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4791101 |
Synergistic mixtures of interferons and tumor necrosis factor
Ternary compositions of an interferon of the alpha and/or beta type with an interferon of the gamma type and tumor necrosis factor having a surprising and unexpected synergistic anti-proliferative...
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4753795 |
Modified (80-113) beta interferons
Modified beta interferons containing amino acid substitutions in the beta interferon amino acids 80 to 113 are described. These modified beta interferons exhibit changes in the antiviral, cell...
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4751077 |
Interferons with novel cysteine pattern
Human interferons containing novel cysteine substitutions and disulfide bonds are disclosed. The amino acid sequence of a first interferon is combined with the cysteine and/or disulfide pattern of...
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4745180 |
Solubilization of proteins for pharmaceutical compositions using heparin fragments
A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is β-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without...
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4738844 |
Modified (1-28) beta interferons
Modified beta interferons containing amino acid substitutions in the beta interferon amino acids 1 to 28 are described. These modified beta interferons exhibit changes in the antiviral, cell growth...
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4738845 |
Modified (115-145) beta interferons
Modified beta interferons containing amino acid substitutions in the beta interferon amino acids 115 to 145 are described. These modified beta interferons exhibit changes in the antiviral, cell...
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4734279 |
Combination of immunoglobulins with therapeutic agents
A compositon for treating diseases which comprises a therapeutically effective amount of an antibacterial, antiviral, or antimycotic agent, antitrypsin, antithrombin, interferon, or lysozyme, and...
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4675183 |
Method for solubilization of interferon
A method for increasing the solubility of interferon in water involves admixing an amino acid selected from the group consisting of arginine, histidine, lysine, hydroxylysine, ornithine, glutamine,...
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4647454 |
Stable interferon β composition and a method of stabilizing interferon β
This disclosure relates to a method of stabilizing Human Fibroblast Interferon (HFIF) known as "Interferon β" with polyvinyl pyrrolidone and to transportable and storable vials containing such...
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4588585 |
Human recombinant cysteine depleted interferon-β muteins
Muteins of biologically active proteins such as IFN-β and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to...
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4572798 |
Method for promoting disulfide bond formation in recombinant proteins
Reduced cysteine-containing proteins consisting of recombinant IFN-β, IL-2 or muteins thereof may be oxidized selectively so that the recombinant proteins have essentially the same disulfide...
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H000022 |
Synergistic effect of chemotherapeutic agents on beta-interferon
A composition of matter exhibiting a synergistic cytotoxic effect in combination therapy of certain breast cancer and myeloma cell lines is prepared by combining synergistically effective amounts...
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4541952 |
Purification method of human interferon
A method for the purification of human interferon by the successive treatments of a crude interferon solution with an immobilized carrier which is coupled with a blue dye and a chelating carrier...
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4530787 |
Controlled oxidation of microbially produced cysteine-containing proteins
Method of oxidizing reduced cysteine-containing microbially produced synthetic proteins, such as synthetic IFN-β or synthetic IL-2, in a controlled manner so that the synthetic proteins have the...
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4503035 |
Protein purification process and product
An improved process for purifying proteins, particularly proteins having molecular weights in excess of 12,000 involves novel applications of high performance liquid chromatography on a preparative...
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4497795 |
Method of regulating appetite and efficiency of food utilization employing interferon
The appetite of a warm-blooded vertebrate can be regulated by administering to the vertebrate a biological active fraction of interferon in an amount effective to modulate the vertebrate's food...
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4480032 |
Natural mixture of Type I and Type II interferons
Pharmaceutical compositions comprising a natural mixture of Type I and Type II interferons which are produced by induction with measles vaccine virus in leukocyte cells obtained from human donors...
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4462985 |
Delivery of biologically active components of heterologous species interferon isolates
Interferon glycoprotein isolates of heterologous species origin are subjected to treatment in a digestive environment and non-species-specific biologically active fractions thereof are...
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4462940 |
Process for the recovery of human β-interferon-like polypeptides
An improved process for recovering and purifying β-HIFN from transformed bacterial comprising concentrating the bacteria; disrupting the cell wall and solubilizing the β-HIFN into an aqueous...
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4460574 |
Prophylaxis or treatment of interferon-sensitive diseases
Prophylaxis or treatment of interferon-sensitive diseases in a human is effected by the rectal or urogenital administration to a human of a liquid pharmaceutical composition of native human...
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4454115 |
Method of reducing the level of low density lipoproteins in the serum of a patient
A method is described for reducing the level of low density lipoproteins in the serum of a patient by administering to the patient human fibroblast interferon.
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4438030 |
Antibodies to immunogenic peptides and their use to purify human fibroblast interferon
Antibodies to the twenty-one acid peptide: (X-Ser-Tyr-Asn-Leu-Leu-Gly-Phe-Leu-Gln-Arg-Ser-Ser-Asn-Phe-G
ln-Y-Gln-Lys-L eu-Leu) n , where X is Met or Ser, Y is His or Cys and n is 1 to 12;...
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4420398 |
Filteration method for cell produced antiviral substances
This invention affords a filtration method and apparatus for extracting cell produced antiviral substances (CPAS) from a production broth using cross-flow membrane filtration. The broth is perfused...
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4364863 |
Extraction of interferon from bacteria
A method of extracting leucocyte interferon from interferon-expressing bacterial cells comprising acidifying a suspension of interferon-containing bacterial cells, removing substantially all of the...
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4359389 |
Method for the purification of interferon
Human fibroblast interferon may be purified to a high degree by using a simple two-step purification method comprising (a) subjecting an aqueous interferon solution to chromatography on porous...
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4357422 |
Method of enhancing interferon production
A method for enhancing the production of interferon from normal human diploid fibroblast cells is disclosed. In this method, a distinct interferon-production phase is established in which the...
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4311639 |
Immunogenic interferon peptides
The twenty-one amino acid peptides, (X-Ser-Tyr-Asn-Leu-Leu-Gly-Phe-Leu-Gln-Arg-Ser-Ser-Asn-Phe-G
ln-Y-Gln-Lys-L eu-Leu) n , where X is Met or Ser, Y is His or Cys and n is 1 to 12, useful for...
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4285929 |
Type II interferon and agents thereof
The present invention relates to processes which are easily applicable for industrial production of Type II interferon and Type II interferon-containing agents. Particularly, the present processes...
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4278661 |
Purification of interferon
Human interferons produced in the absence of added serum or sera can be purified to greater than 95% protein purity by adsorption on immobilized Cibacron Blue F3G-A and eluting the interferon...
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4266024 |
Process for the production of human interferon
This invention is directed to a process of producing interferon which comprises incubating permanent cell lines of lymphoblast origin or human fibroblast cells with interferon inducers and...
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4257938 |
Purification method of human fibroblast interferon
A method for the purification of human fibroblast interferon by the successive treatments of a crude interferon solution with a strongly acidic ion exchanger and a chelating carrier which contains...
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4252791 |
Interferon stabilization
The loss of biological activity of interferons is prevented or reduced by the addition of soluble lanthanide or calcium salts.
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4241174 |
Interferon assay
A rapid cytopathic effect inhibition assay for interferon is disclosed. The assay can be completed in about 16 hours or less, allowing its use to assist in clinical diagnosis of viral infections...
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3548053 |
INTERFERON PRODUCTION
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3256152 |
Concentration and purification of interferons, viral inhibiting substances (vis), viral inhibiting factors (vif), or viral inhibitory material
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3660564 |
Title is not available
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3773924 |
Title is not available
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