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8790621 Nanoparticles and nanoparticle compositions  
The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for...
8784772 Urothelial differentiation of urothelial carcinoma: a bladder cancer stem cell model  
The present invention provides a method of treating cancer in a patient (e.g., a human patient) in need thereof, the method comprising administering a therapeutically effective regimen, the regimen...
8785569 Drug carrier with chelating complex micelles and the application thereof  
This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in...
8784800 Method of delivering cell therapy to a target site  
A method of delivering therapy to a target site. The method includes (a) obtaining a base image of the target site, (b) injecting a dose of a mix of a therapeutic agent and a contrast agent into a...
8778344 Method of treating atopic dermatitis with antibody to zcytor17 ligand  
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for...
8778411 Heat generating nanomaterials  
The present invention relates to a heat-generating composition, comprising a hetero-structure nanomaterial which comprises (a) a first material comprising at least one component selected from the...
8778304 TSPO-targeting compounds and uses thereof  
Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
8765099 Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum  
In magnetic resonance imaging (MRI), selected magnetic dipoles in a subject are aligned with a main magnetic field for later manipulation, and signals received after such manipulations are used to...
8763410 Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media  
Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized...
8758778 Polymeric nano-carriers with a linear dual response mechanism and uses thereof  
The present invention features compositions in which nano-carriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to...
8758726 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a...
8747811 Perylenequinone derivatives and uses thereof  
The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or...
8747839 Tracking of bone marrow cells for metastasis screening  
At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method,...
8741264 Self-sterilizing products  
Self-sterilising products, and in particular novel products comprising phthalocyanine derivatives bound to polymers, a process for the preparation of said products and their use for preparing...
8740872 Magnetically-targeted treatment for cardiac disorders  
The present disclosure describes a method for targeted delivery of permanently-acting or temporarily-acting neurotoxins, neurosuppressants, or other compounds having a neurologic effect to specific...
8741262 Targeted radiotherapy  
The present invention concerns a therapeutically labeled napthodianthrone or phenanthro[1,10,9,8-opqra]perylene-7,14-dione compound, which comprises a chemical element or an isotope that has an...
8734761 Responsive MRI contrast agents  
The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen...
8728529 Nanoparticle contrast agents for diagnostic imaging  
Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The...
8728440 Nanoparticulate compositions for diagnostic imaging  
The present invention provides a trialkoxysilanes having structure I wherein R1 and R2 are independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or...
8731640 Fluid path system for dissolution and transport of a hyperpolarized material  
A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end...
8728439 System and method for indirectly measuring calcium ion efflux  
A system and method for indirectly measuring calcium ion efflux from a cell of a subject by using manganese ions as a surrogate marker for calcium is disclosed. Manganese ion efflux is measured...
8722018 Method for preparing nanoparticles covered with a gem-bisphosphonate stabilizing layer coupled to hydrophilic distribution ligands  
A novel method for preparing nanoparticles for medical imaging, including a metal core, an organic stabilizing layer containing gem-bisphosphonate compounds and at least one hydrophilic...
8722420 Method for detecting an endogenous biomolecule  
Provided is a method for the real-time visualization of an endogenous biomolecule to clarify the mechanisms of various diseases and enable diagnosis and treatment of these diseases. Specifically...
8715621 Radical polarizing agents for dynamic nuclear polarization  
The present invention provides a variety of radicals, which are useful as polarizing compounds. Exemplary radicals are represented by compounds of Structural Formulae (I), (II), (III) and (IV) as...
8709382 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of 18F- or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to...
8709379 Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery  
Formulations of neutral retinoids, in particular fenretinide (HPR) in the form of lipid nanoparticles, solid dispersions and emulsions are disclosed. These compositions are used to treat diseases...
8703102 Systems and methods for producing hyperpolarized materials and mixtures thereof  
The present disclosure provides various methods and systems for manufacture, transport and delivery of material including highly polarized nuclei that is in a hyperpolarized state.
8703201 Hyperpolarization methods, systems and compositions  
The disclosure provides various methods and systems for providing hyperpolarized materials as well as the hyperpolarized materials so provided. In addition, methods of providing hyperpolarized...
8679456 Method of hyperpolarising a magnetic resonance agent  
A method of hyperpolarising a magnetic resonance (MR) agent is suitable for use in magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (MRS). The method includes providing a...
8658129 Agents and methods for the imaging of myelin basic protein  
The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying a...
8642013 Nano-scale contrast agents and methods of use  
Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a...
8642257 Vaccinia virus for diagnosis and therapy of tumors  
Described are diagnostic and pharmaceutical compositions comprising a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable...
8636980 MRI thermometry combined with hyperpolarisation device using photons with orbital angular momentum  
A magnetic resonance examination system comprises an RF-system for inducing resonance in polarized dipoles and receiving magnetic resonance signals from an object to be examined. A thermometry...
8632752 In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents  
The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes....
8632751 Scanning suspension comprising a particle with a diameter of at least 1 micrometer  
The invention provides a scanning suspension comprising a particle which is capable of at least in part disturbing a magnetic field, wherein said particle comprises a diameter of at least 1 μm, ...
8628751 Pyrazine derivatives for optical imaging and therapy  
The invention provides compounds, including compositions, preparations and formulations, and methods of using and making such compounds. Compounds of the present invention include pyrazine...
8623327 Imaging agents for use in magnetic resonance blood flow/perfusion imaging  
In one aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the...
8617515 Imaging of myelin basic protein  
The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering...
8617514 Tumor-targeted nanodelivery systems to improve early MRI detection of cancer  
The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted...
8609073 Compositions and methods for reducing photosensitivity associated with photodynamic therapy  
The present invention provides compositions and methods for decreasing photosensitivity induced by photodynamic therapy (PDT). The compositions and methods of the present method employ porphyrin...
8603436 Methods and compositions for targeted drug delivery  
Disclosed are Drug Delivery Molecules (DDMs) which both facilitate functional imaging, as by PET, MRI or SPECT, and create a biological effect and methods of their use. These DDMs which are...
8591864 Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents  
Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The...
8586095 Thermosensitive nanostructure for hyperthermia treatment  
A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of...
8586022 Light emitting microorganisms and cells for diagnosis and therapy of tumors  
Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a...
8574546 Substituted aryl-fluoroborates as imaging agents  
Substituted aryl-boron compounds comprising at least one 18F atom, as illustrated by the formula (I), where at least one of Y1 or Y2 is 18F and A1 is a substituted aromatic ring, with G1-5 being,...
8568694 Nanoparticulate probe for in vivo monitoring of tissue oxygenation  
A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic...
8568707 Light emitting microorganisms and cells for diagnosis and therapy of tumors  
Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a...
8562944 PAA nanoparticles for enhancement of tumor imaging  
A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.
8562953 Dendritic polymers and magnetic resonance imaging contrast agent employing the same  
A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of...
8563298 NMR systems and methods for the rapid detection of analytes  
This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.