|
Match
|
Document |
Document Title |
|
|
7385395 |
Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis
The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which...
|
|
|
7385041 |
Dual functioning excipient for metal chelate contrast agents
A novel dual functioning excipient for metal chelate contrast agents is disclosed. The present excipient,
X m [X′(L′)] n...
|
|
|
7373782 |
Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during...
|
|
|
7371365 |
Methods for detecting parenchymal plaques in vivo
Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity...
|
|
|
7368099 |
MRI contrast agents
An MRI contrast agent enables direct detection and imaging of exfoliated vascular endothelial sites. The MRI contrast agent includes an imaging unit which contains an unpaired electron-carrying...
|
|
|
7368254 |
Lipid-based systems for targeting diagnostic agents
The invention relates to targeting of diagnostic agents by use of lipid-based compositions. The invention is useful in the diagnosis of various disorders which are associated with or resulting from...
|
|
|
7361336 |
Methods of cancer therapy targeted against a cancer stem line
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous...
|
|
|
7357917 |
Diagnostic procedures using 129Xe spectroscopy characterstic chemical shift to detect pathology in vivo
An in vivo non-invasive method for detecting and/or diagnosing a pathological condition using hyperpolarized 129 Xe spectroscopy is disclosed. Generally stated, the method includes determining the...
|
|
|
7354568 |
Magnetic resonance imaging agents for the detection of physiological agents
The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
|
|
|
7351402 |
Polarizing agents for dynamic nuclear polarization
We describe polarizing agents for use in enhancing NMR and MRI signals via dynamic nuclear polarization (DNP). The polarizing agents include two or more paramagnetic centers, preferably two...
|
|
|
7344704 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
|
|
|
7341711 |
Porphyrin compounds and their use in high-field MRI
A new use in magnetic resonance imaging employing a field greater than 1.5 Tesla, of a porphyrin compound of the following general formula I is provided:
in which R 0 and R′ 0 are such that...
|
|
|
7338651 |
Multi-use multimodal imaging chelates
Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10...
|
|
|
7330748 |
Method for determining in vivo concentration of a metabolite
Method for determining in vivo concentration of a metabolite that includes administering a contrast agent to a subject, allowing the contrast agent to disperse to tissue of interest, performing...
|
|
|
7326402 |
Method of diagnosing, monitoring, staging, imaging and treating cancer
The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer.
|
|
|
7320784 |
Immobilized labeling compounds and methods
The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to the...
|
|
|
7306785 |
Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety...
|
|
|
7303741 |
Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional...
|
|
|
7289840 |
Method for monitoring early treatment response
Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline...
|
|
|
7288244 |
Determining vulnerable plaque in blood vessels
The invention is based on the realisation that inflamed plaques in blood vessel walls, which are potentially vulnerable to rupture, can be detected at elevated temperatures which are lower than...
|
|
|
7279150 |
Chelating agents with lipophilic carriers
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
|
|
|
7261876 |
Multivalent constructs for therapeutic and diagnostic applications
The invention provides compositions and methods for therapeutic and diagnostic applications.
|
|
|
7238341 |
Peptide-based multimeric targeted contrast agents
Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
|
|
|
7235227 |
Paramagnetic particles that provide improved relaxivity
An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the...
|
|
|
7229606 |
Diagnostic imaging contrast agents with extended blood retention
The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
|
|
|
7220402 |
Alpha-fetoprotein peptides and uses for imaging
The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include...
|
|
|
7208139 |
Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic...
|
|
|
7201891 |
Pharmaceutical preparation for the diagnosis of helicobacter pylori infection
A coated preparation for the detection of a H. pylori infection according to a urea breath test protocol which comprises a core composition containing at least an isotope C-labeled urea, an...
|
|
|
7203350 |
Display for computer-aided diagnosis of mammograms
A method for displaying a computer-generated determination of the likelihood of malignancy in a mammogram lesion. The method requires providing a digitized image of a mammogram, displaying the...
|
|
|
7198777 |
Optical contrast agents for optically modifying incident radiation
A method of enhancing the contrast of an image of a sample, comprises forming an image of a mixture, by exposing the mixture to electromagnetic radiation. The mixture comprises the sample and...
|
|
|
7198775 |
Detectably labeled porphyrin compound for identifying the sentinel lymph node
A detectably labeled porphyrin compound for identifying a sentinel lymph node in patients, particularly those with cancer. A method of identifying a sentinel lymph node, comprising the steps of:...
|
|
|
7186399 |
Methods for targeted drug delivery
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated...
|
|
|
7186400 |
Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
Compounds of general formula (I): in which: R 1 is hydrogen, C 1 –C 20 alkyl, C 3 –C 10 cycloalkyl, C 4 –C 20 cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight...
|
|
|
7182934 |
Contrast agents
The invention provides a composition of matter of formula I
V-L-R (I)
where...
|
|
|
7181266 |
Materials and methods for near-infrared and infrared lymph node mapping
A lymphatic system can be imaged with emissive semiconductor nanocrystals, for example, in the near infrared.
|
|
|
7179450 |
Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129 Xe in a selected structure, environment, or system. The signal data...
|
|
|
7175829 |
Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an...
|
|
|
7172749 |
Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and...
|
|
|
7174200 |
Optimized high-speed magnetic resonance imaging method and system using hyperpolarized noble gases
A system and method for using hyperpolarized noble gases together with an appropriately designed and optimized magnetic resonance imaging pulse sequence to rapidly acquire static or dynamic...
|
|
|
7163935 |
Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging...
|
|
|
7161352 |
Beam current measuring device and apparatus using the same
A beam current measuring device (BMD) capable of measuring beam current while radiating the beam on a target, such as a semiconductor wafer. The BMD at least includes: (a) a detecting part operable...
|
|
|
7151117 |
Concentrated X-ray contrast media can act as universal antigens and can inhibit or prevent allergic reactions
The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to...
|
|
|
7138104 |
Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
The present invention describes a method of concurrent imaging in a mammal comprising:
a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging...
|
|
|
7138105 |
Compositions for delivery of therapeutics and other materials, and methods of making and using the same
In part, the present invention is directed to compositions comprising a carrier with a metal binding domain, a metal ion, and an active agent.
|
|
|
7138103 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
|
|
|
7128895 |
Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability
The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the...
|
|
|
7127092 |
Reduction of motion artifact in NMR images using spherical navigator signals
A series of fMRI image frames are acquired along with interleaved navigator signals. The navigator signals are acquired while three orthogonal readout gradients are applied such that a spherical...
|
|
|
7122133 |
Finely particulate functional metal and finely particulate functional semiconductor each with dispersion stability and process for producing the same
A stabilized dispersion of metal fine particles comprising, fine particles of metal which is obtained by reducing at least one metallic acid or salt thereof selected from the group consisting of...
|
|
|
7118730 |
Quinoline derivative as diagnostic probe for disease with tau protein accumulation
The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits...
|
|
|
7115249 |
Solid-phase electrophilic fluorination
The invention relates to compounds of formula (I); wherein R 1 and R 2 independently selected from C 1-6 alkyl; P 1 , P 2 , P 3 , and P 4 are each independently hydrogen or a protecting group;...
|