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Document Title |
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7618624 |
Weight control using an anti-lipase antibody
A method for regulating the body weight of an animal by feeding it a liposome-encapsulated antibody against lipase.
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7560097 |
Pharmaceutical preparation containing magnetic vesicular particles, manufacturing method thereof and diagnostic therapeutic system
A pharmaceutical preparation containing magnetic vesicular particles is disclosed, wherein the magnetic vesicular particles each include magnetic microparticles within a lipid membrane, an organic...
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7462703 |
Agent for gene transfer
An agent for the transfer of genetic material comprising a genetic material, PEG-containing liposomes, one or more additional polymer particles and a contrasting agent. The invention also is...
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7419796 |
Method of making a test device
The present invention relates to a method for making a test device for detecting or quantifying an analyte in a sample. This method involves contacting a membrane with a mixture including...
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7411042 |
Tumor associated nucleic acids and uses therefor
The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments...
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7378078 |
Compositions and methods for detecting proteolytic activity
The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The...
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7368129 |
Amphiphilic materials and liposome formulations thereof
Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain...
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7344704 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
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7285289 |
Nanoparticle vaccines
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
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7244413 |
Functionalized encapsulated fluorescent nanocrystals
Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated...
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7229773 |
Screening method for apoptosis-suppressing or-promoting substance
To provide a screening method for an apoptosis-suppressing substance or an apoptosis-promoting substance, the application of which substances to pharmaceuticals or diagnostic drugs are expected,...
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7217427 |
Polymersomes and related encapsulating membranes
The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more...
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7179449 |
Enhanced ultrasound detection with temperature-dependent contrast agents
Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are...
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7166297 |
Lipid-based drug delivery systems against parasitic infections
The present invention is directed to a lipid-based delivery system for administration of an active drug substance selected from lysolipid derivatives which are particularly useful in the treatment...
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7108863 |
Liposome composition for improved intracellular delivery of a therapeutic agent
A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and...
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7094424 |
Cationic lipid compositions targeting angiogenic endothelial cells
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth....
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7070801 |
Sugar-modified liposome and products comprising the liposome
The present invention provides a sugar-modified liposome having a sugar chain bonded to its membrane surface, preferably through a linker protein, and having excellent absorption qualities,...
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7060291 |
Modular targeted liposomal delivery system
A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound...
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6991776 |
Intracorporeal medicaments for high energy phototherapeutic treatment of disease
New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described,...
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6991805 |
Temperature sensitive control of liposome-cell adhesion
The present invention provides a liposomal composition for targeted delivery of drugs. The composition comprises poloxamer molecules and liposomes encapsulating one or more delivery agents. At...
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6989153 |
Radiation sensitive liposomes
The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a...
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6986902 |
Polyanionic polymers which enhance fusogenicity
The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make...
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6979460 |
Vinyl ether lipids with cleavable hydrophlic headgroups
A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be...
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6974589 |
Neutral-cationic lipid for nucleic acid and drug delivery
A lipid represented by the formula:
wherein each of R 1 and R 2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0–20; L is selected from the group consisting...
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6958160 |
Self forming, thermodynamically stable liposomes and their applications
A liposome suspension forms spontaneously upon adding a lipid composition to an aqueous solution. The liposomes include diacylglycerol-PEG compounds. The melting point of the diacylglycerol-PEG is...
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6916488 |
Amphiphilic polymeric vesicles
Vesicles made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. AB copolymers can also...
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6884407 |
Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
Improved methods for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a...
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6818227 |
Liposome composition and method for administration of a radiosensitizer
A method for administering a radiosensitizer to a tumor site in a subject is described. The method includes preparing liposomes composed of a vesicle-forming lipid and a lipid-derivatized...
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6765104 |
Transition metal complexes of n, n',n″trialkyl-cis-1,3,5-triaminocyclohexane and related compositions and methods of synthesis and use
The present invention provides transition metal complexes of N,N′,N″-trialkyl-cis,cis-1,3,5-triaminocyclohexane and related compositions and methods of synthesis and use in vitro and in vivo,...
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6749831 |
Vaccine against lipopolysaccharide core
Compare core LPS (lacking O-polysaccharide side chains) from Gram-negative bacteria are incorporated into a vaccine typically in liposomes. The complete core of E. coli K 12 is particularly...
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6726925 |
Temperature-sensitive liposomal formulation
A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid...
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6676963 |
Ligand-targeted emulsions carrying bioactive agents
A composition for use in delivering a bioactive agent to targeted tissues or cells comprises: (a) a site-specific targeting ligand; (b) a lipid encapsulated oil in water emulsion; and (c) a...
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6649366 |
Methods and compositions related to modulators of annexin and cartilage homeostasis
The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the...
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6645464 |
Loading metal particles into cell membrane vesicles and metal particular use for imaging and therapy
Delivery of metal particles to living tissue, then applying external energy that interacts with the metal particles, is found to selectively increase the energy deposition and interaction...
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6627218 |
Cationic amphiphiles of cholesterol
A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and...
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6596543 |
Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
The present invention relates generally to the field of prothrombin time reagents for determining dysfunction in the coagulation system and more specifically to reagents made from native...
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6586001 |
Neutral lipopolymer and liposomal compositions containing same
Liposomes containing PEG-substituted neutral lipopolymers provide similar circulation times to liposomes incorporating conventional, negatively charged PEG-substituted phospholipids. Use of the...
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6576220 |
Non-invasive methods for surgery in the vasculature
Novel methods of non-invasive intravascular surgery are disclosed, which include the intravascular administration of a composition comprising gas or gaseous precursor filled vesicles, followed by...
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6569451 |
Targeted polymerized liposome diagnostic and treatment agents
Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting...
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6562371 |
Liposomes
This invention provides a liposome having a drug included therein, which has active targeting property and ensured stability in blood and can be used effectively in the diagnosis and/or treatment...
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6551576 |
Container with multi-phase composition for use in diagnostic and therapeutic applications
A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic...
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6500646 |
Cell membrane-directed drugs
Drugs in which peptides having affinity specific for phospholipids, preferably those which are contained in the constituents of lipid bilayers forming the surface layers of cells and of which the...
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6475515 |
Process for increasing the stability of liposome suspensions that contain hydrophilic active ingredients
A process for increasing the stability of liposome suspensions that contain hydrophilic active ingredients is described, which is characterized in that the active ingredient that is to be...
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6468505 |
Technique to monitor drug delivery noninvasively in vivo
The present invention relates to the field of diagnostic imaging and more specifically to the field of monitoring drug delivery using non-invasive imaging techniques. The present invention provides...
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6461586 |
Method of magnetic resonance focused surgical and therapeutic ultrasound
A novel method for the controlled delivery of therapeutic compounds to a region of a patient, using magnetic resonance focused therapeutic ultrasound, is disclosed.
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6447800 |
Method of loading preformed liposomes using ethanol
This invention provides methods of loading preformed liposomes by transmembrane permeation induced by alcohols. Solutes loaded into liposomes by this ethanol mediated process include both small...
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6426086 |
pH-sensitive, serum-stable liposomes
This invention relates to the field of liposomes. In particular, this invention provides novel liposomes that are pH-sensitive, yet are also stable in serum. The liposomes are complexed with a...
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6426088 |
Encapsulated cells producing antibodies
The present invention relates to capsules encapsulating antibody-producing cells, and to use of such capsules and encapsulated cells, respectively, for implantation in vivo for long term delivery...
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6423314 |
Tumor derived carbohydrate binding protein
The active, galactose binding site of proteins associated with metastatic tumor cells has been identified and sequenced. The polypeptide comprising the active site may be used as an...
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6403117 |
Archaesomes, archaeosomes containing coenzyme Q10 and other types of liposomes containing coenzyme Q10 adjuvants and as delivery vehicles
Novel archaeosome compositions and their use in vaccine formulations as adjuvants and/or delivery systems, to enhance the immune response to immunogens in an animal such as a human, are described....
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