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8679456 Method of hyperpolarising a magnetic resonance agent  
A method of hyperpolarising a magnetic resonance (MR) agent is suitable for use in magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (MRS). The method includes providing a...
8658129 Agents and methods for the imaging of myelin basic protein  
The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying a...
8642013 Nano-scale contrast agents and methods of use  
Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a...
8642257 Vaccinia virus for diagnosis and therapy of tumors  
Described are diagnostic and pharmaceutical compositions comprising a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable...
8636980 MRI thermometry combined with hyperpolarisation device using photons with orbital angular momentum  
A magnetic resonance examination system comprises an RF-system for inducing resonance in polarized dipoles and receiving magnetic resonance signals from an object to be examined. A thermometry...
8632752 In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents  
The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes....
8632751 Scanning suspension comprising a particle with a diameter of at least 1 micrometer  
The invention provides a scanning suspension comprising a particle which is capable of at least in part disturbing a magnetic field, wherein said particle comprises a diameter of at least 1 μm, ...
8628751 Pyrazine derivatives for optical imaging and therapy  
The invention provides compounds, including compositions, preparations and formulations, and methods of using and making such compounds. Compounds of the present invention include pyrazine...
8623327 Imaging agents for use in magnetic resonance blood flow/perfusion imaging  
In one aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the...
8617515 Imaging of myelin basic protein  
The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering...
8617514 Tumor-targeted nanodelivery systems to improve early MRI detection of cancer  
The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted...
8609073 Compositions and methods for reducing photosensitivity associated with photodynamic therapy  
The present invention provides compositions and methods for decreasing photosensitivity induced by photodynamic therapy (PDT). The compositions and methods of the present method employ porphyrin...
8603436 Methods and compositions for targeted drug delivery  
Disclosed are Drug Delivery Molecules (DDMs) which both facilitate functional imaging, as by PET, MRI or SPECT, and create a biological effect and methods of their use. These DDMs which are...
8591864 Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents  
Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The...
8586095 Thermosensitive nanostructure for hyperthermia treatment  
A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of...
8586022 Light emitting microorganisms and cells for diagnosis and therapy of tumors  
Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a...
8574546 Substituted aryl-fluoroborates as imaging agents  
Substituted aryl-boron compounds comprising at least one 18F atom, as illustrated by the formula (I), where at least one of Y1 or Y2 is 18F and A1 is a substituted aromatic ring, with G1-5 being,...
8568694 Nanoparticulate probe for in vivo monitoring of tissue oxygenation  
A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic...
8568707 Light emitting microorganisms and cells for diagnosis and therapy of tumors  
Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a...
8562944 PAA nanoparticles for enhancement of tumor imaging  
A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.
8562953 Dendritic polymers and magnetic resonance imaging contrast agent employing the same  
A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of...
8563298 NMR systems and methods for the rapid detection of analytes  
This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
8551452 Uridine dietary supplementation compliance methods and use thereof  
This invention relates to determining the compliance of a subject receiving dietary supplementation with uridine or a uridine source. Specifically, the invention relates to the use of MRS for...
8545813 Pre-templated macromolecular architectures with multiple Gd(III) complexes and methods of use as MRI contrast agents  
The present invention relates to contrast agents for MRI and related methods of use.
8540965 Single wall nanotube constructs and uses therefor  
The present invention provides soluble single wall nanotube constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The...
8532735 Device and method for examination and use of an electrical field in an object under examination containing magnetic particles  
The present invention relates to a device for examination and use of an electrical field in a magnetic gradient field, containing magnetic particles in an examination area of an object under...
8524195 Iron oxide nanoparticles as MRI contrast agents and their preparing method  
Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron...
8518373 Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics  
The invention concerns a method for obtaining diagnostic images of a human or animal body organ, region, fluid or tissue by using combined X-ray and/or Magnetization Transfer (MT) based MRI...
8512677 Pyro-glutamate Aβ targeting agents  
A method of inhibiting amyloid beta aggregation in a mammal includes administering an amount of a pyro-Glu-(3-40/42)-Aβ targeting agent and/or fragment thereof that specifically binds to an ...
8501158 Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents  
Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral...
8501159 Magnetic nanoparticles for the application in hyperthermia, preparation thereof and use in constructs having a pharmacological application  
There are described nanoparticles of magnetic metal oxides employable in constructs consisting in polymer particles possibly also incorporating pharmacologically active substances.
8486409 Alpha-emitting constructs and uses thereof  
The present invention discloses alpha particle emitting, radioactive constructs capable of killing large tumors (>1 mm in diameter), or other cells involved in human or animal diseases such as...
8486372 Cyclic azapeptides as integrin markers and methods of using  
The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic...
RE44354 Amyloid plaque aggregation inhibitors and diagnostic imaging agents  
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to...
RE44338 Amyloid plaque aggregation inhibitors and diagnostic imaging agents  
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to...
8470528 Methods and compositions related to adenoassociated virus-phage particles  
Embodiments of the invention are generally directed to compositions and methods of delivering one or more transgene to a target cell, such as a tumor cell, in a site-specific manner to achieve...
8465725 Process for production of heterodimers of glutamic acid  
A manufacturing process for the preparation of radiolabeled compounds of formula (I) includes reacting compounds of formula (II) with a source of radionuclide of a halogen in the presence of an...
8460636 Complex compound and MRI probe made of same  
Novel gadolinium complex compounds responsive to ions and compounds other than zinc ion, as well as MRI probes made of the compounds are disclosed. Since the gadolinium complex compounds of the...
8454935 Cell permeable probe  
A cell permeable probe is disclosed. The cell permeable probe includes a cell membrane translocating element, which facilitates transport of the probe into the intracellular component of a cell....
8454936 Metal chelators and methods of their use  
Metal chelators of Formula I and Formula II are disclosed: or a pharmaceutically acceptable salt thereof. Also disclosed are metal chelator-targeting moiety complexes, metal chelator-targeting...
8445021 Functionalized magnetic nanoparticles and methods of use thereof  
The present disclosure provides compositions comprising 2-deoxyglucose-functionalized magnetic nanoparticles. The compositions are useful in various applications, which are also provided.
8435496 Nanoparticle clusters and methods for forming same  
A method for providing nanoparticle clusters of controlled dimensions is described. The method involves an activation of individual nanoparticles and the subsequent interaction between activated...
8431723 Radicals and their use as paramagnetic agents in a DNP process  
The invention relates to new radicals, their use as paramagnetic agents in a method for the dynamic nuclear polarisation and a method for the dynamic nuclear polarisation of compounds comprising...
8414866 Method of magnetic resonance imaging of the heart with paramagnetic MN2+  
The present invention relates to a magnetic resonance imaging (MRI) method, in particular to a MRI method enabling early detection of myocardial ischemia.
8404216 Dendritic chelated compounds, methods for making the same and pharmaceutical compositions containing the same  
The invention relates to dendritic chelated compounds, to methods for producing the same and to pharmaceutical compositions containing the same. The dendritic chelated complexes of the present...
8394356 Diagnostic imaging contrast agents with extended blood retention  
The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
8388936 In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging  
A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging...
8391959 Composition for improving efficiency of drug delivery  
Method and composition suitable for administering by direct convective interstitial infusion are disclosed. The method comprises: placing at least one direct convective interstitial infusion...
8388932 Ligands to radiation-induced molecules  
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to...
8386012 Screening test for recognizing prostate diseases and apparatus and diagnosis substance for carrying out the test  
In a screening test method, and a device for implementing the screening test method, a diagnostic substance is provided that contains at least one biomarker connected with at least one...