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7048906 |
Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia,...
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7045495 |
Combination of bryostatin and paclitaxel for treating cancer
This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
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7045134 |
Borellia burgdorferi epitope peptides
Immunologically invisible carrier molecules connect a plurality of copies of an immunologically active molecule in an immunologic assay.
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7041466 |
Mouse disease model for evaluation of prophylactic and therapeutic treatments of Chlamydia
Compositions and methods are provided for evaluating the progress of disease induced by infection with Chlamydia spp. Specifically, the invention provides a mouse lung disease model of infection...
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7041275 |
Irrigating fluid
A surgical irrigating fluid composition, especially for endoscopic surgery, is provided comprising a rinsing fluid and nitrous oxide added as a marker to the rinsing fluid in an amount which is...
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7037487 |
Method for diagnosing lactose intolerance and diagnostic kit for performing the method
The method for diagnosing lactose intolerance in patients by the oral administration of defined amounts of lactose, followed by assaying metabolites of lactose, is performed in a way where the...
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7037510 |
Hybrids of M. tuberculosis antigens
The present invention discloses fusion proteins of the immunodominant antigens ESAT-6 and Ag85B from Mycobacterium tuberculosis or homologues thereof, and a tuberculosis vaccine based on the...
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7038106 |
Detection of neural activity
The present invention discloses an in situ method of screening a compound for pharmacological activity comprising the steps of detecting an initial pattern of neural activity in brain tissue,...
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7033573 |
Diagnoses and treatment of disorders using an alternative glucose pathway
This invention proposes the existence of an alternate glucose pathway different from that presently accepted and offers different methods of proving this. The proposed alternate glucose pathway...
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7029653 |
Method of the administration of drugs having binding affinity with plasma protein and preparation to be used in the method
A method of the administration of drugs with binding affinity for plasma protein and drugs regulating the effective ingredient dose of drugs with binding affinity for plasma protein; and a...
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7029869 |
Feeding assay for identifying nematicidal compounds
The invention relates to any assay for the identification of nematicidal compounds such as anthelmintics for the control of nematodes. The assay comprises: (i) incubating a nematode sample (i.e. a...
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7018616 |
Rapid serological test for paratuberculosis using fluorescence polarization technology
The present invention provides an assay for detection of serum antibodies to M. paratuberculosis . A tracer, comprising a carbohydrate antigen isolated from M. paratuberculosis that is...
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7018613 |
Preparations for evaluating eliminative ability of stomach
Preparations whereby reduction or acceleration of the gastric emptying rate can be noninvasively evaluated: and a method of evaluating the gastric emptying rate by using these preparations. Thus,...
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7018617 |
Methods and compositions associated with nociceptive pain
Provided are methods and compositions corresponding to a genetic locus associated with nociceptive pain. In addition, method of identifying or modulating nociceptive pain and associated disorders...
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7014838 |
Use of biomolecular targets in the treatment and visualization of brain tumors
The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor...
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7011814 |
Systems, methods and devices for in vivo monitoring of a localized response via a radiolabeled analyte in a subject
Methods, systems, devices and computer program products monitor in vivo detected radiation in a target localized site within a subject, over a selected time period, to do one or more of: (a)...
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7008625 |
Recombinant constructs of Borrelia burgdorferi
Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins...
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7008921 |
Materials and methods relating to endothelial cell growth inhibitors
Proteolytic enzymes are involved in generation of a number of endogenous angiogenesis inhibitors and it has been shown that urokinase-activated plasmin can process plasminogen to release an...
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7002002 |
Abundant extracellular products and methods for their production and use
Vaccines based on one or more combinations of majorly abundant extracellular products of pathogens and methods for their use and production are presented. The most prevalent or majorly abundant...
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6998513 |
Human inflammatory breast carcinoma xenograft capable of lymphovascular invasion and methods for its use
The present invention provides human transplantable inflammatory breast carcinoma xenografts. Such xenografts exhibit a number of unique characteristics which allows their use in experimental...
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6995255 |
Cellular delivery agent
One aspect of the present invention relates to a nucleic acid construct which includes a first nucleic acid and a second nucleic acid operatively coupled to the first nucleic acid. The first...
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6989278 |
Method of identifying therapeutic compounds for a treatment of hepatic disorders
The present invention relates to methods of identifying potentially therapeutic compounds for the treatment of hepatic disorders, preferably alcohol-induced hepatitis. Further, use of mammals in...
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6986881 |
Identification of compounds that modify transcriptional responses to hypoxia
The invention provides methods for identifying compounds that can be used to modify transcriptional responses to hypoxia, and use of such compounds in therapeutic and diagnostic methods.
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6986882 |
Therapy for functional dyspepsia
The invention features a method of identifying a candidate drug for treating functional dyspepsia. The invention also features a method of diagnosing a patient with functional dyspepsia.
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6982252 |
Inhibition of vacuolar proton ATPase activity and/or the modulation of acidic organelle function sensitizes cells to radiation, chemotherapy and biological agents
The present invention relates to methods and compositions for inhibiting cell survival and/or promoting cell death following exposure to cytotoxic agents and stress such as radiation or...
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6982085 |
TB diagnostic based on antigens from M. tuberculosis
The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the...
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6982361 |
Method of screening a compound for anxiolytic activity in an Apolipoprotein e knockout animal
Methods and compositions for use in treating anxiety are provided. In the subject methods, an effective amount of an agent having ApoE3 activity is administered to a host suffering from an anxiety,...
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6979450 |
Method and compositions for detection and diagnosis of infectious diseases
Methods and compositions for the detection and diagnosis of infectious diseases are provided. In particular, efficient and sensitive methods and compositions for the detection of active...
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6974867 |
Compositions and methods for treating neoplastic disease using chemotherapy and radiation sensitizers
Inhibitors of KIAA0175 are provided that reduce the expression or biological activities of KIAA0175, p53 and/or p21 in a mammalian cell. KIAA0175 inhibitors include anti-sense molecules, ribozymes,...
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6969507 |
Imaging sexual response
The present invention relates to methods for contrast-enhanced imaging of sexual response. In particular, the present invention relates to methods of magnetic resonance imaging (MRI), computerized...
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6967016 |
Method of determining therapeutic activity and/or possible side-effects of a medicament
The invention relates to the diagnosis of disease or the determination of functioning of cellular organisms, being of multi-cellular or unicellular nature, being visible by the naked eye or being a...
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6964856 |
Animal models and methods for sepsis
Methods for selecting a candidate drug for treating sepsis are disclosed. The methods involve labeling a sepsis-causing pathogen with a reporter and monitoring the progress of infection by...
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6962688 |
Methods for modulation of cholesterol transport
Methods for regulation of lipid and cholesterol uptake are described which are based on regulation of the expression or function of the SR-BI HDL receptor. The examples demonstrate that estrogen...
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6955802 |
Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube
Provided are genetically engineered cells comprising a neural stem cell and retroviral expression system in the neural stem cell, which is capable of expressing homeodomain transcription factor...
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6953568 |
Targeting of molecules to large vessel endothelium using EPCR
Endothelial protein C receptor (EPCR) is found primarily on endothelial cells of large vessels. EPCR translocates from the plasma membrane surface to the nucleus. Molecules which bind to EPCR can...
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6949690 |
Methods of assessing the effect of a gene of interest on human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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6939548 |
Methods to produce high levels of C. difficile toxins
The present invention relates to the field of medical immunology and further to pharmaceutical compositions, methods of making and methods of use of vaccines. More specifically this invention...
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6939966 |
Radiolabeled neuropeptide Y Y5 receptor antagonists
The present invention is directed to radiolabeled neuropeptide Y Y5 receptor antagonists which are useful for the labeling and diagnostic imaging of neuropeptide Y Y5 receptors in mammals.
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6929799 |
D-alanine racemase mutants of mycobacteria and uses therefore
The present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of...
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6924147 |
Method of making a polymeric food spoilage sensor
A polymeric food spoilage sensor comprises a polymer containing a polyazamacrocyclic transition metal complex. The complex selectively binds biogenic amines, such as cadaverine, putrescine and...
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6924118 |
Recombinant intracellular pathogen immunogenic compositions and methods for use
Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular...
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6907280 |
Method and apparatus for objectively measuring pain, pain treatment and other related techniques
A method for measuring indices of brain activity includes non-invasively obtaining signals of central nervous system (CNS) activity, localizing signals to specific anatomical and functional CNS...
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6902719 |
Reverse isotope dilution assay and lactose intolerance assay
A “reverse isotope dilution assay” herein, wherein a pathway that produces a given metabolite is assayed by diluting a labelled metabolite produced by a second constitutive pathway. In one...
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6900026 |
Methods for identifying compounds as antioxidants
The present application describes methods for the testing of compounds of potential usefulness as therapeutic antioxidants and/or as therapeutic free radical scavengers. The animal model for...
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6900036 |
Prion isomers, methods of making, methods of using, and compositions and products comprising prion isomers
Prion peptides exhibiting structural isomerism to wild-type prion peptide are disclosed. The invention further discloses methods of making prion isomers, compositions comprising prion isomers, and...
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6897352 |
Animal model system for photodamage, photoaging and skin wounding
Non-human mammalian animals having a higher epidermal expression level of protein kinase Cε than their wild-type counterparts are phenotypically distinguished from wild-type animals in that the...
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6893634 |
Encapsulated cells producing cytochrome P450
The present invention relates to capsules encapsulating cytochrome P450 producing cells and cytochrome P450 producing retroviral packaging cells. Furthermore, the present invention relates to the...
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6887481 |
Bacterial-derived molecules and therapeutic and diagnostic uses therefor
The present invention relates generally to molecules derived from a Mycobacterium species and recombinant, synthetic, derivative, homologue and analogue forms of said molecules. The molecules of...
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6884423 |
Antimicrobial histone H1 compositions, kits, and methods of use thereof
The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of...
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6878364 |
Animal model for flaviviridae infection
The present invention is a woodchuck or an isolated woodchuck cell infected with bovine viral diarrhea virus. The invention can be used to identify new compounds for the treatment of flavivirus,...
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