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6955802 |
Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube
Provided are genetically engineered cells comprising a neural stem cell and retroviral expression system in the neural stem cell, which is capable of expressing homeodomain transcription factor...
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6955813 |
Therapy for injured muscles
Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle.
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6957038 |
Self-scoring method and apparatus for early self-screening of neurological disease
A self-administered and self-scoring test kit and method for early self-screening of neurological disease, by detection of diminished olfactory function. The test kit is comprised of a plurality of...
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6953570 |
Porphyrins with enhanced multi-photon absorption cross-sections for photodynamic therapy
A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin...
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6949345 |
Identification and cloning of a mycobacterial antigen corresponding to a heparin-binding haemagglutinin
The present invention relates to peptide sequences enabling mycobacteria to adhere to host cells (e.g., epithelial cells). More particularly, the invention relates to a mycobacterial...
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6949512 |
Therapeutic agent for the treatment of septicaemia its preparation and use
A therapeutic agent for the treatment of septicemia, its preparation and use, with application in the pharmaceutical industry and medicine. This therapeutic agent contains essential element, the...
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6939548 |
Methods to produce high levels of C. difficile toxins
The present invention relates to the field of medical immunology and further to pharmaceutical compositions, methods of making and methods of use of vaccines. More specifically this invention...
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6939714 |
Epithelial cell growth inhibitors
Epithelial cell growth inhibitors differentially express in normal and cancerous epithelial cells. The ECGI proteins and nucleic acid sequence encoding them are useful in the diagnosis and...
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6936240 |
Method for the preparation of technetium or rhenium complex for radiopharmaceuticals
The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a...
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6930169 |
Method of controlling the binding of calmyrin to presenilin
The present invention describes a calcium-binding myristoylated protein with homology to calcineurin B which interacts preferentially with presenilin 2 protein. Also, the present invention relates...
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6929799 |
D-alanine racemase mutants of mycobacteria and uses therefore
The present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of...
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6926884 |
GPIb-lipid bond construct and use thereof
The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing...
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6926890 |
Non-invasive approach for assessing tumors in living animals
A means for following the growth of experimental neoplasms involves administering recombinant tumor cells containing an expression construct encoding a secretable marker to an experimental animal...
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6923950 |
System and method for radiographic imaging of tissue
System and method for radiographic imaging of tissue using a non-radioactive, radio-opaque imaging agent that accumulates intracellularly in tissue in proportion to its functional, or...
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6924118 |
Recombinant intracellular pathogen immunogenic compositions and methods for use
Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular...
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6924311 |
Methods for affecting various diseases utilizing LXR compounds
The present invention relates to methods for elevating high density lipoprotein (HDL) plasma levels, decreasing the absorption of dietary cholesterol in the intestine, decreasing the plasma level...
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6919312 |
Bone-pathobolism treating agent
A novel bone-pathobolism treating agent is provided. A bone-pathobolism treating agent comprising at least one substance selected from the group consisting of osteoclastogenesis inhibitory factor...
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6916460 |
Macrocyclic chelants for metallopharmaceuticals
This invention relates to macrocyclic chelants comprised of one or two heteroatom-containing bridges, compositions containing them and their use in medicine, particularly in diagnostic imaging and...
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6913743 |
Near infrared imaging agent
This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific...
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6908739 |
Diagnostic assays for detection of Giardia lamblia
This invention provides methods, reagents, and kits that are useful for diagnosing infection by Giardia lamblia . The methods are based on the discovery of binding agents, including recombinant...
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6905669 |
Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
Compositions and methods are provided for treating diseases associated with aberrant silencing of gene expression such as cancer by reestablishing the gene expression through inhibition of DNA...
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6906035 |
Antimicrobial cationic peptides
A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH 2 -KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH 2...
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6902719 |
Reverse isotope dilution assay and lactose intolerance assay
A “reverse isotope dilution assay” herein, wherein a pathway that produces a given metabolite is assayed by diluting a labelled metabolite produced by a second constitutive pathway. In one...
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6900036 |
Prion isomers, methods of making, methods of using, and compositions and products comprising prion isomers
Prion peptides exhibiting structural isomerism to wild-type prion peptide are disclosed. The invention further discloses methods of making prion isomers, compositions comprising prion isomers, and...
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6896871 |
Biphosphonate conjugates and methods of making and using the same
The present invention is directed to particular bisphosphonate compounds, and in particular, to bisphosphonate conjugates that are useful in the treatment of soft tissues surrounding bone and...
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6896872 |
Rapid multiple panel of biomarkers in laboratory blood tests for TIA/stroke
A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor...
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6896870 |
Diagnostic probes and therapeutics targeting uPA and uPAR
A uPAR-targeting protein or peptide is diagnostically or therapeutically labeled and used in methods of diagnosis of therapy. The labeled protein or peptide preferably has the following properties:...
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6896873 |
MR signal-emitting coatings
The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer...
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6896874 |
MR-signal emitting coatings
The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer...
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6890514 |
Methods for determining risk of developing cervical cancer
The present invention relates generally to a method of identifying a subject having an increased risk of developing cervical cancer based on levels of IGF-II in serum and levels of EGF-R and...
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6887481 |
Bacterial-derived molecules and therapeutic and diagnostic uses therefor
The present invention relates generally to molecules derived from a Mycobacterium species and recombinant, synthetic, derivative, homologue and analogue forms of said molecules. The molecules of...
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6884407 |
Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
Improved methods for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a...
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6884774 |
Cyclic hexapeptide derivatives
This invention relates to new polypeptide compound represented by the general formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description or a salt thereof which has...
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6878514 |
Methods for identifying agents that inhibit serum aging factors and uses and compositions thereof
The invention described herein encompasses methods of preventing or treating disorders caused by oxidative damage by an aging-specific isoform of NADH oxidase (AR-NOX). The invention encompasses...
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6878516 |
Autoregulatory system for validating microbial genes as possible antimicrobial targets using a tetracycline-controllable element
A screen has been designed to genetically engineer microbial pathogens so that expression of specific genes can be regulated in vitro and during host infection to facilitate the identification of...
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6875418 |
Method of early detection of Duchenne muscular dystrophy and other neuromuscular disease
The mdx mouse is a model of Duchenne muscular dystrophy. The present invention describes that mdx mice exhibited clinically relevant cardiac phenotypes. A non-invasive method of recording...
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6875843 |
Prevention of diabetes and prolongation of the honeymoon phase of diabetes by administration of GnRH antagonists
A method for reducing the incidence or delaying the onset of diabetes in diabetes-susceptible mammals (e.g., mice, rats, humans) is provided wherein the mammals are treated with a...
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6875419 |
Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use
The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism....
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6872381 |
Radiopharmaceuticals for diagnosing Alzheimer's disease
This invention is directed to the use of radiopharmaceuticals in diagnosing Alzheimer's disease. In particular the radiopharmaceuticals of the invention are able to pass through the blood-brain...
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6872519 |
In vitro process for selecting phage resistant to blood inactivation
The present invention relates to compositions and methods for the selection and use of surface exposed epitopes. The present invention includes in vivo and in vitro phage peptide diplay methods for...
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6872804 |
Glycopeptide disulfide and thioester derivatives
Disclosed are disulfide and thioester derivatives of glycopeptides and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as...
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6869592 |
Method and antibody for imaging lung cancer
The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating lung cancer.
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6869802 |
Combined cholesterol and bilirubin tests as risk predictors for coronary artery disease
A new method for predicting the risk of coronary artery disease (CAD) is disclosed. The method uses a ratio made up of the levels of an individuals LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C)...
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6869610 |
Pain treatment by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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6866837 |
Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors
Compounds and methods for the diagnosis and treatment of tumors, including breast and prostate tumors and metastases thereof using radiolabelled peptides that bind to GRP receptors. The peptides...
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6864093 |
Method of identifying and treating invasive carcinomas
Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein...
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6864247 |
Therapeutic agents for glomerulosclerosis
An object of the present invention is to provide pharmaceutical compositions for inhibiting mesangial cell proliferation or mesangial matrix production without causing hypercalcemia. According to...
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6863881 |
Compositions and methods of nematode control
The present invention provides compositions and methods for identifying agents that stimulate or inhibit nematode reproduction, especially related to oocyte maturation, sheath cell contraction, and...
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6863880 |
Methods to diagnose a required regulation of trophoblast invasion
Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-β 3 , receptors of cytokines of the TGβ family,...
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6861506 |
Compositions and methods for the treatment and diagnosis of breast cancer
Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue,...
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