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4605555 |
Composition and method for treating keratosic disorder of skin and mucosa
A pharmaceutical composition for treating keratosic disorders of skin and mucosa, particularly, lichen planus and leukoplakia, by topical or local administration which comprises an effective amount...
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4530787 |
Controlled oxidation of microbially produced cysteine-containing proteins
Method of oxidizing reduced cysteine-containing microbially produced synthetic proteins, such as synthetic IFN-β or synthetic IL-2, in a controlled manner so that the synthetic proteins have the...
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4518526 |
Purification and activity assurance of precipitated heterologous proteins
A process for isolating and purifying a precipitated heterologous protein from a host cell culture, including treating the host cell culture with a buffered solution of ionic strength suitable to...
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4484923 |
Method for administering immunopotentiator
The invention pertains to the administration of an immunopotentiator to activate an immune response. The administration comprises the controlled and continuous administration of the...
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4474753 |
Topical drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a...
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4474751 |
Ophthalmic drug delivery system utilizing thermosetting gels
This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains...
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4465622 |
Method for purifying interferon
A method for purifying interferon having anti-cancer effects or anti-viral effects, wherein highly purified interferon can be easily obtained by a single operation in a recovery of about 100%. In...
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4426323 |
Selected recovery of proteins from fermentation broths
A process is described for the selective recovery and/or concentration of a protein or a class of proteins from fermentation broth employing a combination of desalting and pH adjustment thereby...
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4414147 |
Methods of decreasing the hydrophobicity of fibroblast and other interferons
A method for improving the stability and usefulness of interferon, including human fibroblast interferon, is disclosed. In this method, interferon is bonded to a non-hydrophobic substance to create...
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4414204 |
Antibiotic preparations having increased effectiveness, processes for their manufacture and method for increasing the antibiotic action of antibiotics
The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for...
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4394372 |
Process for making lipid membrane structures
A process for producing lipid membrane structures (vesicles or liposomes) is disclosed, wherein a solution of bilayer forming compounds in a narrowly-defined two component solvent system is...
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4377567 |
Lipid membrane drug delivery
Lipid Membrane Structures comprising Digalactosyl Diglyceride target the liver of humans and lower animals and are used to carry drugs to that organ, preferentially. Digalactosyl Diglyceride LMS...
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4343735 |
Process for the purification of interferon
The invention concerns a process for the purification of interferon, where interferon is purified by partitioning interferon in an aqueous multi-phase system in the presence of ion exchangers that...
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4309415 |
Method and composition for treating inflammatory disorders
Compositions and use of γ-linolenic acid and related materials with (i) zinc, β-lactam antibiotics or other materials enhancing physiological 1-series PG synthesis and/or (ii) colchicine, Vinca...
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4262090 |
Interferon production
Method for preparing interferon, mRNA for interferon, and competent recombinant DNA containing dsDNA and cDNA from mRNA coding for mammalian interferon. The method employs crossing a mutant...
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4198479 |
Replacement of animal serum proteins by human albumin for growth and interferon production by Namalva cells
The invention provides an improved process for the growth of lymphoblastoid cells in a medium supplemented with human albumin. The invention further provides for the production of interferon by...
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4172071 |
Chromophore blue adsorbent method for the purification of preparations having an interferon type activity
The invention relates to a process for the purification of preparations having an interferon type-activity which comprises contacting the crude preparations with an adsorbent comprising as ligand a...
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4100150 |
Stabilization of interferon against mechanical stress using thioctic acid
The present invention encompasses a method for stabilizing interferon during purification, concentration, packaging, filtering and storage comprising treating an interferon preparation with an...
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4061538 |
Enzymatically oxidizing interferon
The invention provides structurally modified interferons, processes for producing such and a method of purification of interferons and structurally modified interferons. The modified interferons...
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4041152 |
Pharmaceutical formulation of interferon insolubilized by fixation on a support
A pharmaceutical product consists of interferon which has been rendered insoluble by being coupled to a support, such as sepharose.
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4017600 |
Reactivation of interferon
An aqueous interferon solution wherein the interferon has lost at least part of its initial activity is reactivated by treatment with a combination of (a) an agent for disrupting non-covalent...
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3981991 |
Stabilization of interferon
An aqueous interferon solution is stabilized by treatment with a combination of (a) an agent for disrupting non-covalent bonds, (b) an agent for reducing disulfide bridges, and (c) an anionic or...
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3970749 |
Interferon production
Animal tissue is trypsinized to form a cell suspension which is placed in a nutrient medium with a virus. Produced interferon is centrifugally separated, acidified and stored at a low temperature...
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3859433 |
ANTIVIRAL TREATMENT
Certain water-soluble copolymers prepared from divinyl ether and maleic anhydride have been found to suppress virus growth. Administration of said copolymers not only suppresses growth in infected...
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3699222 |
PRODUCTION OF VIRAL INTERFERING SUBSTANCES
1. Interferon.
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3414651 |
Purification of interferon-containing material
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3265581 |
Process of purifying interferon with alumino-silicate adsorbents
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3144390 |
Process for the purification of interferon
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