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7351402 |
Polarizing agents for dynamic nuclear polarization
We describe polarizing agents for use in enhancing NMR and MRI signals via dynamic nuclear polarization (DNP). The polarizing agents include two or more paramagnetic centers, preferably two...
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7108846 |
Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection
The present invention relates to chemical synthesis of radiolabelled perfluorinated bioactive compounds. More particularly, the present invention relates to radiolabelled compounds to be used as...
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7097825 |
Methods and reagents to acquire MRI signals and images
Method for obtaining BOLD MRI images with allosteric effector compounds are disclosed. Methods for the determination of tumor oxygenation and for an optimal time for initiating radiation therapy...
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6991778 |
Use of dendrimers polyl-functionalized with nitroxide groups as contrast enhancing agents in MRI imaging of joints and injectable compositions comprising them
The image obtained by MR imaging of the joint of an animal, including humans, is enhanced by injecting into the joint prior to the scan of an imaging enhancing amount of a nitroxyl functionalized...
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6632975 |
Method for the production of in vivo model of hepatocellular carcinoma without lung metastasis
The present invention provides a method for producing an in vivo model of hepatocellular carcinoma without lung metastasis in an animal by injecting diethylnitrosamine and administering...
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6569688 |
Intravascular apparatus method
Intravascular apparatus and method for locally treating a patient's blood vessel, are provided. The apparatus includes an implanted carrier ( 2 ) for insertion into the vessel; and a biologically...
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6315981 |
Gas filled microspheres as magnetic resonance imaging contrast agents
Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.
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6009342 |
Imaging method for the grading of tumors
The endothelial integrity of microvessels is disturbed in malignant tumors. We invented a method wherein we used MRI to define tumor microvascular permeabilities and correlated these permeabilities...
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5900227 |
Multicyclic nitrone spin trapping compositions
Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds...
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5827501 |
Use of free radicals in ESR and ESREMR imaging
The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance...
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5700448 |
Use of persistent free-radicals in magnetic resonance imaging
The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based π-bonded electronic system available for delocalization of the...
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5622687 |
Calixarene conjugates useful as MRI and CT diagnostic imaging agents
Calixarene conjugates useful for imaging, particularly magnetic resonance imaging (MRI) and computed tomography (CT) are described. Said calixarene conjugates comprise (i) a calixarene backbone,...
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5599522 |
Triarylmethyl radicals and the use of inert carbon free radicals in MRI
A radical compound of formula Ia .C(Ar 12 ) 3 (Ia) wherein: each Ar 12 , which may be the same or different, represents a 6-membered carbocyclic, at...
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5567411 |
Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group
Dendritic derivatives of 3,5-bis(aminomethyl)benzene and aminomethyl benzene core groups are disclosed. In each derivative, termed an "amplifier" because the dendritic structure on each molecule...
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5435991 |
Use of persistent heterocyclic free-radicals in magnetic resonance imaging
The present invention provides the use of a persistent π-system free radical for the manufacture of a contrast medium for use in magnetic resonance imaging, wherein the electron delocalising...
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5431901 |
Selective isotopic labeling of spin labels for electron spin resonance spectroscopy
Selective isotopic-labeling of spin label compounds, used in electron spin resonance spectroscopy to detect, measure and monitor the presence of paramagnetic species, increases the sensitivity of...
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5407657 |
Hybrid magnetic resonance contrast agents
Novel MRI contrast agents that comprise one or more metal-ion chelates in juxtaposition with one or more free-radical nitroxide compounds in a polymeric or oligomeric molecule. Both the chelate...
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5403572 |
Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them
The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and...
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5362477 |
19F magnetic resonance imaging agents which include a nitroxide moiety
Methods and compositions are disclosed for enhancing 19 F magnetic resonance imaging which utilize 19 F magnetic resonance contrast media having enhanced 19 F relaxivity. Fluorine-containing...
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5358703 |
Method for the detection of nitric oxide
A method of detecting nitric oxide in an aqueous body fluid of a mammal comprises introducing into the body fluid the agents required to form a water-soluble, stable, paramagnetic complex with...
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5314681 |
Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
The invention relates to a modification of electron spin resonance enhanced magnetic resonance imaging (ESREMRI) in which two magnetically responsive materials (contrast agents) are introduced into...
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5264204 |
Hydrophilic free radicals for magnetic resonance imaging
Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as magnetic resonance contrast media. Typical magnetic resonance...
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5256397 |
2,2,5,5-tetrasubstituted-pyrrolidine-1-oxyl compounds useful as MRI agents
Nitroxides useful as MRI enhancing agents are of the formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 each are alkyl of 1-4 carbon atoms; and R is --alk--COO - M + or --B--N + (Alk) 3 Hal - ...
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5252317 |
Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid
Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number...
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5250672 |
Contrast agent for NMR imaging
A polysaccharide chemically joined to a nitroxyl spin label (NSL) compound has use for the preparation of an NMR diagnostic composition. An agent for modifying H 2 O relaxation times in NMR...
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5135737 |
Amplifier molecules for enhancement of diagnosis and therapy
Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number...
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5104641 |
Nitroxide NMR contrast enhancing agents and their use in NMR imaging
Nitroxides useful as NMR contrast enhancing agents for organs are of the formula ##STR1## wherein in the above formulae, R 1 , R 2 , R 3 and R 4 are, g., CH 3 ; R is --B--COO--M + or...
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4925652 |
Nitroxyl compounds, and diagnostic media based thereon useful for enhancing NmR imaging
Diagnostic media suitable for NMR diagnoses contain compounds of Formula I ##STR1## wherein is a single bond or a double bond, X is the grouping --(CH 2 ) n -- or , if is a single bond,...
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4863717 |
Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging
Nitroxide contrast agents for MRI have a long useful life and can be administered in low concentration doses. Such agents include nitroxide-doped liposomes that encapsulate an oxidant and large...
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4845090 |
Nitroxyl compound and diagnostic media based thereon useful for enhancing NMR imaging
Diagnostic media suitable for NMR diagnoses contain compounds of Formula I ##STR1## wherein is a single bond or a double bond, X is the grouping --(CH 2 ) n -- or, if is a single bond, also...
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4834964 |
Use of charged nitroxides as NMR image enhancing agents for CSF
Charged, stable, organic nitroxides, e.g., charged by a quaternary ammonium or a Bronsted acid group, are useful as NMR image enhancing agents for cerebrospinal fluid.
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4830858 |
Spray-drying method for preparing liposomes and products produced thereby
A method is provided for preparing a stable liposome precursor in the form of a mixture of spray-dried liposomal components including one or more biologically active compounds which may be stored...
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4656026 |
Magnetic resonance (MR) image enhancement compounds for specific areas of the brain
An improved imaging technique involving nuclear magnetic resonance. Known drug or neurotransmitter receptor ligands are covalently bound to magnetic resonance image enhancing spin label compounds,...
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4099918 |
Proxyl nitroxides as spin labels
Spectrometric analysis of biological molecules with tetraalkylpyrrolidine-N-oxyl nitroxides.
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3489522 |
ELECTRON SPIN RESONANCE LABELING OF BIOMOLECULES
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