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7591996 |
Ultrasound target vessel occlusion using microbubbles
Selective occlusion of a blood vessel is achieved by selectively damaging endothelial cells at a target location in the blood vessel, resulting in the formation of a fibrin clot proximate to the...
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7591997 |
Method for determining the susceptibility of a subject to infection
A method for determining the susceptibility of a subject to infection, which method comprises: (i) providing a sample from said subject; (ii) detecting any LL-37 present in said sample; (iii)...
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7588887 |
Stable isotope metabolic labeling for analysis of biopolymers
Methods for the determination of the rate of synthesis of biopolymer synthesis and degradation in cells, tissues, or cell-free systems using monomer which has been labeled with a stable isotope are...
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7588751 |
Liposome-containing radiographic contrast medium and preparation method thereof
A method of pereparing a rediographic contrast medium containing liposomes is disclosed, comprising (a) dissolving a phospholipid and a sterol in a supercritical or subcritical carbon dioxide in...
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7585492 |
Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams
A bio-molecular contrast agent (BMCA) is introduced into a biological organism such that the agent binds or reacts with target tissue within that organism. The BMCA is also signal-giving, and...
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7586020 |
Methods for determining effects of maternal treatments on offspring
The present invention provides animal models and methods for the evaluation of maternal treatments that could improve or compromise the epigenetic state, the imprinting, or the DNA methylation and...
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7582603 |
Method for treating or inhibiting intestinal inflammation
Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the...
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7582280 |
Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications
The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such...
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7582281 |
Ethylenedicysteine (EC)-drug conjugates compositions and methods for tissue specific disease imaging
The invention provides, in a general sense, a new labeling strategy employing 99m Tc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99m Tc for...
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7579005 |
Process for recombinant expression and purification of antimicrobial peptides using periplasmic targeting signals as precipitable hydrophobic tags
A process was developed for expressing antimicrobial peptides in a recombinant host cell that eliminates host cell toxicity and antimicrobial peptide degradation, as well as providing a process for...
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7579322 |
Compositions and methods for promoting myocardial and peripheral angiogenesis
Methods, compositions and devices are disclosed for use in growing new blood vessels to restore or improve blood flow to ischemic tissues and organs of the body. Compositions comprising IGD...
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7579012 |
Targeting of triacylglycerol synthase gene for tuberculosis treatment
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or...
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7579009 |
Whole bacterial cells as immune modulator
An immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia, Nocardia, Dietzia, Tsukamurella and Nocardioides ,...
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7575877 |
Method of diagnosing tuberculosis
The present invention relates to a method of diagnosing tuberculosis in a subject, said method comprising steps of: detecting anti- Mycobacterium tuberculosis (M.tb.) isocitrate dehydrogenase...
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7575928 |
Genes for diagnosing colorectal cancer
This invention relates to provide the genes for diagnosing colorectal cancer, the gene sequences searching comprise the steps of: (1) deriving epithelium cells from normal intestines, polypus of...
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7576181 |
Method of administering porcine B-domainless fVIII
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
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7572457 |
Use of Streptococcus suis 38 kDa polypeptide as an immunogen
Disclosed are methods, compositions, and kits for inducing polyclonal antibodies against one or more pathogens that include Streptococcus suis . The methods may include administering to an animal...
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7572903 |
Method of regulation of bacterial persister status
In one embodiment, the present invention is a method of controlling persister status in a bacterial cell population comprising the step of modulating the expression of native chromosomal sequences...
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7572434 |
Method for assessing the effect of a drug on long term memory formation
Methods of assessing the effect of a drug on long term memory and for screening a pharmaceutical agent for its ability to modulate long term memory are disclosed.
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7569223 |
Phage-associated lytic enzymes for treatment of Streptococcus pneumoniae and related conditions
The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Streptococcus pneumonia bacteria and spores, and related conditions. The disclosure...
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7569536 |
Method for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity
The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation...
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7570411 |
Optical limiter having trimetallic nitride endohedral metallofullerence films
An exemplary optical limiter device ( 100 ) has an optically transmissive substrate ( 102 ) and a layer ( 104 ) on a first surface ( 106 ) of the substrate, the layer having a trimetallic nitride...
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7569209 |
Method for diagnosis of sepsis by determination of S100B
Method for early differential diagnosis and detection, for prognosis and for assessing the severity and for therapy-accompanying assessment of the course of sepsis and sepsis-like systemic...
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7569229 |
Monocyte locomotion inhibitory factor
The invention relates to an anti-inflammatory oligopeptide which can be obtained from the microorganism Entamoeba histolytica or synthesized by known methods. The oligopeptides are useful in...
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7566444 |
Versatile hydrophilic dyes
Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid)...
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7566547 |
Gene 763 of phytopathogenic fungus Magnaporthe grisea and use thereof for identifying fungicidal compounds
The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus Magnaporthe grisea comprising a gene coding for a protein (hereafter referred to as gene 763) whereof...
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7566459 |
Modified mycobacterium tuberculosis strains and uses thereof
The present invention features modified Mycobacterium tuberculosis strains which lack a functional lspA gene, and vaccine formulations comprising the same. In many embodiments, a modified ...
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7566443 |
Method for diagnosis of chronic allograft rejection
The present invention provides a method for the diagnosis of chronic rejection in allografts. The method comprises identification of tertiary lymphoid organs (TLO) in the transplanted organs as a...
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7560095 |
Cancer specific monoclonal antibodies
Novel monoclonal antibodies and binding fragments thereof specific to human breast cancer, lung cancer, colon cancer and other cancers. The monoclonal antibody does not bind to the cell surface of...
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7560432 |
In situ method for treatment and repair of meniscal injuries
A method for in situ repair of meniscal injuries comprising induction of meniscal repair and regeneration by introducing an adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury...
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7560096 |
Diagnostic procedures using direct injection of gaseous hyperpolarized 129Xe and associated systems and products
A method of screening for pulmonary embolism uses gaseous phase polarized 129 Xe which is injected directly into the vasculature of a subject. The gaseous 129 Xe can be delivered in a controlled...
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7560229 |
Methods of use of the enzymes of mycothiol synthesis
The present invention utilizes three families of bacterial enzymes, which play a key role in mycothiol biosynthesis. The three families are bacterial cysteine:glucosaminyl inositol ligases (MshC)...
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7556810 |
Compositions and methods to control angiogenesis with cupredoxins
The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that...
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7556796 |
Directed complementation
A method of producing a tumorigenic mouse cell, the tumorigenicity of which depends on a recombinant gene of interest is disclosed. The method involves: (a) providing a conditionally tumorigenic...
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7555329 |
Method and apparatus for quantifying pharyngeal residue
A method and apparatus for quantifying pharyngeal residue and aspiration of a patient by x-ray imaging of the patient's head and neck to produce a baseline image, applying an initial volume of...
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7555334 |
Small animal light intensity monitor
Disclosed are methods and apparatus for collecting light emitted from an animal, where a luminescent reporter has been injected into the animal is disclosed. The apparatus includes a chamber for...
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7553478 |
Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level
A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous...
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7547506 |
Peptide-based fluorescence polarization assay for detection of antibodies to Mycobacterium bovis
The present invention provides an assay for detection of M. bovis -infected animals. A tracer, comprising a peptide of M. bovis protein MPB70 conjugated to a fluorophore, is added to a serum...
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7541140 |
Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
The present invention relates to identifying the risk of a subject developing renal stones utilizing an assessment of PTH agonist, antagonist and/or total PTH levels, optionally together with an...
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7541157 |
Method of screening groups of radioactive molecules and applications thereof
The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least...
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7541447 |
Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live...
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7538208 |
Type III secretion pathway in Aeromonas salmonicida, and uses therefor
Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida . The invention also encompasses the use of components of the novel secretion system in...
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7538195 |
Anti-IGF-I receptor antibody
Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these molecules with cytotoxic agents, which specifically bind to and inhibit...
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7534419 |
Methods of diagnosis and treatment of osteoporosis
A method of detecting osteoporosis in a mammalian is disclosed herein which includes:
a) obtaining a sample of a bone related tissue or cells; and b) measuring the concentration of at least a...
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7534418 |
Imaging agents
The present invention provides novel compounds that find use as imaging agents within nuclear medicine applications (e.g., PET imaging and SPECT imaging). The present invention also provides...
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7534437 |
Helminth-derived antigens having capacity of providing protection against parasites
The primary objective of the present invention is the development of new mutant forms of the Sm14 protein, for producing a greater production volume. The recombinant proteins here obtained were...
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7531163 |
Enrichment methods for the detection of pathogens and other microbes
The present invention provides novel enrichment, testing and detection methods for detection of pathogens or other microbes in a food, water, wastewater, industrial, pharmaceutical, botanical,...
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7531164 |
Preventing bacterial or viral infectivity and composition containing infection preventing additive
A nitric oxide synthesis inhibitor or nitric oxide scavenger is administered to prevent development of infection, to prevent development of a cancer where overstimulation of a receptor contributes...
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7531513 |
Therapeutic preparation of very high purity FVIIa and method for obtaining same
The therapeutic preparation of FVIIa having a purity of at least 1000 IU/mg of protein is characterized in that said preparation is free of proteins of non-human origin. In the method for obtaining...
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7531323 |
Diabetes-mediating proteins and therapeutic uses thereof
Provided are protective and deleterious diabetes-mediating proteins and polynucleotides encoding same, transgenic animals expressing a diabetes-mediating protein, drug screening methods for...
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