Match Document Document Title
9040049 ADAM-15 antibodies and immunogenic peptides  
The present invention relates to antibodies and antigen-binding fragments thereof, immunogenic peptide(s), and siRNA molecules which are capable of inhibiting neovascularization and/or...
9034299 ATF4 inhibitors and their use for neural protection, repair, regeneration, and plasticity  
In one aspect, the invention relates to a method for identifying a drug candidate with activity as a neuroprotective agent. The method includes determining whether a compound reduces ATF4...
9023319 Vaccine  
Provided herein are methods for immunizing children under six months of age by administering to the child a pharmaceutical composition comprising at least one antigen derived from an influenza virus.
9011874 Compositions, methods and uses for poxvirus elements in vaccine constructs  
Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza...
9011821 PLA2G16 as a target for antiviral compounds  
In some aspects, the invention provides compositions and methods for inhibiting viral infection. In some aspects, the invention provides compositions and methods useful for identifying antiviral...
9011820 Screening tool for antiviral agents  
A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small...
9005580 Treatment of renal cell carcinoma  
Methods for treating renal cancer by administration of certain 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide compounds, especially 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide...
9005908 Mycobacterial infections  
The present invention relates to Mycobacterial infections and provides a method of diagnosing infections of Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of Johne's...
9005632 Compositions, methods and uses for poxvirus elements in vaccine constructs against influenza virus subtypes or strains  
Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza...
9005579 Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria  
The present invention relates to methods and compositions for use in modulating, including inhibiting the growth and/or reducing the virulence of gram-positive bacteria. The present invention...
9005622 Cell wall components of enterococci and uses thereof  
The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
8999293 Animal model of anxiety and depression  
This invention relates generally to animal models of anxiety and depression. Specifically, this invention relates to an in vivo high utility, high-throughput model for screening...
8999291 Compositions and methods for the removal of biofilms  
This invention provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an...
8999352 Genetically engineered swine influenza virus and uses thereof  
The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
8999292 Methods for treating and diagnosing blinding eye diseases  
This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are...
8986711 Vaccine to protect animals against leishmania  
The present invention is generally related to the prevention of leishmaniasis in animals, particularly infection caused by Leishmania sp., based on the use of Leishmania infantum P36 protein or an...
8980269 G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
8975081 Biomarker for monitoring development of diseases and assessing the efficacy of therapies  
The invention concerns a method for monitoring the development of a disease in a patient, and for assessing the efficacy of a therapy influencing on the CD73 level or activity in the patient, in...
8968702 Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses  
The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) genes in a hypoxic cell....
8962581 Methods and kits to identify invasive glioblastoma  
The invention encompasses methods and kits used in the detection of invasive glioblastoma based upon the expression of NHERF-1. The methods and kits also allow prediction of disease outcome as...
8962614 ON01910.Na enhances chemotherapeutic agent activity in drug-resistant tumors  
The invention includes compositions and methods of treatment of cancers susceptible to treatment with nucleotide analog chemotherapeutic agent, including cancers in which nucleotide analog...
8956618 Vaccine vectors and methods of enhancing immune responses  
Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also...
8945570 Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers  
The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and...
8946169 SPARC and methods of use thereof  
The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying...
8945585 Multi-Target recombination gene and the application of its protein to prevent and cure Helicobacter pylori  
The present invention discloses a multi-target recombination gene and the application of its protein to prevent and cure Helicobacter pylori. It includes a multi-target fusion polypeptide having...
8936942 Polyethyleneglycol-modified lipid compounds and uses thereof  
The present invention provides compositions comprising polytheylyene-dialkyloxypropyl conjugates (PEG-DAA), liposomes, SNALP, and SPLP comprising such compositions, and methods of using such...
8932608 Tuberculosis vaccine and method of using same  
Provided is a pharmaceutical composition that includes one or more inactivated Mycobacterium spp., which are preferably inactivated using gamma irradiation, and which is than formulated for...
8932559 Compositions and methods for preserving insulin-producing cells and insulin production and treating diabetes  
Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a...
8906389 Determination of the efficacy of an anti-mycobacterial vaccination  
The invention relates to methods and reagents for determining efficacy of vaccine, particularly of a tuberculosis vaccine.
8901276 Peptide reagents and methods for detection of colon dysplasia  
The present invention is directed to peptide reagents, methods for detecting colon pre-cancer (dysplasia with non-polypoid or polypoid morphology) or cancer using the peptide reagents, and methods...
8894973 Method and system for differential diagnosis of chronic schizophrenia and chronic alcoholism  
The invention is a method for the differential diagnosis of chronic schizophrenia or chronic alcoholism, by imaging the brain of a subject to detect any or all of the markers phosphocreatine...
8894974 Radiopharmaceuticals for diagnosis and therapy  
A method for treating a human patient is provided, including administering a radiolabeled form of a therapeutic agent to the patient at a first substantially non-therapeutically-effective dose,...
8895029 Compositions and methods for vaccinating cattle  
The present invention relates to compositions, uses thereof, and methods of vaccinating cattle, particularly cows and heifers, against Leptospira borgpetersenii serovar hardjo (type hardjo-bovis)...
8889153 Combination of immunomodulator and anti-pathogenic agent  
A compound comprising combination of an immunomodulator and to at least one anti-pathogenic agent for treating of facultative or strict infections caused by intracellular microorganisms, the...
8883123 Use of vaccines for the treatment/prevention of the transmission of pathogens  
The present invention relates to a method of reducing the transmission of a pathogen from an animal of a first species to an animal of a second species. Specifically, reduction of transmission is...
8883425 Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts  
The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a...
8883173 Synthetic antigenic peptides and lipopeptides derived from Mycobacterium avium subsp. paratuberculosis  
The current invention relates to the diagnosis and treatment of diseases resulting from infections by Mycobacterium avium subsp. paratuberculosis. In particular the invention relates to the use of...
8877483 Dioxin elimination promoter  
An accelerating agent for elimination of dioxins which comprises, as an active ingredient, a microorganism having an activity of accelerating elimination of dioxins in the body to the outside of...
8871995 Method for screening an agent being useful for the treatment of dry eye and/or corneal and conjunctival lesion and pharmaceutical composition obtained by the method  
The present invention provides a method for screening an agent being useful for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to the...
8858938 Human monoclonal antibodies against Hendra and Nipah viruses  
The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah...
8858915 Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome  
The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others. The therapeutic or prophylactic agent for metabolic...
8852556 Animal model for evaluating vasomotor response in vivo  
A method for evaluating the effect of a compound on vasomotor response in vivo comprises the steps of administering said compound to a rabbit and measuring the diameter of the vessel lumen of a...
8847003 Role of proteoglycans in drug dependence  
The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may...
8834843 Imaging method  
The present invention relates to a method useful in facilitating the identification of fibrogenesis in a subject. The method of the invention is particularly useful when applied as part of a...
8828671 Simultaneous assay of target and target-drug binding  
Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding...
8828356 Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis  
Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of...
8816151 Stat5b transgenic mice and methods of use thereof  
It has been discovered that STAT5 phosphorylation and CD150 are effective biomarkers for detecting, diagnosing, and monitoring hematological malignancies, including for example lymphomas....
8815213 RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and Imaging of Necrotic tumors  
RGD-chlorophyll and RGD-bacteriochlorophyll conjugates that home and accumulate in necrotic tumor domains much longer than in tumor non-necrotic domains are provided for use in minimally invasive...
8815254 Method of detoxification  
The present invention relates to a method of detoxifying bacterial cytolysins such as pneumococcal pneumolysin, utilizing chemical cross-linking compounds.
8815253 Compositions for inducing immune responses  
The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) at least first and second adjuvants, wherein the first adjuvant comprises microparticles and...