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5641622 |
Continuous centrifugation process for the separation of biological components from heterogeneous cell populations
A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a...
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5641637 |
Method of preparing lyophilized and frozen cell standards
A method is disclosed for preparing lyophilized and frozen cells as cytometry standards.
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5635387 |
Methods and device for culturing human hematopoietic cells and their precursors
Methods for increasing the number of human hematopoietic precursor cells in vitro are provided. The methods generally comprise (a) separating human hematopoietic precursor cells from mature...
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5614490 |
Administration of low dose hemoglobin to increase perfusion
This invention provides a method to therapeutically increase perfusion in a mammal comprising administering stroma-free hemoglobin at a dose ranging from the least amount effective to increase...
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5612060 |
Enhancement of transplant graft survival through nutritional immunomodulation and immunosuppressive therapy
An improved immunomodulatory therapy for enhancement of depressed host defense mechanisms as shown by improved allograft survival rates is disclosed. The therapy comprises the synergistic...
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5601972 |
Long term storage of red cells in unfrozen solution
A method for prolonging storage shelf-life of red blood cells under refrigerated conditions includes separating plasma from the red blood cells while retaining residual plasma and adding a...
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5599558 |
Selecting amounts of platelet releasate for efficacious treatment of tissue
A method of making a platelet releasate product is disclosed involving performing an assay on a platelet releasate sample for a component of the releasate and forming platelet releasate product by...
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5595735 |
Hemostatic thrombin paste composition
A hemostatic paste composition comprising a hemostatic effective amount of thrombin in a polyethylene glycol base which is preferably prepared by admixing an aqueous solution of thrombin and...
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5580779 |
Method for inducing human myocardial cell proliferation
The present invention relates to a method for inducing myocardial cell proliferation. It is based, at least in part, on the discovery that adult human myocardial cells may be induced to proliferate...
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5580781 |
Three-dimensional tumor cell and tissue culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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5578326 |
Method and an apparatus for preparing tissue repair promoting substances
A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first...
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5567443 |
Method of treating inflammatory diseases
A method of treating inflammatory diseases, in which peripheral blood of a patient suffering from an inflammatory disease is made into contact with a carrier whose affinity for...
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5563120 |
Cytokine preparation for immunotherapy
A cytokine composition is prepared for use in immunotherapy of various diseases. The composition is prepared by culturing leucocytes previously infected with a virus in a culture medium containing...
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5560935 |
Physiologically active substances extracted from activated tissues
The present invention provides a physiologically active substance which inhibits plasma kallikrein production, improves peripheral blood flow, and exhibits analgesic, antiinflammatory and...
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5545516 |
Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
This invention provides methods for inactivating pathogenic contaminants in whole blood, plasma, cellular blood components, or in any combination thereof, by adding a phenthiazin-5-ium dye(s)...
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5506112 |
Reagent used for determining factor VIII activity
To determine the factor VIII activity of a sample, the latter is reacted with a reagent containing thrombin, factor IXaβ, phospholipids and calcium ions so as to form a factor VIIIa-factor...
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5487971 |
Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes...
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5480773 |
Method for preserving blood using ascorbic acid tocopheryl phosphate esters
A method for the preservation of blood and a blood preserving composition comprising a phosphoric acid diester of the following formula: ##STR1## (wherein R 1 and R 2 are the same or different...
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5443984 |
Method for culturing mammalian cells in a medium containing fish serum
A method for culturing mammalian cells using fish serum. The method uses serum extracted from the blood of fishes to culture mammalian cells for various purposes. The technique has the key...
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5439944 |
Red blood cell substitute emulsions containing alkyl- or alkylglyucerophosphoryl choline surfactants and methods of use
Oil and water emulsions containing alkylphosphoryl choline or alkylglycerophosphoryl choline surfactants are disclosed. The surfactants have the following general structures: ##STR1## In the above...
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5432058 |
Method for measuring human cholesterol absorption using metabolically stable isotopes
This invention is a method for measuring the ability of a human to absorb cholesterol. The method uses two different cholesterol tracers, the first injected into the blood stream and the second...
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5425951 |
Method of reconstituting lyophilized cells
A process and medium are disclosed for the lyophilization of cells which comprises the use of solutions including monosaccharide hexoses and pentoses, and/or biocompatible amphipathic polymers to...
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5422393 |
Natriuretic hormone
A purified naturally occurring natriuretic compound, identified as Natriuretic Hormone, and a method for isolation of the compound. The natriuretic compound has a molecular weight of about 360, a...
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5409827 |
Blended bovine sera cellular growth media and their methods of production and use
The present invention provides media and methods for the maintenance or promotion of growth of a cellular line, particularly a hybridoma cellular line. A serum blend is disclosed comprising fetal...
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5407673 |
Fibrinolysis and fibrinogenolysis treatment
Disclosed is a fibrinolysis and fibrinogenolysis treatment which includes parenterally introducing into the body of a human patient human plasmin in fibrinolytically and fibrinogenolytically active...
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5397578 |
Method of treatment of chronic purulent inflammations of ear in children
A method for treating chronic, purulent, middle otitis in children, comprising administering, through a perforation into a middle ear cavity, a freshly prepared donor plasma of one of the parents...
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5332578 |
Platelet membrane microparticles
A heat-treated, viral-inactivated platelet membrane microparticle product is provided. The microparticles may be prepared from outdated mammalian platelets. The microparticle product contains...
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5318782 |
Method for preparing tissue repair promoting substances
A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first...
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5309723 |
Method of freezing red blood cells
A method of freezing a standard donor unit of red blood cells such that it can be stored for long periods and subsequently recovered in a form pure enough for transfusion purposes involves...
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5304325 |
Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
Oil and water emulsions containing alkylphosphoryl choline or alkylglycerophosphoryl choline surfactants are disclosed. The surfactants have the following general structures: ##STR1## In the above...
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5296467 |
Composition comprising an anticoagulant
Pharmaceutical compositions which consist essentially of a vascular anticoagulant annexine, Ca 2 +, Zn 2 +, and a pharmaceutically acceptable carrier are disclosed. Also disclosed are processes for...
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5294544 |
Biologically active factor
The invention comprises a factor having the following characteristics: a) It inhibits granulocyte-macrophage colony and cluster formation; b) It has a molecular weight of about 8 kDa as...
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5277915 |
Gel-in-matrix containing a fractured hydrogel
A three dimensional porous matrix, such as a reticulated open-cell foam, having within its matrix structure a mechanically-fractured hydrogel containing a network of fracture channels. The...
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5250303 |
Procedure for storing red cells with prolonged maintenance of cellular concentrations of ATP and 2,3 DPG
This invention provides an improved method for prolonging the shelf life of transfusible red blood cells by decreasing the effective osmolality of the suspending solution and increasing the...
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5240714 |
Non-digoxin-like Na.sup.+, K.sup.+ -ATPase inhibitory factor
A highly purified, Na + ,K + -ATPase inhibitory factor is disclosed herein. The factor does not cross-react with anti-digoxin antibody and exhibits uniquely characteristic UV absorbance maxima at...
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5232844 |
Photodynamic inactivation of viruses in cell-containing compositions
The present invention concerns the product produced by inactivating extracellular lipid enveloped pathogenic virus or intracellular pathogenic virus in a composition containing >1×10 9 ...
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5214033 |
Factor VIII coagulant polypeptides
Fragments of the factor VIII:C polypeptide have been discovered which exhibit highly specific factor VIII activity. Monoclonal antibodies to the polypeptide fragments and methods for the isolation...
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5213813 |
Pyridoxal-5'-phosphate as an in vitro blood platelet stabilizer
The use of pyridoxal-5'-phosphate as an in vitro anticoagulant agent which retains the platelet activity of stored whole blood or stored plasma for more than about six hours is disclosed.
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5200199 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST*** Method for preparing tissue repair promoting substances
A method for isolating tissue repair promoting substances from human or animal blood which comprises collecting the human or animal blood from a single human or animal individual in a first...
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5199942 |
Method for improving autologous transplantation
There is disclosed a method for autologous hematopoietic cell transplantation of patients receiving cytoreductive therapy, comprising: (1) obtaining hematopoietic progenitor cells from bone marrow...
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5186945 |
Blood plasma antiviral process and composition
The treatment of blood plasma to inactivate or destroy infective viruses, such as the cytomegalovirus CMV, by mixing the plasma with an effective amount of glycyrrhizic triterpenoid compounds is...
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5178884 |
Lyophilized and reconstituted red blood cell compositions
A process and medium are disclosed for the lyophilization of red blood cells which comprises the use of solutions including monosaccharide hexoses and pentoses, and biocompatible amphipathic...
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5149540 |
Thrombin composition for oral administration
A stable thrombin composition for oral administration having an excellent solubility is prepared with thrombin as a hemostatic ingredient, gelatin, albumin and glycine as a stabilizer and sucrose...
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5128150 |
Albumin enhanced antiviral blood product treatment and product produced
The treatment of blood product to inactivate or destroy infective viruses found in animal fluids and tissues, such as the cytomegalovirus, by mixing the blood product with an effective amount of...
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5128149 |
Enhanced blood product antiviral process and product produced
A transfusion blood product container for the introduction of one or more blood products, such as whole blood, platelet concentrations, leukocyte concentrations, plasma, phasma derivatives, whole...
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5108760 |
Enhances LAK cell activation by treatment of human peripheral blood mononuclear cells with amino acid amides
There is provided an improved process for enhanced LAK cell activation wherein the peripheral blood mononuclear cells are treated with an amino acid amide to yield depletion, prior to the...
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5106833 |
Coagulation inhibitors
Novel blood coagulation inhibitors are disclosed which are peptide fragments comprising (A) Kunitz-type domain two of lipoprotein-associated coagulation inhibitor which inhibits Factor Xa...
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5091363 |
Agent for the therapy of factor VIII-resistant hemophilia A, and a process for the preparation thereof
An agent for the therapy of hemophilia A which is resistant to treatment with factor VIII is described, and is obtainable by maintaining a mixture of factor VIII, antithrombin III, a phospholipid...
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5057324 |
Kallikrein inhibitor substance, a process for preparation and pharmaceutical compositions thereof
A physiologically active substance is extracted from infected tissues inoculated with a poxvirus. The novel substance of the present invention has inhibitory action against the formation of...
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5055485 |
Inactivation of viruses in cell- and protein-containing compositions using aryl diol epoxides
A process of inactivating infectious viruses in a cell-containing or a protein-containing composition containing such viruses, comprising contacting such composition with an effective amount of at...
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