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Document Title |
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7390481 |
Mammalian cytokine complexes
Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using...
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7384641 |
Immuno-modulating effects of chemokines in DNA vaccination
The present invention relates to a composition and method for enhancing the efficacy of a vaccine in a subject treated with the vaccine by administering to the subject an antigen in conjunction...
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RE40374 |
Canine IL-13 immunoregulatory proteins and uses thereof
The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon...
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7378387 |
Method of suppressing immune response by reducing intracellular content of glutathione in macrophages and monocytes
A method of suppressing immune responses, comprising administering to a patient in need thereof an effective amount of a composition comprising a substance capable of reducing the content of...
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7371373 |
HSA-free formulations of interferon-β
Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β...
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7368425 |
Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
The present disclosure teaches analogs of human chemokines and methods of using them in the prevention, treatment, and ameliorization of diseases that can benefit from therapeutic angiogenesis. The...
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7365054 |
Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies
The invention provides methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to...
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7361330 |
Methods of using flt3-ligand in the treatment of fibrosarcoma
Methods of treating a fibrosacroma using flt-3 ligand are disclosed, as well as methods of increasing the number of dendritic cells in a patient having a fibrosarcoma.
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7361329 |
Compositions for inducing an immune response
This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune...
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7347995 |
Compositions and methods for achieving immune suppression
Disclosed herein are therapeutic compositions containing agents that modulate the immune response in a patient.
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7345154 |
Cysteine variants of erythropoietin
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7344716 |
Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
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7344709 |
Treatment of hepatitis C in the Asian population with subcutaneous interferon-beta
The present invention relates to the use of recombinant IFN-beta for the production of a medicament for the treatment of HCV infection by subcutaneous administration to patients of Asian race,...
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7344699 |
Drug conjugate comprising an erythropoietin receptor ligand and an anticancer agent
A drug conjugate comprising a targeting agent and an anti-cancer agent, wherein said targeting agent comprises an erythropoietin receptor ligand, is described. The drug conjugate can be used in...
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7338653 |
Amino-terminally truncated MCP-2 as chemokine antagonists
The present invention relates to amino-terminally truncated MCP-2, lacking NH 2 -terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3, 1-4 or 1-5 of the naturally-occurring MCP-2...
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7335365 |
HIV-encoded chemoattractant
The combination of HIV proteins Tat and Nef is chemotactic for CD4+ cells. Utilizing the capacity of Tat and Nef to modulate CD4+ cell trafficking and infiltration, the invention provides various...
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7335350 |
Chemokines mutants having improved oral bioavailability
The oral efficacy of C—C chemokines containing a dibasic site in the 40's conserved cationic sequence, such as RANTES and MIP-1β, is improved by substituting at least one of the residues in the...
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7326775 |
Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
A method of preparing an ultra-cleansed lactoferrin preparation, termed treatment for contaminant reduction (TCR) is provided which includes the steps of treating commercial lactoferrin preparation...
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7326411 |
Use of amino-terminally truncated RANTES to inhibit HIV viral replication
The present invention relates to amino-terminally truncated RANTES, lacking NH 2 -terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3 or 1-4 of the naturally-occurring RANTES (SEQ...
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7323443 |
Lactoferrin in the reduction of pain
The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone...
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7323164 |
Use of interleukin-24 to treat ovarian cancer
The present invention relates to the anti-cancer activity of IL-24 polypeptide molecules. IL-24 is a cytokine involved in inflammatory processes and human disease. The present invention includes...
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7309483 |
Method of treatment using Tie2 ligand2
The invention provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or...
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7306791 |
Agent for preventing and/or treating multiple organ failure
The present invention provides methods of preventing and/or treating multiple organ failure comprising the step of administering a therapeutically effective amount of agent comprising tumor...
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7294331 |
Methods of using flt3-ligand in hematopoietic cell transplantation
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is...
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7285622 |
Releasable linkage and compositions containing same
A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.
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7282567 |
Monoclonal antibody hPAM4
This invention relates to monovalent and multivalent, monospecific antibodies and to multivalent, multispecific antibodies. One embodiment of these antibodies has one or more identical binding...
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7282483 |
Method of ameliorating the harmful effects of TNF using a polypeptide having the ability to bind to TNF
The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for...
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7279289 |
Method of evaluating myelosuppressive state
The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By...
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7279155 |
Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof,...
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7276344 |
Methods for using the osteoclastogenesis inhibitory factor (OCIF) protein
A protein which inhibits osteoclast differentiation and/or maturation and a method of production of the protein. The protein is produced by human embryonic lung fibroblasts and has molecular weight...
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7276248 |
Conjugate having a cleavable linkage for use in a liposome
Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by...
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7268112 |
Use of insulin for the treatment of cartilaginous disorders
The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or cartilaginous disorders, including arthritis, comprising the...
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7261882 |
Methods for treating neuropathic pain by administering IL-10 polypeptides
Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous...
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7261881 |
Modulation of angiogenesis and wound healing
Methods of regulating angiogenesis, ischemic injury and/or wound healing by modulating the activity of leptin, particularly as mediated by the leptin receptor, and/or the interaction between leptin...
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7255854 |
Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases
Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signaling and are useful for altering immunological diseases, and particularly...
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7253267 |
Cysteine variants of interleukin-11
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7250161 |
Equine GM-CSF
Disclosed and/or claimed is subject matter including: equine GM-CSF, its amino acid sequence, nucleic acid molecules encoding equine GM-CSF, use of equine GM-CSF as an adjuvant or non-specific...
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7247310 |
Tumor vaccines
A tumor vaccine which comprises a microparticle or a lysate prepared from a solidified tumor material selected from the group consisting of a tumor tissue, a tumor cell, and a component thereof,...
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7241438 |
AK155 polypeptides
Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using...
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7238786 |
Monoclonal antibody cPAM4
This invention relates to monovalent and multivalent, monospecific antibodies and to monovalent and multivalent, multispecific antibodies. One embodiment of these antibodies has one or more...
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7238776 |
TNF binding proteins
The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for...
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7232888 |
Antibodies against tumor surface antigens
The present invention relates to improved antibodies against tumor surface antigens and their use in the treatment of tumors. Of particular interest are highly stable, humanized, high affinity...
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7232885 |
Termini cysteine-added variants of granulocyte colony stimulating factor
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7232801 |
IL-16 antagonists
In accordance with the present invention, novel IL-16 antagonists, preferably peptides derived from CD4, have been isolated and synthesized. These peptides possess IL-16 antagonistic properties...
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7220407 |
G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
The present invention relates to methods of using Granulocyte Colony Stimulating Factor (G-CSF) polypeptide in conjunction with reperfusion therapy in the treatment of acute myocardial infarction...
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7214658 |
Method of delivering a TNF antagonist to the brain of a human by perispinal administration without direct intrathecal injection
The present invention provides specific methods of using and administering etanercept to improve cognitive function in a human, for both the treatment and prevention of cognitive impairment, or,...
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RE39614 |
Canine IL-4 immunoregulatory proteins and uses thereof
The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon...
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7211432 |
Recombinant vector expressing multiple costimulatory molecules and uses thereof
The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more...
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7211246 |
Compositions comprising oestrone-3-0-sulphamate and trail (TNF-related apoptosis inducing ligand)
The present invention provides a composition comprising (i) a compound comprising a sulphamate group (“a sulphamate compound”); and (ii) an apoptosis inducer.
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7208473 |
Nucleic acids and protein variants of hG-CSF with granulopoietic activity
The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
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