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7338651 |
Multi-use multimodal imaging chelates
Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10...
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7276254 |
Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same
A method of forming polymeric microspheres for biomedical applications includes forming polymeric microspheres by an emulsion/aggregation process from a precursor monomer species, and treating the...
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7255851 |
Non-invasive localization of a light-emitting conjugate in a mammal
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for...
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7244413 |
Functionalized encapsulated fluorescent nanocrystals
Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated...
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7235228 |
Fluorescent-magnetic nanoparticles with core-shell structure
This invention comprises nanoparticles for use with biosensors. The nanoparticles have core/shell architecture. The nanoparticles can be detected by two means, magnetic and optical by virtue of the...
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7235227 |
Paramagnetic particles that provide improved relaxivity
An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the...
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7220401 |
Blood clot-targeted nanoparticles
Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said...
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7186399 |
Methods for targeted drug delivery
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated...
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7179450 |
Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129 Xe in a selected structure, environment, or system. The signal data...
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7163935 |
Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging...
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7081452 |
Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging...
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7052677 |
Substituted octanuclear pyrazolato clusters with electron transfer and MRI contrast agent properties
The present invention is directed to an Fe(III) complex comprising a redox-active metal cluster in a chemically inert shell. The inventive complex has electron transfer and paramagnetic properties.
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7018611 |
Vitronectin receptor antagonist pharmaceuticals
The present invention describes novel compounds of the formula:
(Q) d —L n —C h ,
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6924150 |
Magnetic resonance imaging contrast system
A method for improving the magnetic resonance imaging contrast of a selected portion of a sample. A selected ferrimagnetic constituent is associated with the sample portion, by molecular or...
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6896874 |
MR-signal emitting coatings
The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer...
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6896873 |
MR signal-emitting coatings
The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer...
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6884407 |
Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
Improved methods for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a...
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6818203 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
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6808699 |
Methods for imaging pulmonary and cardiac vasculature and evaluating blood flow using dissolved polarized 129Xe
MR spectroscopy and imaging methods for imaging pulmonary and cardiac vasculature and the cardiac region and evaluating blood flow or circulatory deficits use dissolved phase polarized 129 Xe gas...
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6797257 |
Paramagnetic polymerized protein microspheres and methods of preparation thereof
The present invention relates to a composition that includes gadolinium particles encapsulated in microsphere shells. The composition is suitable for use as a contrast agent with a plurality of...
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6680047 |
Diagnostic/therapeutic agents
Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or...
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6645464 |
Loading metal particles into cell membrane vesicles and metal particular use for imaging and therapy
Delivery of metal particles to living tissue, then applying external energy that interacts with the metal particles, is found to selectively increase the energy deposition and interaction...
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6638494 |
Super-paramagnetic particles with increased R1 relaxivity, process for producing said particles and use thereof
The invention relates to super-paramagnetic single domain particles with increased R 1 relaxivity and with surface-stabilizer substances. The particles are characterized in that they consist of...
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6599497 |
Hyperpolarized helium-3 microbubble gas entrapment methods and associated products
Methods for increasing the T 1 of injectable microbubble formulations of hyperpolarized 3 He include the step of introducing the hyperpolarized 3 He to a quantity of microbubbles held in a...
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6596259 |
Metal based cubane structure contained in an octanuclear complex stable over several oxidation states and a method of producing the same
The present invention is directed to a complex comprising a redox-active metal cluster in a chemically inert shell. The inventive complex has the formula M 8 (μ 4 -E) 4 (μ-L) 12 X, where M is...
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6589506 |
Method for magnetic resonance imaging of the lung
A method for the assessment of pulmonary ventilation and lung perfusion through Magnetic Resonance Imaging (MRI), comprising the steps of: positioning a human subject in an MRI apparatus,...
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6576221 |
Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes. The nanoparticles according to...
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6576220 |
Non-invasive methods for surgery in the vasculature
Novel methods of non-invasive intravascular surgery are disclosed, which include the intravascular administration of a composition comprising gas or gaseous precursor filled vesicles, followed by...
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6534039 |
Extended organic cobalt and nickel magnetic complexes
Disclosed is a method for in vivo imaging tissue of a individual, by performing magnetic resonance imaging utilizing an extended cobalt complex as a contrast enhancement agent. The extended cobalt...
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6514481 |
Magnetic nanoparticles for selective therapy
The present invention provides novel nanosized particles termed as “nanoclinics” for therapeutic and/or diagnostic use. The particles have a core made of a therapeutic or diagnostic material...
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6479033 |
Antitumor cystostatic and contrast agent
The invention concerns a composition for the treatment of tumors, of (i) at least one cytostatic drug component which is unencapsulated or is encapsulated in a PEG-, immuno-, or immuno/PEG...
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6461587 |
Perfluoroalkylamides, their production and their use in diagnosis
The invention relates to macrocyclic perfluoroalkylamides, their production and their use in diagnosis.
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6461586 |
Method of magnetic resonance focused surgical and therapeutic ultrasound
A novel method for the controlled delivery of therapeutic compounds to a region of a patient, using magnetic resonance focused therapeutic ultrasound, is disclosed.
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6423296 |
Constrast media
The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved...
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6368574 |
Contrast agent-enhanced magnetic resonance imaging of tissue perfusion
This invention relates to a method of contrast agent-enhanced magnetic resonance imaging of perfusion in vasculated tissue within a human or non-human animal body in which a bolus comprising a...
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6355225 |
Fullerene contrast agent for magnetic resonance imaging and spectroscopy
A non-toxic contrast agent for enhancing contrast in in vivo magnetic resonance measurements, comprised of a water-soluble, stable paramagnetic fullerene that is free of paramagnetic metal species....
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6352683 |
Apparatus and method for the local delivery of drugs
A local and site-specific drug delivery apparatus for delivering a drug to a specific site is characterized by the combination of a carrier material which reflects or absorbs or emits...
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6333110 |
Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging
Provided is a method of fluorescence imaging of living tissue using functionalized nanocrystals. The method comprises contacting an effective amount of functionalized nanocrystals with the living...
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6319607 |
Purification of functionalized fluorescent nanocrystals
Provided are methods for purifying functionalized fluorescent nanocrystals having affinity ligand operably bound thereto by using a solid support matrix in a reactor through which solutions are...
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6315981 |
Gas filled microspheres as magnetic resonance imaging contrast agents
Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.
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6309701 |
Fluorescent nanocrystal-labeled microspheres for fluorescence analyses
Provided are a fluorescent microsphere comprised of a plurality of fluorescent nanocrystals operably bound to a polymeric microsphere, and a method of producing the fluorescent microspheres which...
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6274120 |
Dry microparticles for use as a contrast agent
Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting...
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6261537 |
Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming...
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6261535 |
Diagnostic methods for targeting the vasculature of solid tumors
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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6258338 |
Hollow or cup-shaped microparticles and methods of use
A particulate material which comprises hollow or cup-shaped ceramic microspheres having a diameter in the range of from 5 to 200 microns. The material may comprise a beta- or gamma-emitting...
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6251366 |
Use of dispersions of magneto-ionic particles as MRI contrast media
The invention relates to the use of dispersions of magneto-ionic particles consisting essentially of superparamagnetic solid particles and at least one polyelectrolyte as dispersing substance in...
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6232295 |
Cell-specific contrast agent and gene delivery vehicles
A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the...
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6200547 |
Magnetically responsive compositions for carrying biologically active substances and methods of production and use
A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a...
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6168780 |
Marker for determining its position in a cavity inside the organism of a living being
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6146657 |
Gas-filled lipid spheres for use in diagnostic and therapeutic applications
A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic...
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