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7601863 |
Use of PPAR agonists for the treatment of congestive heart failure
The invention describes the use of PPAR agonists of the formulae (I) or (II)
for the treatment of congestive heart failure (CHF).
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7513903 |
Organ culture in situ
A method of increasing blood supply to an ischemic area with a cultured vessel in situ, comprising: 1) selecting a narrow artery responsible to an ischemic area; 2) selecting a vein drawing blood...
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7479278 |
Troponin I polypeptide fragments and uses thereof
Polypeptides corresponding to stable, circulating degradation products of troponin I (TnI) are described. The fragments comprise a sequence of the N-terminus of native cardiac TnI with 95-115 amino...
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7144588 |
Method of preventing surgical adhesions
The present invention relates to a method and composition for preventing surgical adhesions during surgery. Tissue surfaces and/or surgical articles involved in the surgery are separated by a...
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7067276 |
Method of using metaloporphyrins for treatment of arteriosclerotic lesions
A method for treating arteriosclerotic lesions is provided wherein the method is characterized by administering a chemical compound to the patient, the compound being a porphyrin complexed with a...
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7022348 |
Method of creating biological and biosynthetic material for implantation
A method of creating an implantation material from biological and tissue engineered biosynthetic and biological tissue of autogenic, allogenic and xenogenic origin suitable for implantation into...
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7014655 |
Method for conserving biological prostheses, conserved biological prostheses and conserving solutions
The invention concerns a method of conserving biological prostheses, wherein the method includes the following steps: (a) treating biological prostheses with a solution which contains a mixture of...
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6933278 |
Treatment of hypertension using growth hormone in mammals subjected to fetal programming
Embodiments of this invention include methods for decreasing hypertension in mammals subjected to adverse cardiovascular fetal programming or a long-term adverse postnatal environment. Fetal...
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6881546 |
Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
Methods and compositions are disclosed that are useful for the prevention and/or treatment of cardiovascular and cardiac diseases and disorders, or damage resulting from surgical or medical...
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6849262 |
Vascular coating composition
This invention relates to methods of coating the lumenal surface of a blood vessel, or other tissue cavity, and to compositions suitable for use in same.
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6790634 |
Methods and compositions relating to phosphorylated myosin light chain 1
Two novel phosphorylation sites of myosin light chain 1 (MLC 1 ) are described. Methods of monitoring phosphorylation of MLC 1 to identify new cardiac and skeletal muscle protective agents,...
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6690970 |
Biological pacemaker and implantation catheter
A biological pacemaker and implantation catheter for restoring normal or near normal heartbeat function without a mechanical pacemaker. The biological pacemaker is provided by a bridge of...
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6673832 |
Methods for identifying compounds for treating pain
The invention provides a method of determining whether a compound alleviates vasoconstriction-independent nerve pain mediated by endothelin-1 (ET-1). The method involves (i) determining whether the...
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6573061 |
Sarcomere protein composition
The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed...
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6544946 |
Inhibitors for use in hemostasis and immune function
The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a...
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6537567 |
Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells
Improved methods for the production of tissue-engineered constructs, including muscular tissue constructs such as vascular constructs, are disclosed. The methods include the use of improved...
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6521244 |
Body filling material
A body filling agent is formed of a collagen in the form of powder, fiber or gel, and at least one kind of implantable particles selected from a group consisting of implantable polymer and...
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6503540 |
Cloning and characterization of bves, a novel gene expressed in heart and uses thereof
The present invention is directed to cloning and characterization of bves (blood vessel/epicardial substance), a cDNA expressed in developing and adult heart and skeletal muscle cells in chick,...
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6479079 |
Anticalcification treatments for fixed biomaterials
A method for treating biomaterial is provided in which a biological tissue, typically after being cross-linked, is contacted with an anticalcification treatment solution under condition effective...
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6368614 |
Biological material, method of preparing such materials
A biological material is prepared for use in ophthalmology by steps of providing animal pericardium, subjecting the animal pericardium to multiple steps of freezing and thawing in a salt solution...
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6368573 |
Diagnostic uses of 2-substituted adenosine carboxamides
The present invention discloses a method for measuring myocardial function in a mammal in need of such measurement by: a) administering 2-substituted adenosine carboxamide derivatives at a dosage...
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6268336 |
Pharmaceutical composition for treatment of hepatic diseases
The present invention relates to a pharmaceutical composition for treatment of hepatic diseases which comprises erythropoietin as an active ingredient to reduce excess iron ions in the liver of a...
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6248933 |
Cellular basis of vascular-graft stenosis
A mouse model for vein graft stenosis useful for identifying compounds which reduce or prevent such stenosis, consisting of a mouse engrafted with an autogenous vein which exhibits detectable...
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6238429 |
Biologic cabling
A length of living conductive cells may be injected directly or may be grown to be attached to a fibrous matrix of material that provides for flexible structure so as to deliver a stimulation...
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6231879 |
Biocompatible devices with foam scaffolds
This invention is directed to methods of manufacturing implantable biocompatible cell encapsulation devices, wherein the cell encapsulation devices have a jacket made of a permeable, biocompatible...
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6203818 |
Nutritional supplement for cardiovascular health
A nutritional supplement for improving cardiovascular health via aiding in preventing, delaying the onset of and/or slowing the progression of atherosclerosis and coronary heart disease, the...
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6190916 |
Troponin I composition
The present invention relates to stable compositions useful as primary standards and calibrators and controls comprising a cardiac troponin I (cTnI) such as native, recombinant, addition and...
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6114180 |
Synthetic calibrators for use in immunoassays, comprising the analytes or partial sequences thereof which are conjugated to inert carrier molecules
The invention relates to synthetic calibrators for immunological tests, analyte-specific epitopes being coupled to other proteins or to synthetic carriers.
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5851554 |
Purified cardiac troponin I
A method is provided for isolating substantially intact cardiac troponin I from cardiac tissue comprising extracting the, troponin I and purifying it in the presence of an effective amount of a...
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5733549 |
Peptides including amino acid sequences selected from lipoprotein (a) and apolipoprotein (a), antibodies recognizing these amino acid sequences, and methods of determination using these antibodies
Amino acid sequences having specificity as lipoprotein (a) and low homology with LDL and plasminogen are selected from the amino acid sequence of lipoprotein (a), and antibodies to lipoprotein (a)...
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5716787 |
Immunological detection method for organ transplant rejection
Antibodies that are indicative of organ transplant rejection, for example, cardiac or kidney transplant rejection, and of associated pathological conditions, for example, accelerated (or...
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5675062 |
Cellular basis of transplant arteriosclerosis in mice
A mouse model for transplant arteriosclerosis useful for identifying compounds which reduce or prevent such arteriosclerosis, consisting of a mouse engrafted with a histoincompatible artery which...
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5645587 |
Prevention of calcification and degeneration of biological tissue grafts for implantation in humans
The present invention relates to chemical treatment for prevention of calcification and degeneration of biological tissue grafts used as a whole or in a part as heart valve substitutes, substitutes...
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5560937 |
Method for purification of cardiac troponin I
A method is provided for isolating substantially intact cardiac troponin I from cardiac tissue comprising extracting the troponin I and purifying it in the presence of an effective mount of a...
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5558875 |
Method of preparing collagenous tissue
A process of preparation of a collagenous prosthesis for removing cell membrane proteins from a biological collagenous tissue and preserving elasticity of the collagenous prosthesis comprises the...
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5534615 |
Cardiac hypertrophy factor and uses therefor
Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological...
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5403914 |
Biological mediators of immune functions
A chemotactic factor released from tissue in response to injury represents the initial signal that recruits neutrophils to the tissue. As released, the factor exists as a positively charged protein...
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5198216 |
Performance enhancing compositions of matter, and methods of preparing and utilizing same
A composition for enhancing the performance of animals, such as horses or dogs, is composed of adrenal and pituitary raw tissue concentrates, vitamin C, bioflavonoid complex, pantothenic acid,...
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4908206 |
Extracts of embryonic organs, process for their preparation and pharmaceutical preparation containing them
From organs of embryonic mammalia a new extract of active ingredients is recovered which extract can be used for controlling a reduced blood flow through periperhic organs and through the brain and...
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4749522 |
Supercritical fluid extraction of animal derived materials
Supercritical fluids (SCF) are found to be useful in extracting desired materials from animal tissues, cells, and organs. By varying the choice of SCF, experimental conditions, and animal source...
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4647455 |
Process for extracting atrial natriuretic factor
Diuretic and natriuretic extracts, at least partially characterized as peptides, have been obtained by homogenization of mammalian heart atria with an aqueous solution of a lower carboxylic acid....
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4544552 |
Process for the preparation of cell and tissue regenerating substances
Glycolipids having cell- and tissue-regenerating properties are isolated from the blood or organ homogenates of mammals by subjecting the starting material to autolysis and dialysis against an...
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4515778 |
Preparation for conditioning and grooming the hair
The present invention provides a preparation for conditioning and grooming the hair. The active ingredients are vegetable lecithins, as well as cytochromes, phosphatidyl inositols, phosphatides and...
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4485096 |
Tissue-equivalent and method for preparation thereof
A tissue-equivalent, useful in the treatment of burns or other skin wounds and in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by a...
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4374830 |
Platelet aggregating material from equine arterial tissue
Novel hemostatic agent comprises equine arterial fibrillar collagen in a carrier. The agent is useful for the aggregation of platelets for clinical diagnostic tests and for the clotting of blood,...
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4347243 |
Acid soluble, pepsin resistant platelet aggregating material
Acid soluble, pepsin resistant, platelet aggregating material isolated from equine arterial tissue by extraction with dilute aqueous acid, method of isolation and use to control bleeding.
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RE30239 |
Cell proliferation and tissue invasion inhibitor
A composition of matter having activity as an inhibitor of cell proliferation and tissue invasion is obtained by aqueous extraction of tissue having a high content of collagen and/or proteoglycans.
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4042457 |
Preparation of tissue invasion inhibitor and method of treatment utilizing the inhibitor
A composition of matter having activity as an inhibitor of cell proliferation is obtained by aqueous extraction of tissue having a high content of collagen and/or proteoglycans.
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3691274 |
COMPOSITIONS CONTAINING A HEART EXTRACT
The invention provides myocardiotonic compositions comprising a non-specific heart extract and one or more of adenosine-triphosphoric acid or salt thereof, aspartic acid or a salt thereof, and...
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3676551 |
PROCESS FOR OBTAINING EXTRACTS FROM ANIMAL TISSUES
Extracts of animal organs, useful in opotherapy, are prepared by removing from the organ aseptically collected immediately after slaughtering the animal, foreign matter, debris and fat. The...
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