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9017655 Bispecific EGFR/IGFIR binding molecules  
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The...
9017656 Small cationic antimicrobial peptides  
The present invention relates generally to peptides and more specifically to antimicrobial and immunomodulatory host defense peptides.
9017654 Preparation for vaccination, vaccination method and use of a vaccination preparation  
The present invention relates to a pharmaceutical preparation, comprising at least one Toll-like receptor ligand and at least one peptide. The invention also relates to the use of such a...
8993519 Method of treatment for neutropenia using stable formulations of recombinant human albumin-human granulocyte colony stimulating factor  
Described herein are compositions and methods for treating, preventing and ameliorating diseases and conditions characterized by a lower than normal white blood cell count, such as leukopenia and...
8980265 Site-specific antibody-mediated activation of proapoptotic cytokines: AMAIZEe (antibody-mediated apoptosis inducing cytokines)  
Subject matter of the invention are antibody-cytokine fusion proteins having proapoptotic and immune modulating properties, but wherein the cytokine moiety a priori has a bioactivity which is very...
8968716 In situ-forming hydrogel for tissue adhesives and biomedical use thereof  
Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over...
8951529 Methods of using small compounds to enhance myeloid derived suppressor cell function for treating autoimmune diseases  
Methods for enhancing the suppressive function of myeloid derived suppressor cells (MDSCs) for the treatment of autoimmune diseases using small compounds are disclosed. In certain aspects, the...
8940288 Method for treating cancer by administering IL-15 and IL-15Ralpha complexes  
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention...
8932806 Method for identifying t-cell stimulating protein fragments  
The invention relates to a method for identifying T-cell stimulating protein fragments using the following steps: a) detecting the amino acid sequence of an antigen; b) subdividing the found amino...
8926956 Antibody recognizing human leukemia inhibitory factor (LIF)  
The invention relates to antibodies directed against human Leukemia Inhibitory Factor (LIF) and to a hybridoma cell line producing said antibodies. The invention also relates to a method for...
8921519 Single chain fusion polypeptides comprising soluble light cytokine domains  
The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion...
8916616 Multi-functional polymeric materials and their uses  
Multifunctional polymers are disclosed having a smart segment and a biodegradable segment. Advantageously, the biodegradable segment includes a hydrophilic segment and a hydrophobic segment....
8900565 Indole derivatives as inhibitors of histone deacetylase  
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using...
8900564 Vaccine composition comprising an antigen and a peptide having adjuvant properties  
The invention relates to a vaccine which comprises at least one antigen and a peptide comprising a sequence R1—XZXZNXZX—R2, whereby N is a whole number between 3 and 7, preferably 5, X is a...
8895700 Monkey homolog of human interferon omega  
Cytokine IFNω nucleic acids from the Cynomolgus monkey are useful for expression of IFNω proteins that are functional homologs of human IFNω. The nucleic acids and proteins produced therefrom are...
8889630 Method for hair regrowth using Granulocyte-Colony Stimulating Factor  
The present invention provides a method for re-growing hair in patients with androgenic alopecia by administering effective consecutive courses of Granulocyte-Colony Stimulating Factor or...
8889117 Modular nanoparticles for adaptable vaccines  
Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric...
8883982 Compositions and methods for increasing serum half-life  
Provided herein are glycovariant Fc fusion proteins having increased serum half lives. Also provided are methods for increasing the serum half life of an Fc fusion protein by introducing one or...
8859497 Method of treatment using cysteine mutants of beta interferon  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
8858927 Method for protection of peptides or proteins against non-enzymatic deamidation  
Stabilization of water-containing solutions or lyophilizates of proteins and peptides against non-enzymatic deamidation degradation reactions at asparaginyl or glutaminyl residues is achieved...
8840877 Polysaccharide-protein conjugates reversibly coupled via imine bonds  
Method for preparing an oxidized polysaccharide-protein composition, by (a) oxidizing a polysaccharide with an oxidizing agent to form an oxidized polysaccharide where less than 20% of the...
8828375 Expansion of haemopoietic precursors  
The present invention relates to a method of transplanting haematopoietic precursor cells into a subject in need thereof which involves culturing the haematopoietic precursor cells in the presence...
8815277 In situ forming hydrogel and biomedical use thereof  
Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by...
8795674 Methods and compositions for modulating immune tolerance  
The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for increasing T cell mediated immune...
8784794 Long-term storage of non-glycosylated recombinant human G-CSF  
The present invention provides a method for stable long-term storage of non-glycosylated recombinant human Granulocyte-Colony Stimulating Factor (“G-CSF”), wherein an aqueous acetate or glutamate...
8784795 Methods for determining personalized treatment compositions for prostate cancer and breast cancer  
The present disclosure provides methods for selecting a treatment composition, or therapy, for the treatment of a cancer, such as prostate or breast cancer, in a patient wherein the treatment...
8771701 Compositions for immunotherapy and uses thereof  
The present invention relates to a method of eliciting a cytotoxic T lymphocyte response to an antigen in an animal, the method comprising pulsing mannose receptor-bearing antigen presenting cells...
8771663 Formulation having mobilising activity  
The present innovation relates to a novel formulation capable of increasing the amount of stem cells and progenitor cells in circulation in the peripheral blood of a mammal; the formulation is...
8765914 Interleukin-B30 proteins  
Purified genes encoding a cytokine referred to as interleukin-B30 (IL-B30) from a mammal, and reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding...
8747904 Polymeric micelles for polynucleotide encapsulation  
The present invention provides micelles having a polynucleotide encapsulated therein, the micelle comprising copolymers comprising hydrophobic moieties in a cationic complexing block. The...
8747833 B7-H1 and methods of diagnosis, prognosis, and treatment of cancer  
The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere...
8734774 Protease activated cytokines  
Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with...
8734777 Heterocyclic antiviral compounds  
Compounds having the formula (I) wherein R1, R2, R3 and X are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV...
8735358 Methods for treating cancer by regulation of tumor necrosis factor-alpha  
The present invention relates to compositions and methods relating to an interleukin18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In...
8729236 Selection and characterization of novel plant-derived recombinant human interferons with broad spectrum activity  
Methods to derive novel hybrid type 1 interferons that are broadly active against highly pathogenic viruses of biodefense significance are described. Libraries of hybrid interferon genes were...
8728523 Transdiscal administration of specific inhibitors of pro-inflammatory cytokines  
The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
8728456 Programming of cells for tolerogenic therapies  
Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation....
8722618 IL4/IL13 binding repeat proteins and uses  
IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1...
8716222 Methods and compositions for promoting organ development  
Compositions and methods are provided for promoting organ development in warm blooded animals, and in particular in certain aspects a premature infant or fetus. Compositions and methods are also...
8697107 Flowable implant with crosslinkable surface membrane  
A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable...
8652457 Interleukin-10 peptides and antibodies thereof for inhibiting adverse effects of protozoan infection  
The present disclosure is directed to interleukin-10 (IL-10) peptides and isolated antibodies that specifically bind to the IL-10 peptides. The IL-10 peptides and the isolated antibodies may be...
8636996 Crystalline polymorphic forms of monosodium N-[-8-(2-hydroxybenzoyl)amino]caprylate  
The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate (“SNAC”), including two hydrates, a methanol solvate, and an ethanol solvate, of...
8636995 Methods and devices to regulate stem cell homing  
A device for altering the expression or activation of adhesion molecules on cells including endothelial cells, as well as methods for altering the expression or activation of adhesion molecules on...
8633277 Methods for forming polymer-drug conjugates  
Methods for preparing polymer-drug conjugates are provided. The disclosed methods involve polymeric reagents comprising a moiety of atoms arranged in a specific order, wherein the moiety is...
8629098 Compositions and methods for adoptive and active immunotherapy  
Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents...
8629104 G-CSF and water-soluble polymer conjugate  
Provided are a G-CSF and water-soluble polymer conjugate, or a pharmaceutically acceptable salt thereof, comprising a water-soluble polymer, a protein, and a linking group; a method for preparing...
8629117 Method for stimulating the immune system  
Medicament comprising a combination of at least one inhibitor of the effect of a substance negatively effecting an immune response, the substance selected from the group consisting of TGF-β and...
8623335 Scar and rosacea and other skin care treatment composition and method  
The present invention relates generally to composition and methods for topical application to skin. More particularly, it relates to treatment of scars and rosacea, and other aspects of skin care....
8609607 Modified defensins and their use  
This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or...
8603455 Removal promoters and inhibitor for apoptosis cells in vivo  
The present invention is to provide a removal promoter for apoptotic cells which is capable of immediately removing apoptotic cells in vivo by macrophages, or a removal inhibitor which inhibits...