|
Match
|
Document |
Document Title |
|
|
8445021 |
Functionalized magnetic nanoparticles and methods of use thereof
The present disclosure provides compositions comprising 2-deoxyglucose-functionalized magnetic nanoparticles. The compositions are useful in various applications, which are also provided.
|
|
|
8435496 |
Nanoparticle clusters and methods for forming same
A method for providing nanoparticle clusters of controlled dimensions is described. The method involves an activation of individual nanoparticles and the subsequent interaction between activated...
|
|
|
8431723 |
Radicals and their use as paramagnetic agents in a DNP process
The invention relates to new radicals, their use as paramagnetic agents in a method for the dynamic nuclear polarisation and a method for the dynamic nuclear polarisation of compounds comprising...
|
|
|
8414866 |
Method of magnetic resonance imaging of the heart with paramagnetic MN2+
The present invention relates to a magnetic resonance imaging (MRI) method, in particular to a MRI method enabling early detection of myocardial ischemia.
|
|
|
8404216 |
Dendritic chelated compounds, methods for making the same and pharmaceutical compositions containing the same
The invention relates to dendritic chelated compounds, to methods for producing the same and to pharmaceutical compositions containing the same. The dendritic chelated complexes of the present...
|
|
|
8394356 |
Diagnostic imaging contrast agents with extended blood retention
The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
|
|
|
8388936 |
In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging...
|
|
|
8391959 |
Composition for improving efficiency of drug delivery
Method and composition suitable for administering by direct convective interstitial infusion are disclosed. The method comprises: placing at least one direct convective interstitial infusion...
|
|
|
8388932 |
Ligands to radiation-induced molecules
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to...
|
|
|
8386012 |
Screening test for recognizing prostate diseases and apparatus and diagnosis substance for carrying out the test
In a screening test method, and a device for implementing the screening test method, a diagnostic substance is provided that contains at least one biomarker connected with at least one...
|
|
|
8377419 |
Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging
An imaging agent is disclosed for use in nuclear magnetic resonance imaging. The imaging agent includes a first substance and a second substance. The first substance includes at least one atom...
|
|
|
8377420 |
Injectable void filler for soft tissue augmentation
The present invention teaches a micro-porous injectable, soft elastic, fully resorbable fibrin-based composition for use as a soft tissue lumen and void filler. The composition of the present...
|
|
|
8372654 |
Method for investigating the fate of a test compound or the stateof a biological system by means of NMR of hyperpolarised NMR active nuclei
The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering...
|
|
|
8343458 |
Probes for in vivo targeting of active cysteine proteases
Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an...
|
|
|
8343462 |
Formulations for use in medical and diagnostic procedures
The present invention relates to formulations for use in medical or diagnostic procedures comprising a stabilizing agent alone or in combination with an osmotic agent. In one embodiment, the...
|
|
|
8337813 |
Contrast agents
The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate...
|
|
|
8329161 |
Red blood cell-derived vesicles as a nanoparticle drug delivery system
Red blood cell-derived vesicles (RDV) as a nanoparticle drug delivery system. The RDV are smaller than one micrometer, capable of encapsulating and delivering an exogenous substance into cells. The...
|
|
|
8323621 |
Multi-use multimodal imaging chelates
Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10...
|
|
|
8303937 |
Dendritic polymers and magnetic resonance imaging contrast agent employing the same
A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of...
|
|
|
8303931 |
Multimodal imaging using a three compartment polymer nanoparticle with cell specificity
The present invention pertains to a three compartment structured polymer nanoparticle (core-shell-corona) for multimodal imaging with specificity for cells or cellular components, thus enabling...
|
|
|
8303960 |
Radiolabeled affibody molecules
The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from Staphylococcus aureus, a bifunctional linker, and a radiolabel comprising...
|
|
|
8293213 |
Method and apparatus for thrombus removal using magnetic particles
A method and system for affecting a thrombus after ischemic stroke. The method may include injecting a plurality of magnetic particles into a bloodstream and moving or distorting a thrombus formed...
|
|
|
8277775 |
Boron dipyrromethene difluoro (BODIPY) conjugates
The present invention relates to FTY720 analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the alkyl side chain and methods of preparation. The compounds of the present...
|
|
|
8263042 |
Contrast agents for myocardial perfusion imaging
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds...
|
|
|
8258190 |
Encapsulated contrast agents
The present invention relates to the field of polymer chemistry and more particularly to encapsulated contrast agents and methods for using the same.
|
|
|
8246932 |
Non-radioactive traceable metal isotope-enriched nanoparticles and method of their use for determining biodistribution
Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a)...
|
|
|
8236572 |
Chemical exchange saturation transfer based MRI using reporter genes and MRI methods related thereto
Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide...
|
|
|
8211404 |
Ionic and non-ionic radiograhic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics
The invention discloses the use of ionic and non-ionic radiographic contrast agents for combined X-ray and nuclear magnetic resonance (MRI) diagnostics.
|
|
|
8192721 |
Compositions useful for reducing toxicity associated with gadolinium-based contrast agents
The invention relates to compositions comprising a gadolinium-based contrast agent and a derivatized cyclodextrin. Further provided are methods for reducing the toxicity associated with...
|
|
|
8163270 |
Methods of diagnosing and treating migraine
The present invention provides methods of diagnosing migraine attacks and determining predisposition of an individual to the development of migraine based on sodium level in the cerebrospinal fluid...
|
|
|
8153581 |
Process for producing an injectable medicament preparation
The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective substance which is comprised of an active agent, of a...
|
|
|
8147802 |
Chelator-functionalized nanoparticles
Provided herein are chelator-functionalized nanoparticles comprising a passive core; and an active coating that demonstrate T1 magnetic resonance pattern upon exposure to a magnetic field. Also...
|
|
|
8133473 |
Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and...
|
|
|
8133471 |
CLK-peptide and SLK-peptide
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially...
|
|
|
8128907 |
CSF biomarker dilution factor corrections by MRI imaging and algorithm
A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated...
|
|
|
8128908 |
Nanoparticles and their use for multifunctional bioimaging
The present invention relates to fluorescent, radio-opaque and magnetic quantum nanoparticles, useful as multifunctional contrast agents or probes for in vivo bioimaging, and methods of their use....
|
|
|
8097252 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
|
|
|
8092779 |
Post-biopsy cavity treatment implants and methods
A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix...
|
|
|
8092782 |
Polybiotin compounds of magnetic resonance imaging and drug delivery
The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds...
|
|
|
8088381 |
Methods of treatment of cardiovascular disease using anti-CTGF agents
The present invention relates to methods for treating impaired cardiac function. Methods for treating various physiological and pathological features associated with cardiac dysfunction by...
|
|
|
8084017 |
Contrast agents for magnetic resonance imaging and methods related thereto
In certain aspects the present invention provides methods and compositions related to contrast agents for magnetic resonance imaging. In certain variations, contrast agents provided herein are...
|
|
|
8071737 |
Nucleic acid ligand complexes
This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound...
|
|
|
8066973 |
Nanoparticulate probe for in vivo monitoring of tissue oxygenation
A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging...
|
|
|
8053415 |
Compounds having RD targeting motifs
The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated...
|
|
|
8038987 |
Process for the preparation of coated polymer particles
A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting porous, surface-functionalized, superparamagnetic...
|
|
|
8021646 |
Compositions and methods for magnetic resonance imaging contrast agents
The present application provides for compositions and methods of creating and applying contrast agents that find use in magnetic resonance imaging (MRI). In particular, contrast agents that...
|
|
|
8017105 |
Diagnostic imaging contrast agents with extended blood retention
The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image...
|
|
|
8012458 |
Rare-earth amidate coordination compounds
The invention is directed to a lanthamide chelate composition having a lanthamide, a charged amidate ligand, and a mono- or bidentate neutrally charged coordination compound, the composition being...
|
|
|
8003077 |
Method for the production of hyperpolarized 129Xe
The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent.
|
|
|
8003078 |
Targeted MR imaging agents
MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient...
|