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8048043 |
Method of administration of a pulmonary surfactant
The present invention concerns a method for treating a respiratory distress in a infant in need of such treatment, the method comprising intratracheal administration of a pulmonary surfactant by a...
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7582312 |
Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
Methods of producing lung surfactant formulations through solvent dissolution and lyophilization are described as well as surfactant formulations derived therefrom. Methods of treating respiratory...
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7538090 |
Exogenous surfactant protein B mimic
A composition including a C terminal region having residues corresponding to a peptide identified by PDB ID: 1RG3; an N terminal region having residues corresponding to a peptide identified by PDB...
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7498047 |
Methods for treatment of thiol-containing compound deficient conditions
Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system...
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7432308 |
Therapeutic compositions for the treatment of a respiratory tract disease
The equilibrium between G actin and F actin is shifted towards the F actin confirmation with compounds such as the ionic form of magnesium or potassium. The higher amount of F actin decreases the...
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7247317 |
Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS)
Novel compositions for the treatment of IRDS and ARDS are indicated which contain a compound of formula (I), in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable...
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RE39337 |
Nude mouse model for human neoplastic disease
A nude mouse model for human neoplastic diseases having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the...
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6982161 |
Process for the utilization of ruminant animal methane emissions
A process for the utilization of the methane contained within ruminant animal exhalation, specifically to a process that utilizes the methane contained within ruminant animal exhalation as a source...
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6838428 |
Surfactant protein D for the prevention and diagnosis of pulmonary emphysema
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted...
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6770619 |
Lung surfactant compositions with dynamic swelling behavior
Lung surfactant compositions are provided which can form a swelling phase when dispersed in a medium containing electrolytes. Hereby, a more active spreading of the lung surfactant into the alveoli...
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6569436 |
Method of using a vaccine
This invention is directed to methods of preventing or reducing the severity of asthma or the risk of development of same in an individual. The method relies on administration to the airways of the...
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6255354 |
Preparation of a pulmonary surfactant for instillation and oral application
A pulmonary surfactant formulation for instillation and oral application, containing at least 0.1% by weight of 2,3 -dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone in addition to an effective...
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6231879 |
Biocompatible devices with foam scaffolds
This invention is directed to methods of manufacturing implantable biocompatible cell encapsulation devices, wherein the cell encapsulation devices have a jacket made of a permeable, biocompatible...
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6228891 |
Use of 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone
2,3-Dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone can be used for the topical and oral treatment of diseases of the skin and the mucosae of the mouth, the stomach, the bowels, the vagina and the...
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6180142 |
Reduction of surfactant inactivation in pulmonary surfactant therapy
Nonionic hydrophilic polymers or carbohydrates are administered either individually or in conjunction with therapeutically active pulmonary surfactants for the treatment of a variety of lung...
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6129934 |
Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction
The present invention relates to the method of using a composition of matter that maintains the biophysical and physiological characteristics of natural surfactant, including the rapid and...
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5952303 |
Lyophilized pulmonary surfactant peptide compositions
An improved solid pharmaceutical composition comprising a lyophilized liposomal KL4 pulmonary surfactant composition comprising: (a) about 1 to about 10 percent weight KL4 polypeptide; and (b) 50...
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5708144 |
Process for the purification of natural pulmonary surfactant material using supercritical fluids
A process for purifying natural pulmonary surfactant by dispersing animal lung tissue on an inert carrier and extracting with a supercritical fluid.
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5667766 |
Non-human animal model of a human airway, methods of use
A non-human animal characterized by a human airway, the human airway being open-ended. The human airway is characterized by cells derived from the human respiratory system. The non-human animal and...
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5560935 |
Physiologically active substances extracted from activated tissues
The present invention provides a physiologically active substance which inhibits plasma kallikrein production, improves peripheral blood flow, and exhibits analgesic, antiinflammatory and...
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5552161 |
Low viscosity, highly concentrated surfactant suspension
Low viscosity, highly concentrated surfactant suspensions for replacement therapy In diseases of the respiratory tract are described. The suspensions are characterised in that they contain calcium...
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5538713 |
Primordial implants in immunodeficient hosts
Primordial tissue is introduced into immunodeficient hosts, where the primordial tissue develops and differentiates. The chimeric host allows for investigation of the processes and development of...
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5491284 |
Nude mouse model for neoplastic disease
A nude mouse model for human neoplastic disease having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the...
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5198216 |
Performance enhancing compositions of matter, and methods of preparing and utilizing same
A composition for enhancing the performance of animals, such as horses or dogs, is composed of adrenal and pituitary raw tissue concentrates, vitamin C, bioflavonoid complex, pantothenic acid,...
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5057324 |
Kallikrein inhibitor substance, a process for preparation and pharmaceutical compositions thereof
A physiologically active substance is extracted from infected tissues inoculated with a poxvirus. The novel substance of the present invention has inhibitory action against the formation of...
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5024995 |
Natural pulmonary surfactant, method of preparation and pharamceutical compositions
A pulmonary surfactant of animal origin made up of a high percentage of phospholipids (.perspectiveto.99%), by a protein fraction and characterized by the absence of carbohydrates and...
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4985254 |
Method of treating ischemic diseases
The present invention relates to physiologically active substances extracted from infected tissues inoculated with a poxvirus. The substances of the present invention have excellent actions to...
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4963358 |
Agent for inhibiting proliferation of human malignant tumor cells
An agent for inhibiting proliferation of human malignant tumor cells is obtained by culturing the human malignant tumor cells in a medium and removing the malignant tumor cells from the cultured...
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4908206 |
Extracts of embryonic organs, process for their preparation and pharmaceutical preparation containing them
From organs of embryonic mammalia a new extract of active ingredients is recovered which extract can be used for controlling a reduced blood flow through periperhic organs and through the brain and...
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4749522 |
Supercritical fluid extraction of animal derived materials
Supercritical fluids (SCF) are found to be useful in extracting desired materials from animal tissues, cells, and organs. By varying the choice of SCF, experimental conditions, and animal source...
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4571334 |
Composition for curing respiratory diseases
A composition for curing respiratory diseases which contains a medicine such as antibiotic, chemotherapeutic and anticancer drug for respiratory disease and lung surfactant.
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4544552 |
Process for the preparation of cell and tissue regenerating substances
Glycolipids having cell- and tissue-regenerating properties are isolated from the blood or organ homogenates of mammals by subjecting the starting material to autolysis and dialysis against an...
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4402872 |
Protein and process for isolating it
What are disclosed are an isolated tissue protein, denominated PP16, which can be used to prepare anti-sera useful as diagnostic agents, said protein being found in extracts of some human organs...
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4397839 |
Surface active material and process for preparing same
A surface active material having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. This material comprises, based on the dry weight of the material,...
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4338301 |
Lung tissue extract useful for treating hyaline-membrane disease and method for producing the extract
A surface active material may be produced from the lung tissue of mammal by means of employing an acetone-treatment procedure as well as an organic solvents mixture-treatment procedure other than...
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4190573 |
Process for the isolation of the polyvalent proteinase inhibitor
What is disclosed is a method for the isolation of the polyvalent proteinase inhibitor from aqueous extracts of animal organs by adsorbing the inhibitor from its aqueous solutions at pH 0.5 to 10.5...
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4083961 |
Plasminogen activator pharmaceutical compositions
The present invention relates to a pharmaceutical composition comprising a plasminogen activator and a polysaccharide sulphate. The invention also covers a process for preparing the pharmaceutical...
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3983004 |
Preparation of a diagnostic agent for measuring the coagulability of blood
A diagnostic agent containing thromboplastin sensitive to factor VII and factor X for measuring the coagulability of blood is prepared by extracting an aqueous suspension of thrombogenic tissue at...
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3846544 |
SPARINGLY-SOLUBLE KALLIKREIN-INACTIVATOR DERIVATIVE AND PROCESSES INVOLVING SAID DERIVATIVE
A sparingly soluble derivative of kallikrein-inactivator and metaphosphoric acid or metaphosphoric acid salts are prepared. The method may also be used as part of a purification procedure for...
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3558773 |
CRYSTALLINE KALLIKREIN-INACTIVATOR AND PROCESS FOR PREPARING THE SAME
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3810978 |
PROCESS FOR PRODUCING ANTILIPEMIC SUBSTANCE
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3308028 |
Process for the purification of biologically active preparations
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3181997 |
Process for preparing purified solutions of kallikrein inactivator
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2881114 |
Process for the removal of pyrogens from therapeutically active preparations with insoluble phosphate salts
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