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8182802 |
Composition of polymers
Compositions are described comprising a of a block copolymer having an overall ionic charge and in which one of the blocks has pendant zwitterionic groups and a biologically active compound having...
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8173765 |
Polymers, uses and methods of manufacture thereof
A polymer having a number average molecular weight (Mn) of about 10 000 g/mol comprising a monomeric rigid moiety R and a monomeric flexible moiety F, wherein R comprises a main-chain polycyclic...
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8153111 |
Photo-triggered release of active substances from dendrimer-photosensitizer complexes
Compositions of dendrimer-photosensitizer complexes including therapeutic molecules, and methods for their synthesis and use are disclosed. The therapeutic molecules and the photosensitizers are...
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8153112 |
Compositions and methods for treating cavity conditions
Compositions, methods and kits to be used as a lubricant and for treatment of a cavity pathology including joint pathology are provided. The composition comprises therapeutically effective amounts...
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8119115 |
Antiviral method
This invention provides a method of inactivating non-enveloped virus particles. The method includes the step of contacting the virus with a virucidally-enhanced alcoholic composition that includes...
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8110179 |
Cyclodextrin-based polymers for therapeutics delivery
The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical...
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8105391 |
Merhods of treatment with devices having a coating containing pegylated hyaluronic acid and a pegylated non-hyaluronic acid polymer
Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid...
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8101706 |
Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be...
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8101164 |
Dual phase drug release system
The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a...
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8097343 |
Functionalized dendritic polymers for the capture and neutralization of biological and chemical agents
The present invention describes compositions and methods for trapping/capturing and/or destroying dangerous substances such as chemical and biological warfare agents. The present invention relates...
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8071692 |
Multi-arm block copolymers as drug delivery vehicles
The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a...
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8067505 |
Method of preparing carboxylic acid functionalized polymers
Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as...
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8048408 |
Polymer conjugates
The present invention relates to conjugates of biologically active compounds, preferably therapeutically active compounds, with polymeric moieties having low polydispersity, as well as controlled...
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7883694 |
Method for preventing the formation of adhesions following surgery or injury
Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple...
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7858080 |
Aldehyde conjugated flavonoid preparations
There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8...
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7803899 |
Methods to reduce organic impurity levels in polymers and products made therefrom
Various methods are described for preparing dry water-soluble polymers with reduced organic impurity content by combining water-soluble polymer in water with at least one dry polar solvent to form...
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7790150 |
Dual phase drug release system
The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a...
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RE41615 |
Crosslinked, water-soluble or water-dispersible polyurethanes
The present invention relates to crosslinked, water-soluble or water-dispersible polyurethanes of A) at least one water-soluble or water-dispersible polyurethane prepolymer having terminal...
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7736636 |
Method for treating occlusive vascular diseases & wound healing
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of Nicotine, nicotinic acid analogs thereof,...
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7713637 |
Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer
Provided herein are a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
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7556799 |
Ion binding polymers and uses thereof
The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and...
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7473733 |
Cationic graft-copolymer for non-viral gene delivery vector
A cationic graft-copolymer for a non-viral gene delivery vector comprising a unit derived from a cationic derivative of a water-soluble linear polymers having a hydroxyl groups, namely, a cationic...
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7361726 |
Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles
Polymers containing poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles are disclosed along with methods of fabricating medical articles comprising these polymers. The...
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7265186 |
Multi-arm block copolymers as drug delivery vehicles
The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a...
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7052686 |
Pegylated interleukin-10
Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The...
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7018624 |
Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates...
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6939562 |
Collagen/polysaccharide bilayer matrix
Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure....
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6908609 |
In vivo use of water absorbent polymers
The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states....
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6831107 |
Emulsification systems and emulsions
Personal care or cosmetic oil in water emulsions include an oil emulsifier and a combination of a Xanthan polysaccharide and a polyglucomannan polysaccharide to provide enhanced stability even at...
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RE38362 |
Compositions for making up the eyes
Cosmetic composition, in particular one for making up the eyes, comprising: (a) at least one aqueous phase comprising at least one film-forming polymer,(b) at least one fatty phase comprising at...
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6638499 |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
The present invention is directed to polymeric-prodrug transport forms of the formula: wherein:E1-4 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched...
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6616923 |
Aqueous compositions for facial cosmetics
The present invention describes a highly versatile and effective facial composition containing two very simple human endogenous compounds, glycerin or any other nonvolatile, pharmacologically...
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6566345 |
Polyacid/polyalkylene oxide foams and gels and methods for their delivery
The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of...
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6458347 |
Drug complex
Disclosed is a drug complex of a drug having a hydroxyl group, which is capable of controlling the rate of the release of the drug therefrom in blood, the drug complex being represented by the...
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6184030 |
Biologically-active polymers
This invention relates to biologically-active polymers that are useful for analyte detection and isolation and delivery of substances. The biologically-active polymers are capable of specifically...
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6150489 |
Thermoplastic polyurethanes containing active substances
This invention relates to thermoplastic polyurethanes (TPUs) which contain pharmaceutical active ingredients in a homogeneous distribution, to a method of producing them, and to their use in...
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6048523 |
Polyester cyclic compounds, their complexes and bonded bodies
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6042820 |
Biodegradable copolymer containing α-hydroxy acid and α-amino acid units
Copolymers designed for use as particulate carriers containing functionalizable amino subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of α-hydroxy ...
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6033656 |
Method of preventing or alleviating mammalian obesity
The present invention provides methods of suppressing the activation of Peroxisome Proliferator-Activated Receptor gamma in a mammalian body by administering an effective amount of bisphenol A...
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5993797 |
Vascular intimal hyperplasia-inhibitory composition
The invention provides an excellent vascular intimal hyperplasia-inhibitory composition which comprises a sea cucumber-derived sulfated polysaccharide as an active ingredient and which causes no...
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5919830 |
Stable non-aqueous blends for personal care compositions
A stable non-aqueous carrier for personal care compositions comprising: a) about 80-98% by weight of a liquid polyoxyalkylene glycol of MW=3000-100000; b) about 2-20% by weight of a non-ionic solid...
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5866165 |
Collagen-polysaccharide matrix for bone and cartilage repair
A matrix and a method for preparing it are provided to support the growth of bone or cartilage tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide...
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5776479 |
Stable, germicidal film-forming teat-dip solutions
Improved, stable, germicidal, aqueous teat-dip compositions are disclosed, which include a film-forming agent selected from the group consisting of hydroxyethylcellulose, methyl...
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5720950 |
Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use
The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog,...
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5690961 |
Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
Acidic polysaccharides crosslinked by reaction with di- or polyanhydrides. The use of anhydride-crosslinked hyaluronic acid as a treatment for arthritis, as a drug delivery vehicle, to reduce the...
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5686066 |
Polyaspartic acid Zwitterionic derivatives, preparation processes thereof, hair-treating compositions and cosmetic compositions
Disclosed are polymers (polyaspartic acid Zwitterionic derivatives) containing, in the molecule, 1 mol % or more of at least one repeating unit selected from the group consisting of repeating units...
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5616317 |
Polycationic polymer and polycationic microbicidal and algaecidal agent
A polycationic microbicidal and algaecidal agent containing as an active ingredient a polymer comprising repeating units represented by the formula (I) and having a number average molecular weight...
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5575993 |
Ionene polymers containing biologically-active anions
Ionene polymers having biologically-active organic and/or inorganic anions are described. Methods to prepare the ionene polymers, compositions containing them and their methods of use are also...
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5567422 |
Azlactone activated polyalkylene oxides conjugated to biologically active nucleophiles
Water-soluble azlactone activated polyalkylene oxides having improved hydrolytic stability and conjugates of the azlactone activated polyalkylene oxides with biologically active nucleophiles are...
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5498409 |
Material for adsorbing pyrogen
An insoluble material for adsorbing a pyrogen comprising a polymer of an aziridine compound. According to the present invention, a large amount of the pyrogen can be easily removed from a solution...
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