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9055763 Probiotics for use in relieving symptoms associated with gastronitestinal disorders  
The present invention provides probiotic compositions suitable for relieving symptoms associated with gastrointestinal disorders. In particular, the present invention provides compositions and...
9040020 Muteins of hNGAL and related proteins with affinity for a given target  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related...
9040049 ADAM-15 antibodies and immunogenic peptides  
The present invention relates to antibodies and antigen-binding fragments thereof, immunogenic peptide(s), and siRNA molecules which are capable of inhibiting neovascularization and/or...
9034585 Diabetes-related biomarkers and methods of use thereof  
The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify...
9034586 Method of detecting pancreatic disease and pancreas testing kit  
A pancreatic disease is tested for with high sensitivity even with simple equipment and a simple procedure. Provided is a method of detecting pancreatic disease including detecting a concentration...
9028802 Method of differentially diagnosing different types of dementia  
The present invention relates to a method of differentially diagnosing different types of dementia. In particular, the method relates to the use of specific SPECT tracers for differentially...
9028801 Diagnosis of neurodegenerative diseases  
The invention relates to a method of diagnosis of vCJD in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein...
9023314 Surface treatment for a medical device  
A surface coating for a medical device is provided that may prevent or slow the formation of medical biofilms on the surface of the device. Covalent attachment of certain analogues of N-acyl...
9023604 Method of reversibly staining a target cell  
The present invention relates to methods of reversibly staining a target cell. The invention also relates to methods of isolating a target cell or a target cell population that is defined by the...
9017955 Fibrinogen assay  
The present invention is directed to a method of detecting intact fibrinogen, comprising the steps of: a) providing a sample containing at least some fibrinogen optionally converted at least in...
9011819 Optical imaging contrast agents and uses thereof  
The present invention generally relates to microbubble contrast agent compositions which are detectable by optical imaging methods, such as fluorescence, near-infrared or bioluminescence. Uses of...
9012136 Detection of an analyte in a sample  
There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte...
9011818 Materials and methods for biological imaging  
Water soluble InAs(ZnCdS) semiconductor nanocrystals with bright and stable emission in the near infrared (NIR) wavelength range have been prepared. The NIR semiconductor nanocrystals can be...
9011820 Screening tool for antiviral agents  
A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small...
9012160 Monitoring skin metabolism products for evaluating burn injury  
The present invention relates to methods and kits for evaluating the severity of a burn injury, which are based on the detection in a clinical fluid sample of skin metabolism products, such as...
9005581 Modified pyrazine derivatives and uses thereof  
Provided herein are compounds, preparations and formulations comprising pyrazine derivatives having multiple poly(ethylene glycol) containing substituents. Many of the compounds disclosed herein...
9005580 Treatment of renal cell carcinoma  
Methods for treating renal cancer by administration of certain 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide compounds, especially 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide...
9005621 Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof  
Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses....
9005908 Mycobacterial infections  
The present invention relates to Mycobacterial infections and provides a method of diagnosing infections of Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of Johne's...
9005582 Hyperthermia therapeutic agent delivery system  
A medical delivery system that enables the delivery of therapeutic agents to malignant tissue utilizing delivery agents and heating of the delivery agents thereby causing the release of the...
9005579 Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria  
The present invention relates to methods and compositions for use in modulating, including inhibiting the growth and/or reducing the virulence of gram-positive bacteria. The present invention...
9005887 Detection of an analyte in a sample  
There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte...
9005583 Chain-end functionalized poly(ethykene oxide) and process for the preparation of a nano-sized transition metal or metal salt using the same  
There is provided a novel chain-end functionalized PEO of formulas (I) to (IV) prepared via living anionic polymerization and chain-end functionalization, as well as a simple method of preparing...
8999291 Compositions and methods for the removal of biofilms  
This invention provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an...
8999290 Papillomavirus pseudoviruses for detection and therapy of tumors  
Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a...
8992961 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles  
This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended...
8992887 Method for medical imaging of body cavities  
The present invention relates to an image enhancing composition for the enhancement of contrast in a body cavity, wherein the viscosity of the composition is between 2000 and 4000 mPa·sec. It also...
8993250 Methods and compositions for diagnosis and prognosis of renal injury and renal failure  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal...
8992886 Cyclic peptide analogues for non-invasive imaging of pancreatic beta-cells  
Compositions, methods of using and methods of making a cyclic peptide analog imaging agent that includes at least portions of a peptide or protein that binds specifically to the GLP-1 receptor...
8986711 Vaccine to protect animals against leishmania  
The present invention is generally related to the prevention of leishmaniasis in animals, particularly infection caused by Leishmania sp., based on the use of Leishmania infantum P36 protein or an...
8986655 Compositions, devices, and methods related to prostate-specific membrane antigen  
PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence X1X2CVEVX3QNSCX4X5 where X1-X5 are independently a natural or non-natural amino...
8987429 GO-Gd-DTPA complex, preparation method thereof, and MRI contrast agent comprising the same  
Disclosed herein is a GO-Gd-DTPA (gadolinium-diethylenetriamine pentaacetic-graphene oxide) complex, which is formed by an ester bond of graphene oxide (GO) and gadopentetic acid (Gd-DTPA). Since...
8980223 Methods of preventing ischemic injury using peripheral nociceptive stimulation  
Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and...
8980820 Fatty acid binding proteins as drug targets for endocannabinoids  
The invention provides a method of modulating the level of an endocannabinoid in a subject in need thereof comprising administering an effective amount of an agent that inhibits the interaction of...
8980269 G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
8980222 Diagnostic use of endothelin ETB receptor agonists and ETA receptor antagonists in tumor imaging  
Methods of imaging tumors are disclosed. The methods utilize an endothelin ETB receptor agonist or an endothelin ETA receptor antagonist, in combination with an imaging agent, to detect a tumor in...
8975026 Method for generating aptamers with improved off-rates  
The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods....
8974767 Fluorescent nanoparticles  
The use of fluorescent nanoparticles is disclosed which includes an inorganic core, a passivating layer and specific ligands having a hydrodynamic diameter of the inorganic core with the...
8974768 Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates  
The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate...
8969027 Protease assay  
The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell....
8969018 Methods and compositions for monitoring and risk prediction in cardiorenal syndrome  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods...
8969016 Resonance energy transfer assay with cleavage sequence and spacer  
A molecular construct comprises a donor label, an acceptor label, a linker peptide disposed between the donor and the acceptor, the linker having a cleavage site sequence, and a spacer between at...
8969017 Metabolite biomarkers for diagnosis and prognosis of pediatric septic shock  
The present invention provides methods for differentiating a pediatric subject with pediatric septic shock from a healthy pediatric subject or one having sudden inflammatory response syndrome...
8962581 Methods and kits to identify invasive glioblastoma  
The invention encompasses methods and kits used in the detection of invasive glioblastoma based upon the expression of NHERF-1. The methods and kits also allow prediction of disease outcome as...
8961928 Ligand and metal complex having the same  
A ligand and a metal complex having the ligand are provided. The ligand and a paramagnetic metal ion form a metal complex with high stability, high relaxivity and high biocompatibility. The metal...
8962597 Alkyl ketal esters as dispersants and slip agents for particulate solids, methods of manufacture, and uses thereof  
Disclosed herein is a dispersion comprising a liquid or semi-solid continuous phase, a dispersed solid phase comprising a plurality of organic, inorganic or inorganic-organic particles, and an...
8961932 “Micro-patch” for assessment of the local microvasculature and microcirculatory vasoreactivity  
A method for interrogating the microcirculation of a subject for use in characterizing function in health and disease, monitor changes in microcirculation over time, and identify responses in...
8962614 ON01910.Na enhances chemotherapeutic agent activity in drug-resistant tumors  
The invention includes compositions and methods of treatment of cancers susceptible to treatment with nucleotide analog chemotherapeutic agent, including cancers in which nucleotide analog...
8961934 Fibrosis specific multimeric peptidomimetic radiotracers  
The present invention describes peptidomimetic radiotracers. In particular, the present invention discloses fibrosis specific multimeric small-molecule peptidomimetic radiotracers.
8961930 Isatin derivatives for use as in vivo imaging agents  
Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders...