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7531323 |
Diabetes-mediating proteins and therapeutic uses thereof
Provided are protective and deleterious diabetes-mediating proteins and polynucleotides encoding same, transgenic animals expressing a diabetes-mediating protein, drug screening methods for...
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7414038 |
Embolic materials
The object of the present invention is to provide an embolizing material which is easily handleable and stable in quality and is solved by providing an embolizing material comprising an ester...
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7411042 |
Tumor associated nucleic acids and uses therefor
The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments...
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7407646 |
Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial
A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or...
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7285289 |
Nanoparticle vaccines
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
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7235227 |
Paramagnetic particles that provide improved relaxivity
An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the...
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7223388 |
Modified reoviral therapy
The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the...
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7087372 |
Compositions and methods for detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies
The invention provides methods and compositions for the detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies and antibody fragments.
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7083777 |
Immunomodulating polymers
A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the...
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7026285 |
Immunomodulating polymers
Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing...
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6984373 |
Fibrin binding moieties useful as imaging agents
The present invention provides binding moieties for fibrin which have a variety of uses wherever detecting, isolating or localizing fibrin, and particularly fibrin as opposed to fibrinogen, is...
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6896873 |
MR signal-emitting coatings
The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer...
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6887458 |
Vascular embolic materials having multifunctions
The present invention relates to a vascular embolic material for use in the treatment of an angiotropy of various tumors and a vascular malformation. Specifically, the present invention relates to...
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6814980 |
Microspheres containing condensed polyanionic bioactive agents and methods for their production
The present invention relates to novel compositions comprising microspheres and/or nanospheres containing condensed polyanionic bioactive agents, such as DNA. The polyanionic bioactive agent in the...
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6797257 |
Paramagnetic polymerized protein microspheres and methods of preparation thereof
The present invention relates to a composition that includes gadolinium particles encapsulated in microsphere shells. The composition is suitable for use as a contrast agent with a plurality of...
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6638494 |
Super-paramagnetic particles with increased R1 relaxivity, process for producing said particles and use thereof
The invention relates to super-paramagnetic single domain particles with increased R 1 relaxivity and with surface-stabilizer substances. The particles are characterized in that they consist of...
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6630121 |
Supercritical fluid-assisted nebulization and bubble drying
A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure...
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6596543 |
Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
The present invention relates generally to the field of prothrombin time reagents for determining dysfunction in the coagulation system and more specifically to reagents made from native...
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6576746 |
Site-specific labeling of disulfide-containing targeting vectors
A method of producing a diagnostic or therapeutic conjugate of a protein, polypeptide or peptide containing at least one disulfide bond which is necessary to maintain its biological activity, and...
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6576221 |
Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes. The nanoparticles according to...
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6573363 |
Cystine knot protein and materials and methods for making it
The present invention relates to polynucleotide and polypeptide molecules for zsig51, a novel member of the cystine knot family of polypeptides. The polypeptides comprise a sequence of amino acid...
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6517813 |
Device and process for separating magnetic materials from pharmaceutical preparations, their starting or intermediate products, as well as agents that are produced with the aid of said device
The invention relates to a device for magnetic separation of pharmaceutical preparations, their starting or intermediate products that contain a separation space, in which a magnetic gradient field...
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6458847 |
Method for screening for drugs useful in inhibition of polymerization of aβ and tau peptides
A method of stimulating polymerization of a tau protein, comprising the step of contacting said protein with a fatty acid. In another embodiment of the present invention, there is provided a method...
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6426088 |
Encapsulated cells producing antibodies
The present invention relates to capsules encapsulating antibody-producing cells, and to use of such capsules and encapsulated cells, respectively, for implantation in vivo for long term delivery...
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6423314 |
Tumor derived carbohydrate binding protein
The active, galactose binding site of proteins associated with metastatic tumor cells has been identified and sequenced. The polypeptide comprising the active site may be used as an...
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6423296 |
Constrast media
The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved...
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6372194 |
MRI contrast media recognizing minor environmental changes
This relates to a contrast medium containing a complex of a gadolinium (Gd) type contrast agent and a polymer. More particularly, the contrast medium wherein the polymer capable of phase transit in...
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6368574 |
Contrast agent-enhanced magnetic resonance imaging of tissue perfusion
This invention relates to a method of contrast agent-enhanced magnetic resonance imaging of perfusion in vasculated tissue within a human or non-human animal body in which a bolus comprising a...
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6355224 |
Conductive polymer contrast agent compositions and uses therefor
The use of electroactive materials having regions of high electron density as contrast agents in magnetic resonance imaging is described. The electroactive materials may be electroactive polymers,...
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6315981 |
Gas filled microspheres as magnetic resonance imaging contrast agents
Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.
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6303102 |
Cutaneously applied biodegradable tell-tale having controllable clearing time
The instant invention provides a biodegradable tell-tale composition which is applied cutaneously or subcutaneously to a human or animal subject for aiding in the determination of instillation or...
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6300062 |
Enamel matrix related polypeptide
The invention relates to novel nucleic acid fragments encoding polypeptides which are capable of mediating contact between enamel and cell surface. The invention also relates to expression vectors...
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6274120 |
Dry microparticles for use as a contrast agent
Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting...
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6270748 |
Contrast enhancing agent having a polymeric core and polymeric shell
The present invention pertains to an image enhancing agent having a polymeric core including an image-enhancing compound chemically bound thereto and a polymeric shell surrounding the core and...
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6251366 |
Use of dispersions of magneto-ionic particles as MRI contrast media
The invention relates to the use of dispersions of magneto-ionic particles consisting essentially of superparamagnetic solid particles and at least one polyelectrolyte as dispersing substance in...
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6207134 |
Ultrafine lightly coated superparamagnetic particles for MRI
The invention relates to particulate contrast agents, especially contrast agents for MR imaging having a metal oxide core which is preferably superparamagnetic iron oxide. The particulate contrast...
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6203777 |
Method of contrast enhanced magnetic resonance imaging using carbohydrate particles
In a method of contrast MR imaging, using parenterally administered contrast agents, the improvement comprising using as the contrast agent, e.g. to achieve a negative contrast effect, composite...
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6168780 |
Marker for determining its position in a cavity inside the organism of a living being
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6165378 |
Polysaccharide derivative/magnetic metal oxide composite
The present invention provides a polysaccharide-magnetic metal oxide complex consisting of a polysaccharide derivative obtained by carboxyalkyl-etherifying and unsubstituted or substituted...
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6153172 |
Reflective microspheres for ultrasonic imaging
The present invention provides a method of contrast enhanced ultrasonic diagnostic imaging comprising administering to a subject a contrast enhancing amount of spheres or particles comprising a...
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6136292 |
Determination of non-functioning areas of the g.i. tract using MRI of manganese composition
The invention provides a method of functional imaging of a human or non-human animal body, which method comprises administering into the gastrointestinal tract of a said body an effective amount of...
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6123920 |
Superparamagnetic contrast media coated with starch and polyalkylene oxides
The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved...
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6107102 |
Therapeutic microdevices and methods of making and using same
A suspension of microfabricated microdevices for use in therapeutic applications is disclosed. The microdevices have a selected shape, and uniform dimensions preferably in the 100 nm to 10 Am...
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6093381 |
Modulation of the sensitivity of tumor cells to chemotherapeutics
Disclosed is a method for improving the treatment of a cancer patient which is undergoing (adjuvant) chemotherapy. Prior to or concomitant with the patient receiving adjuvant chemotherapy, the...
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6017522 |
Segmented chelating polymers as imaging and therapeutic agents
A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said compisition having...
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5968527 |
Protection of living systems from the adverse effects of stress
Methods and apparatus are described to inhibit the adverse health effects of ischemia, hypoxia, anoxia or other stress by the application of a time-varying field to the region of the affected...
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5916539 |
Superparamagnetic particles, process for producing the same and their use
New superparamagnetic particles useful in medicine for destroying tumors, increasing immunity and diagnosing conditions are disclosed. For that purpose, very small superparamagnetic single-domain...
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5886110 |
Binary-branched polyoxaalkylene macromolecules process for making them and their uses
Branched, dendrimeric macromolecules having a central nucleus and a series of polyoxaalkylene chains that radiate from the nucleus and spread into the surrounding space branching a cascade fashion...
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5871937 |
Acute phase protein modulating endotoxic activity of lipopolysaccharides, assay methods and polypeptides
A lipopolysaccharide binding protein is disclosed as are an assay method, polypeptides and antibodies related to that binding protein. The binding protein: (a) is present in impure form in acute...
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5866099 |
Magnetic-polymer particles
A magnetic-polymer particle, useful in immunoassay techniques and various other biological/medical applications is produced by coprecipitation of transition metals in the presence of a polymer...
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