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7527973 |
Antibodies against West Nile Virus and therapeutic and prophylactic uses thereof
The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV),...
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7527783 |
Methods for deactivating allergens and preventing disease
This invention relates to articles of manufacture containing liquid compositions of hypohalous acid or hypohalous acid salt for deactivating allergens and preventing diseases on hard surfaces, soft...
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7521040 |
Immunotherapy for humans
An immunotherapy useful for treating a cancer and/or treating and preventing a microbial infection is provided. A pharmaceutical composition which comprises a bacterial component as an effective...
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7514090 |
Monocyte locomotion inhibitory factor
The invention relates to an anti-inflammatory oligopeptides which contain the terminal pharmacophore Cys-Asn-Ser which is capable of inhibiting the NF-κβ signaling pathway. The oligopeptides are...
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7510718 |
Expression vectors and uses thereof
The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing the vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics...
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7507871 |
Rat model of diabetic nephropathy
A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound's effect of diabetic nephropathy is disclosed. In one embodiment,...
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7507725 |
Compounds with sulphonamide group and pharmaceutical compositions containing these compounds
The invention relates to compounds which, acting as a prodrug and/or support, enable an active agent to be taken up by the erythrocytes and/or an active agent to bind to the erythrocytes. The...
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7507727 |
Substituted quinobenzoxazine analogs and methods of using thereof
The present invention relates to quinobenzoxazines analogs having the general formula:
and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein V, A, X, Z, W, U and R 5 ...
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7504233 |
Methods for determining the metabolism of sugars and fats in an individual
Provided herein are methods for determining the metabolism of one or more sugars and/or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis...
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7501395 |
Method of screening for antianxiety drugs
An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a...
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7491381 |
Method of evaluating compound efficacious in treating obesity
Examination of obesity or emaciation is performed based on expression levels of LCE gene or protein in a test tissue or a test cell or a polymorphism of the gene. Evaluation of compounds including...
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7491395 |
Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination
The present invention provides methods and means for preparing vaccines that are capable of eliciting strong immune responses, especially through intranasal delivery. The invention discloses...
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7491312 |
Identifying therapeutic compounds based on their physical-chemical properties
The present invention is directed to rapid and efficient methods of identifying therapeutic compounds by allowing only the most favorable molecules initially selected based on their...
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7489964 |
Electroencephalography based systems and methods for selecting therapies and predicting outcomes
A method and system for utilizing neurophysiologic information obtained by techniques such as quantitative electroencephalography (QEEG), electrode recordings, MRI in appropriately matching...
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7488466 |
Preparation for determining pyrimidine metabolic capacity
The present invention provide a method for measuring and assessing the capacity in an individual subject to metabolize a variety of fluorouracil drugs, such as 5-fluorouracil, which are degraded in...
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7488467 |
High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds
The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid...
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7485284 |
Method for characterizing the efficacy of an agent targeting a primary cystic fibrosis defect
Generally, the method for characterizing the efficacy of an agent targeting a primary cystic fibrosis defect comprises measuring a change in the status of lung infection in a sample population of...
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7482507 |
Methods of screening agents for activity using teleosts
The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity...
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7479278 |
Troponin I polypeptide fragments and uses thereof
Polypeptides corresponding to stable, circulating degradation products of troponin I (TnI) are described. The fragments comprise a sequence of the N-terminus of native cardiac TnI with 95-115 amino...
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7479267 |
Cell-or organ-differentiation controllers and method of controlling morphogenesis by using the same
A method of regulating flowering of a plant by applying an effective amount of a substance that affects the synthesis or amount of glutathione in cells to the plant and cultivating the plant under...
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7473414 |
Compositions and methods for wound healing
Mice in which enhance wound healing occurs can be used to identify genes and gene products which are involved in enhanced wound healing in mammals, including humans. Methods and compositions for...
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7468190 |
Reduction in the virulence of Mycobacterium tuberculosis and protection against tuberculosis by means of phoP gene inactivation
The construction of a mutant in the phoP gene by means of homologous recombination from a clinically isolated Mycobacterium tuberculosis reduces the virulence thereof in mouse bone marrow...
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7468178 |
Methods for identifying compounds that modulate vigilance states
The invention provides a method of identifying a compound that alters vigilance. The method consists of contacting an invertebrate with a candidate compound, evaluating a vigilance property in the...
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7465548 |
Methods of screening for potential therapeutics for diseases associated with G-protein coupled receptor HM74a
The invention provides a human HM74a which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation,...
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7465848 |
Zebrafish assay
The invention includes a zebrafish assay for cardiac response.
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RE40594 |
Inhibitors of the bitter taste response
The present invention relates to methods for identifying inhibitors of the bitter taste response, and by methods of using such inhibitors to either block the perception of bitterness and/or promote...
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7449307 |
Raised surface assay plate
The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving...
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7445904 |
Cysteine string protein and its role in neurodegenerative diseases
The present invention relates to in vitro and in vivo assays for the identification of agents that are useful in the treatment of neurodegenerative diseases that are associated with defects in...
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7447340 |
Device and method for automatically producing a thermal recoil response in nematodes
The invention relates to a device ( 10 ) and a method for automatically eliciting a thermal avoidance response in nematodes, particularly in order to test pharmaceutical substances. The device ( 10...
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7439415 |
Population of Hoxb8 mutants and uses in identifying agents for treating repetitive behaviors
This invention provides in vivo and in vitro methods of screening for an agent or a combination of agents that reduces one or more repetitive behaviors, comprising contacting neuronal cells of an...
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7429374 |
Process for the measurement of the potency of glatiramer acetate
The subject invention provides a process for measuring the relative potency of a test batch of glatiramer acetate. In addition, the subject invention provides a process for preparing a batch of...
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7427392 |
Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
This invention provides methods useful in aiding in the diagnosis of Alzheimer's disease. The methods involve measuring the amount of amyloid-β peptide (x−≧41) in the cerebrospinal fluid of a...
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7416840 |
Replication of hepatitis C virus in non-hepatic epithelial and mouse hepatic cells
Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the...
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7413729 |
Sialic acid permease system
This invention relates to purified sialic acid permease systems, and inhibitory agents of sialic acid permease systems.
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7413728 |
Immune modulator
Use of an immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia, Nocardia, Dietzia, Tsukamurella and ...
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7411042 |
Tumor associated nucleic acids and uses therefor
The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments...
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7408095 |
Methods for introducing heterologous cells into fish to determine if the heterologous cells contain cancer cells or a pathogen
Methods of introducing heterologous cells into fish are provided. After introduction cells remain viable, and in some instances proliferate, for sufficient time to conduct a variety of analyses on...
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7404945 |
Method of evaluating pharmacological effects of medicine
A diagnostic reagent for use in the evaluation of a pharmacological effect of a medicine containing a pharmaceutical agent including an enzyme, an enzyme inhibitor or a receptor ligand or a prodrug...
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7402388 |
Expression analysis of FKBP54 in assessing prostate cancer therapy
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of...
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7402727 |
Non-human animal exhibiting bone metastasis of tumor cells
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for...
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7402299 |
Intracorporeal medicaments for photodynamic treatment of disease
New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a...
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7396524 |
Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy
Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (τ) of I Ca,L recovery...
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7393539 |
Mycobacterial antigens expressed under low oxygen tension
A method is provided for identifying mycobacterial genes that are induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of up to 10% air saturation...
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7393540 |
Mycobacterial antigens expressed during latency
A method is provided for identifying mycobacterial genes that are induced or up-regulated under culture conditions that are nutrient-starving and which maintain mycobacterial latency, said...
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7387773 |
Vaccine
The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis ( M. ptb ) substantially free of whole organisms of that species either dead...
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7387882 |
Predictive assay for immune response
The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more...
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7384623 |
High energy phototherapeutic agents
High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive...
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7381401 |
T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase
T cell anergy has been correlated with defective Ras signaling. However, neither a causal relationship nor the mechanism of Ras hypoactivation have been established. Using adenoviral transduction...
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7378080 |
Methods for identifying compounds for motion sickness, vertigo and other disorders related to balance and the perception of gravity
The present invention provides a method of identifying a compound that modulates a mammalian vestibular system. The method consists of administering a test compound to an invertebrate, and...
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7364719 |
Vasoregulating compounds and methods of their use
Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of blood vessels, by administering to a subject a...
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