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8137702 |
Conformable tissue repair implant capable of injection delivery
A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of...
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8084628 |
Substituted chroman derivatives, medicaments and use in therapy
Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and...
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8039257 |
Pre-transplant accomodated organs resistant to anti-donor immunity
This invention includes the composition of organ grafts accommodated prior to transplantation and therefore resistant to rejection by preformed antibodies. Accommodation is achieved within the...
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8039021 |
Bioresorbable polymer matrices and methods of making and using the same
A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a...
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8039016 |
Malleable implants containing demineralized bone matrix
Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids can include particulate collagen and particulate demineralized...
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7959682 |
Method for producing bone substitution material
In order to provide a bone substitution material which enables mechanical stability and long-term in-vivo biocompatibility which can also be used for guided bone healing, the invention provides a...
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7939108 |
Method of making demineralized bone particles
Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
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7914821 |
Pharmaceutical composition for prevention and/or treatment of bone loss
A pharmaceutical composition for preventing and/or treating bone loss is disclosed. The pharmaceutical composition includes an effective amount of a licorice, black bean, Cnidi Fructus, and buckhorn.
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7897180 |
Enamel matrix protein composition for treatment of systemic inflammatory response
The present invention relates to the use of a preparation of an active enamel matrix substance, such as an amelogenin, for the manufacture of a pharmaceutical composition for modulating an immune...
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7892577 |
Bone graft materials derived from mineralized gelatin
The present invention provides novel methods of forming mineralized gelatin carriers from bone. The present invention further provides mineralized gelatin carriers themselves; bone products that...
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7875296 |
Conformable tissue repair implant capable of injection delivery
A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of...
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7847072 |
Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
A method for purifying bone-derived osteogenic proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight...
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7838022 |
Malleable implants containing demineralized bone matrix
Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone...
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7838040 |
Method for regenerating cartilage
Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a...
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7812125 |
Cartilage intermediate layer protein 2 C1 and its use to differentiate osteoarthritis from rheumatoid arthritis and non-disease conditions
A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage intermediate...
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7811608 |
Tissue repair compositions and methods for their manufacture and use
An osteogenic composition is prepared by a process including the steps of subjecting demineralized bone to an extraction medium to produce an insoluble extraction product and a soluble extraction...
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7807463 |
Pre-transplant accommodated organs resistant to anti-donor immunity
This invention includes the composition of organ grafts accommodated prior to transplantation and therefore resistant to rejection by preformed antibodies. Accommodation is achieved within the...
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7785634 |
Bone graft materials derived from mineralized gelatin
The present invention provides novel methods of forming mineralized gelatin carriers from bone. The present invention further provides mineralized gelatin carriers themselves; bone products that...
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7776361 |
NELL-1 enhanced bone mineralization
This invention pertains to the discovery that the human NELL-1 gene induces or upregulates bone mineralization. The NELL-1 gene or gene product thus provides a convenient target for screening for...
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7758895 |
Methods for purifying insoluble bone gelatin
The present invention provides methods for purifying insoluble bone gelatin and uses for insoluble bone gelatin. The process for isolating insoluble bone gelatin from bone tissue includes grinding...
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7754244 |
Compositions and methods for treating or preventing hair loss and processes for making the same
The present invention relates to composition useful in growing hair. The compositions are particularly suited for re-growing hair in subjects who have experienced hair loss due to any cause. The...
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7722900 |
Effect of porcine sheath proteins on the regeneration activity of periodontal ligament
The purpose of this study was to identify the periodontal regeneration factors in enamel protein shown to induce cementum- and osteo-promotive activities in vivo. The cementum regeneration (CR), a...
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7709018 |
Composite structures containing hyaluronic acid the derivatives thereof as new bone substitutes and grafts
A composite material comprising: (i) hyaluronic acid and/or hyaluronic acid derivatives, (ii) demineralised bone and/or biocompatible partially or totally demineralised bone tissue matrix and/or...
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RE41286 |
Compositions for regeneration and repair of cartilage lesions
Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating...
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7670384 |
Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is...
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7658768 |
Bone graft substitute composition
Bone graft substitute compositions and methods of making the compositions are disclosed. In some embodiments, a method of making a composition includes contacting a mixing solution with a first...
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7651701 |
Bone cement composition and method of making the same
Disclosed herein is a composition suitable for use in spinal surgery. The composition generally includes a reaction product or settable mixture of first and second components, the first component...
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7622562 |
Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
A method for purifying bone-derived osteoinductive proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular...
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7608284 |
Enamel matrix protein composition for treatment of systemic inflammatory response syndrome
The present invention relates to the use of a preparation of an active enamel matrix substance, such as an amelogenin, for the manufacture of a pharmaceutical composition for modulating an immune...
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7534264 |
Delivery system for bone growth promoting material
A delivery system that includes a bone growth promoting material encapsulated within a water absorptive gelatinizable covering is used to promote bone growth in order to repair a bone defect and/or...
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7534419 |
Methods of diagnosis and treatment of osteoporosis
A method of detecting osteoporosis in a mammalian is disclosed herein which includes: a) obtaining a sample of a bone related tissue or cells; andb) measuring the concentration of at least a marker...
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7527799 |
ENA mineral bioactive solution, manufacturing method thereof and its application for the osteoporosis prevention
The present invention is related to a method of manufacture of an alkaline mineral bioactive solution of which raw materials are squid bones burnt at a high temperature and crushed powder of red...
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7399739 |
Vertebral augmentation composition and method
A flowable vertebral augmentation composition for the treatment and repair of a vertebral body defect, e.g., an osteoporotic condition, contains biocompatible, optionally osteoconductive, support...
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7371408 |
Bone graft substitute composition
A bone graft substitute composition comprising calcium sulfate; a mixing solution selected from the group consisting of sterile water, sodium chloride, phosphate buffered saline, potassium...
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7341999 |
Povidone-containing carriers for polypeptide growth factors
A liquid carrier medium is provided which is suitable for solubilizing growth factors, such as mixtures of bone morphogenetic proteins, that are found to induce an angiogenic response in ischemic...
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7335381 |
Transplantable particulate bone composition having high osteoinductive capacity and methods for making and using same
A particulate bone of defined sizes which has a unique property of direct bone osteoinduction without going through endochondral ossification stage is disclosed. The bone is not subjected to...
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7323193 |
Method of making demineralized bone particles
Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
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7316822 |
Conformable tissue repair implant capable of injection delivery
A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of...
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7294352 |
Matrix protein composition for treating inflammation
Active enamel substances may be used for the preparation of a pharmaceutical or cosmetic composition for healing of a wound, improving healing of a wound, soft tissue regeneration or repair, or for...
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7208179 |
Methods for treating disease and forming a supplemented fibrin matrix
This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one...
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7179492 |
Traditional chinese pharmaceutical formulation for treatment of paradentosis&comma process for preparation and use thereof
This invention involves a traditional Chinese medical preparation, its preparation and use. The present Chinese medicine that treats periodontitis is a pharmaceutically acceptable oral preparation...
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7132110 |
Tissue repair compositions and methods for their manufacture and use
An osteogenic composition is prepared by a process including the steps of subjecting demineralized bone to an extraction medium to produce an insoluble extraction product and a soluble extraction...
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7081240 |
Protein mixtures for wound healing
A protein mixture that is useful in the treatment of wounds, where the mixture is isolated from bone or is produced from recombinant proteins and may include two or more of BMP-2, BMP-3, BMP-4,...
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7033611 |
Matrix protein compositions for guided connective tissue growth
The present invention relates to the use of enamel matrix, enamel matrix derivatives and/or enamel matrix proteins as therapeutic and/or cosmetic agents. These substances are used for the...
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7022347 |
Restorative and grafting material for hard tissue defects prepared from animal teeth
The restorative and grafting material for reconstruction of hard tissue defects and the fabrication method of the same are provided. In particular, the restorative and grafting material of this...
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7005144 |
Antler composition and its manufacturing process
An antler composition and its manufacturing process are disclosed, the composition comprises an antler extract mixture and a matrix which comprises β-cyclodextrin, a higher ester compound, a ...
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6979670 |
Matrix protein compositions for grafting
Enamel matrix, enamel matrix derivatives and/or enamel matrix proteins are used in the preparation of a pharmaceutical composition for promoting the take of a graft, e.g. in soft tissue such as...
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6844424 |
Method for obtaining avian biological products
This invention provides a method for separating and extracting biological products of avian origin. The method allows for the production of avian cartilages and of active ingredients which can be...
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6830763 |
Continuous acidification demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby
The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by...
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6787159 |
Process for the preparation of a cosmetic extract from marine ooze
The invention relates to a process for the preparation of extracts from marine ooze. To extract a larger proportion of the cosmetically and balneologically active ingredients from the ooze, the...
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