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8182800 |
Metal ion modified high surface area materials for odor removal and control
This invention relates to high surface area materials, such as nanoparticles, that are coated with metal ions. These modified nanoparticles have active sites that bind various gases and/or odorous...
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8178131 |
Pyrrolopyridines as kinase inhibitors
Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in...
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8178081 |
Method for reducing odor using coordinated polydentate compounds
A method for reducing odor is provided. The method comprises forming a coordination complex between a transition metal and a polydentate compound, and contacting the coordinated complex with an...
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8147860 |
Porous calcium phosphate bone material
Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an...
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8119116 |
Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production
The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising...
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8097581 |
Anti-wrinkle cosmetic composition
The present invention relates to a composition for treating skin comprising an acylated short chain bioactive peptide and fulvic acid, and optionally colloidal gold. The invention further relates...
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8088744 |
Cholestanol derivative for combined use
The invention provides a cancer chemotherapeutic agent which has fewer side effects and excellent efficacy. The cancer chemotherapeutic agent of the invention includes a cholestanol derivative...
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8088740 |
Gold binding peptides and shape-and size-tunable synthesis of gold nanostructures
The present invention relates to gold binding peptides and shape- and size-tunable synthesis of gold nanostructures. The present inventions are very useful for the production of well-designed,...
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8066971 |
Targeting pulmonary epithelium using ADRP
This invention provides novel compositions and methods for the specific and/or preferential delivery of an effector (e.g. a drug or label) to an epithelial cell (e.g. a pulmonary epithelium). The...
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8034964 |
Phosphaplatins and their use in the treatment of cancers resistant to cisplatin and carboplatin
The present invention provides phosphaplatins, stable isolated monomeric phosphato complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and...
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8003630 |
Combinatorial therapies for the treatment of neoplasias using the opioid growth factor receptor
The present invention relates to pharmaceutical compositions for treating neoplasias in an animal or human comprised of a carrier and therapeutically effective amounts of at least one...
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7981445 |
Compositions and methods for preparation of poorly water soluble drugs with increased stability
The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The...
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7976835 |
Methods and compositions for preventing and treating solid tumors
Compositions and methods of preventing or treating a breast cancer are disclosed. The composition and method can utilize an endothelin B agonist and a chemotherapeutic agent as active ingredients...
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7951405 |
Combined treatment with cisplatin and an epidermal growth factor receptor kinase inhibitor
The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective...
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RE42377 |
Composition for creating vascular occlusions
A composition including 2-hexyl cyanoacrylate and gold is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked.
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7943600 |
Antimicrobial combination therapy
This invention provides methods and pharmaceutical compositions for treating a subject having a condition associated with an antibiotic resistant bacterial infection. The invention includes...
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7906554 |
Combination chemotherapy compositions and methods
This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention further relates to compounds, methods and...
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7879367 |
Metallic implant which is degradable in vivo
The invention relates to a medical implant made of a metallic material. After fulfilling its temporary support function, the implant is degraded by corrosion at a predetermined rate. Negative...
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7868040 |
Anti-cancer combinations
The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and an alkylating agent, which has anti-tumour activity. Preferably, the...
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7863320 |
Anti-cancer combinations
The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a platinum compound which has anti-tumour activity. Preferably, the...
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7837663 |
Odor controlling article including a visual indicating device for monitoring odor absorption
The present invention relates to a visual indicating device and an article for controlling odors, in particular foot, garbage, basement, cooking, pet, tobacco, feces and urine odors. The article...
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7838043 |
Superoxide anion decomposing agent
A scavenger of superoxide anion or nitric oxide comprising finepowder of a transition metal such as platinum. The scavenger is preferably provided as an aqueous solution containing transition metal...
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7829537 |
Receptor associated protein (RAP) conjugates
The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
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7820205 |
Platinum colloid-containing aqueous solution for treating schizophrenia
The present invention provides a composition comprising precious metal particles for treating or preventing a psychiatric symptom. The composition of the invention is able to improve various...
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7812002 |
Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer
The invention provides novel double stranded oligoribonucleotides that inhibit the Nrf2 gene. The invention also provides a pharmaceutical composition comprising one or more such...
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7807683 |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7803408 |
Method of treating endothelial injury
The use of human erythropoietin (EPO) to prevent or treat endothelial injury due to chemotherapy, radiation therapy, mechanical trauma, or to a disease state which damages the endothelium (such as...
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7790167 |
Methods and compositions for enhancing immune response and for the production of in vitro Mabs
The methods and compositions of the present invention are directed to enhancing an immune response and increasing vaccine efficacy through the simultaneous or sequential targeting of specific...
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7781607 |
Method for producing polymerized coordination compounds of platinum complex
There is provided a production method in which bis(nitrato)platinum complex, optionally in the concurrent presence of dihalo-platinum complex, and poly(ethylene glycol)-block-poly(glutamic acid)...
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7758897 |
Method for the production of metal complexes
The invention relates to a process for preparing metal complexes containing carbene ligands by reacting metal compounds with ligand precursors II and/or III and to the use of the thus obtained...
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7754197 |
Method for reducing odor using coordinated polydentate compounds
A method for reducing odor is provided. The method comprises forming a coordination complex between a transition metal and a polydentate compound, and contacting the coordinated complex with an...
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7744854 |
Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium
This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an...
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7700554 |
Compositions for modulating blood-brain barrier transport
This invention provides conjugates of therapeutic or active agents with melanotransferrin or with other ligands of a melanotransferrin receptor, melanotransferrin receptor modulators, and related...
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7695738 |
Carbohydrate encapsulated nanoparticles
The present invention provides carbohydrate encapsulated nanoparticles. In particular, the present invention provides metallic nanoparticles (e.g. gold nanoparticles) that are encapsulated in...
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7683050 |
Formulations and methods of administration of cephalotaxines, including homoharringtonine
The present invention is directed to compositions and methods for the treatment of patients with cephalotaxines, for example, homoharringtonine. The invention is also directed to improvements in...
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7682630 |
Antitumor agent and process for producing the same
The present invention relates to polymeric antitumor agent which is formed in polymeric micelle complex by intermolecular bonding or mutual interaction between styrene maleic acid copolymer (SMA)...
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7655261 |
Medicament and method of treatment of patients with heavy metals
A method of treatment of a diseased patient in which a dose of at least one heavy metal is delivered to the patient, with a surface area which is accessible for direct contact with the patient's...
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7651979 |
Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same
The present invention relates to novel coordination complexes, methods for synthesizing and identifying coordination complexes, using combinatorial techniques, and assaying their activity. In...
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7635708 |
Methods and pharmaceutical compositions for inhibiting tumor cell growth
The present invention is based on the finding that activation of PPARĪ³ plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that ...
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7611733 |
Nanoparticle formulations of platinum compounds
Solid Lipid Nanoparticles of platinum compounds, particularly of antitumor platinum complexes are disclosed. The Nanoparticles of the invention are obtained by a process comprising: a) preparing a...
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7578997 |
Metal ion modified high surface area materials for odor removal and control
This invention relates to high surface area materials, such as nanoparticles, that are coated with metal ions. These modified nanoparticles have active sites that bind various gases and/or odorous...
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7537786 |
Complex of drug-carbon nanohorn and a process for producing the complex
The present invention provides a carbon nanohorn complex that is excellent in characteristics of adsorption or inclusion of drugs and release, in particular, a sustained release of drugs as a novel...
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7531501 |
Method of treating endothelial injury
The use of human erythropoietin (EPO) to prevent or treat endothelial injury due to chemotherapy, radiation therapy, mechanical trauma, or to a disease state which damages the endothelium (such as...
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7514442 |
Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7470695 |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7470714 |
GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent
An antitumor effect enhancer for enhancing the antitumor effects of an antitumor substance, which comprises a compound represented by the following formula (1): wherein each R independently...
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7465754 |
Method of potentiating chemotherapy and treating solid tumors
This invention provides a method of treating solid tumors which comprises administering an effective amount of a combination of (1) a bioresponse modifier and (2) a chemotherapeutic agent. This...
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7452554 |
Platinum nanocolloid solution, process for producing the same and drink containing platinum nanocolloid
A nanocolloidal platinum dispersion comprising nanocolloidal platinum and a polyacrylic acid salt, the nanocolloidal platinum having an average particle size of 1-5 nm, 90% or more of the...
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7445764 |
Carrier-drug conjugate
The invention relates to a carrier-drug conjugate comprising a carrier containing a polypeptide sequence having one or several cysteine radicals and a pharmacon containing a pharmaceutical and/or...
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7445799 |
Compositions for microbial and chemical protection
An antimicrobial and chemical deactivating composition for use in a liquid medium or for incorporation into a coating, structural plastic materials, thin microporous membranes, textiles and...
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