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7384626 |
Functionalized dendritic polymers for the capture and neutralization of biological and chemical agents
The present invention describes compositions and methods for sorbing and/or destroying dangerous substances such as chemical and biological warfare agents. The present invention relates to...
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7345117 |
Sulphated hyaluronic acid and sulphated derivatives thereof covalently bound to polyurethanes, and the process for their preparation
The present invention relates to the synthesis of a haemocompatible polymer, consisting of a polyurethane bound covalently to sulphated hyaluronic acid. These sulfated derivatives have...
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7326426 |
Compositions and medical devices utilizing bioabsorbable liquid polymers
The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic...
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7316811 |
Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles
The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more)...
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7311901 |
Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic...
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7288264 |
Contact-killing antimicrobial devices
Contact killing antimicrobial articles, devices and formulations are described which kill microorganisms on contact. The articles, devices or formulations contain a non-leaching antimicrobial...
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7244444 |
Graft material, stent graft and method
This invention is directed to graft materials for implanting, transplanting, replacing, or repairing a part of a patient and to methods of making the graft materials. The present invention is also...
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7217770 |
Stable polymeric micelle-type drug composition and method for the preparation thereof
A biocompatible stable composition containing a hydrophobic drug, such as paclitaxel. The composition, which forms a syringeable polymeric micellar solution in aqueous or body fluids, is a...
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7214366 |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
Water soluble activated polymers are provided containing an active ethyl sulfone moiety having a reactive site located at the second carbon from the sulfone group. In an embodiment, a poly(ethylene...
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7199098 |
Copolymer-1 improvements in compositions of copolymers
The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
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7169410 |
Targeted liposomal drug delivery system
A metal targeting complex which associates with a charged liposomal structure is provided. The metal targeting complex provides the targetability of the liposomal construct to the desired receptor...
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7166306 |
Method for preparation of block copolymeric nanoparticles
A method for preparation of block copolymeric nanoparticles is disclosed. The method is a single-step preparation in which block copolymeric nanoparticles are produced directly from a solution of...
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7163677 |
Cationic polymers having degradable crosslinks
A synthetic polymer comprises a cationic recurring unit and a crosslinking unit, wherein the crosslinking unit comprises at least a first degradable unit (preferably acid-labile) and at least a...
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7160941 |
Dental composite materials and method of manufacture thereof
A dental composite material that comprises a polyhedral oligomeric silsesquioxane is disclosed. The dental composite material is useful for a variety of dental materials, treatments, and...
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7144573 |
Latent reactive blood compatible agents
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a...
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7125546 |
Polymeric micelle containing cisplatin enclosed therein and use thereof
Provided is a complex comprising cisplatin encapsulated therein in a form in which a chlorine ion thereof is ligand-exchanged with a carboxyl anion of a block copolymer comprising poly(ethylene...
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7122618 |
Quaternary polyamidoamines, the production thereof, corresponding agents and the use thereof
The present invention relates to quaternized polyamidoamines which have at least one structural unit of the formula VII
in which R 1 , R 2 , R 4 are straight-chain or branched organic...
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7122615 |
Polyanhydrides with therapeutically useful degradation products
An aromatic polyanhydride having a repeating unit with structure (I) wherein Ar is a substituted or unsubstituted aromatic ring and R is a difunctional organic moiety substituted on each Ar ortho...
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7101954 |
Polymeric urethane ester quats and their use in personal care compositions
The present invention relates to a composition and use of polymeric urethane esters quats as an active ingredient for skin and hair contacting personal care compositions and products related...
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7041280 |
Aryl boronate functionalized polymers for treating obesity
Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by...
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7014860 |
Hyaluronic acid gel, process for producing the same, and medical material containing the same
Production of a hyaluronic acid gel, which comprises keeping hyaluronic acid in water at a hyaluronic acid concentration of at least 5 wt % in the presence of an acid component in an amount at...
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7014845 |
Crosslinked copolymers based on non-crosslinked polycarboxylic copolymers
The invention relates to cross-linked copolymers based on non cross-linked polycarboxylic copolymers, said non cross-linked copolymers containing at least one polysaccharide. The invention also...
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7005143 |
Gel materials, medical articles, and methods
A gel material and medical articles including such material, wherein the transparent gel material includes a polymerized poly(alkylene oxide) macromonomer that, prior to polymerization, is...
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7005124 |
Dendritic-antineoplastic drug delivery system
Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared by obtaining a dendritic polymer having...
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6969528 |
Phosphorus-containing dendrimers as transfection agents
The invention concerns phosphorus-containing dendrimers and their uses, as gene transfection agents, in vitro and in vivo, including in the treatment of human and animal diseases. These agents or...
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6962954 |
Activated polyethylene glycol compounds
Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to...
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6956077 |
Temperature-responsive polymer compound and process for producing the same
A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by...
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6951642 |
Water-in-oil emulsions with anionic groups, compositions, and methods
Water-in-oil emulsions, compositions, and methods that include a vinyl polymer having a pKa of less than 4 that includes anionic group-containing side chains and alkyl-Y-containing side chains,...
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6946527 |
Modified polymeric shaped body, method for producing the same and use thereof
AGE precursors can be removed from blood, plasma or PBS buffer using a modified polymeric shaped body that can be produced by reaction of diaminoguanidine and/or triaminoguannidine with a staring...
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6939938 |
Amphiphilic cationic associative polymers, preparation process, use as thickeners and composition comprising them
Novel water-soluble or water-dispersible amphiphilic cationic associative polymers, a process for preparing them and their use in compositions for topical application, such as for cosmetic use, as...
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6930098 |
Use of polysulphated cyclodextrins for treating osteoarthritis
The present invention relates to the method of using polysulphated cyclodextrins or addition salts thereof for use in the treatment of arthrosis, and pharmaceutical compositions thereof.
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6913805 |
Controlled release ampule containing a fumigant
The present invention provides an apparatus and method for controlled release of a fumigant into a wooden structure to prevent decay of that structure. According to the present invention, a...
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6884778 |
Biocompatible macromers
A new oligomer based on alternating fumaric acid and poly(ethylene glycol) (PEG) units is provided. The oligo(PEG fumarate) (OPF) may be functionalized by modification with a biocompatible organic...
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6864350 |
Soluble, degradable poly (ethylene glycol) derivatives for controllable release of bound molecules into solution
PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small...
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6861065 |
Method of producing intraocular lenses in vivo
Methods of producing an intraocular lens in vivo comprise preparing a composition of discrete water soluble macromolecular particles, mixing the composition with a water soluble photoinitiator and...
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6841617 |
Thermogelling biodegradable aqueous polymer solution
Disclosed is a thermogelling biodegradable aqueous polymer solution useful in providing a bioactive agent delivery system. The present invention provides a thermogelling biodegradable aqueous...
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6830747 |
Biodegradable copolymers linked to segment with a plurality of functional groups
Biocompatible biodegradable polymer or copolymer is capped at one end and has free hydroxyl at the other end. The free hydroxyl can be reacted to link a plurality of functional groups some or each...
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6828412 |
Degradable polymers
A polymer comprising: a polymeric backbone comprising at least one unit having the structure (I), wherein R-R 4 comprise groups selected from the group consisting of H, C 1 -C 12 alkyl, C 6 -C 18...
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6828392 |
Hydroxy and amine functionalized resins
A star-blocked polymeric material based on polyethylene glycol and having a uniform distribution of both hydroxy and amine functional groups throughout the polymeric material is described. The...
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6811771 |
Bactericidal organic polymeric material
An object of the present invention is to provide a filter material capable of killing microorganisms, bacteria, fungi or viruses in air or liquids. Antimicrobial organic polymer materials of the...
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6805857 |
Method of modulating factor D, factor H and CD4 cell immune response with a polystyrene sulfonate, alginate, and saline infusion solution
Anthrax bio-terrorism is a poor man's nuclear bomb with devastating effects on the freedom and economy of any nation. No nation is immune. Urgently, there is a need for life saving technology that...
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6800716 |
Polymeric urethane ester quats and their use in personal care compositions
The present invention relates to a composition and use of polymeric urethane ester quats as an active ingredient for skin and hair contacting personal care compositions and products related...
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6790438 |
Cross-linked collagenic peptide for preventing post-surgical adhesions
The aim of the invention is to provide a modified collagen peptide for preventing post-operative adhesions that is non-toxic, economic, in addition to being easy to obtain, sterilize, manipulate...
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6790437 |
Method of treating cancerous tumors with a dendritic-platinate drug delivery system
Dendritic polymer conjugates which are useful drug delivery systems for carrying platinum containing anti-tumor agents to malignant tumors are prepared by obtaining a dendritic polymer having...
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6777387 |
Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
The present invention is directed to polymeric prodrug transport forms and methods of making and using the same. In one preferred aspect, the prodrugs are of the formula: wherein G is a...
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6730295 |
Anionic polymers as species specific antibacterial agents
The present invention relates to the discovery that certain anionic polymers have useful antibacterial activity.
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6730293 |
Compositions and methods for treating inflammatory diseases of the skin
This invention provides compositions and methods for enhancing delivery of glucocorticoids and ascomycins such as hydrocortisone, cyclosporin and FK506 across into and across one or more layers of...
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6726904 |
Method for transmitting acoustic waves
The invention relates to the use of a gel mass based on reaction products of polyols and polyisocyanates, wherein the polyol component consists of one or more polyols with hydroxyl numbers below...
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6706892 |
Pulmonary delivery for bioconjugation
Methods of and compositions for pulmonary delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest or which have formed a covalent bond with a pulmonary...
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6706344 |
Controlled fumigation of wooden structures
The present invention provides an apparatus and method for controlled release of a fumigant into a wooden structure to prevent decay of that structure. According to the present invention, a...
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