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9011913 Use of functionalized magnetic nanoparticles in cancer detection and treatment  
The present invention provides methods of detecting a cancer cell in an individual, methods of grading a cancer, and methods of treating a cancer. The methods involve use of functionalized magnetic...
9005582 Hyperthermia therapeutic agent delivery system  
A medical delivery system that enables the delivery of therapeutic agents to malignant tissue utilizing delivery agents and heating of the delivery agents thereby causing the release of the...
8987429 GO-Gd-DTPA complex, preparation method thereof, and MRI contrast agent comprising the same  
Disclosed herein is a GO-Gd-DTPA (gadolinium-diethylenetriamine pentaacetic-graphene oxide) complex, which is formed by an ester bond of graphene oxide (GO) and gadopentetic acid (Gd-DTPA). Since...
8986657 Methods and system for detecting soluble amyloid-β  
The present invention provides methods of detecting soluble amyloid β using curcumin-derived near infrared (NIR) imaging probes. Upon interacting with soluble amyloid β, these probes undergo a r...
8980225 Magnetic resonance imaging and/or spectroscopy contrast agents and methods of use thereof  
The presently disclosed subject matter demonstrates that a spin state which has zero magnetic resonance signal, but an extremely long lifetime, can be used to store magnetization, which can then be...
8980224 Method of cardiac imaging  
The invention relates to a method of cardiac imaging using hyperpolarised 13C-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium.
8969100 Method for detecting afferent lymph vessel inflow regions and method for identifying specific cells  
Regions where metastatic cancer cells can exist are detected with high accuracy in a sentinel lymph node. Quantum dots are injected into the vicinity of a cancer in a living body, thereby...
8968703 13C-MR detection using hyperpolarised 13C-fructose  
The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fructose and to an imaging medium containing hyperpolarised 13C-fructose for use in said...
8961926 Method of imaging localized infections  
The invention relates to a method for targeting an imaging agent to cells of an animal to detect localized infections. More particularly, localized infections are detected by targeting imaging...
8961933 Process for the preparation of aqueous solutions of hyperpolarized molecules  
The invention relates to a one-step process for the preparation of aqueous solutions of hyperpolarized molecules in which, in a single step, the said hyperpolarized molecules are separated from the...
8957215 Heteroaryl substituted benzothiazoles  
The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: and to...
8951500 13C-MR imaging or spectroscopy of cell death  
The invention relates to method of 13C-MR imaging and/or 13C-MR spectroscopy of cell death using an imaging medium which comprises hyperpolarized 13C-pyruvate.
8951501 Noninvasive thermometry monitoring system  
A noninvasive thermometry monitoring system for determining a temperature of tissue to which hyperthermia treatment is administered is disclosed. The monitoring system may incorporate magnetic...
8936809 Method for treating prostate diseases based on local delivery of active substances  
A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs,...
8934959 Physiological pharmacokinetic analysis for combined molecular MRI and dynamic PET imaging  
Magnetic resonance (MR) imaging typically has excellent spatial resolution, but relatively poor temporal resolution. In contrast, positron emission tomography (PET) typically has excellent temporal...
8926947 Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents  
Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The...
8916132 Benzimidazole-derived compounds use as markers in the case of neurodegenerative diseases  
Use of benzimidazole-derived compounds of formula (I) according to the following structure, wherein x is a heteroatom selected from N, S, O, P, SO, SO2 and SO3, preferably from N, S and SO3 and...
8911709 Systems and methods for assessing pulmonary gas transfer using hyperpolarized 129XE MRI  
Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one MRI image and/or image data of 129Xe dissolved in the red blood...
8906345 Multimeric particles  
The invention provides multimeric particle comprising metal-containing particles covalently bonded to one another by linker groups wherein at least some of said linker groups are cleavable. The...
8906343 PAA nanoplatforms containing fluorophores and targeted moieties covalently linked and photosensitizer post-loaded  
A PAA nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer.
8906268 Bimodal organ phantom and associated production method  
A phantom for medical imaging instrumentation, the phantom including a first hydrogel matrix, said matrix containing additives for simulating the optical and acoustic properties of a living organ...
8901276 Peptide reagents and methods for detection of colon dysplasia  
The present invention is directed to peptide reagents, methods for detecting colon pre-cancer (dysplasia with non-polypoid or polypoid morphology) or cancer using the peptide reagents, and methods...
8894975 Methods of leukemia cell detection  
Methods are provided for, inter alia, determining the presence of leukemia cells in a subject, determining the change or potential change in the number of leukemia cells in the subject with time,...
8895068 Nanoparticle composition and associated methods thereof  
A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises...
8894973 Method and system for differential diagnosis of chronic schizophrenia and chronic alcoholism  
The invention is a method for the differential diagnosis of chronic schizophrenia or chronic alcoholism, by imaging the brain of a subject to detect any or all of the markers phosphocreatine (PCr),...
8889102 Neuromyelitis optica autoantibodies as a marker for neoplasia  
The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO).
8889211 Coating process for drug delivery balloons using heat-induced rewrap memory  
A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap memory...
8889103 Diagnostic agent composition and associated methods thereof  
A diagnostic agent composition is provided which comprises a nanoparticle composition and a pharmaceutically acceptable carrier or excipient. The nanoparticle composition comprises a...
8871182 3D nanocrystals and manufacturing methods  
The invention relates to nanocrystals, containing one or more metals as defined in the specification; having a size of 2 to 200 nm; having a defined, three-dimensional polyhedral structure,...
8846006 MRI markers, delivery and extraction systems, and methods of manufacture and use thereof  
Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast...
8834840 Magnetic resonance imaging of self-assembled biomaterial scaffolds  
Compositions and/or mixtures comprising peptide amphiphile compounds comprising one or more contrast agents, as can be used in a range of magnetic resonance imaging applications.
8834844 Chemical exchange saturation transfer based MRI using reporter genes and MRI methods related thereto  
Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide...
8828357 Iron oxide nanoparticles as MRI contrast agents and their preparing method  
Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron...
8815212 Nanocarriers for imaging and therapy applications  
Nanocarriers and methods of preparation and use of nanocarriers are presented. In some embodiments, a nanocarrier composition comprises an organic liquid comprising a plurality of nanoparticles...
8802055 Use of the spin crossover complex [mx+(LY)HW]AN)Z as a magnetic resonance imaging contrast agent  
A method for magnetic resonance imaging of a human or animal body includes providing a spin crossover complex having the general formula [Mx+(Ly)Hw]AN)z wherein, MX+ is a positively charged metal...
8795628 Molecular imaging of living subjects using Raman spectroscopy and labeled Raman nanoparticles  
Methods of imaging a living host using Raman nanoparticles; methods of generating a true image of a living host having been administered Raman nanoparticles; methods of multiplex imaging of a...
8795629 Radio-methyl vorozole and methods for making and using the same  
Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same...
8790621 Nanoparticles and nanoparticle compositions  
The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for...
8784772 Urothelial differentiation of urothelial carcinoma: a bladder cancer stem cell model  
The present invention provides a method of treating cancer in a patient (e.g., a human patient) in need thereof, the method comprising administering a therapeutically effective regimen, the regimen...
8785569 Drug carrier with chelating complex micelles and the application thereof  
This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in...
8784800 Method of delivering cell therapy to a target site  
A method of delivering therapy to a target site. The method includes (a) obtaining a base image of the target site, (b) injecting a dose of a mix of a therapeutic agent and a contrast agent into a...
8778344 Method of treating atopic dermatitis with antibody to zcytor17 ligand  
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for...
8778411 Heat generating nanomaterials  
The present invention relates to a heat-generating composition, comprising a hetero-structure nanomaterial which comprises (a) a first material comprising at least one component selected from the...
8778304 TSPO-targeting compounds and uses thereof  
Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
8765099 Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum  
In magnetic resonance imaging (MRI), selected magnetic dipoles in a subject are aligned with a main magnetic field for later manipulation, and signals received after such manipulations are used to...
8763410 Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media  
Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized...
8758778 Polymeric nano-carriers with a linear dual response mechanism and uses thereof  
The present invention features compositions in which nano-carriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to...
8758726 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules  
The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a...
8747811 Perylenequinone derivatives and uses thereof  
The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or...
8747839 Tracking of bone marrow cells for metastasis screening  
At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method,...