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7378237 |
Development of method for screening physiologically active pyrrole imidazole derivative
A method for screening the effect of a segment A (chemical species A) on a substance (for example, a cell) containing DNA or RNA by using artificial chemical species. Namely, a method of detecting...
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7378079 |
Agents for imaging and diagnostic methods using them
The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser...
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7378387 |
Method of suppressing immune response by reducing intracellular content of glutathione in macrophages and monocytes
A method of suppressing immune responses, comprising administering to a patient in need thereof an effective amount of a composition comprising a substance capable of reducing the content of...
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7378078 |
Compositions and methods for detecting proteolytic activity
The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The...
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7378077 |
High dose radionuclide complexes for bone marrow suppression
The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases,...
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7374769 |
Method for treating a trigeminal neuralgia by peripheral administration of a neurotoxin
Methods for treating a trigeminal neuralgia by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7375085 |
Melanocyte-stimulating hormone inhibitors
In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl...
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7374901 |
Method of analyzing coenzyme Q-10 and two-electron reduction product thereof and analysis system
The present invention relates to an analysis method and analysis system that can accurately analyze the contents of coenzyme Q-10 and a 2-electron reduced form thereof in a specimen, in which human...
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7371365 |
Methods for detecting parenchymal plaques in vivo
Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity...
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7368099 |
MRI contrast agents
An MRI contrast agent enables direct detection and imaging of exfoliated vascular endothelial sites. The MRI contrast agent includes an imaging unit which contains an unpaired electron-carrying...
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7368254 |
Lipid-based systems for targeting diagnostic agents
The invention relates to targeting of diagnostic agents by use of lipid-based compositions. The invention is useful in the diagnosis of various disorders which are associated with or resulting from...
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7365047 |
Use of pentagastrin to inhibit gastric acid secretion or as a diuretic
This invention pertains to the discovery that pentagastrin, when administered in conjunction with a proton pump inhibitor (PPI) is synergistic with the PPI and significantly increases the efficacy...
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7364719 |
Vasoregulating compounds and methods of their use
Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of blood vessels, by administering to a subject a...
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7361358 |
Treatment of a facial pain by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7361336 |
Methods of cancer therapy targeted against a cancer stem line
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous...
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7357916 |
Method for creating a uniform vascular wound in zebrafish or zebrafish larva
Disclosed are improved methods for creating a uniform vascular wound in a zebrafish larva or zebrafish. The methods illustratively include subjecting a zebrafish larva to laser irradiation in an...
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7357915 |
Method of imaging cell death in vivo
A method of imaging apoptosis in vivo, using radiolabeled annexin, is described.
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7357913 |
Methods for detecting, prognosing, or monitoring a disorder by comparing relative flux rates of two or more biological molecules in vivo
The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or...
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7354900 |
Treatment and inhibition of ocular infections and wounds by CAP37 and CAP37 peptides
A method for treating ocular conditions such as bacterial keratitis, bacterial conjunctivitis, corneal ulcers and wounds, endophthalmitis, and blebitis in mammals, by using a native, synthetic, or...
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7354905 |
Prodrugs of thrombin inhibitors
There is provided compounds of formula I,
R 1 O(O)C—CH 2 —(R)Cgl-Aze-Pab-R 2 I
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7348400 |
α-conotoxin peptides with analgesic properties
This invention relates to novel α-conotoxin-like peptides comprising the following sequence of amino acids: Xaa 1 CCSXaa 2 Xaa 3 Xaa 4 CXaa 5 Xaa 6 Xaa 7 Xaa 8 Xaa 9 Xaa 10 Xaa 11 C—NH 2 in...
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7347984 |
Mammalian agmatinase inhibitory substance
The present invention provides for methods and compounds for treating brain trauma and disorders such as: ischemia, stroke, neurodegenerative disorders, opioid addiction, idiopathic pain, epilepsy,...
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7344703 |
Mycobacterial sulfation pathway proteins and methods of use thereof
Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid...
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7344701 |
Xanthene dyes
The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like....
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7344704 |
Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10 −3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm...
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7341832 |
Genes involved in neuropsychiatric disorders
The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these...
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7342089 |
Cyclic peptides for treatment for cachexia
A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula
where R 1 , R 2 , R 3 , R 4a , R 4b , R 5 , R 6 , R 7 , x, y and z are as defined in the specification, and a...
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7341710 |
Method of identifying molecules that home to a selected organ in vivo
The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
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7338938 |
Methods for treating a patient undergoing chemotherapy
The present invention provides improved methods, kits, and pharmaceutical compositions for increasing hematopoietic cell survival and/or reducing or preventing the side effects of chemotherapy, and...
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7338652 |
Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents
New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such...
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7335369 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M....
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7335639 |
IGF-1 composition and its use
A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I...
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7335480 |
Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same
The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is...
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7335632 |
Beta-secretase inhibitors and methods of use thereof
The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
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7332590 |
Molecular characteristics of non-small cell lung cancer
We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung...
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7329400 |
Generator for rhenium-188
Radioisotope generators comprising inorganic layered hydroxide composition, such as magnesium aluminates and lithium aluminates. These inorganic layered hydroxides form anion exchange materials...
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7326775 |
Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
A method of preparing an ultra-cleansed lactoferrin preparation, termed treatment for contaminant reduction (TCR) is provided which includes the steps of treating commercial lactoferrin preparation...
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7323566 |
Radiopharmaceutical and methods of synthesis and use thereof
A novel group of apomorphine derivatives are provided that are well suited as radioimaging agents upon incorporation of radionuclides. Through reaction of D ring sites, the less reactive sites of...
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7323175 |
Immunogenicity of glucan binding protein
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7323443 |
Lactoferrin in the reduction of pain
The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone...
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7320785 |
Compositions and methods for modulation of DARPP-32 phosphorylation
The present invention provides methods and compositions for modulating the phosphorylation of DARPP-32 in a serotonergic receptor intracellular signaling pathway. The invention provides methods and...
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7320783 |
Methods and compositions for the enhancement of wound healing
The present invention relates to methods and compositions for wound healing, and in particular, methods and compositions to promote and enhance wound healing. In particular, the present invention...
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7320784 |
Immobilized labeling compounds and methods
The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to the...
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7317002 |
Site-specific preparation of polyethylene glycol-GRF conjugates
A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys 12 and/or Lys 21 and/or N α ,...
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7314609 |
Stereoisomers of fatty acid analogs for diagnostic imaging
The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a...
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7315787 |
Multi-marker screening protocol for fetal abnormalities
A method of assessing a pregnant woman's risk of having a fetus with a fetal abnormality by determining the fetus' BPD/OFD ratio and using the BPD/OFD ratio in conjunction with one or more other...
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7312195 |
Cyclised conotoxin peptides
This invention relates to cyclised conotoxin peptides, processes for their preparation and their pharmaceutical use.
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7311893 |
Amyloid targeting imaging agents and uses thereof
Amyloid-targeting imaging agents such as radiolabeled amyloid targeting molecules and amyloid targeting molecule-chelator conjugates for imaging, e.g., amyloid plaques in vivo, and/or for the...
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7309759 |
Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues...
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7306784 |
Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant...
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