing and/or monitoring thrombophilic disease in a patient that can result from the antiphospholipid antibody syndrome (aPL syndrome). The methods of...
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7232689 |
Calibration procedure for investigating biological systems
Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly...
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7229773 |
Screening method for apoptosis-suppressing or-promoting substance
To provide a screening method for an apoptosis-suppressing substance or an apoptosis-promoting substance, the application of which substances to pharmaceuticals or diagnostic drugs are expected,...
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7223847 |
Method for producing cobalt-protein complex
A method for obtaining a cobalt-apoferritin complex according to the present invention includes: the step a) of preparing a solution including a Co 2+ ion, a protein, a pH buffer agent and a Co 2+...
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7220402 |
Alpha-fetoprotein peptides and uses for imaging
The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include...
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7199100 |
Cyclic peptides, method for preparing and use as angiogenesis inhibitors or activator
The invention relates to cyclopeptides, the method of their preparation and their utilization as inhibitors or activators of angiogenesis. These cyclopeptides comprise the following peptide...
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7175828 |
Modulators of β-amyloid peptide aggregation comprising D-amino acids
Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely...
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7172751 |
D-amino acid peptides
The present invention provides compounds of the formula X—R 1 -D-[Dpr, Orn or Lys](A)-R 2 (Z)-D-[Dpr, Orn or Lys](B)—R 3 (Y)—NR 4 R 5 ; or R 1 (X)-D-[Dpr, Orn or Lys](A)-R 2 (Z)-D-[Dpr, Orn...
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7153506 |
Use of anti-ferritin monoclonal antibodies in the treatment of some cancers
The invention concerns the use, in the preparation of a medicine for treating cancer whereof the cells exhibit overexpression of a product of a gene of the myc-related family, of an anti-ferritin...
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7138104 |
Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
The present invention describes a method of concurrent imaging in a mammal comprising:
a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging...
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7115268 |
Peptides useful for reducing symptoms of toxic shock syndrome and septic shock
This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates...
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7091325 |
Fibrin/fibrinogen-binding conjugate
A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding...
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7090846 |
Method for preparing polycation based bioconjugates suitable for transporting different kinds of active substances within the body
Polycation bioconjugates and a method for producing them. The polycations are capable of transporting active substances of different types. The polycations function as carrier molecules that...
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7087722 |
Fibrin binding domain polypeptides and uses and methods of producing same
This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding...
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7067135 |
Methods and compositions for the treatment and prevention of Staphylococcus aureus infections
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, Staphylococcus spp., particularly S. aureus.
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7056506 |
Methods for detecting and inhibiting angiogenesis
The present invention provides methods for reducing or inhibiting angiogenesis in a tissue, by contacting α5β1 integrin in the tissue with an agent that interferes with specific binding of the...
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7029859 |
Sequences for targeting metastatic cells
The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to...
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7022483 |
Methods for identifying and isolating antigen-specific T cells
The present invention is directed to methods for the identification and isolation of antigen-specific T cells using a novel class of artificial antigen presenting cells. The resulting T cells may...
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7022310 |
Stable isotope-labeled amino acid and method for incorporating same into target protein
The present invention provides a stable isotope-labeled amino acid which is at least one of amino acids constituting a protein and which has at least one of the following labeling patterns:
...
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7022309 |
Targeting molecule linked to an imaging agent
Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three...
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7005517 |
Paramagnetic metal-phthalocyanine complex compounds and contrast agent using the same
The present invention provides a novel paramagnetic metal-phthalocyanine complexes and pharmaceutically acceptable salts thereof, which are useful as contrast agents for MRI(Magnetic Resonance...
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6994975 |
Expression and purification of ATM protein using vaccinia virus
The present disclosure concerns methods for recombinantly producing functional ataxia-telangiectasia (ATM) protein, methods for isolating recombinant functional ATM protein, and uses of ATM...
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6926884 |
GPIb-lipid bond construct and use thereof
The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing...
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6908619 |
Camp factor of streptococcus uberis
The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the...
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6893625 |
Chimeric antibody with specificity to human B cell surface antigen
A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production,...
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6869592 |
Method and antibody for imaging lung cancer
The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating lung cancer.
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6849415 |
TRAF-3 deletion isoforms and uses thereof
The present invention provides an isolated TRAF-3 deletion isoform encoded by the nucleic acid sequence (SEQ ID NO:1) shown in FIG. 15 (deletion isoform Δ130 nucleid acid). One embodiment of the...
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6821506 |
Site specific binding system, imaging compositions and methods
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated...
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6815169 |
Identification and expression of a novel kinesin motor protein
The invention provides isolated nucleic acid and amino acid sequences of TL-γ, antibodies to TL-γ, methods of screening for TL-γ modulators using biologically active TL-γ, and kits for...
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6790661 |
System for detecting bacteria in blood, blood products, and fluids of tissues
The invention provides methods for screening for the presence of a clinically relevant amount of bacteria in donor blood or a blood product from a donor mammal, particularly blood or a blood...
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6737040 |
Method and antibody for imaging breast cancer
The present invention provides a new method of detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating breast cancer.
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6727347 |
Method for preparing polycation based bioconjugates suitable for transporting different kinds of active substances within the body
Polycation bioconjugates and a method for producing them. The polycations are capable of transporting active substances of different types. The polycations function as carrier molecules that...
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6713046 |
Magnetic resonance imaging agents for the delivery of therapeutic agents
The invention relates to novel magnetic resonance imaging contrast agents and methods of delivering therapeutically active agents.
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6685915 |
Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
Linear extended polymeric paramagnetic chelates for use as MRI contrast agents are synthesized by conjugating DTPA chelator moieties to higher than 90% of the monomer residues of the polyamino acid...
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6676941 |
Antibody conjugate formulations for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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6649591 |
Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications
In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
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6630146 |
Candida albicans phosphomannan complex as a vaccine
A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans . The composition includes phosphomannan of C. albicans...
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6559287 |
Artificial proteoglycans
Novel articifial proteoglycans containing a GAG assembly site and a control sequence required for assembly, method for enhancing the biological activity of a glycosaminoglycan binding protein using...
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6555091 |
Polypeptide capable of reacting with antibodies of patients suffering from multiple sclerosis and uses
The invention concerns a polypeptide specifically reacting with the antibodies of patients suffering from multiple sclerosis (SEP) and whereof the peptide sequence comprises at least one sequence...
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6551576 |
Container with multi-phase composition for use in diagnostic and therapeutic applications
A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic...
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6548295 |
Complex of lipo-viro-particles, method of preparation and applications
The complex consists of LVPs associated with human immunoglobulins having a density of less than 1.063 g/ml. It may be obtained by a method according to which a plasma or serum sample taken from a...
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6540980 |
Method of detecting endometriosis
Kits for detecting and treating endometriosis are provided, which contain a targeting molecule comprising an eosinophil peroxidase-binding component. Methods of detecting and treating endometriosis...
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