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8173198 |
Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers
Intermediates and methods for forming activated metal complexes bound to surfaces on oxide layers, immobilizing beads to the modified surface and articles produced thereby are described. Hydroxyl...
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8158129 |
Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in vivo
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using...
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8128908 |
Nanoparticles and their use for multifunctional bioimaging
The present invention relates to fluorescent, radio-opaque and magnetic quantum nanoparticles, useful as multifunctional contrast agents or probes for in vivo bioimaging, and methods of their use....
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8119764 |
Medical devices made of a polymer material
Medical device (Δ) comprising at least one part (π) consisting of a polymer material (M) comprising at least one kinked rigid-rod polyarylene (P) of which more than 50 wt. % of the recurring u...
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8114832 |
Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
The invention relates to the detection and/or removal of conformationally altered proteins and/or molecules comprising a cross-β structure from a pharmaceutical composition. Disclosed is that ...
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8048659 |
Conjugated polymer tag complexes
A tagged water-soluble polymer linked to a solid support is provided and includes a solid support optionally including a spacer sequence including one or more spacer monomer units attached to the...
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8038987 |
Process for the preparation of coated polymer particles
A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting porous, surface-functionalized, superparamagnetic...
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8003111 |
Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivo
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using...
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7981601 |
Method of preparing polyepitope chimeric gene vaccine
The invention relates to a method for preparing polyepitope chimeric gene vaccines, designated as Epitopes Assemble Library Immunization (EALI). It involves the construction of expression libraries...
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7981398 |
PEGylation by the dock and lock (DNL) technique
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using...
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7927579 |
Tandem analyses of noncovalently driven effectors for modulatory mapping of activities of protein sites
The present invention provides methods of discovering and mapping secondary binding sites on biological molecules (e.g., proteins), the effects, if any, of site occupancy on the primary function of...
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7894880 |
Measurement of renal extraction fraction using contrast enhanced computed tomography
Renal extraction fraction (EF) is determined through use of computed tomography (CT) measurements of arterial blood before and after injection of a radiographic contrast agent into the blood and CT...
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7825083 |
Synovial fluid barrier
A composite tissue formed in situ is provided. The composite tissue includes a synovial joint tissue; and a barrier material adhered thereto for sealing the synovial joint tissue against synovial...
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7776361 |
NELL-1 enhanced bone mineralization
This invention pertains to the discovery that the human NELL-1 gene induces or upregulates bone mineralization. The NELL-1 gene or gene product thus provides a convenient target for screening for...
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7531323 |
Diabetes-mediating proteins and therapeutic uses thereof
Provided are protective and deleterious diabetes-mediating proteins and polynucleotides encoding same, transgenic animals expressing a diabetes-mediating protein, drug screening methods for...
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7414038 |
Embolic materials
The object of the present invention is to provide an embolizing material which is easily handleable and stable in quality and is solved by providing an embolizing material comprising an ester...
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7411042 |
Tumor associated nucleic acids and uses therefor
The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments...
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7407646 |
Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial
A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or...
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7285289 |
Nanoparticle vaccines
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
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7235227 |
Paramagnetic particles that provide improved relaxivity
An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the...
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7223388 |
Modified reoviral therapy
The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the...
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7087372 |
Compositions and methods for detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies
The invention provides methods and compositions for the detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies and antibody fragments.
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7083777 |
Immunomodulating polymers
A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the...
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6984373 |
Fibrin binding moieties useful as imaging agents
The present invention provides binding moieties for fibrin which have a variety of uses wherever detecting, isolating or localizing fibrin, and particularly fibrin as opposed to fibrinogen, is...
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6896873 |
MR signal-emitting coatings
The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer...
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6887458 |
Vascular embolic materials having multifunctions
The present invention relates to a vascular embolic material for use in the treatment of an angiotropy of various tumors and a vascular malformation. Specifically, the present invention relates to...
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6814980 |
Microspheres containing condensed polyanionic bioactive agents and methods for their production
The present invention relates to novel compositions comprising microspheres and/or nanospheres containing condensed polyanionic bioactive agents, such as DNA. The polyanionic bioactive agent in the...
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6797257 |
Paramagnetic polymerized protein microspheres and methods of preparation thereof
The present invention relates to a composition that includes gadolinium particles encapsulated in microsphere shells. The composition is suitable for use as a contrast agent with a plurality of...
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6638494 |
Super-paramagnetic particles with increased R1 relaxivity, process for producing said particles and use thereof
The invention relates to super-paramagnetic single domain particles with increased R1 relaxivity and with surface-stabilizer substances. The particles are characterized in that they consist of iron...
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6630121 |
Supercritical fluid-assisted nebulization and bubble drying
A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure...
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6596543 |
Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
The present invention relates generally to the field of prothrombin time reagents for determining dysfunction in the coagulation system and more specifically to reagents made from native...
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6576221 |
Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes. The nanoparticles according to...
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6576746 |
Site-specific labeling of disulfide-containing targeting vectors
A method of producing a diagnostic or therapeutic conjugate of a protein, polypeptide or peptide containing at least one disulfide bond which is necessary to maintain its biological activity, and...
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6573363 |
Cystine knot protein and materials and methods for making it
The present invention relates to polynucleotide and polypeptide molecules for zsig51, a novel member of the cystine knot family of polypeptides. The polypeptides comprise a sequence of amino acid...
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6517813 |
Device and process for separating magnetic materials from pharmaceutical preparations, their starting or intermediate products, as well as agents that are produced with the aid of said device
The invention relates to a device for magnetic separation of pharmaceutical preparations, their starting or intermediate products that contain a separation space, in which a magnetic gradient field...
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6458847 |
Method for screening for drugs useful in inhibition of polymerization of aβ and tau peptides
A method of stimulating polymerization of a tau protein, comprising the step of contacting said protein with a fatty acid. In another embodiment of the present invention, there is provided a method...
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6426088 |
Encapsulated cells producing antibodies
The present invention relates to capsules encapsulating antibody-producing cells, and to use of such capsules and encapsulated cells, respectively, for implantation in vivo for long term delivery...
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6423314 |
Tumor derived carbohydrate binding protein
The active, galactose binding site of proteins associated with metastatic tumor cells has been identified and sequenced. The polypeptide comprising the active site may be used as an...
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6423296 |
Constrast media
The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved...
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6372194 |
MRI contrast media recognizing minor environmental changes
This relates to a contrast medium containing a complex of a gadolinium (Gd) type contrast agent and a polymer. More particularly, the contrast medium wherein the polymer capable of phase transit in...
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6368574 |
Contrast agent-enhanced magnetic resonance imaging of tissue perfusion
This invention relates to a method of contrast agent-enhanced magnetic resonance imaging of perfusion in vasculated tissue within a human or non-human animal body in which a bolus comprising a...
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6355224 |
Conductive polymer contrast agent compositions and uses therefor
The use of electroactive materials having regions of high electron density as contrast agents in magnetic resonance imaging is described. The electroactive materials may be electroactive polymers,...
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6315981 |
Gas filled microspheres as magnetic resonance imaging contrast agents
Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.
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6303102 |
Cutaneously applied biodegradable tell-tale having controllable clearing time
The instant invention provides a biodegradable tell-tale composition which is applied cutaneously or subcutaneously to a human or animal subject for aiding in the determination of instillation or...
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6300062 |
Enamel matrix related polypeptide
The invention relates to novel nucleic acid fragments encoding polypeptides which are capable of mediating contact between enamel and cell surface. The invention also relates to expression vectors...
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6274120 |
Dry microparticles for use as a contrast agent
Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting...
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6270748 |
Contrast enhancing agent having a polymeric core and polymeric shell
The present invention pertains to an image enhancing agent having a polymeric core including an image-enhancing compound chemically bound thereto and a polymeric shell surrounding the core and...
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6251366 |
Use of dispersions of magneto-ionic particles as MRI contrast media
The invention relates to the use of dispersions of magneto-ionic particles consisting essentially of superparamagnetic solid particles and at least one polyelectrolyte as dispersing substance in...
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6207134 |
Ultrafine lightly coated superparamagnetic particles for MRI
The invention relates to particulate contrast agents, especially contrast agents for MR imaging having a metal oxide core which is preferably superparamagnetic iron oxide. The particulate contrast...
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6203777 |
Method of contrast enhanced magnetic resonance imaging using carbohydrate particles
In a method of contrast MR imaging, using parenterally administered contrast agents, the improvement comprising using as the contrast agent, e.g. to achieve a negative contrast effect, composite...
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