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7169564 |
FKBP51/52 and CyP40-mediated mammalian hair growth
The present invention relates to drug screening assays designed to identify non-immunosuppressive agents that modulate hair growth and the use of such agents for modulation of hair growth.
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7166270 |
Methods of screening compounds useful for prevention of infection or pathogenicity
Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.
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7163682 |
Glucan binding protein and glucosyltransferase immunogens
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7160548 |
Mycobacterium strains with modified erp gene and vaccine composition containing same
Mycobacterium strains in which the erp gene is modified, and vaccine compositions comprising such Mycobacterium strains are provided. The modification of the erp gene may decrease the virulence...
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7161059 |
Human hookworm model and method for maintaining human hookworm in a non-human primate
A method for maintaining a human hookworm strain is provided by infecting a non-human primate with a non-adapted or non-passaged human hookworm and maintaining the non-human primate. Methods of...
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7157436 |
Therapeutically useful synthetic oligonucleotides
The present invention provides a composition and method comprising a 2–20 base 3′-OH, 5′-OH synthetic oligonucleotide (sequence) selected from the group consisting of (G x T y ) n , (T y G x...
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7153491 |
Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders...
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RE39436 |
Interventions to mimic the effects of calorie restriction
Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for...
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7147839 |
Methods for evaluating tissue morphogenesis and activity
The present invention is based on the discovery that a true tissue morphogen such as OP-1 provided systemically, alone in its mature dimeric form, or as part of a soluble complex, can induce new...
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7148001 |
In vitro formation of congophilic maltese-cross amyloid plaques to identify anti-plaque therapeutics for the treatment of Alzheimer's and Prion diseases
Co-incubation of an amyloid protein with sulfated macromolecules as a method for the formation of amyloid plaques. The amyloid protein may be the beta-amyloid protein or the prion protein or the...
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7142911 |
Method and apparatus for monitoring drug effects on cardiac electrical signals using an implantable cardiac stimulation device
An implantable cardiac stimulation device, such as a pacemaker or Implantable Cardioverter Defibrillator, is configured to automatically monitor the effects of antiarrhythmic drugs on cardiac...
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7141234 |
Imaging of drug accumulation as a guide to antitumor therapy
The present invention describes the use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labelled anticancer drug to a patient and imaging at...
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7135280 |
Assay to determine efficacy of treatment for mycobacterial infection
Method of determining the efficacy of treatment for mycobacterial infection in an individual comprising determining in samples from the individual whether the level of T cells specific for a...
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7132096 |
Antimicrobial activity of gemfibrozil
The present invention provides methods for inhibiting growth of a bacterium which consists essentially of contacting the bacterium with gemfibrozil, or a related compound, in a concentration...
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7132234 |
Methods and compositions for the identification of anti-poxvirus agents
The invention provides methods for identifying an anti-poxviral agents. In many embodiments, the methods involve contacting a poxviral p28 polypeptide with a candidate agent, and determining an...
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7128895 |
Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability
The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the...
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7125667 |
Polymorphic markers of the LSR gene
The invention provides novel LSR genomic sequences, polypeptides, antibodies, and polynucleotides including biallelic markers derived from the LSR locus. Primers hybridizing to regions flanking...
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7122194 |
Vaccine compositions comprising Streptococcus pneumoniae polypeptides having selected structural motifs
A vaccine composition is disclosed that comprises polypeptides and fragments of polypeptides containing histidine triad residues or coiled-coil regions, some of which polypeptides or fragments lie...
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7122195 |
Mutant mycobacteria for use in therapy
This invention relates to recA mutant mycobacteria, particularly mutants of mycobacterial species which are members of the Mycobacterium tuberculosis complex, such as M. bovis BCG and M....
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7122173 |
Agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia
The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a...
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RE39337 |
Nude mouse model for human neoplastic disease
A nude mouse model for human neoplastic diseases having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the...
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7115361 |
Detection of CD8+ T cell responses to M. tuberculosis
A method of detecting an anti-mycobacterial CD8 T cell response comprising contacting a population of CD8 T cells of an individual with one or more peptides selected from the peptides represented...
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7112319 |
Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using microelectrodes with microvoltammetry
The present invention relates to devices and methods of use thereof for making semiderivative voltammetric and chronoamperometric measurements of chemicals, e.g. neurotransmitters, precursors, and...
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7112716 |
Methods for screening and identifying host pathogen defense genes
Disclosed are methods for identifying nematodes having enhanced susceptibility to a pathogen; for identifying pathogen defense response genes; and for identifying compounds that enhances a host's...
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7105150 |
In vivo screening methods using enriched neural stem cells
Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
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7105170 |
Latent human tuberculosis model, diagnostic antigens, and methods of use
Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens...
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7105292 |
Screening methods used to identify compounds that modulate a response of a cell to ultraviolet radiation exposure
The cellular response to ultraviolet radiation exposure has been characterized on the molecular level through the use of high density gene array technology. Nucleic acid molecules and protein...
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7097967 |
Method of predicting drug-food interaction
The present invention provides a method of predicting a food-drug interaction in vivo, in the case of an orally administered drug interactive with digestive enzymes in the gastrointestinal tract,...
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7094391 |
Compositions and methods for administering Borrelia burgdorferi antigens
Mucosal administration of OspA and compositions therefor are disclosed and claimed. More particularly, oral administration of OspA and compositions therefor for eliciting an immunological response...
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7094417 |
Fish hatching method and apparatus
The invention is a method and kit for conducting a rapid toxicity test. Methods and kits according to the invention include an animal or plant species in diapause.
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7090864 |
Non-invasive gene targeting to ocular cells
Liposomes containing therapeutic genes are conjugated to multiple targeting agents to provide transport of the encapsulated gene across the blood-retinal barrier and the plasma membrane of ocular...
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7090852 |
Venezuelan equine encephalitis virus replicon encoding marburg virus proteins
Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
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7090989 |
Recombinant human SM-11044-binding receptor proteins exhibiting ligand-binding activities, and their uses
Transformed cells designed to express a recombinant human SMBP at an elevated level to the extent that its ligand-binding activity can be measured, and cellular membrane fractions thereof;...
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7087371 |
Material and methods for the production of sperm and analysis thereof
Provided herein are methods of producing viable sperm from neonatal mammalian testes which have been engrafted in mice.
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7083796 |
Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
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7083797 |
32-kDa protein derived from Mycobacterium tuberculosis and related peptides
The invention relates to recombinant polypeptides and peptides and particularly to the polypeptide containing in its polypeptidic chain the following amino acid sequence: the one extending from the...
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7081239 |
Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
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7081347 |
Method for predicting cardiovascular events
A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is...
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7078044 |
Anti-amoebic vaccine
The invention relates to an anti-amoebic vaccine containing an oligopeptide which can be obtained from the microorganism Entamoeba histolytica or synthesized by known methods. The anti-amoebic...
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7074620 |
Controlling protein levels in eucaryotic organisms
Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having...
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7067113 |
Methods for identifying compounds for regulating muscle mass or function using dopamine receptors
Screening methods for identifying compounds that bind to or activate (D 1 or D 5 dopamine receptors individually or in combination) or potentially regulate skeletal muscle mass or function in...
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7067136 |
Method of screening anti-mycobacterial molecules
This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic...
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7064195 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins of Mycobacterium tuberculosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis...
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7060249 |
Neurodegeneration mutants, method for identifying same, and method for screening neuroprotective agents
A method for obtaining a Drosophila neurodegeneration mutant includes the steps of selecting at least one Drosophila mutant having an aberrant phenotype selected from the group consisting of...
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7056517 |
Glucosyltransferase immunogens
Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a...
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7056492 |
Mycoplasma hyopneumoniae vaccine and methods for reducing Mycoplasma bovis pneumonia in cattle
The present invention relates to methods for treating or preventing a disease or disorder in an animal caused by infection by Mycoplasma bovis ( M. bovis ) by administering to the animal an...
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7052675 |
Antibodies specific for native PrPSc
Antibodies are disclosed which specifically bind to native PrP Sc in situ. Preferred antibodies bind only to the native PrP Sc of a particular species e.g., human, cow, sheep, pig, etc....
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7052676 |
Methods for inhibition of HIV replication using a small molecule inhibitor
Methods are provided for inhibiting or suppressing viral replication in an infected host cell. More specifically, methods are provided for inhibiting or suppressing viral replication in an infected...
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7049098 |
Method of vaccination comprising linear and circular expression elements
The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention...
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7048907 |
Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
Stable isotope labeling and neutron activation to measure biological functions are provided, as are the use and method of adding a chemical monitor to correct for neutron flux to sample vials prior...
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