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7341873 |
Method for determination of platelets quality
There is provided a method for assessing the quality of platelet concentrates for determining their suitability for transfusion. More specifically dynamic light scattering measurements of the...
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7202020 |
Compositions, methods and apparatuses for preserving platelets
A platelet composition suitable for direct transfusion into a patient is provided. The platelet composition includes a preservation medium comprising plasma and a gel-forming material in a...
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7169606 |
Lyophilization of human platelets
A protectant mixture for use in preserving biological materials comprising at least one polyhydroxy compound, and phosphate ions; a preservation medium comprising a biological material, at least...
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7112342 |
Enriched platelet wound healant
An improved platelet gel wound healant, and methods of preparation and use thereof for healing wounds are disclosed. The improved wound healant comprises a therapeutically effective amount of...
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7094378 |
Method and apparatus for inactivation of biological contaminants using photosensitizers
Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein,...
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7011852 |
Separation of platelets from whole blood for use as a healant
A method is described for separating, retrieving and concentrating platelets from whole blood relying on aggregation of the platelets followed by filtration. This method eliminates the need of a...
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6942880 |
Autologous platelet gel having beneficial geometric shapes and methods of making the same
The present invention relates to the production of platelet gels formed into beneficial geometric shapes. Specifically the present invention provides a simpler way to introduce platelet gel for...
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6863829 |
Anti-bacteria agent made from shell, and methods for purifying and desalinating water and for washing agricultural products with use thereof
For providing an anti-bacteria which is made from a natural material, therefore harmless if it is absorbed in the human body, can be produced in mass production with low cost, and shows a high...
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6841170 |
Process for preparing an autologous platelet gel and membrane thereof
A process is disclosed for preparing an autologous platelet gel and membranes thereof comprising mixing a platelet concentrate with a calcium salt and batroxobin. This process encompassing the use...
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6830762 |
Autologous fibrin sealant and method for making the same
The present relates to an autologous bioadhesive sealant composition or fibrin glue prepared by a two-phase method, wherein all of the blood components for the bioadhesive sealant are derived from...
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6723497 |
Therapeutic platelets and methods
A dehydrated composition is provided that includes freeze-dried platelets. The platelets are loaded with trehalose which preserves biological properties during freeze-drying and rehydration. The...
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6695805 |
Systems and methods for removing free and entrained contaminants in plasma
Systems and methods treat plasma carrying contaminants and leukocytes that are capable of entraining contaminants. The systems and methods separate leukocytes from the plasma by filtration, thereby...
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6653063 |
Hematology composition using preserved white blood cells in combination with source particles to simulate native white blood cells and method of making same
A hematology control composition and method of making the composition is provided. The control employs a plurality of components including a synthetic plasma component, a red blood cell component,...
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6649072 |
Method for producing autologous platelet-rich plasma
A novel method for producing an autologous platelet rich blood composition is described. The resulting blood composition is useful in procedures for enhancing bone fusion, hemostasis, and repairing...
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6610291 |
Ready-to-use ristocetin cofactor test reagent possessing long-term stability
The present invention relates to a ready-to-use ristocetin cofactor test reagent possessing long-term stability for use in coagulation tests.
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6599881 |
Antithrombotic materials and methods
Antithrombotic materials and methods are provided for the treatment of thrombotic disorders, in which therapeutically effective amounts of BPI protein products are administered.
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6599724 |
Stable factor VIII compositions
The present invention relates to a pharmaceutical composition comprising Factor VIII and the divalent metal ions Zn 2+ and Cu 2+ , optionally in the presence of Ca 2+ ions and/or Mn 2+ ions,...
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6596180 |
System and method for the production of autologous platelet gel
A centrifuge system for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet...
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6589759 |
Compositions and methods for producing platelets and/or proplatelets from megakaryocytes
The present invention describes novel compositions and methods to enhance the in vitro and in vivo production of platelets and/or proplatelets from megakaryocytes. The present invention describes...
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6362003 |
Hematological reference control composition containing leukocyte analogs, methods of making, and uses thereof
A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an...
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6303152 |
Process for the production of substances that have been bactericidally treated and/or exhibit immune-modulatory activity, and the use thereof
A process is disclosed for the production of immune-genetically active suspensions of which the initial substances are fluids or tissues from the human or animal body. Autohemotherapy,...
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6284871 |
Factor IX binding peptides, derived from factor VIII and their use as inhibitors of blood coagulation
The present invention relates to biologically active peptides which specifically inhibit the Factor IX-dependent pathway of blood coagulation. These peptides are based on a specific motif which...
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6284285 |
Tissue repair promoting composition
A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first...
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6221575 |
Methods for producing dried storage-stable platelets and compositions obtained thereby
The invention provides methods for drying platelets to obtain compositions which are storage stable over a wide range of temperatures and for an extended period of time. The invention also provides...
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6139878 |
Method for preparing a diafiltered stabilized blood product
A method using diafiltration to prepare a blood product is described. The method removes contaminating plasma proteins from whole blood or blood products. Diafiltration may be used on...
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6114135 |
Multiple coagulation test system and method of using a multiple coagulation test system
A multiple coagulation test system and method for determining an appropriate coagulation promoting substance for administration to a patient as a therapy for improving clotting function in said...
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6087118 |
Method for diagnosing alzheimer's disease
A method is provided for diagnosing Alzheimer's disease using human blood platelets wherein the presence or absence of functioning calcium-dependent potassium channels in blood platelets are...
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6046340 |
Imidazole containing pseudodipeptide product and compositions containing the same
Product pseudodipeptide of general formula: ##STR1## in which A is: a) under the form: ##STR2## B represent an amine which nitrogen atom which is directly linked to the atom of carbon and chosen...
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6033688 |
Cystic fibrosis therapy
The invention provides methods for treating cystic fibrosis and other pathological conditions in mammals using hepatocyte growth factor ("HGF"). The invention also provides articles of manufacture...
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6022306 |
Method and apparatus for collecting hyperconcentrated platelets
The instant invention relates to a method and the apparatus for collecting a hyperconcentrated platelet product. A fluid containing platelets and other particles flows into a fluid chamber at a...
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5993804 |
Pharmaceutically acceptable fixed-dried human blood platelets
Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic...
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5965349 |
Methods of photodecontamination using synthetic media
Methods of photodecontamination are described which employ phosphate buffered aqueous solutions. Blood products comprising plasma are diluted with these solutions and treated with psoralen.
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5945297 |
Process for screening candidate agents that modulate the hemostatic system
The present invention provides a method for screening candidate agents to identify compounds that modulate the hemostatic system. The method of the invention involves a screening medium comprised...
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5919909 |
Process for the preparation of factor IX from biological sources
A process for the preparation of factor IX from a biological source by chromatography involves prior treatment with ammonium sulfate as a protein precipitant at a concentration of from 1.5-2.3 mol/l.
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5902608 |
Surgical aids containing pharmaceutically acceptable fixed-dried human blood platelets
Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces;...
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5876676 |
Preservation of blood platelets
Methods and compositions for preserving platelets at cryogenic temperatures with retention of hemostatic activity are provided. The compositions include a first agent for inhibiting actin filament...
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5843436 |
Method of preventing and treating bacterial infection of sutures and prosthetic devices, and promoting ingress of leukocytes into tumor foci
An agent capable of inhibiting signalling mediated by a β 1 integrin cell surface receptor of leukocyte cells will treat a bacterial infection associated with a surface of a foreign body over and...
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5834424 |
Use of lactoferrin for therapy of acute of chronic infectious diseases by the intracellular gram-positive pathogens streptococcus pyogenes and staphylococcus aureus
Compositions of lactoferrin, ovotransferrin or serotransferrin in apo or iron-saturated form are provided which have bacterial anti-invasive properties against Streptococcus pyogenes and...
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5831026 |
Process for purifying factor VIII
A process for reducing degradation of recombinant coagulation factor VIII caused by metal-dependent proteases requiring Zn 2 + for activity or containing Zn 2 + as an integral part of their...
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5795571 |
Composition containing autologous thrombin blood fraction for use in a medical procedure
The subject invention relates to the use of thrombin in a medical procedure in an animal. More specifically, the subject invention relates to such use of thrombin wherein the thrombin is a thrombin...
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5773033 |
Fibrinogen/chitosan hemostatic agents
Autologous fibrinogen and chitosan containing hemostatic adhesive agents having strong hemostatic properties when applied to a bleeding wound or vessel. Fibrinogen is isolated and purified using...
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5759764 |
Cryopreservation solution
A simple, inexpensive, physiologically compatible, cryopreservation solution which includes the innocuous components of (i) glycerol, (ii) an alkali metal chloride salt, (iii) a monosaccharide, and...
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5733545 |
Platelet glue wound sealant
A plasma-buffy coat concentrate that comprises plasma, platelets at a concentration of at least 1.0×10 9 cells/ml, and fibrinogen at concentration of at least 5 mg/ml is described. The...
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5731007 |
Pharmaceutical composition for skin diseases
The present invention relates to novel pharmaceutical composition for skin diseases, in particular to novel pharmaceutical composition useful for treatment of skin diseases; e.g. burns, wounds,...
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5710131 |
Inhibitor of collagen-stimulated platelet aggregation
A protein isolated from crude extracts of Hirudo medicinalis is disclosed, which strongly inhibits the binding to collagen of platelets and their subsequent activation, which leads to platelet...
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5618662 |
Intravenous administration of psoralen
Intravenous administration of 8-methoxypsoralen is disclosed, and more specifically intravenous administration of 8-methoxypsoralen-blood preparations, including platelets. Random donor platelet...
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5599558 |
Selecting amounts of platelet releasate for efficacious treatment of tissue
A method of making a platelet releasate product is disclosed involving performing an assay on a platelet releasate sample for a component of the releasate and forming platelet releasate product by...
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5580779 |
Method for inducing human myocardial cell proliferation
The present invention relates to a method for inducing myocardial cell proliferation. It is based, at least in part, on the discovery that adult human myocardial cells may be induced to proliferate...
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5578326 |
Method and an apparatus for preparing tissue repair promoting substances
A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first...
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5569579 |
Synthetic-based platelet storage media
Synthetic-based platelet storage media are provided along with methods of using the media for the storage of platelets for an extended period of time. The synthetic-based media contain phosphate...
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