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8119756 |
Hydrolytically degradable polymers and hydrogels made therefrom
Methods for delivering a biologically active agent into the body of a mammal are provided, the method comprising administering a carbamate-containing conjugate to the mammal.
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8105570 |
Methods and compositions for controlled release of drugs
This invention provides a method and compositions for the controlled release of drugs that have been attached by means of a covalent bond to a polymer or other moiety that blocks activity of the...
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8058344 |
Glycodendrimers having biological activity
The present invention relates to new anionic glycodendrimers having new biological activity, processes for preparing them and their use in medicine including veterinary medicine.
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8058235 |
Water-mediated control of depolymerization step of glatiramer acetate synthesis
Methods of making copolymers are described.
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7985414 |
Polyurethanes for osteoimplants
Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated...
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7976834 |
Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles
The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more)...
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7968050 |
Method for sterilization of hydrogel contact lenses
The present invention provides an aqueous solution for sterilizing and storing ophthalmic devices, preferably a contact lens, made of a hydrogel material, preferably a poly(oxyalkylene)-containing...
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7968085 |
Hydrogel formulations
A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active...
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7947262 |
Use of fullerenes for the treatment of mast cell and basophil-mediated disease
Mast cell (MC) and peripheral blood basophil (PBB)-associated diseases are treated or prevented, or their symptoms are alleviated by the administration of water soluble fullerenes (buckeyballs) to...
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7947263 |
Biocompatible surgical compositions
Biocompatible synthetic macromer compositions are provided including a first polymer having multiple functional groups and a second functionalized polyurethane prepolymer, which can be employed as...
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7947261 |
Conjugates formed from polymer derivatives having particular atom arrangements
Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric...
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7939055 |
Polymeric aromatic N-halo sulfonamides
A polymer comprises a monomer having a N-halo sulfonamide pendant group and having the formula: wherein A is a trivalent linkage;wherein Q is a divalent linkage and y is 0 or 1;wherein R1, R2, R3,...
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7927619 |
In situ bulking composition
The present invention relates to a hydrated, biocompatible tissue-augmentation compound and methodology for its implantation into mammalian tissue. The tissue-augmentation compound is comprised of:...
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7914776 |
Solid dispersions of opioid antagonists
Solid dispersions of stable, amorphous opioid antagonists, particularly [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-piperidinyl]
methyl]-1-oxo-3-phenylpropyl]amino]acetic acid, with improved...
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7910685 |
Hydrolytically degradable polymers and hydrogels made therefrom
Conjugates between a protein and a water soluble polymer comprising multiple degradable carbonate linkages are provided.
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7897563 |
Use of oligomers and polymers for drug solubilization, stabilization, and delivery
The invention relates to the use of oligomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action....
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7892834 |
Cellular signal-responsive gene transcriptional regulation system
A gene complex-forming material which comprises a water-soluble polymer having a peptide containing an amino acid sequence serving as the substrate of an intracellular signal-responsive enzyme and...
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7888316 |
Polypeptide films and methods
Disclosed herein are polypeptide multilayer films comprising a hybrid polypeptide comprising a first polypeptide segment and a second segment, the two segments being covalently joined by one or...
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7879317 |
Polymeric micelle compositions with improved stability and methods of making thereof
Polymeric compositions capable of forming stable micelles in an aqueous solution, comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block, and a polylactic acid...
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7863408 |
Body fluid compatible and biocompatible resin
A body fluid compatible and biocompatible resin for use in a medical treatment involving a contact of said resin with at least one member selected from the group consisting of a body fluid and a...
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7858079 |
Tissue adhesives and sealants and method for their use
Compositions provided by mixing a biotin-containing component and an avidin-containing component are useful as an adhesive or sealant for medical/surgical uses.
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7858078 |
Bioabsorbable surgical composition
Bioabsorbable macromer compositions are provided including a diisocyanate-functional bioabsorbable polymer. In some embodiments, the diisocyanate-functional bioabsorbable polymer can be combined...
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7858679 |
Polymeric compositions and related methods of use
Methods for surface-initiated atom transfer radical polymerization, which can utilize a catecholic alkyl halide initiator.
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7851565 |
Stabilized polymeric thiol reagents
Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y—S—W]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, and S—W is a thiol...
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7833978 |
Thrombomodulin derivatives and conjugates
The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured...
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7825083 |
Synovial fluid barrier
A composite tissue formed in situ is provided. The composite tissue includes a synovial joint tissue; and a barrier material adhered thereto for sealing the synovial joint tissue against synovial...
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7803899 |
Methods to reduce organic impurity levels in polymers and products made therefrom
Various methods are described for preparing dry water-soluble polymers with reduced organic impurity content by combining water-soluble polymer in water with at least one dry polar solvent to form...
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7794696 |
Biodegradable polyacetals for in vivo polynucleotide delivery
Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications.
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7794700 |
Multimeric VLA-4 antagonists comprising polymer moieties
Disclosed are conjugates exhibiting VLA-4 antagonistic properties. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. The...
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7772357 |
Hydrolytically degradable polymers and hydrogels made therefrom
A water soluble polymer comprising multiple degradable carbonate linkages in a backbone and, for each carbonate linkage in the backbone, an oligomer linked thereto by the carbonate linkage, wherein...
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7771711 |
Sphingolipids' polyalkylamines conjugates
The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present...
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7754782 |
Medical adhesives for surgery
The present invention relates to novel, rapidly curing adhesives based on hydrophilic polyisocyanate prepolymers for use in surgery.
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7741454 |
Biological low-molecular-weight derivatives
The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized...
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7705185 |
Alkylated and polymeric macromolecular antioxidants and methods of making and using the same
Alkylated antioxidant macromolecules are represented by Structural Formula 1: wherein the variables are described herein. Also included are methods of making the molecules and methods of using the...
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7674452 |
Polymer coating of cells
Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.
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7662365 |
Polymer conjugates of opioid antagonists
The invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and...
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7625552 |
Bioactive polymers for imparting bioactive character to hydrophobic medical article surfaces
According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the...
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7597882 |
Protein crosslinkers, crosslinking methods and applications thereof
Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the...
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7588754 |
Biodegradable polyacetals and methods
Condensation polymerization methods are used to prepare various biodegradable polyacetals of the general formula (I). Such polymers are useful for variety of drug, biomolecule and imaging agent...
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7534907 |
Absorbable α-cyanoacrylate compositions
A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the ge...
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7534852 |
Polyanhydrides with therapeutically useful degradation products
An aromatic polyanhydride comprising a repeating unit having the structure is disclosed, wherein Ar and R are selected so that the aromatic polyanhydride hydrolyzes to form a therapeutic...
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7442370 |
Polymer conjugates of mutated neublastin
A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity...
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7316811 |
Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles
The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more)...
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7311901 |
Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic...
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7265186 |
Multi-arm block copolymers as drug delivery vehicles
The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a...
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7226586 |
Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene...
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7208145 |
Polymeric reagents comprising a ketone or a related functional group
Polymeric reagents comprising a polymer attached, either directly or through one or more atoms to a ketone or a related functional group such as ketone hydrate, thione, monothiohydrate,...
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7083634 |
Stabilized polyester/cyanoacrylate tissue adhesive formulation
The present invention is directed to adhesive/hemostatic formulations of 2-alkoxyalkyl cyanoacrylate, an absorbable liquid or solid polymeric modifier, and a general stabilizer against premature...
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7074459 |
Method for preserving wood
A method for preserving wood which comprises contacting the wood with a complex of a cationic monomeric or polymeric biocide and an anionic monomeric or polymeric biocide. Insoluble complexes may...
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7049285 |
Biocompatible polymers including peptide spacer
The present invention relates to new biocompatible polymer derivatives including peptide spacers of formula (I) and their methods of preparation. The present invention also relates to the...
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