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8182803 |
C-terminally truncated interferon alpha variants
The present invention provides biologically active variants of human α-2b-interferon. The variants contain carboxy terminus truncations when compared with the amino acid sequence of full-length ...
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8168751 |
Interferon alpha mutant and its polyethylene glycol derivative
IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in...
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8158129 |
Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in vivo
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using...
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8147818 |
Hepatitis C virus inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
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8143214 |
Protein-polymer conjugates
Protein-polymer conjugates are described. Also described are a method for preparing a protein-polymer conjugate and its use in treating hepatitis B virus or hepatitis C virus infection.
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8137661 |
Controlled release interferon drug products and treatment of HCV infections using same
The invention relates to controlled release formulations comprising a microparticle comprising a biodegradable polymer and one or more interferon compounds and methods of using the formulations.
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8119116 |
Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production
The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising...
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8114395 |
Treatment of viral diseases with recombinant interferon α
This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor...
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8110182 |
Treatment of multiple sclerosis by administration of interferon alpha and C-phycocyanin
The present invention consists of the combination of Interferon alpha and C-Phycocyanin (IFN-α/C-Phyco) for obtaining a pharmaceutical preparation for autoimmune disease, allergy and cancer ...
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8105608 |
Method of treatment using ligand-immunogen conjugates
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic...
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8088368 |
Antiviral compounds
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and...
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8084022 |
Stabilizing alkylglycoside compositions and methods thereof
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity,...
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8075916 |
Poly(organophosphazene) hydrogels for drug delivery, preparation method thereof and use thereof
A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.
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8075877 |
Broad spectrum immune and antiviral gene modulation by oral interferon
An antiviral/immunomodulatory response in an animal is induced by oral administration to an infected animal, including humans, of a human α-interferon. Methods of conferring resistance or ...
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8075878 |
Broad spectrum immune and antiviral gene modulation by oral interferon
An antiviral/immunomodulatory response in an animal is induced by oral administration to an infected animal, including humans, of a human α-interferon. Methods of conferring resistance or ...
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8048862 |
Macrocyclic inhibitors of hepatitis C virus replication
The embodiments provide compounds of the general Formulae I, II, III, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The...
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7993639 |
Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases
In one embodiment, a therapeutic composition containing a pentavalent antimonial is provided. The pentavalent antimonial can be sodium stibogluconate, levamisole, ketoconazole, and pentamidine and...
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7993648 |
Immunostimulatory regimen comprising administering type 1 interferon and agonistic anti-CD40 antibody
A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or...
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7993638 |
Cancer treatment combining lymphodepleting agent with CTLs and cytokines
In a cancer treatment combining cell therapy with chemotherapy, autologous CD8+ T cells are obtained from a patient, activated ex vivo by contacting them with xenogenic antigen presenting cells...
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7976835 |
Methods and compositions for preventing and treating solid tumors
Compositions and methods of preventing or treating a breast cancer are disclosed. The composition and method can utilize an endothelin B agonist and a chemotherapeutic agent as active ingredients...
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7959910 |
C-terminally truncated interferon alpha variants
The present invention provides biologically active variants of human α-2b-interferon. The variants contain carboxy terminus truncations when compared with the amino acid sequence of full-length ...
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7956161 |
Interferons of rhesus and cynomolgus origin and uses thereof
Disclosed are interferons of Rhesus and Cynomolgus origin and methods of production and use thereof.
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7951770 |
Peptides, peptidomimetics and small molecule inhibitors of the Epstein-Barr virus mediated fusion and entry process
Disclosed are compositions and methods for modulating Epstein-Barr virus (EBV) infection in a patient. The compositions may include peptides or peptidomimetics that are related to gp42 and function...
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7947261 |
Conjugates formed from polymer derivatives having particular atom arrangements
Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric...
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7923004 |
4-ethynyl pyrazole derivative compounds and methods for treatment of HCV
Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a...
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7919078 |
Recombinant interferon α2 (IFNα2) mutants and methods of use thereof
The present invention provides IFNα2 mutants and active fragments, analogs, derivatives, and variants thereof, nucleotide molecules encoding same, pharmaceutical compositions containing the same, ...
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7868151 |
Recombinant human interferon-like proteins
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and...
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7867482 |
Recombinant human interferon-like proteins
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and...
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7829077 |
Treatment of hepatitis C with compositions comprising oncostatin M and interferon alpha
The invention relates to the use of at least one cytokine from the IL-6 family -gp130, preferably selected from among IL-11, the leukaemia inhibitory factor (LIF), oncostatin M (OSM),...
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7803362 |
Glycosylated interferon alpha
The invention relates to interferon-α molecules having certain O-linked oligosaccharide structures.
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7790153 |
Method of treating rheumatoid arthritis using orally administered type one interferons
The present invention provides a method of treating auto-immune diseases in an animal comprising the step of orally administering a type one interferon to said animal. Also provided is a method of...
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7772184 |
Use of a cyclosporin for the treatment of hepatitis C infection and pharmaceutical composition comprising said cyclosporin
This invention relates to the use in the treatment of HCV infection, either as single active agents or in combination with another active agent, of a cyclosporin having increased cyclophilin...
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7744867 |
PTPase inhibitors and method of using same
The various embodiments of the present invention are directed to pentavalent antimonials, purified pentavalent antimonials, and pentavalent antimonials that are comprised of an antimonial portion...
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7736674 |
Controlled release compositions for interferon based on PEGT/PBT block copolymers
The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The...
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7732572 |
Cysteine variants of alpha interferon-2
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7731949 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
4-ethynyl pyrazole derivative compounds and methods for treatment of HCV
Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a...
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7727519 |
Method for treating hepatitis C virus with omega interferon
Methods for the treatment of interferon-response disorders by administration of an interferon alone or in combination with adjunctive therapy are described. The invention encompasses providing to a...
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7695710 |
Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
Interferon-alpha (IFNα) analog proteins modified by chemical attachment of at least one hydrophilic polymer moiety, such as polyethylene glycol chain, are described for use in combination ...
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7678774 |
Treating severe acute respiratory syndrome
Severe acute respiratory syndrome is treated with a natural human alpha interferon, a dsRNA or both natural human alpha interferon and a dsRNA.
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7671017 |
Use of a combination of cyclosporine and pegylated interferon for treating hepatitis C (HCV)
A method of treating a patient having a HCV infection which method comprises administering to said patient a cyclosporin A or a cyclosporin A derivative in association with a conjugate of...
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7666403 |
Mutant interferon α protein and use thereof
The present invention has objects to provide a mutant interferon-α protein having a higher anti-viral and anti-tumor activity and to provide an agent for susceptive diseases, which contains the ...
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7662370 |
Low-toxicity, long-circulating human interferon-alpha PEGylated mutants
Interferon-alpha (IFNα) analog proteins modified by chemical attachment of at least one hydrophilic polymer moiety, such as polyethylene glycol chain, are described. In one embodiment, the IFNα a...
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7632491 |
Stable pegylated interferon formulation
The present invention relates to lyophilized formulations of pegylated interferon which are prepared using trehalose as a cryoprotectant. The formulations have a low moisture content, which helps...
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7625555 |
Recombinant human interferon-like proteins
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and...
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7619067 |
Evolved interferon-alpha polypeptides
The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these...
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7611700 |
Protease resistant modified interferon alpha polypeptides
Processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided is a rational...
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7597884 |
Hyperglycosylated polypeptide variants and methods of use
The present invention provides synthetic Type I interferon receptor polypeptide agonists comprising consensus or hybrid Type I interferon receptor polypeptide agonists, containing one or more...
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RE40882 |
Antiviral nasal drops comprising recombinant interferon a biocompatible polymer and an antioxidant
The present invention can be used in pharmacology specifically in the preparation of interferon-containing compositions, which are capable of conserving their biological activity and can be...
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7547436 |
Receptor specific transepithelial transport of therapeutics
The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke...
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7541436 |
Interferon-alpha polypeptides and conjugates
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides,...
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