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7357916 |
Method for creating a uniform vascular wound in zebrafish or zebrafish larva
Disclosed are improved methods for creating a uniform vascular wound in a zebrafish larva or zebrafish. The methods illustratively include subjecting a zebrafish larva to laser irradiation in an...
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7351542 |
Methods of modulating tubulin deacetylase activity
The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention...
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7353153 |
Method and system for modeling bone structure
The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model...
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7344703 |
Mycobacterial sulfation pathway proteins and methods of use thereof
Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid...
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7344701 |
Xanthene dyes
The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like....
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7341710 |
Method of identifying molecules that home to a selected organ in vivo
The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
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7335369 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M....
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7335480 |
Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same
The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is...
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7335640 |
Administration of hypocretin-1 for treatment of narcolepsy
The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a...
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7335632 |
Beta-secretase inhibitors and methods of use thereof
The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
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7323175 |
Immunogenicity of glucan binding protein
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7320785 |
Compositions and methods for modulation of DARPP-32 phosphorylation
The present invention provides methods and compositions for modulating the phosphorylation of DARPP-32 in a serotonergic receptor intracellular signaling pathway. The invention provides methods and...
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7318917 |
Rapid assays for neurotransmitter transporters
The invention describes the finding that 4-(4-dimethylaminostyrl)-N-methylpyridinium or ASP + is a fluorescent substrate that is transported by several neurotransmitter transporters. Provided are...
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7314724 |
Therapeutic applications of laminin and laminin-derived protein fragments
Laminin and specific laminin-derived protein fragments are disclosed as potent inhibitors of Alzheimer's disease type amyloidoses. A specific region is identified within laminin which interacts...
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7303739 |
Prodrugs for liver specific drug delivery
The present invention is directed towards novel cyclic phosph(oramid)ate prodrugs of alcohol-, amine-, and thiol-containing drugs, their preparation, their synthetic intermediates, and their uses....
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7303740 |
Methods for the diagnosis and treatment of breast cancer
The present invention provides a method for diagnosing breast cancer in a subject. The present invention also provides a method for treating breast cancer in a subject. Finally, the present...
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7300763 |
Method of testing myelotoxicity with the use of flow cytometer
The objects of the present invention are to solve low test efficiency and low accuracy which are problems encountered in the conventional methods for testing myelotoxicity of a drug by observing...
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7297339 |
Rhodococcus equi mutants and vaccines comprising same
Mutant strains of Rhodococcus equi are disclosed, and vaccines comprising same.
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7294738 |
Phosphorous containing steroid mimics
The present invention discloses novel steroid mimics wherein a tri- or tetravalent phosphorous atom is isosterically substituted at any one of the seventeen positions occupied by the carbon atom in...
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7291710 |
Detection of spectrin and spectrin proteolytic cleavage products in assessing nerve cell damage
Methods for detecting a cell damage relate to the discovery that proteases are selectively activated in subjects suffering from nervous system damage compared to samples from healthy subjects....
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7288244 |
Determining vulnerable plaque in blood vessels
The invention is based on the realisation that inflamed plaques in blood vessel walls, which are potentially vulnerable to rupture, can be detected at elevated temperatures which are lower than...
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7288261 |
Mid-life vaccine and methods for boosting anti-mycobacterial immunity
Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective...
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7283940 |
Multidirectional morphology and mechanics of osteonic lamellae
The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model...
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7279170 |
32-kDa protein derived from Mycobacterium tuberculosis and related peptides
The invention relates to recombinant polypeptides and peptides and particularly to the polypeptide containing in its polypeptidic chain the following amino acid sequence: the one extending from the...
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7276581 |
Mutated Src oncogene composition and methods
The present invention provides a mutant oligonucleotide composition encoding a cellular c-Src tyrosine kinase oncogene. Methods for isolating, expressing and characterizing recombinant Src mutant...
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7276350 |
Method for diagnosing infectious diseases
A method for diagnosing the presence in an animal of an infection due to a microorganism in which a test sample obtained from the animal is exposed to a population of the microorganism and the...
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7270800 |
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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7270801 |
Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof
The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and...
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7270962 |
Method of identifying modulators of nogo-functions
A method of identifying a modulator Nogo function, the method comprising:
(i) providing
(a) a BACE polypeptide; (b) a Nogo polypeptide; (c) a test agent
under conditions that...
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7264815 |
Process for producing a recombinant protein in a mycobacterium host plasmid pJAM2
This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic...
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7252824 |
Anti-neovasculature preparations for cancer
Disclosed herein are immunogenic compositions, methods of designing immunogenic compositions, methods of treatment using immunogenic compositions, methods of evaluating cell-mediated immunity...
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7247302 |
Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
The present invention provides a method for inhibiting immunoglobulin-induced toxicity resulting from immunotherapy in a subject comprising administering an immunoglobulin or Ig fusion protein...
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7244412 |
Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
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7238359 |
Antigen ORF Rv2430c and a method thereof
The present invention relates to a PPE family antigenic protein Rv2430c of SEQ ID No. 1; a set of three high antigenic index peptides of SEQ ID Nos. 2 to 4; an antigenic ORF Rv2430c of SEQ ID No. 5...
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7235375 |
Organic anion transport proteins
The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with...
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7229605 |
Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles
Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index...
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7229773 |
Screening method for apoptosis-suppressing or-promoting substance
To provide a screening method for an apoptosis-suppressing substance or an apoptosis-promoting substance, the application of which substances to pharmaceuticals or diagnostic drugs are expected,...
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7220890 |
Chimeric mouse model for endometriosis
A non-human animal model for endometriosis is provided as well as methods of making and using the animal.
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7217411 |
CeSERT genes, proteins, and modulatory compounds
The invention features substantially pure nucleic acid sequences encoding wild-type or mutant serotonin reuptake transporter (SERT) polypeptides, as well as the polypeptides themselves. The...
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7211659 |
Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and...
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7196115 |
Pharmaceutical composition containing brevifoliol for use in chemotherapeutic treatment of human beings, method therefor
The present invention relates to the bioactivity of taxanes isolated from the leaves of Himalayan Yew tree Taxus wallichiana against human cancer cell lines grown in-vitro and subsequent...
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7186556 |
Modulating transcription of genes in vascular cells
A method of modulating the transcription of one or more genes in a vascular or cardiac cell, wherein the method comprises a step of contacting the cell with a composition comprising one or more...
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7179447 |
Type I interferon-producing cells and uses thereof
The present invention provides compositions for the treatment, inhibition or prevention of diseases or disorders, including cancer, immune diseases or disorders, and infectious diseases, comprising...
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7175830 |
Imaging of drug accumulation as a guide to antitumor therapy
The use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labeled anticancer drug to a patient and imaging at least a part of the patient...
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7176181 |
Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth
The present invention provides compositions that enhance or inhibit the interactions of galectin-8 and galectin-8-like proteins with other extracellular matrix proteins or cell surface receptors,...
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7172750 |
Compositions and methods for the treatment and diagnosis of immune disorders
The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are...
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7169564 |
FKBP51/52 and CyP40-mediated mammalian hair growth
The present invention relates to drug screening assays designed to identify non-immunosuppressive agents that modulate hair growth and the use of such agents for modulation of hair growth.
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7166270 |
Methods of screening compounds useful for prevention of infection or pathogenicity
Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.
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7163682 |
Glucan binding protein and glucosyltransferase immunogens
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7160548 |
Mycobacterium strains with modified erp gene and vaccine composition containing same
Mycobacterium strains in which the erp gene is modified, and vaccine compositions comprising such Mycobacterium strains are provided. The modification of the erp gene may decrease the virulence...
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