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7371373 |
HSA-free formulations of interferon-β
Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β...
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7357925 |
Method for treating disorders and diseases treatable with human fibroblast interferon
PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys 17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A...
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7345149 |
Cysteine substitution variants of beta interferon
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7344709 |
Treatment of hepatitis C in the Asian population with subcutaneous interferon-beta
The present invention relates to the use of recombinant IFN-beta for the production of a medicament for the treatment of HCV infection by subcutaneous administration to patients of Asian race,...
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7258859 |
Method for the treatment of multiple sclerosis
A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to...
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7182942 |
Vaccine immunotherapy for immune suppressed patients
A method of immunotherapy to treat cancer or a synergistic anti-cancer treatment by administering an effective amount of a natural cytokine mixture (NCM), an effective amount of cyclophosphamide...
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7150882 |
Enhanced circulation effector composition and method
A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the...
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7144574 |
Interferon β variants and conjugates
The invention relates to a conjugate exhibiting interferon β (IFNB) activity and comprising at least one first non-polypeptide moiety covalently attached to an IFNB polypeptide, the amino acid...
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7067129 |
Receptor specific transepithelial transport in therapeutics
The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke...
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7052687 |
Human recombinant beta-interferon with improved solubility
The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu (5), Phe(8), Phe(15),...
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6994847 |
Stabilized interferon compositions
Stabilized pharmaceutical formulations comprising IFN-β and highly purified mannitol are provided. The highly purified mannitol stabilizes the compositions by reducing the formation of IFN-β...
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6991785 |
Method for administering a cytokine to the central nervous system and the lymphatic system
The present invention is directed to a method for delivering cytokines to the central nervous system and the lymphatic system by way of a tissue innervated by the trigeminal nerve and/or olfactory...
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6962978 |
Polymer conjugates of interferon beta-1a and uses
An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are...
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6923956 |
Liquid interferon-β formulations
The present invention relates to liquid formulations of human interferon-β. The formulations are characterized in that they have a buffer with a pH in the weakly acidic to neutral range of between...
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6908611 |
Combination therapies using vitamin B12 and interferon for treatment of viral, proliferative and inflammatory diseases
Pharmaceutical compositions for treating viral, proliferative and inflammatory diseases are disclosed comprising an amount of pharmaceutically acceptable vitamin B12 compound in combination with an...
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6872385 |
Adjuvant preparation for the induction of specific immunity
Disclosed are methods and compositions useful in the recruitment, activation and initiation of proliferation of immune cells. The instant invention relates to the discovery that specific insect...
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6869600 |
Combined treatment of multiple sclerosis
The use of growth hormone (GH) together with an interferon (IFN) to produce a pharmaceutical composition for treating multiple sclerosis and/or other demyelinating diseases is disclosed. Disclosed...
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6866782 |
Process for the purification of pharmacologically active proteins through cationic exchange chromatography
There is disclosed a process for the purification of pharmacologically active proteins based on the use of the cationic exchange chromatography on a solid matrix carried out at a more basic pH,...
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6843988 |
Synferon
The present invention relates to a novel Synferon protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a synthetic interferon...
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6800735 |
Interferon-beta fusion proteins and uses
A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety;...
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6787132 |
Combined chemo-immunotherapy with liposomal drugs and cytokines
A method of antitumor therapy is described in which administration of a chemotherapeutic drug, encapsulated in liposomes, is supplemented by administration of an immunostimulating cytokine. The...
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6752986 |
Composition and methods for affecting metallocorrinoid uptake
The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the...
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6667033 |
Therapeutic agent for chronic hepatitis B
The present invention provides an effective method for treating chronic hepatitis B. Specifically, the present invention provides a method for treating chronic hepatitis B wherein interferon (IFN)...
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6663859 |
Compositions for enhancing the immune response
D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration...
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6638500 |
Polyol-IFN-βconjugates modified at Cys-17 and composition containing same
PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys 17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A...
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6635243 |
Antiviral nasal drops comprising recombinant interferon a biocompatible polymer and an antioxidant
The present invention can be used in pharmacology specifically in the preparation of interferon-containing compositions, which are capable of conserving their biological activity and can be...
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6620411 |
Method for inhibiting brain tumor or colon carcinoma
A method for inhibiting cell growth is provided. The method includes the step of systemically administering a pharmaceutical preparation containing an interferon as an active ingredient two or more...
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6572853 |
Recombinant human beta interferon with enhanced solubility
The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu(5), Phe(8), Phe(15),...
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6569420 |
Human interferon-&egr : a type I interferon
The invention concerns a novel human interferon-ε, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-α family...
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6524233 |
Electromagnetic stimulation of cartilage tissue
The Invention relates to the use of pulsating electromagnetic signals for stimulating chondrogenesis. The invention especially relates to the use of FGF (Fibroblast Growth Factor) in combination...
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6514729 |
Recombinant interferon-beta muteins
The invention relates to novel interferon-beta activity (IbA) proteins and nucleic acids. The invention further relates to the use of the IbA proteins in the treatment of IFN-β related disorders.
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6489330 |
Use of penciclovir for the treatment of human herpes-virus-8
The present invention is directed to the use of a compound of Formula (A), or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the...
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6479049 |
Methods and compositions for the dry powder formulation of interferons
According to the present invention, methods and compositions are provided for spray-dried, interferon-based dry powder compositions, particularly interferon-beta. The compositions are useful for...
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6444200 |
Composition and method for dermal and transdermal administration of a cytokine
A composition for transdermal administration of a cytokine is described. The composition includes a conjugate composed of a cytokine, such as an interferon, and at least one fatty acid moiety...
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6433144 |
Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods
This invention relates to methods for isolating highly purified mixtures of natural Type I interferon from white blood cells. The invention also relates to highly-purified mixtures of Type I...
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6417237 |
Macromolecular drug complexes and compositions containing the same
Macromolecular drug complexes containing a drug, like human growth hormone, and a polymer having a plurality of acid moieties, like carboxyl moieties or phosphonic acid moieties, and compositions...
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6372258 |
Methods of spray-drying a drug and a hydrophobic amino acid
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible...
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6372218 |
Interferon dosage form and method therefor
Neoplastic disease, hyperallergenicity, autoimmune disorders characterized by chronic tissue degenerative inflammation and immuno-resistant viral infections are treated by the administration of...
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6372207 |
IFNAR2/IFN complex
The in vivo effect of Type I interferon (IFN) can be prolonged by administering the interferon in the form of a complex with an IFN binding chain of the human interferon α/β receptor (IFNAR)....
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6361769 |
Stimulation of host defense mechanisms against viral challenges
A method for stimulating host defense mechanisms in a mammal via administering to the mammal a therapeutically effective amount of an interferon via oromucosal contact. The amount of interferon...
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6346243 |
Inhibition of transplant rejection by type one interferon
The present invention provides a method of using a convenient, oral administered and non-toxic immunomodulating agent to suppress transplant rejection. Such agent is a type one interferon.
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6323006 |
Recombinant human beta-CIS interferon
The invention provides a new human interferon (IFN)-β variant cloned from an amniotic cell library, a cDNA encoding it, and processes for its production and purification. The variant, termed...
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6300474 |
Modified interferons
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and...
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6296844 |
Asialocytokines and treatment of liver disease
The invention features methods for treating liver disease (e.g., viral hepatitis) by administering an asialocytokine (e.g., asialointerferon). The invention also includes methods of targeting a...
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6207146 |
Gene expression in mammalian cells
Proteins such as human β-interferon or human erythropoietin are prepared by culturing mammalian cells which harbour a nucleic acid sequence comprising: (i) a coding sequence which encodes the...
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6207145 |
Therapeutic applications of high dose interferon
Interferon composition for oromucosal contact to stimulate host defense mechanisms or an immune response in a mammal with a stimulating amount of the interferon which exceeds parenterally...
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6200559 |
Use of antibodies against MxA or MxB to determine levels of type I interferons in vivo
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6174996 |
Hybrid interferon τ/type I interferon polypeptides
The invention provides fusion proteins comprising an N-terminal region derived from an interferon-tau (IFN-τ) polypeptide and a C-terminal region derived from another type I interferon...
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6156789 |
Method for treating abnormal cell proliferation in the brain
This invention relates to a method for treating abnormal cell proliferation in the brain by administering a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof:...
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6156302 |
Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes
The present invention relates to methods and compositions for enhancing immunological responses and for the prevention and treatment of infectious diseases or primary and metastatic neoplastic...
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