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8105391 |
Merhods of treatment with devices having a coating containing pegylated hyaluronic acid and a pegylated non-hyaluronic acid polymer
Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid...
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8106146 |
Therapeutic polymers and methods of generation
The invention describes poly(ortho ester) polymers that include at least one therapeutic compound in the polymer backbone. The therapeutic compound includes at least one phenol residue and an...
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8097274 |
Skin substitutes, preparation methods and uses thereof
Provided herein are skin substitutes suitable for use in a living subject for purpose of repairing damaged tissues, methods of producing the skin substitutes and their uses. A biocomposite membrane...
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8067505 |
Method of preparing carboxylic acid functionalized polymers
Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as...
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8003089 |
Y shape branched hydrophilic polymer derivatives, their preparation methods, conjugates of the derivatives and drug molecules, and pharmaceutical compositions comprising the conjugates
The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules,...
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7964182 |
Pharmaceutical compositions comprising phosphate-binding polymer
The present invention discloses pharmaceutical composition comprising phosphate binding polymers such as Sevelamer carbonate substantially free of monovalent anion other than bicarbonate anion....
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7943141 |
Activated polyoxazolines and compositions comprising the same
The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a...
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7919562 |
Preparation of supramolecular polymers containing sequence-selective hydrogen bonding subunits in their backbone which form double helices
The present invention relates to supramolecular polymers containing sequence-selective hydrogen bonding subunits in their backbone which form double helices. The invention allows for tuning of the...
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7897698 |
Method of modifying a macromolecular system
The present application discloses a method of modifying a macromolecule, the method comprising the steps of (i) providing the macromolecule; (ii) providing a compound of the general formula (I):...
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7846426 |
Compositions and methods for treating and preventing cardiomyopathy and heart disease
The present invention relates to compositions and methods for treating and preventing heart disease. In particular, the present invention provides compositions comprising poloxamers (e.g.,...
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7838122 |
Hydrazide compounds with angiogenic activity
Compounds exhibiting angiogenic properties incorporating the structure of Formula I: R3—NH—NH—C(═O)—R2—P—R1 (I) wherein P is a water-soluble, biodegradable polymer, R1 is hydrogen, lower alkyl, ...
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7820734 |
Antimicrobial lubricious coating
The present disclosure provides lubricious antimicrobial coating vehicles for medical devices capable of reducing the coefficient of friction of such devices upon exposure thereof to moisture and...
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7714114 |
Conjugates of an EPO moiety and a polymer
Conjugates of an EPO moiety and one or more non-peptidic water-soluble polymers are provided. Typically, the non-peptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof....
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7674452 |
Polymer coating of cells
Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.
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7588754 |
Biodegradable polyacetals and methods
Condensation polymerization methods are used to prepare various biodegradable polyacetals of the general formula (I). Such polymers are useful for variety of drug, biomolecule and imaging agent...
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7563460 |
Enteric coated oral pharmaceutical to erode kidney stones
A treatment protocol by which a renal stone patient is administered a chelating agent, generally once a day and preferably by mouth, during a treatment phase and is later administered the same...
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7504095 |
Method for obtaining precursor Z and use thereof for the production of a means for therapy of human molybdenum cofactor deficiency
The invention relates to a method for obtaining the molybdopterin derivative precursor Z, wherein an over-production of precursor Z occurs in host organisms by recombinant expression of precursor Z...
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7052686 |
Pegylated interleukin-10
Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The...
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7041281 |
Natural feel polymers
Natural feel polymers exhibit an advantageous blend of flexibility and a strong affinity to natural fibers imparting a natural feel when applied to keratin-based fibers, e.g. hair, skin, or...
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7018625 |
Personal care compositions
Personal care compositions, particularly hair care products, include a polymer mixture made from (A) a derivatized polymer of maleic anhydride having defined repeat units of a monomer (e.g....
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7005125 |
Personal care products
Personal care products, particularly hair care products, are made herein by mixing (A) a polymer having defined repeat units of a monomer (e.g. α-olefin) maleic anhydride alkyl half-ester or full ...
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6989362 |
Methods of treating dopamine dysregulation using agents that regulate phosphorylation/dephosphorylation in dopamine signaling
The present invention discloses that DARPP-32 is substrate for the cyclin dependent kinase Cdk5. The phosphorylation takes place at a specific threonine residue of DARPP-32 (Threonine 75). The Cdk5...
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6732573 |
Single riser/single capillary blood viscometer using mass detection or column height detection
An apparatus and method for determining the viscosity of the circulating blood of a living being over plural shear rates caused by a decreasing pressure differential by monitoring the changing...
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6630167 |
Hyaluronic acid anti-adhesion barrier
Methods of forming crosslinked hyaluronic acid anti-adhesion barriers, crosslinked hyaluronic acid anti-adhesions barriers, methods for preventing or inhibiting adhesions, and methods of promoting...
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RE37950 |
Biogradable in-situ forming implants and methods of producing the same
A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to...
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6464970 |
Method and composition for preventing surgical adhesions
An improved method and composition for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric...
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6419916 |
Assay for compounds which affect conformationally altered proteins
An assay comprises contacting cells containing a conformationally altered protein with test compound and determining if the altered protein is cleared. The cells may be scrapie-infected...
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6387391 |
Bioresorbable polymeric clayey and sticky substance
This invention provides a claycy and sticky substance as a new biomaterial that cannot be found in the current medical field, which is bioresorbable, shows tackiness, plasticity and shape holding...
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6277889 |
Molluscicide formulation
A molluscicide containing a non-toxic animal repellant and metaldehyde, in which the molluscicidal efficacy of the molluscicide greater than that of the molluscicide if it did not contain...
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6271264 |
Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective...
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6214366 |
Clearance and inhibition of conformationally altered proteins
The present invention provides a method of arresting, preventing and/or reversing the impairment of central and peripheral nervous system function comprising reducing insoluble protein deposit...
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6190688 |
Material for elimination or detoxification of super antigens
A material with excellent selective absorption of super antigens. Said material contains urea bonds or thiourea bonds and remains active even in a high protein concentration solution in the neutral...
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6048523 |
Polyester cyclic compounds, their complexes and bonded bodies
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6037387 |
Blood-compatible material of a supramolecular structure
A platelet metabolism suppressing blood compatible material has a supramolecular structure containing a plurality of cyclic compounds and a hydrophilic straight-chain polymer threading into...
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5962566 |
Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery
The presently claimed invention comprises a biopolymer nanoparticle for drug delivery wherein the nanoparticle comprises a homogeneous blend of an aliphatic polyester polymer blended with a...
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5939537 |
Acid-functionalized saccharide monomers
The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. The monomer can have a polymerizable functional group, such as an olefinic bond, to which...
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5922682 |
Polyol esters, their preparation and use in depot forms of pharmacologically active agents
This invention provides a polyester of a polyol, said polyol containing at least 3 hydroxyl groups and having a molecular weight of up to 20,000 at least 1 hydroxyl group in said polyol being in...
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5919830 |
Stable non-aqueous blends for personal care compositions
A stable non-aqueous carrier for personal care compositions comprising: a) about 80-98% by weight of a liquid polyoxyalkylene glycol of MW=3000-100000; b) about 2-20% by weight of a non-ionic solid...
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5902589 |
Method for treating hydratable polymers, compositions obtained therefrom, and methods of using same
Aqueous solutions of hydratable polymers are prepared by hydrating a hydratable polymer in water without agitation sufficient to shear the molecular structure of the polymer thereby maintaining...
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5888518 |
Method for preventing and treating coccidiosis
A method for preventing and treating parasitic infections in animals by administering a lysine analog, such as EACA, to the animals on a continuous basis. In the preferred embodiment, the method of...
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5858348 |
Perfume composition containing (4R)-cis-4-methyl-2-substituted-tetrahydro-2H-pyran derivative and method for improving fragrance by using (4R)-cis-4-methyl-2-substituted-tetrahydro-2H-pyran derivative
A perfume composition which contains a (4R)-cis-4-methyl-2-substituted-tetrahydro-2H-pyran derivative represented by formula (I): ##STR1## wherein ---- represents a single or double bond, and a...
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5853713 |
Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
A linear block copolymer comprising units of an alkylene oxide, linked to units of peptide via a linking group comprising a --CH2 CHOHCH2 N(R)-- moiety, is useful as an imaging agent, drug, prodrug...
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5844061 |
Polyphenol derivative compositions and perparation thereof
Polyphenol derivative compositions including oligomer or polymer esters containing N+2 monomer moieties, whose monomer moieties correspond to the following formula ##STR1## in which N is a number...
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5788958 |
Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as an antitumor therapy to reduce tumor blood flow and...
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5719194 |
Prevention and treatment of topical viral infections with perfluoropolyethers or compositions thereof
Use of perfluoropolyethers with non reactive terminals or compositions thereof for the prevention and/or the treatment of topical vital infections, in particular of Herpes Simplex I and II and of...
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5718909 |
Sheet containing carbohydrate derivative for removal of E. coli
A sheet of nonwoven material which can be used as cleansing product in the form of a wet tissue for effective removal of bacteria, especially type 1 piliated E. coli, when wiping for example the...
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5711936 |
Ultramulsion based ingestible compositions
The present invention relates to various ingestible products containing stable, dispersions of certain high viscosity silicones in certain surfactants for use in treating mucus containing surfaces...
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5702695 |
Osseointegration promoting implant composition, implant assembly and method therefor
A liquid composition comprising a transforming growth factor β(TGF-/β in a polyoxyalkylene block copolymer--containing liquid carrier which gels at about 37 C, promotes osseointegration of an i...
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5575993 |
Ionene polymers containing biologically-active anions
Ionene polymers having biologically-active organic and/or inorganic anions are described. Methods to prepare the ionene polymers, compositions containing them and their methods of use are also...
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5567422 |
Azlactone activated polyalkylene oxides conjugated to biologically active nucleophiles
Water-soluble azlactone activated polyalkylene oxides having improved hydrolytic stability and conjugates of the azlactone activated polyalkylene oxides with biologically active nucleophiles are...
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