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7316811 |
Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles
The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more)...
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7311901 |
Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic...
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7265186 |
Multi-arm block copolymers as drug delivery vehicles
The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a...
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7226586 |
Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene...
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7208145 |
Polymeric reagents comprising a ketone or a related functional group
Polymeric reagents comprising a polymer attached, either directly or through one or more atoms to a ketone or a related functional group such as ketone hydrate, thione, monothiohydrate,...
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7083634 |
Stabilized polyester/cyanoacrylate tissue adhesive formulation
The present invention is directed to adhesive/hemostatic formulations of 2-alkoxyalkyl cyanoacrylate, an absorbable liquid or solid polymeric modifier, and a general stabilizer against premature...
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7074459 |
Method for preserving wood
A method for preserving wood which comprises contacting the wood with a complex of a cationic monomeric or polymeric biocide and an anionic monomeric or polymeric biocide. Insoluble complexes may...
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7056500 |
Polymer conjugates of opioid antagonists
The invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and...
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7049345 |
Fat-binding polymers
The present invention provides fat-binding polymers, which comprise dialkanolamine, dialkanolammonium, aminoalkylpolyol, and ammoniumalkylpolyol pendant groups for subjects in need of fat removal...
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6887485 |
Nitric oxide-releasing metallic medical devices
Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian...
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6841166 |
Nitric oxide-releasing polymers incorporating diazeniumdiolated silane derivatives
Biocompatible polymeric materials capable of providing in situ release of nitric oxide (NO) included diazeniumdiolated fumed silica as a filler in a multilayer polymer structure to release NO upon...
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6835712 |
Compounds
Spermine:peptide-based surfactant compounds are disclosed. The compounds are based on a spermine backbone with peptide groups and optionally hydrocarbyl groups linked thereto. Uses of the...
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6811771 |
Bactericidal organic polymeric material
An object of the present invention is to provide a filter material capable of killing microorganisms, bacteria, fungi or viruses in air or liquids. Antimicrobial organic polymer materials of the...
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6805857 |
Method of modulating factor D, factor H and CD4 cell immune response with a polystyrene sulfonate, alginate, and saline infusion solution
Anthrax bio-terrorism is a poor man's nuclear bomb with devastating effects on the freedom and economy of any nation. No nation is immune. Urgently, there is a need for life saving technology that...
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6790437 |
Method of treating cancerous tumors with a dendritic-platinate drug delivery system
Dendritic polymer conjugates which are useful drug delivery systems for carrying platinum containing anti-tumor agents to malignant tumors are prepared by obtaining a dendritic polymer having...
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6730295 |
Anionic polymers as species specific antibacterial agents
The present invention relates to the discovery that certain anionic polymers have useful antibacterial activity.
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6692734 |
N,O-amidomalonate platinum complexes
The present invention relates to purified platinum complexes in which platinum is coordinated to form a single N,O- or O,O-chelate of an amidomalonate. The chelates, and pharmaceutically acceptable...
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6565840 |
Monomeric compositions effective as wound closure devices
A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of...
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6555656 |
Covalent modification of abnormal prion protein
A prion-physiological structure and associated method of formation. A provided abnormal prion has a transforming power over a normal prion to convert the abnornal prion into defective prion that...
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6517855 |
Method of sterilizing
A method of sterilizing objects as well as the sterilized objects obtained from the method are disclosed. The method involves contacting an object such as a medical device to be reused with...
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6517824 |
Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor
A method for treating pulmonary hypertension and other diseases involving a defect in collagen metabolism, by administration of an effective amount of a liposome encapsulated copolymer conjugate...
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6497868 |
Graft polymer and moulded medical articles employing this
The present invention relates to graft polymer which is characterized in that it is formed by graft polymerization of structural units containing. a quaternary ammonium group represented by general...
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6468522 |
Controlled release of thioamide moiety-containing therapeutic agents
This invention pertains to disulfide-linked conjugates of therapeutic agents containing at least one thioamide group with polymer comprising at least one thiol group, so as to provide a controlled...
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6464971 |
Anionic or cationic dendrimer antimicrobial or autiprotozoan compositions
To inhibit, prophylactically or therapeutically, a bacterial, yeast, fungal, or parasitic agent in a patient, an effective amount of a dendrimer is administered to the patient, which dendrimer has...
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6423754 |
Method for treating hypercholesterolemia with polyallylamine polymers
A method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of a non-absorbable amine polymer characterized by a repeat unit having...
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6342213 |
Methods for treating non-suturable wounds by use of cyanoacrylate adhesives
A cyanoacrylate adhesive is applied to non-suturable, non-sterile wound surfaces to protect and/or treat such surfaces, to promote wound healing and to retard infection of the wound.
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6331296 |
Food additives which affect conformationally altered proteins
An assay comprises contacting cells containing a conformationally altered protein with test compound and determining if the altered protein is cleared. The cells may be scrapie-infected...
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6268126 |
Antiviral polymers comprising acid functional groups and hydrophobic groups
The present invention relates to a method of treating a viral infection in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer comprising a...
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6190650 |
Antiviral dendrimers
An antiviral compound comprises a dendrimer such as a polyamidoamine or polyly sine dendrimer having a plurality of terminal groups, wherein at least one of the terminal groups has an anionic- or...
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6129910 |
Water-insoluble noncrosslinked bile acid sequestrants
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises the step of orally administering to a...
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6110483 |
Adherent, flexible hydrogel and medicated coatings
The adherent coating of the invention comprises a stabilizing polymer together with an active agent (a hydrophilic polymer and/or a bioactive agent) in a layer bonded to the surface of a medical...
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6110453 |
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical compositions including...
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6096834 |
Hydrolyzable delivery system using crosslinked polymeric resins as vehicles
This invention provides a method of preparing a polymeric delivery system for active ingredients. The delivery system is formed either by attaching the active ingredient to a linker through a...
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6040415 |
Biocompatible polymers
Tpresent invention provide a biocompatible polyurethane or oplyurethane urea containing, in the side chain, phosphorylcholine structure represented by the formula (1) ##STR1## wherein R 1 is C 1...
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6040315 |
Antacid co-polymer of guanidine and polyethylenimine
Herein is disclosed how to make and to use a nonmetallic antacid composition which is the product of the co-polymerization of guanidine and polyethylenimine. The resultant polymer is useful as an...
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6036970 |
Rodenticidal foams
The present invention relates to rodenticidal foams based on hydrophilic polymers, of the following composition: a) rodenticidal active compound, b) hydrophilic polymers having an average...
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5969090 |
Hydrophobic sequestrant for cholesterol depletion
The present invention relates to a poly(allylamine) polymer and, more generally, a hydrocarbon amine polymer. Preferably, these polymers are crosslinked. The present invention also relates to...
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5958399 |
Sulfonic acid and aldehyde condensation polymers for preventing pregnancy
This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalenesulfonic acid condensation...
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5935564 |
Use of hydrophobic interaction chromatography to purify polyethylene glycols
The present invention relates to a process for purifying polyethylene glycols (PEGs) which utilizes hydrophobic interaction chromatography (HIC) to separate the PEGs based on their size and on...
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5827925 |
Polymeric drug delivery system
A drug delivery system adapted to release an effective amount of a drug at pH values of about 1 to 7 without releasing a significant amount of the drug at pH values of about 7 and above, the system...
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5762918 |
Methods of using steroid-polyanionic polymer-based conjugated targeted to vascular endothelial cells
This invention discloses new targeted conjugates for the delivery of a compound, and particularly, a steroid, to vascular endothelial cells. The conjugates comprise two components, preferably...
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5733538 |
Surface-modifying copolymers having cell adhesion properties
A hemocompatible surface-modifying additive is provided for modifying polyurethane or polyurethane urea substrates. The additive has a polyurethane or polyurethane urea hard block or an alternative...
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5618530 |
Hydrophobic amine polymer sequestrant and method of cholesterol depletion
An amine polymer includes a substituent bound to an amine of the polymer. The substituent includes a quaternary amine-containing moiety having at least one hydrophobic moiety. A method for binding...
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5527524 |
Dense star polymer conjugates
Dense star polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared....
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5516881 |
Aminoxyl-containing radical spin labeling in polymers and copolymers
Aminoxyl-containing radical is provided in polymers and copolymers by replacing a hydroxyl moiety in a carboxyl group at a chain end of a starting material biodegradable polymer or copolymer with...
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5494894 |
Agent for the regulation of the appetite or a sleeping agent
An agent for the regulation of the appetite or a sleeping agent, which consists of the activation peptide in procolipase, consisting of the peptide sequence X-Pro-Y-Pro-Arg wherein a) X is Ala...
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5474765 |
Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
This invention discloses new targeted conjugates for the delivery of a compound, and particularly, a steroid, to vascular endothelial cells. The conjugates comprise two components, preferably...
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5468478 |
Conjugates of superoxide dismutage coupled to high molecular weight polyalkylene glycols
A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene...
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5417969 |
Process for reducing the thrombogenicity of biomaterials
Processes for forming a uniform, continuous coating of heparin covalently bonded to blood-contacting polyvinylchloride surfaces of a medical device are disclosed. These processes include coating...
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5364638 |
Antimicrobial material for breeding or keeping fish and process for producing the same
An antimicrobial material for fish breeding or keeping comprising a formed article of a pulp and/or polyolefin base material and a process for producing the same are disclosed, in which said formed...
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