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7371819 |
Polypeptides of the IFNα-17 gene
The present invention relates to new polynucleotides derived from the nucleotide sequence of the IFNα-17 gene comprising new SNPs, and new polypeptides derived from the natural wild-type IFNα-17...
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7371372 |
Compositions comprising IMPDH inhibitors and uses thereof for treating HCV infection
The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or pegylated alpha-interferon and an IMPDH inhibitor...
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7364724 |
Recombinant super-compound interferon
This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor...
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7358333 |
Polypeptides of the IFNα-5 gene
The present invention relates to new polynucleotides derived from the nucleotide sequence of the IFNα-5 gene comprising new SNPs, and new polypeptides derived from the natural wild-type IFNα-5...
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7338654 |
Glycosylated interferon alpha obtained from a transgenic chicken
This invention includes compositions comprising glycosylated human interferon-α derived from a chicken.
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7311903 |
Glycosylated human interferon alpha isoform
The present invention relates to an amino acid-modified human interferon alpha isoform having at least one of the Asn-Xaa-Ser/Thr (N-X-S/T) sequence formed at a specific site so that glycosylation...
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7294332 |
Combination therapy (temozolomide and α-IFN) for advanced cancer
There is disclosed a method for treating advanced cancer in patients in need of such treating. Temozolomide and alpha interferon are administered in combination in amounts sufficient to achieve a...
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7270809 |
Cysteine variants of alpha interferon-2
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7232563 |
Hybrid interferon/interferon tau proteins, compositions and methods of use
The present invention relates to hybrid interferon fusion proteins formed of an interferon-α protein where the C-terminal region of the interferon-α protein is replaced by a C-terminal region of...
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7201897 |
Interferon conjugates
Physiologically active PEG-IFNα conjugate having a formula as follows:
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7189389 |
Pharmaceutical composition of human interferon-α2 and interferon α8 subtypes
The objects of the present invention are to reveal a specific combination of human interferon-α subtypes that remarkably enhances the expression of protein synthesis inhibitory genes, and to...
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7182942 |
Vaccine immunotherapy for immune suppressed patients
A method of immunotherapy to treat cancer or a synergistic anti-cancer treatment by administering an effective amount of a natural cytokine mixture (NCM), an effective amount of cyclophosphamide...
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7175839 |
Cancer immunotherapy using allostimulated cells in a multiple sequential implantation strategy
This invention provides medicaments and methods for managing cancer using donor cells that are alloactivated in culture. Alloactivated cells are implanted into the bed of a solid tumor and initiate...
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7160554 |
Enhanced circulation effector composition and method
A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the...
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7138376 |
Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted...
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7115578 |
Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
Ribavirin derivatives represented by the formula V, pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula V for the preparation of a...
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7067129 |
Receptor specific transepithelial transport in therapeutics
The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke...
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7041301 |
Interferon immunotherapy
A method for reducing the recurrence of a resectable malignant tumor includes administering an immunostimulatory dosage of an α-interferon composition, then surgically resecting the malignant...
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7033594 |
Method of treatment using ligand-immunogen conjugates
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic...
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7030086 |
Stabilized liquid polypeptide-containing pharmaceutical compositions
Stabilized liquid polypeptide-containing pharmaceutical compositions are provided. The compositions comprise an amino acid base, which serves as the primary stabilizing agent of the polypeptide,...
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6995133 |
Utilization of interferon alpha 5 in the treatment of viral hepatopathies
The invention relates to the use of interferon alpha 5 in the treatment of viral hepatopathies. The invention describes the reduced synthesis of IFNα5 in the livers of patients with hepatitis C in...
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6991785 |
Method for administering a cytokine to the central nervous system and the lymphatic system
The present invention is directed to a method for delivering cytokines to the central nervous system and the lymphatic system by way of a tissue innervated by the trigeminal nerve and/or olfactory...
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6987103 |
Treatment of chronic myelogenous leukmia, resistant or intolerant to ST1571, involving homoharringtonine alone or combined with other agents
The present invention concerns a method of treating chronic myelogenous leukemia, a related myeloproliferative disorder or a Ph-positive acute lymphocytic leukemia in a subject animal, comprising:
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6962695 |
Modification of interferon alpha production
A process for the production of α-interferon comprising the steps: i) inducing of human leukocytes by means of a virus; ii) treating the leukocytes with an enhancing agent selected from: a)...
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6956027 |
N-terminally chemically modified protein compositions and methods
Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and...
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6949520 |
Methods related to immunostimulatory nucleic acid-induced interferon
Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides...
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6924270 |
Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
Ribavirin derivatives represented by the formula II, pharmaceutical compositions containing them as well as methods of using the ribavirin derivatives represented by the formula II for the...
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6908611 |
Combination therapies using vitamin B12 and interferon for treatment of viral, proliferative and inflammatory diseases
Pharmaceutical compositions for treating viral, proliferative and inflammatory diseases are disclosed comprising an amount of pharmaceutically acceptable vitamin B12 compound in combination with an...
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6905677 |
Combined hepatitis B treatment
The invention relates to a method of treating patients infected with hepatitis B virus comprising the adminstration of both a nucleoside analogue and interferon-α over a prolonged period of time.
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6902729 |
Murine interferon-α
Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain...
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6884411 |
Method of treating viral hepatitis by administration of liquid human α-interferon
Use of natural human α-interferon for the preparation of a medicament in liquid form to be administered through peroral route at dosages comprised between 100 UI and 500 UI/day, for therapy of...
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6866782 |
Process for the purification of pharmacologically active proteins through cationic exchange chromatography
There is disclosed a process for the purification of pharmacologically active proteins based on the use of the cationic exchange chromatography on a solid matrix carried out at a more basic pH,...
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6849254 |
HCV combination therapy
Methods of treating patients having susceptible viral infections, especially chronic hepatitis C infection by administering to said patient a therapeutically effective amount of a combination...
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6843988 |
Synferon
The present invention relates to a novel Synferon protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a synthetic interferon...
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6838081 |
Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient
The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in...
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6833256 |
Interferon tau mutants and methods for making them
The present invention is directed to the field of animal and human health, and more particularly to pharmacological uses of analogs or mutants of interferon-tau (IFN-τ) that differ from native...
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6830744 |
Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b
Stable aqueous formulations which are free of products derived from human or animal origin and which maintain high biological activity and high chemical and physical stability of alpha-type...
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6824769 |
Optimal compositions and methods thereof for treating HCV infections
The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or a derivative thereof and an IMPDH inhibitor,...
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6824768 |
Ribavirin-pegylated interferon alfa induction HCV combination therapy
There is disclosed a method for treating antiviral treatment naives patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving a combination therapy using (1) a...
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6815422 |
Molecules with anti-inflammatory activity
Here is described the use of angiostatin or its fragments to prepare a drug active against pathologies where is beneficial to obtain the inhibition of the migration, activation and release of...
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6787132 |
Combined chemo-immunotherapy with liposomal drugs and cytokines
A method of antitumor therapy is described in which administration of a chemotherapeutic drug, encapsulated in liposomes, is supplemented by administration of an immunostimulating cytokine. The...
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6773701 |
Expression enhancer for protein synthesis inhibitory genes
The objects of the present invention are to reveal a specific combination of human interferon-α subtypes that remarkably enhances the expression of protein synthesis inhibitory genes, and to...
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6746670 |
Regulatory T cells; methods
Methods for increasing yields of Tr1 cells, useful, e.g., in transplantation contexts. Use of interferon and IL-15 are described.
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6703225 |
Interferon-α
A novel human IFN-α subtype and its derivative having an unprecedentedly high specific activity, DNA encoding these proteins, an expression vector having said DNA, a transformant transformed with...
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6685931 |
Treatment of hepatitis C virus infections with interleukin-10
The hepatoprotective effect of IL-10 is described, in particular, the use of interleukin-10 in the treatment of liver damage (e.g. fibrosis or cirrhosis) in a difficult-to-treat patient afflicted...
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6667033 |
Therapeutic agent for chronic hepatitis B
The present invention provides an effective method for treating chronic hepatitis B. Specifically, the present invention provides a method for treating chronic hepatitis B wherein interferon (IFN)...
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6663859 |
Compositions for enhancing the immune response
D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration...
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6635243 |
Antiviral nasal drops comprising recombinant interferon a biocompatible polymer and an antioxidant
The present invention can be used in pharmacology specifically in the preparation of interferon-containing compositions, which are capable of conserving their biological activity and can be...
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6607914 |
Camello gene family and uses thereof
The present invention provides a purified and isolated nucleic acid encoding a camello protein. The present invention also provides a vector comprising nucleic acid encoding camello, a host cell...
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6605273 |
Renal cell carcinoma treatment
Methods for treating treatment-naive as well as treatment-experienced patients having RCC to achieve at least a partial tumor response involving administering a therapeutically effective amount of...
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