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7625573 |
Sensitization process for antigen-presenting cells and means for implementing the process
The object of the invention is a novel sensitization process for antigen-presenting cells, novel means for implementing the process and novel membrane vesicles possessing immunogenic potency. The...
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7479269 |
Methods for selectively enriching TH1 and TH2 cells
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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7393628 |
Method for enriching adherent monocyte populations
The present invention provides methods and apparatus for the rapid and efficient collection and purification of activated monocytes. The methods and apparatus of the present invention provide means...
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7364729 |
Method of inducing a CTL response
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system....
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7232566 |
Methods for treating HIV infected subjects
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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7179447 |
Type I interferon-producing cells and uses thereof
The present invention provides compositions for the treatment, inhibition or prevention of diseases or disorders, including cancer, immune diseases or disorders, and infectious diseases, comprising...
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7175843 |
Methods for selectively stimulating proliferation of T cells
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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7169547 |
High concentration white blood cells as a therapeutic product
A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in...
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7144575 |
Methods for selectively stimulating proliferation of T cells
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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7094378 |
Method and apparatus for inactivation of biological contaminants using photosensitizers
Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein,...
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7078034 |
In vitro activated γ δ lymphocytes
Patients who develop increased numbers of γδ+ cytotoxic T lymphocytes 2–6 months after allogeneic bone marrow transplantation are less likely to relapse than those who do not. The γδ+ T cells...
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7041302 |
Therapeutic modulation of the tumor inflammatory response
The invention relates to compositions, kits, and methods for alleviating cancer (i.e., a tumor) in a human patient. The therapeutic modality effected by the invention involves inducing a type 1...
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6994851 |
Method of inducing a CTL response
A method of inducing a cytotoxic T-lymphocyte (CTL) response to an antigen is disclosed. The method involves delivering the antigen to the lymphatic system of an animal regularly over a sustained...
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6899863 |
Method for preparing membrane vesicles
This invention relates to a method of preparing membrane vesicles from a biological sample, characterised in that it comprises at least one anion exchange and/or gel permeation chromatography...
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6844011 |
Methods for inhibiting rejection of transplanted tissue
A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell...
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6783987 |
Method for obtaining components from cultured leucocyte
A method for obtaining leucocyte components from human blood including (A) a first step for fracturing the cell membrane of leucocytes of human blood by using a freezing and defrosting method, a...
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6713056 |
Combined preparation for the treatment of neoplasic diseases or of infectious diseases
The present invention relates to combined preparation containing as active substance the following individual components, in the form of a kit-of-parts: monocyte derived cells, particularly...
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6713053 |
Use of IL-7 for treating auto-immune diseases and insulin-dependent diabetes mellitus in particular
The use of interleukin 7 or T cells pre-incubated in the presence of IL-7 for preparing a drug or pharmaceutical composition for treating an auto-immune disease, particularly an auto-immune disease...
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6696092 |
Endothelial lining effects and treatment of vasospastic disorders
Vasospastic disorders are treated by administering to the patient an aliquot of autologous blood which has been subjected simultaneously to heat, ultraviolet irradiation and oxidative environment...
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6686332 |
Method of treating depressed reticuloendothelial system function
The present invention provides methods of treating adverse physiological effects associated with depressed reticuloendothelial system function comprising administering to a subject suffering from...
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6673832 |
Methods for identifying compounds for treating pain
The invention provides a method of determining whether a compound alleviates vasoconstriction-independent nerve pain mediated by endothelin-1 (ET-1). The method involves (i) determining whether the...
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6669965 |
Method of treating atherosclerosis
A method of treating or preventing atherosclerosis in a mammalian subject comprises: (a) extracting the aliquot of blood from the subject; (b) treating the aliquot of blood ex vivo with at least...
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6653063 |
Hematology composition using preserved white blood cells in combination with source particles to simulate native white blood cells and method of making same
A hematology control composition and method of making the composition is provided. The control employs a plurality of components including a synthetic plasma component, a red blood cell component,...
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6632622 |
Assay for evaluation of cellular response to allergens
An assay method for detecting the response or activation of cells, including lymphocytes, and a method for detecting immunological sensitization in a subject, which involves the introduction of...
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6596691 |
Therapeutic uses of BPI protein products for human meningococcemia
Methods and materials for the treatment of human meningococcemia are provided in which therapeutically effective amounts of BPI protein products are administered.
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6593457 |
Lymphocyte-derived antimicrobial protein (LDAP) and methods of isolating and producing and using the protein
A purified, soluble lymphocyte-derived antimicrobial protein that has a molecular weight of 16 kD on SDS-PAGE, is inactivated by heating at 56° C. for 30 minutes or by treatment with trypsin, is...
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6589526 |
Enrichment of dendritic cells from blood
A method for the enrichment of dendritic cells from the peripheral blood of a mammal is described. Peripheral blood having mononuclear cells from a mammal is provided. The mononuclear cells are...
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6586400 |
Human therapeutic uses of BPI protein products
Disclosed are methods for treatment of humans exposed to bacterial endotoxin in circulation by administration of bactericidal/permeability-increasing (BPI) protein products. Serologically and...
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6497876 |
Method of stimulating an immune response with activated dendritic cells
Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols....
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6485928 |
Use of granulysin as an antimicrobial agent
The T cell activation marker, granulysin, is demonstrated to be an effective antimicrobial agent. It is used in vitro and in vivo to reduce the population of viable cells in a microbial population....
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6362003 |
Hematological reference control composition containing leukocyte analogs, methods of making, and uses thereof
A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an...
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6352694 |
Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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6303152 |
Process for the production of substances that have been bactericidally treated and/or exhibit immune-modulatory activity, and the use thereof
A process is disclosed for the production of immune-genetically active suspensions of which the initial substances are fluids or tissues from the human or animal body. Autohemotherapy,...
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6284285 |
Tissue repair promoting composition
A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first...
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6255278 |
Composition containing pooled transferrins as an active principle for the induction of immune tolerance against antigens
A method for controlling immune reactions to a foreign tissue or a foreign cell in a recipient host mammal to enhance tolerance of the recipient host mammal towards a grafted foreign tissue or a...
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6231879 |
Biocompatible devices with foam scaffolds
This invention is directed to methods of manufacturing implantable biocompatible cell encapsulation devices, wherein the cell encapsulation devices have a jacket made of a permeable, biocompatible...
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6132775 |
Therapeutic uses of biologically active bactericidal/permeability-increasing protein fragments
Therapeutic methods using a purified isolated human bactericidal/permeability-increasing protein and biologically-active fragments thereof is provided.
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6093801 |
Recombinant analogs of bactericidal/permeability increasing protein
The present invention provides a composition comprising a BPI Protein and an anionic compound which composition exhibits (1) no bacterial activity and (2) endotoxin neutralizing activity. Also,...
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6093381 |
Modulation of the sensitivity of tumor cells to chemotherapeutics
Disclosed is a method for improving the treatment of a cancer patient which is undergoing (adjuvant) chemotherapy. Prior to or concomitant with the patient receiving adjuvant chemotherapy, the...
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6060643 |
Mouse model with human immune system
The present invention provides a non-human genetically immunodeficient mammal the peripheral blood of which contains a non-lethal percent of T-cells of human origin which is at least 20% as well as...
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5962325 |
Three-dimensional stromal tissue cultures
The present invention relates to a method of stimulating the proliferation and appropriate cell maturation of a variety of different cells and tissues in three-dimensional cultures in vitro using...
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5945399 |
Therapeutic uses of BPI protein products in humans with hemorrhage due to trauma
Methods and materials for the treatment of humans suffering from hemorrhage due to trauma are provided, in which therapeutically effective amounts of BPI protein products are administered.
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5888551 |
Hair growth stimulating composition
The present invention relates to compositions useful in the stimulation of hair growth. These compositions comprise a conditioned medium obtained from a cell culture of human mononuclear cells or a...
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5882934 |
Composition and method for hemoglobin and cell analysis
A cyanide-free lytic reagent composition and method for measuring the total hemoglobin concentration in a blood sample, for counting the number of leukocytes and for deferential counting of...
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5874307 |
Process for induction culture of cytotoxic T lymphocytes having killing activity against tumor cells
A process for an induction culture of a cytotoxic T lymphocyte having cell killing activities against a tumor cell which comprises the step of coculturing a tumor tissue containing said tumor cell...
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5861311 |
Preserved, non-infectious control cells prepared by the modulation or modification of normal leukocytes
The invention describes the preparation of preserved, non-infectious control cells. The control cells are prepared by modification, activation or otherwise changing selected normal leukocyte cells,...
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5861158 |
Method and composition for transfer of active tumor-specific immunization from an immunized allogeneic bone marrow donor
This invention provides a method of improving a transplantation of hematopoietic cells from a donor to a recipient to treat a hematopoietic cell tumor in the recipient comprising immunizing the...
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5834027 |
Injection of rhea and ostrich oils in animals
A method of treating animals, particularly rhea and ostrich chicks with adipose depletion, by injection with an oil derived from rhea or ostrich adipose or by injection with an active component of...
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5820872 |
Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor
Methods and pharmaceutical compositions for improving the effectiveness of radiation therapy for treating a subject having an internal solid tumor malignancy are disclosed. The methods include...
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5820856 |
Modified TALL-104 cells to treat cancer
This invention provides a method of using modified human cytotoxic TALL-104 cell line, which is characterized by activity against tumor cells. More particularly, the method comprises treating bone...
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