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6018098 |
In vivo and in vitro model of cutaneous photoaging
A transgenic mouse capable of expressing a reporter gene regulated by human elastin promoter is provided. Mouse fibroblast cultures derived from this transgenic mouse are also provided. In...
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6008435 |
Detecting cow, sheep and human prions in a sample and transgenic mice used for same
Transgenic animals are produced which animals have (1) their endogenous PrP gene ablated; and (2) have an exogenous PrP gene from a genetically diverse animal. The transgenic animal is preferably a...
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6002066 |
H2-M modified transgenic mice
A transgenic mouse with alterations in the H2-Ma gene is prepared by introduction of an altered H2-Ma gene into a host mouse. The resulting transgenic mice do not produce functional H2-M molecules.
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5993779 |
Method for producing non-human animal having spinal cord injury
A method for producing a non-human animal suffering from a spinal cord injury, which comprises interrupting an aorta at least at two sites, thereby forming an isolated segment of the aorta...
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5989844 |
Method for evaluating drug metabolism and reagent compositions therefor
This invention relates to a method for evaluating the susceptibility of pharmaceutical drugs to metabolism by a specific cytochrome P-450 isozyme, which comprises contacting the sample compound...
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5985243 |
Mouse model for Helicobacter pylori infection
A mouse model for Helicobacter pylori infection prepared by infecting a euthymic mouse with a dose of bacteria freshly isolated from an infected human.
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5986171 |
Method for examining neurovirulence of polio virus
The present invention relates to a method of examining the neurovirulence of a polio virus, which comprises inoculating a polio virus into the spinal cord of a transgenic mouse comprising a gene...
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5981548 |
N-Hydroxypiperidines as superoxide radicals scavengers
Compositions including as active ingredients cyclical hydroxylamines of the formula (I) are usefull for treating and preventing pathologies concerned with over production of oxygen-centered free...
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5976499 |
Macroscopic sweat test for cystic fibrosis
The present invention relates to methods of diagnosing CF comprising: stimulating sweat production via β-adrenergic pathway, by increasing cAMP production; collecting sweat into a sweat collection...
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5976797 |
Method for quantifying total mRNA with poly(A)-complementary oligonucleotide-immobilized microtiter plate
A method for quantifying total mRNA in a biological sample containing RNA such as crude cell lysates containing cytosolic mRNA, which method comprises the steps of: (a) incubating the sample with...
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5969210 |
Methods for the characterization of compounds which stimulate STF-1 expression in pancreatic islet cells
One embodiment of the present invention provides a method of testing for compounds which may induce STF-1 transcription. Pancreatic islet cells which express the STF-1/lacz fusion gene are isolated...
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5955056 |
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences
An assay for monitoring and assessing the mutagenic potential of agents which involves creating transgenic non-human animals carrying a test DNA sequence or sequences that can be quickly recovered...
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5948952 |
Xeroderma pigmentosum-deficient mouse
An Xeroderma pigmentosum-deficient mouse, as well as methods for screening for the damaging and tumorigenic effect of ultraviolet light or a chemical DNA damaging agent, are disclosed.
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5948768 |
Treatment of otitis media by sublingual administration of DNA
Methods for treating symptoms of otitis media in a patient, are presented. Methods comprise administering an effective amount of DNA to a subject in a manner so as not to effect gene transfer.
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5948951 |
DNA vector for bone-specific gene expression
An expression vector for use in producing transgenic animals and cell lines, the expression vector comprising a portion of the 5' flanking sequence of the human osteocalcin gene and a portion of...
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5945576 |
Mouse model of psoriasis
Methods and compositions for preparing a mouse model of an inflammatory skin condition are disclosed. The methods involve administering donor lymphocytes to a recipient immune deficient mouse to...
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5932418 |
Fish embryo screening test for genotoxic agents using three different developmental life stages
A sensitive bioassay, consisting of two assay techniques applied to embryos of a teleost (bony fish), is utilized in testing for genotoxic agents. The assay allows genotoxic effects to be scored at...
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5925803 |
Testing method using transgenic mice expressing an oncogene
A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.
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5922302 |
Detection and therapy of lesions with biotin/avidin-metal chelating protein conjugates
Improved methods of detecting and/or treating lesions in a patient are provided. The improved methods comprise the steps of (a) parenterally injecting a subject with a targeting composition...
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5919997 |
Transgenic mice having modified cell-cycle regulation
The present invention relates to transgenic mice in which the biological function of at least one cell cycle regulatory proteins of the INK4 family is altered.
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5912410 |
Transgenic non-human mice displaying the amyloid-forming pathology of alzheimer's disease
Cloned recombinant or synthetic DNA sequences related to the pathology of Alzheimer's disease are injected into fertilized mammalian eggs (preferably mouse eggs). The injected eggs are implanted in...
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5905023 |
Maspin, a serpin with tumor suppressing activity
An isolated DNA encoding a polypeptide substantially identical to maspin (SEQ ID NO:1); a substantially purified preparation of maspin; an antibody specific for maspin; and use of such DNAs and...
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5898094 |
Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
A method of preparing a transgenic animal model with enhanced, accelerated pathology for Alzheimer's Disease (AD) and the transgenic animal made by the method is disclosed. The method includes...
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5894078 |
Transgenic mouse expressing C-100 app
A transgenic mouse whose genome comprises a DNA sequence encoding the carboxy-terminal 100 amino acids of the human β-amyloid precursor protein C-100 APP) inserted into exon I of the neurofilament...
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5876920 |
Methods for identifying anti viral agents and viruses that can be inhibited by such agents based on viral protein phenylation
Viral morphogenesis, production, release or uncoating can be inhibited by effecting inhibition of prenylation of, or inhibition of post-prenylation reactions of, at least one viral protein. The use...
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5877398 |
Biological systems incorporating stress-inducible genes and reporter constructs for environmental biomonitoring and toxicology
A method and kit for detecting toxins and pollutants is disclosed. The kit includes a transgenic organism having a stress-inducible control region linked to a gene encoding a detectable protein...
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5877399 |
Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
Provided is a transgenic non-human eukaryotic animal whose germ cells and somatic cells contain the amyloid precursor protein sequence introduced into the animal, or an ancestor of the animal, at...
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5876954 |
Cytotoxic factor as is associated with multiple sclerosis, its detection and its quantification
Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological...
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5877396 |
Mice mutant for functional Fc receptors and method of treating autoimmune diseases
Disclosed herein is a non-naturally occurring non-human vertebrate animal incapable of expressing a functional Fc receptor which may optionally be capable of expressing a protein which comprises a...
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5866757 |
Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and optionally in which xenogeneic...
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5866098 |
Assay for identifying extracellular signaling proteins
The present invention concerns a novel paracrine signaling assay.
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5866760 |
Stat6 deficient transgenic mice
The invention provides methods and compositions for evaluating modulators of the Stat6 signaling pathway; in a particular, transgenic mice comprising a transgene within a Stat6 allele locus,...
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5859314 |
Mice with targeted tyrosine kinase, lyn, disruption
A non-human animal carrying a disruption of a gene encoding a lyn protein tyrosine kinase provides a convenient system for the study of diseases associated with or caused by lyn deficiency, and for...
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5858326 |
Methods of increasing amyloid deposition
In vivo and in vitro methods of increasing amyloid deposition using amyloid-enhancing compounds are described. Methods of forming amyloid fibrils and screening for agents useful in treating...
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5858328 |
Animal model for hepatitis virus infection
A non-human chimeric animal is obtained by transplanting a non-human mammal host having a T cell deficiency with a human liver tissue preparation or with a liver tissue preparation from a non-human...
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5859311 |
Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use
Transgenic mice express increased levels of neurotrophin-3 (NT-3) in epithelium when their ancestors are microinjected with the NT-3 gene. The NT-3 growth factor expressing transgenic mice are...
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5859307 |
Mutant RAG-1 deficient animals having no mature B and T lymphocytes
Immunodeficient animals are generated by introducing a mutation in RAG-1 into the germline of the animals via gene targeting in embryonic stem cells. The production of mutant RAG-1 deficient mice...
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5853697 |
Methods of treating established colitis using antibodies against IL-12
The present invention provides a method for treating the inflammatory response of an established colitis in a subject with inflammatory bowel disease (IBD), comprising administering to a subject...
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5851789 |
Methods and agents for measuring and controlling multidrug resistance
The predominant effect of pH change on multidrug resistance (MDR) independent of active drug efflux has been demonstrated in tumor cells through studies of the drugs doxorubicin and daunomycin....
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5849988 |
Rat comprising straight filaments in its brain
Methods of generating a rat having Aβ deposits in the brain of the rat by injecting an amount of human A68 protein sufficient to result in formation of the deposits and subsequently examining the...
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5849995 |
Mouse model for Huntington's Disease and related DNA sequences
Isolation, cloning and sequencing of the murine Huntington's Disease gene as well as its transcripts and gene products are provided. A transgenic mouse model for Huntington's Disease exhibits...
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5850004 |
Transgenic mouse deficient in inducible nitric oxide synthase
The present invention provides an inducible nitric oxide synthase ("iNOS")-deficient transgenic mouse, novel replacement vectors designed for the disruption of the iNOS gene, embryonic stem (ES)...
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5849990 |
Animal model for a non-hodgkin's lymphoma
A non-human animal model for CNS and eye-infiltrating lymphomas is produced by inoculating a rodent with the cells of a lymphoma causing cell line capable of infiltrating into the CNS or eye of the...
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5849993 |
Transgenic mice as a model for metabolic bone diseases
Transgenic mice carrying a recombinant DNA construct comprising the gene encoding diphtheria toxin A chain operably linked to a osteocalcin promoter. The transgenic mice can be used as a model for...
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5849994 |
Animal model for HIV-1 induced disease
HIV-1 does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing or ameliorating disease caused by this virus....
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5837220 |
Method for analyzing the immunosuppressant activity of ion channel blockers using the mini-pig
A method for analyzing the immunosuppressant activity of Kv1.3 inhibitors using the mini- and micro-pig. These pig models have been found to have K v 1.3 channels very similar to man both in...
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5833946 |
Dissemination of fungal infections: animal model and method of prophylaxis
Aspartyl protease inhibitors such as pepstatin A have been found to prevent dissemination of Candida species across an epithelial barrier in mammals. Accordingly, a method for reducing adverse...
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5830434 |
Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide
The present invention provides a method of treating NIDDM in a patient diagnosed with NIDDM by administering to the patient a compound in a pharmaceutically acceptable carrier that reduces hepatic...
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5824287 |
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences
An assay for monitoring and assessing the mutagenic potential of agents which involves creating transgenic non-human animals carrying a test DNA sequence or sequences that can be quickly recovered...
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5824837 |
Expression of human interleukin-1β in a transgenic animal
A transgenic mouse has been prepared that expresses a human interluekin-1β transgene. Expression of the transgene is mediated by a mouse metallothionein promoter. As a result of the expression of...
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