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7354575 |
Method and pharmaceutical composition for treating inflammation
A method of treating an inflammation in a subject in need thereof is disclosed. The method comprises locally or systemically administering to the subject IFN-gamma in an amount so as to achieve an...
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7338654 |
Glycosylated interferon alpha obtained from a transgenic chicken
This invention includes compositions comprising glycosylated human interferon-α derived from a chicken.
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7232562 |
E38N interferon gamma polypeptide variants
A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence...
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7230081 |
Interferon gamma conjugates
A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence...
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7229614 |
Interferon gamma in the detection and treatment of angiomyolipomas
The present invention is directed to methods of treating or preventing angiomyolipomas by administering interferon gamma. It also encompasses methods for assessing the risk of a patient developing...
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7153499 |
Vaccine immunotherapy for immune suppressed patients
The present invention provides a formulation for inhibiting metastasis which includes 150–600 units of IL-2, a nonsteroidal anti-inflammatory drug (NSAID), and cyclophosphamide. The present...
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7138115 |
Use of IL-12 and IL-12 antagonists in the treatment of autoimmune diseases
Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one...
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7115263 |
Compositions and methods for treating hyperimmune response in the eye
The present invention comprises and utilizes methods and compositions for treating hyperimmune reactions in the eye. Compositions comprising antibodies to gamma interferon alone and in combination...
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7084257 |
Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
Selective binding agents of interferon-gamma (IFNγ) are provided by the invention. More particularly, the invention provides for antibodies and antigen binding domains which selectively bind to...
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7067129 |
Receptor specific transepithelial transport in therapeutics
The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke...
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7038015 |
Interferon gamma polypeptide variants
The present invention relates to novel interferon gamma polypeptide variants having interferon gamma (IFNG) activity, methods for their preparation, pharmaceutical compositions comprising the...
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7033594 |
Method of treatment using ligand-immunogen conjugates
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic...
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6991785 |
Method for administering a cytokine to the central nervous system and the lymphatic system
The present invention is directed to a method for delivering cytokines to the central nervous system and the lymphatic system by way of a tissue innervated by the trigeminal nerve and/or olfactory...
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6989364 |
Methods for treating cardiac hypertrophy by administering IFN-γ
The invention concerns the treatment of cardiac hypertrophy by interferon-gamma (IFN-γ). Cardiac hypertrophy may result from a variety of diverse pathologic conditions, including myocardial...
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6964761 |
Method of treating idiopathic pulmonary fibrosis with aerosolized IFN-γ
A method of treating idiophathic pulmonary fibrosis (IPF), comprising administering aerosolized interferon-γ in a therapeutically effective amount to achieve improved or ameliorated symptoms of IPF.
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6958388 |
Interferon gamma polypeptide variants
When interferon gamma (IFNG) is produced in mammalian cell lines a heterogenous population of IFNG polypeptides is obtained due to C-terminal processing of the IFNG polypeptide. Clearly, this...
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6956027 |
N-terminally chemically modified protein compositions and methods
Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and...
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6896879 |
Method of pre-sensitizing cancer prior to treatment with radiation and/or chemotherapy and a novel cytokine mixture
This invention relates to a breakthrough method for pre-sensitizing cancer prior to a therapeutic treatment such as chemotherapy, radiation therapy or immuno-therapy and a novel cytokine mixture...
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6866782 |
Process for the purification of pharmacologically active proteins through cationic exchange chromatography
There is disclosed a process for the purification of pharmacologically active proteins based on the use of the cationic exchange chromatography on a solid matrix carried out at a more basic pH,...
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6846486 |
Method of treating allergy by administering an anti-histamine antibody
The present invention relates to allergy vaccines and methods of treating and/or preventing asthma, and allergic conditions. The invention is based on the discovery that inhibiting the...
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6787634 |
Isolated peptide or polypeptide of the extracellular portion of the human interferon receptor (IFN-R).
A monoclonal antibody is provided which is directed against the human interferon type I receptor (IFN-R), which recognizes the extracellular domain of the human IFN-R and which has neutralizing...
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6719977 |
Methods to potentiate cancer therapies
Disclosed are methods for potentiating the anti-cancer properties of an anti-cancer therapy in a mammal by administering with the therapy a compound (such as relaxin or γ-IFN) that has a tissue...
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6710025 |
Treatment of damaged tissue using agents that modulate the activity of alpha-smooth muscle actin
The present invention is directed to therapeutic methods that are based upon an ability to modulate cellular contraction. This is accomplished by administering agents that either inhibit or induce...
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6683052 |
Lipopeptides containing an interferon-&ggr fragment, and uses thereof in pharmaceutical compositions
The invention concerns any lipopeptide characterized in that it comprises: a peptide part comprising the peptide sequence consisting of about 30 to about 50 of the last contiguous amino acids of...
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6663859 |
Compositions for enhancing the immune response
D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration...
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6635243 |
Antiviral nasal drops comprising recombinant interferon a biocompatible polymer and an antioxidant
The present invention can be used in pharmacology specifically in the preparation of interferon-containing compositions, which are capable of conserving their biological activity and can be...
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6497876 |
Method of stimulating an immune response with activated dendritic cells
Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols....
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6497871 |
Recombiniant gamma interferons having enhanced stability and methods therefor
The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties...
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6489330 |
Use of penciclovir for the treatment of human herpes-virus-8
The present invention is directed to the use of a compound of Formula (A), or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the...
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6455051 |
Ameliorant for hepatitis C therapeutic effect and application thereof
The present invention provides an ameliorant for enhancing the therapeutic effect of IFN-α on hepatitis C; a therapeutic composition for the treatment of hepatitis C which comprises IFN-α and...
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6444200 |
Composition and method for dermal and transdermal administration of a cytokine
A composition for transdermal administration of a cytokine is described. The composition includes a conjugate composed of a cytokine, such as an interferon, and at least one fatty acid moiety...
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6417237 |
Macromolecular drug complexes and compositions containing the same
Macromolecular drug complexes containing a drug, like human growth hormone, and a polymer having a plurality of acid moieties, like carboxyl moieties or phosphonic acid moieties, and compositions...
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6391296 |
Method of stabilizing useful protein and useful protein compositions
A method of stabilizing a useful protein by mixing a useful protein and an aqueous solution of a compound having the basic structure of arabic acid, and a stabilizied useful protein compositon...
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6372218 |
Interferon dosage form and method therefor
Neoplastic disease, hyperallergenicity, autoimmune disorders characterized by chronic tissue degenerative inflammation and immuno-resistant viral infections are treated by the administration of...
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6361769 |
Stimulation of host defense mechanisms against viral challenges
A method for stimulating host defense mechanisms in a mammal via administering to the mammal a therapeutically effective amount of an interferon via oromucosal contact. The amount of interferon...
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6300474 |
Modified interferons
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and...
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6299871 |
Orally-administrable therapeutic and/or prophylactic agent for HTLV-1-related diseases
Disclosed are an orally-administrable therapeutic and/or prophylactic agent for HTLV-1-related diseases, which comprises an interferon-γ as an effective ingredient and a...
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6270756 |
Weight loss induced by alpha interferon and gamma interferon
The invention is based on the discovery that substances which release ZAG proteins from lymphocytes also cause accelerated weight loss in humans. By administering an amount of the substance which...
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6207145 |
Therapeutic applications of high dose interferon
Interferon composition for oromucosal contact to stimulate host defense mechanisms or an immune response in a mammal with a stimulating amount of the interferon which exceeds parenterally...
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6203822 |
Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection
This invention relates to the use of gallium-containing compounds, to inhibit intracellular pathogens including pathogens that are members of the genus Mycobacteria, Legionella, Histoplasma, and...
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6200559 |
Use of antibodies against MxA or MxB to determine levels of type I interferons in vivo
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6197292 |
Therapeutic agent and treatment for canine intractable dermatitis
The present invention relates to a therapeutic agent, composed of canine interferon-γ, for canine intractable dermatitis and a treatment for canine intractable dermatitis using the agent.
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6187304 |
Effects of IFN-γ on cardiac hypertrophy
The invention concerns the treatment of cardiac hypertrophy by interferon-gamma (IFN-γ). Cardiac hypertrophy may result from a variety of diverse pathologic conditions, including myocardial...
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6162904 |
Manufacturing method for intraveneously administrable immune globulin and resultant product
A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by heat treating for viral inactivation and fractionating an impure gamma...
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6156789 |
Method for treating abnormal cell proliferation in the brain
This invention relates to a method for treating abnormal cell proliferation in the brain by administering a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof:...
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6156302 |
Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes
The present invention relates to methods and compositions for enhancing immunological responses and for the prevention and treatment of infectious diseases or primary and metastatic neoplastic...
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6143292 |
Allogeneic cell therapy for cancer following allogeneic stem cell transplantation
A method of treating a human cancer patient having a solid tumor comprising malignant cells is disclosed, wherein the patient having undergone a cancer therapy regimen comprising allogeneic stem...
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6124437 |
Immunoglobulin preparation and preparation process thereof
An immunoglobulin preparation comprising an immunoglobulin, wherein the preparation contains, as a contaminant, serum albumin in an amount not greater than 10 μg per 50 mg of immunoglobulin;...
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6120762 |
C-terminal peptides of interferon γ
The subject invention concerns novel peptides of gamma interferon (IFNγ) and methods of use of these peptides. Specifically exemplified are peptides from the C-terminus of IFNγ. The subject...
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6110955 |
Metabolically stabilized oxyalkylene esters and uses thereof
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
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