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5545516 |
Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
This invention provides methods for inactivating pathogenic contaminants in whole blood, plasma, cellular blood components, or in any combination thereof, by adding a phenthiazin-5-ium dye(s)...
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5487971 |
Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes...
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5474891 |
Plasma-based platelet concentrate preparations with additive
The present invention provides a composition and method for improving the storage of platelets and optimizing the viability of stored platelets. The present invention allows platelets to be stored...
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5466573 |
Platelet storage method in a medium containing acetate and phosphate
The invention is an improved platelet storage method and composition. Medium for the storage of platelets for transfusion comprising acetate or an acetate-like compound and phosphate is disclosed.
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5462752 |
Inhibition of platelet binding
Methods for inhibiting the attachment of platelets to a site of an injury are provided. The methods involve administering to a subject that has sustained an injury an effective amount of a platelet...
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5459030 |
Synthetic media compositions for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen
Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the...
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5428008 |
Therapeutic composition of micellar structures capable of promoting hemotasis
A reconstituted platelet membrane vesicle or micellar structure preparation is provided. The preparation, directed at promoting hemostasis, may be prepared from proteins and lipids derived from...
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5378601 |
Method of preserving platelets with apyrase and an antioxidant
The invention provides a method and composition for preserving platelets which is based on the use of a composition which includes apyrase and an antioxidant. Preferred compositions will also...
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5376524 |
Platelet storage medium containing acetate and phosphate
The invention is an improved platelet storage method and composition. Medium for the storage of platelets for transfusion comprising acetate or an acetate-like compound and phosphate is disclosed.
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5366869 |
Multiple coagulation test device and method
A multiple coagulation test device has a plurality of tubes, each tube having associated coagulation detection means, and containing a treatment dosage of a coagulation enhancing agent. Whole blood...
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5332578 |
Platelet membrane microparticles
A heat-treated, viral-inactivated platelet membrane microparticle product is provided. The microparticles may be prepared from outdated mammalian platelets. The microparticle product contains...
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5318782 |
Method for preparing tissue repair promoting substances
A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first...
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5304542 |
Use of platelet factor 4 to inhibit osteoblast proliferation
The invention features a method for inhibiting proliferation of osteoblasts in a mammal in need of such inhibition. The method entails administering PF4. PF4 can be used to treat both diseases...
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5292524 |
Blood platelet loaded with diagnostic or therapeutic-containing liposome or reconstituted Sendai virus
The invention provides loaded platelets that include an absorbed loading vehicle having associated diagnostic or therapeutic agents. A method of loading platelets with diagnostic or therapeutic...
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5236716 |
Platelets concentrate with low white blood cells content
Platelet concentrate containing less then 10 6 white blood cells and prepared from a unit of whole blood sample in a closed multiple blood bag system within less than about eight hours after the...
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5213814 |
Lyophilized and reconstituted blood platelet compositions
A process and medium are disclosed for the lyophilization of cells, specifically platelets, and cell-like matter, which comprises the use of solutions including monosaccharide hexoses and pentoses,...
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5213813 |
Pyridoxal-5'-phosphate as an in vitro blood platelet stabilizer
The use of pyridoxal-5'-phosphate as an in vitro anticoagulant agent which retains the platelet activity of stored whole blood or stored plasma for more than about six hours is disclosed.
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5200199 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Method for preparing tissue repair promoting substances
A method for isolating tissue repair promoting substances from human or animal blood which comprises collecting the human or animal blood from a single human or animal individual in a first...
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5185160 |
Platelet membrane microvesicles
A heat-treated, viral-inactivated platelet membrane microparticle fraction is provided. The microparticles may be prepared from outdated platelets. The microparticle fraction is substantially free...
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5178883 |
Method for promoting hair growth
Platelet enriched plasma is produced from blood. The platelets are activated by thrombine which causes therelease of platelet-derived growth and angiogenesis factors. A carrier such as a...
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5176921 |
Method of blood component decontamination by glucose addition
Biological compositions are freed of functional polynucletides by treatment of the biological composition with psoralen derivatives under irradiation conditions in which the proteins retain their...
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5165938 |
Wound healing agents derived from platelets
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5147776 |
Use of 2,5-anhydromannitol for control of pH during blood storage
2,5-anhydro-D-mannitol is added to blood platelet storage containers at a sufficient level to maintain pH stability of blood platelets within the suitable range (pH 7.2 to 7.4) for use in blood...
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5128150 |
Albumin enhanced antiviral blood product treatment and product produced
The treatment of blood product to inactivate or destroy infective viruses found in animal fluids and tissues, such as the cytomegalovirus, by mixing the blood product with an effective amount of...
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5019402 |
Composition and procedure for disinfecting blood and blood components
There is disclosed a composition and process for disinfecting or essentially sterilizing blood fractions and components of blood. The composition is formed by adding a chlorine dioxide liberating...
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4994367 |
Extended shelf life platelet preparations and process for preparing the same
A first aspect of the present invention is a blood platelet preparation comprising blood platelets, an adenylate cyclase stimulator, a phosphodiesterase inhibitor, a thrombin inhibitor, and a...
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4992363 |
Method for preparing glucose free media for storing blood platelets
Novel methods and storage media for storing platelets in a viable condition for at least five days are disclosed. The disclosed methods comprise the steps of providing a platelet rich suspension of...
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4983581 |
Wound healing composition of IGF-I and TGF-β
Healing an external wound of a mammal by administering to the mammal a composition containing purified Insulin-like growth factor-1 and purified transforming growth factor beta.
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4954264 |
Apparatus for separating mononuclear cells from blood and method of manufacturing and using the same
A device for separating mononuclear cells from blood includes a collection tube, a first layer of a liquid density gradient material placed in the tube, a second layer of a gel-like substance...
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4940581 |
Platelet cryopreservation
A method for preserving blood platelets by freezing the platelets in contact with a cryoprotectant solution containing a sufficient quantity of prostacyclin for the substantially complete...
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4925665 |
Glucose free primary anticoagulant for blood containing citrate ions
The present invention provides a novel primary citrate anticoagulant which is essentially free of glucose and its use to optimize the viability of stored platelets. The present invention allows...
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4900541 |
Sunscreen composition
A skin care composition which contains platelet derived growth factors is provided. Such a composition in the form of a shave cream or foam, after shave lotion, moisturizing cream, sun tan lotion,...
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4828976 |
Glucose free media for storing blood platelets
Novel methods and storage media for storing platelets in a viable condition for at least five days are disclosed. The disclosed methods comprise the steps of providing a platelet rich suspension of...
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4764463 |
Platelet cyropreservation
A method for preserving blood platelets by freezing the platelets in contact with a cryoprotectant solution containing a sufficient quantity of prostacyclin for the substantially complete...
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4753797 |
Enhancing platelet morphology prior to patient use
Platelet morphology in platelet concentrates is significantly enhanced by subjecting the platelets to a gentle heating step. Platelets heated at 37° C. for one hour have at least a 25% increase in...
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4695460 |
Synthetic, plasma-free, transfusible platelet storage medium
The invention is a sterile, plasma-free platelet storage medium. The platelet storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte...
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4680177 |
Processes for the production of blood products
Blood products and derivatives, such as procoagulants--e.g. Factor VIII and rothrombin--plasma proteins, immunoglobulin and complement growth factors and various leucocytes, are obtained from shed...
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4676983 |
Tumor cytostatic-citocidal factor from blood platelets
A tumor cytostatic-cytocidal factor is produced by disrupting platelets, extracting the disrupted platelets with an acidic aqueous solution or an acidic water-organic solvent mixture, and, after...
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4656035 |
Method of separating blood platelets
A method of obtaining young blood platelets is disclosed which comprises adding at least one lectin to a mixture of blood platelets allowing this mixture to agglutinate, isolating the agglutinated...
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4608255 |
Biocompatible method for in situ production of functional platelets and product produced thereby lacking immunogenicity
The present invention discloses the effect of ultraviolet (UV) radiation on platelet concentrates collected in a plastics container, particularly in a polypropylene bag. Samples irradiated at 310...
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4505822 |
Process for separating substances from one another using a fibrin gel filter
There is disclosed a filter comprising fibrin in gel form, the gel having substantially uniform pore sizes, and the filter comprising means for retaining the shape of at least one surface of the...
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4489162 |
Fresh blood (unfixed) hematology control
Hematologic control and calibration standards are disclosed which are essentially plasma-free. These controls are prepared by the suspension of red blood cells in an appropriate buffer containing a...
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4485096 |
Tissue-equivalent and method for preparation thereof
A tissue-equivalent, useful in the treatment of burns or other skin wounds and in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by a...
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4479896 |
Method for extraction localization and direct recovery of platelet derived growth factor
A process for the localization and direct recovery of active platelet derived growth factor (PDGF) from stained sodium dodecyl sulfate/polyacrylamide gels is provided. This technique allows the...
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4471051 |
Stabilization of neutrophils and platelets
Neutrophils and platelets from human blood are stabilized for storage and subsequent reconstitution for use by reacting with a chemical cross-linking agent having functional groups reactive to form...
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4455299 |
Storage of blood platelets
Blood platelet pH is maintained between 6.0 and 7.6 for up to at least five days in relatively low gas permeability containers, e.g., standard polyvinyl chloride containers, by exposing the...
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4427651 |
Enriched plasma derivative for enhancement of wound closure and coverage
A sprayable preparation for accelerated hemostasis and optimized biochemical control of wound closure contains a powdery mixture of 15 to 60% by weight of thrombin, 5 to 80% by weight of a...
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4427650 |
Enriched plasma derivative for advancement of wound closure and healing
A preparation for accelerated hemostasis and optimized biochemical control of wound closure ("tissue adhesive") consists only of solid, powdery, biologically active constituents and contains 60 to...
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4405719 |
Method of stabilizing platelets for determining multiple platelet parameters in reference control and calibrator compositions; diluents therefor; and combination stabilization procedures
This invention utilizes for stabilization of platelets a combination of iodoacetamide and an iminodiacetic acid or salt thereof, together with a compatible bacteriostatic agent, in an aqueous...
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4390619 |
Leukocyte or platelet storage using ion-exchange resins
A method of storing and preserving the shelf life of leukocytes or platelets suitable for transfusion is extended by maintaining viable platelets having adequate ATP and pH levels using an...
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