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8163270 |
Methods of diagnosing and treating migraine
The present invention provides methods of diagnosing migraine attacks and determining predisposition of an individual to the development of migraine based on sodium level in the cerebrospinal fluid...
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8153581 |
Process for producing an injectable medicament preparation
The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective substance which is comprised of an active agent, of a...
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8147802 |
Chelator-functionalized nanoparticles
Provided herein are chelator-functionalized nanoparticles comprising a passive core; and an active coating that demonstrate T1 magnetic resonance pattern upon exposure to a magnetic field. Also...
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8133473 |
Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and...
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8133471 |
CLK-peptide and SLK-peptide
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially...
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8128907 |
CSF biomarker dilution factor corrections by MRI imaging and algorithm
A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated...
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8128908 |
Nanoparticles and their use for multifunctional bioimaging
The present invention relates to fluorescent, radio-opaque and magnetic quantum nanoparticles, useful as multifunctional contrast agents or probes for in vivo bioimaging, and methods of their use....
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8097252 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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8092779 |
Post-biopsy cavity treatment implants and methods
A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix...
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8092782 |
Polybiotin compounds of magnetic resonance imaging and drug delivery
The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds...
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8088381 |
Methods of treatment of cardiovascular disease using anti-CTGF agents
The present invention relates to methods for treating impaired cardiac function. Methods for treating various physiological and pathological features associated with cardiac dysfunction by...
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8084017 |
Contrast agents for magnetic resonance imaging and methods related thereto
In certain aspects the present invention provides methods and compositions related to contrast agents for magnetic resonance imaging. In certain variations, contrast agents provided herein are...
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8071737 |
Nucleic acid ligand complexes
This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound...
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8066973 |
Nanoparticulate probe for in vivo monitoring of tissue oxygenation
A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging...
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8053415 |
Compounds having RD targeting motifs
The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated...
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8038987 |
Process for the preparation of coated polymer particles
A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting porous, surface-functionalized, superparamagnetic...
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8021646 |
Compositions and methods for magnetic resonance imaging contrast agents
The present application provides for compositions and methods of creating and applying contrast agents that find use in magnetic resonance imaging (MRI). In particular, contrast agents that...
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8017105 |
Diagnostic imaging contrast agents with extended blood retention
The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
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8012458 |
Rare-earth amidate coordination compounds
The invention is directed to a lanthamide chelate composition having a lanthamide, a charged amidate ligand, and a mono- or bidentate neutrally charged coordination compound, the composition being...
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8003077 |
Method for the production of hyperpolarized 129Xe
The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent.
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8003078 |
Targeted MR imaging agents
MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient...
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7993628 |
Higher fatty acid triester and amide derivative having diethylenetriamine-type metal chelate structure
A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula...
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7981399 |
Method to determine state of a cell exchanging metabolites with a fluid medium by analyzing the metabolites in the fluid medium
The present invention relates to a method for determining the ideal time for and outcome of reproductive health procedures including in vitro fertilization by establishing a correlation between the...
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7968082 |
Evaluating mixtures of low molecular weight heparins by NMR
Methods for analyzing mixtures of polysaccharides, for example heparin such as enoxaparin are described. In some instances, the mixtures are analyzed using 1D NMR and/or 2D NMR.
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7966056 |
Magnetic resonance imaging method and compounds for use in the method
The present invention relates to a magnetic resonance imaging (MRI) method, in particular to a MRI method enabling early detection of myocardial ischemia and to compounds for use as MR contrast...
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7943775 |
Small molecules for imaging protein-protein interactions
A tissue is imaged to detect the presence of amyloid deposits or other target proteins prior to their aggregation into plaques, with the assistance of the administration of a labeled bifunctional...
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7943161 |
Contrast agent coated medical device
A magnetically opaque medical device is disclosed wherein a contrast agent is incorporated into the actual device. The medical device is generally comprised of a base material forming the structure...
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7927581 |
Peptide-based multimeric targeted contrast agents
Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
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7914787 |
Production and use of novel peptide-based agents with bispecific antibodies
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a...
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7906104 |
Methods for detecting pancreatic beta-islet cells and diseases thereof
The role of synaptic adhesion molecules in human cell development and function is largely unknown. This invention provides methods to study β-cell function in native tissue through the use of ...
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7902333 |
Labeling methods with oxygen isotopes
The present invention provides methods for labeling One or two oxygen atom(s) in a carboxyl group of a carboxyl-containing compound with an oxygen isotope selected from oxygen-17 (17O) or oxygen-18...
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7897140 |
Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in...
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7892547 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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7871597 |
Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral...
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7867477 |
Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized 129Xe
In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data...
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7842281 |
Magnetic particle composition for therapeutic hyperthermia
Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The...
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7833964 |
Methods of reducing visceral fat by increasing levels of insulin-like growth factor-I (IGF-I)
The present invention provides methods and compositions for reducing visceral fat by administering to the subject a therapeutically effective amount of a compound that increases the bioactive serum...
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7820143 |
Water soluble tetrapyrollic photosensitizers for photodynamic therapy
A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bac...
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7820144 |
Receptor selective cannabimimetic aminoalkylindoles
Disclosed are cannabimimetic aminoalkylindole compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. The disclosed compounds may...
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7815894 |
Compounds, compositions and methods for medical imaging of neuropsychiatric disorders
Compounds, compositions and methods for the diagnosis of Alzheimer's disease. Synthesized Glycerophosphocholine (GPC) may be used as a diagnostic aid to measure progression of Alzheimer's disease....
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7811549 |
Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects
Methods are presented that comprise the administration of a pharmaceutical composition comprising adenosine and dipyridamole, as well methods comprising the combined administration of dipyridamole...
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7809424 |
Method of off-resonance detection using complementary MR contrast agents
Off-resonance imaging uses two complementary contrast agents with the first agent (iron-oxide) particles transfected into cells which provide localized signals. The second agent is detected from a...
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7803352 |
Method for continuous visualization of a blood clot or plaque in body lumen
A method for visualizing a blood clot or plaque disposed within a body lumen comprising: binding a contrasting complex comprising a contrast material and a thrombolytic material or a clot...
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7780948 |
Post biopsy cavity treatment implants and methods
A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix...
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7780952 |
Agents for magnetic imaging method
The invention provides MRI detectable species of formula (I): Dp-Sn-Nm, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer,...
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7780953 |
Compositions magnetic particles covered with gem-bisphosphonate derivatives
The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds,...
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7771706 |
Method for monitoring protein translation
Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline...
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7744854 |
Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium
This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an...
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7745590 |
Degradable macromolecular magnetic resonance imaging contrast agents and methods thereof
Degradable macromolecular magnetic resonance imaging contrast agents for use in various diagnostic procedures, and methods for synthesizing, using and degrading these agents, are described. The...
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7740830 |
Imaging, diagnosis and treatment of disease
The present invention relates to endothelial cell-specific genes and encoded polypeptides and materials and uses thereof in the imaging, diagnosis and treatment of conditions involving the vascular...
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