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7582312 |
Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
Methods of producing lung surfactant formulations through solvent dissolution and lyophilization are described as well as surfactant formulations derived therefrom. Methods of treating respiratory...
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7537787 |
Method for modulating glutamate and/or aspartate release in a central nervous system locus
Methods and compositions are disclosed for providing prolonged-release of therapeutic agents by way of in situ stereotaxic implantation in specific loci, including pathways, to treat know...
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7534449 |
Targeted and high density drug loaded polymeric materials
Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to...
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7479490 |
Pellet for a presurrized pipeline
A system of equipment allowing addition of solid materials to a pressurized pipeline wherein said solid material is conveyed in such a way as to be readily dissolved by the liquid in said pipeline....
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7473433 |
Pulmonary delivery of polyene antifungal agents
The present invention provides spray-dried polyene compositions for oral inhalation to the lung. The polyene antifungal compositions demonstrate superior aerosol properties, do not exhibit...
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7442388 |
Phospholipid-based powders for drug delivery
Phospholipid based powders for drug delivery applications are disclosed. The powders comprise a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature...
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7442385 |
Chemoembolisation
A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer...
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7407667 |
Pesticidal preparations comprising copolymers
The present invention relates to aqueous concentrates and solid formulations of pesticide preparations comprising copolymers which may be obtained by copolymerization of a) glycerol, b) at least...
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7404966 |
Transfer-resistant makeup removing compositions
The invention relates to a cleansing composition suitable for topical application to human skin, more particularly to an oil-based cleansing composition containing a silicone elastomer gelling...
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7399488 |
Abuse-deterrent pharmaceutical compositions of opiods and other drugs
An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug...
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7291348 |
Compositions and methods for biodegradable microspheres as carriers of bioactive substances
A cost-effective, scalable technique for producing microspheres loaded with biologically active solid proteins is provided. The microspheres degrade over time and release biologically active VEGF,...
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7282221 |
Antiviral product, use and formulation thereof
An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the C max for the antiviral product being reached in less than about twelve...
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7279182 |
Formulation for spray-drying large porous particles
Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a...
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7276251 |
Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid
A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in...
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7252840 |
Use of simple amino acids to form porous particles
Particles having a tap density of less than 0.4 g/cm 3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred...
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7220433 |
Compositions for parenteral administration and sustained-release of therapeutic agents
The present invention is directed to parenterally-administrable microparticles for providing sustained-release of a therapeutic agent in the body, where the microparticles include a polymeric core...
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7217427 |
Polymersomes and related encapsulating membranes
The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more...
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7205343 |
Stabilized bioactive preparations and method of use
Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that...
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7195780 |
Nanoparticle delivery system
The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials. The invention also describes the use of such nanotubes for the...
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7179490 |
Sustained release ionic conjugate
A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded...
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7176171 |
Low-viscosity opacifiers without anionic surface-active agents
An emulsifier mixture for use in a wax-based opacifier composition is comprised of: (a) an alkyl and/or alkenyl oligoglycoside; (b) a fatty acid partial glyceride and optionally (c) at least one...
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7163697 |
Biodegradable polymer compositions, compositions and uses related thereto
The present application is directed to biodegradable polymers, compositions, including microspheres and nanospheres, formed of such polymers, and methods of using such polymers and compositions. In...
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7160557 |
Matrices formed of polymer and hydrophobic compounds for use in drug delivery
A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release...
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7141593 |
Pharmaceutical formulations
Improved pharmaceutical compositions are provided comprising one or more solubilized HIV protease inhibiting compounds having improved solubility properties in a medium and/or long chain fatty...
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7108859 |
Antineoplastic product, use and formulation thereof
An antineoplastic product is comprised of at least three dosages forms, each of which has a different release profile, with the C max for the antineoplastic product being reached in less than...
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7105174 |
Multiple-delayed release anti-neoplastic product, use and formulation thereof
An anti-neoplastic product is comprised of at least three delayed release dosages forms, each of which has a different release profile, with the C max for the anti-neoplastic product being reached...
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7101568 |
Methods and compositions for treating solid tumors
A biodegradable polymer composition comprising:
(a) a poly(phosphoester) biodegradable polymer and (b) at least one antineoplastic agent in an amount effective to inhibit the growth of a...
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7097849 |
Injectable aqueous dispersions of propofol
Irritation upon injection of a formulation containing propofol is reduced or substantially eliminated by administering a stable, sterile, and antimicrobial aqueous dispersion comprising a...
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7090831 |
Pharmaceutical aerosol formulation
The present invention relates to novel pharmaceutical aerosol formulations comprising: (A) salmeterol xinafoate in the form of particles coated by spray-drying with at least one surfactant in the...
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7074430 |
Controlled release tramadol tramadol formulation
A controlled release preparation for oral administration contains tramadol, or a pharmaceutically acceptable salt thereof, as active ingredient.
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7074417 |
Multiple-delayed release anti-viral product, use and formulation thereof
An anti-viral product is comprised of at least three delayed release dosage forms, each of which has a different release profile, with the C max for the anti-viral product being reached in less...
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7074395 |
Cosmetic formulations of quaternary ammonium compounds incorporating polyhydric alcohols
Cosmetic, dermatological and pharmaceutical compositions containing quaternary ammonium compounds, particularly for hair-treatment, require low setting points, good solubility and dispersibility in...
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7060263 |
Super absorption Coenzyme Q10
An improved soft gelatin formulation and process methodology that increases single Coenzyme Q 10 molecules presented to the absorption channels of the small intestines by providing medium chain...
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6994873 |
Multiparticulate formulations of lithium salts for oral administration suitable for once-a-day administration
This invention refers to:
multiparticulate formulations of Lithium salts for oral administration constituted by either modified release granules or mixtures of modified and conventional...
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6991804 |
Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia
The invention provides methods for treating injuries to one or more internal structures of a subject by administering a drug delivery vehicle to an external surface of the injured structure. The...
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6982091 |
Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy
Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.
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6979452 |
Low pH, high skin friction cosmetic creams
A high skin friction cosmetic composition that can provide the consumer-desired sensory properties of traditional vanishing creams, stable at low pH, containing solid asymmetric particles and an...
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6977087 |
Aerodynamically light particles for pulmonary drug delivery
Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically...
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6967028 |
Prolonged release microspheres for injectable administration
The present invention provides microspheres intended to be administered by injection comprising a protein active ingredient and an agent coating the active ingredient intended to prolong its...
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6953588 |
Multi-vitamin and mineral supplement
This invention is directed to a multi-vitamin and mineral supplement tailored to men and post-menopausal women, pre-menopausal women, and athletes which supplies the right amount of the right...
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6936277 |
Pharmaceutical excipient having improved compressibility
A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant...
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6921541 |
Formulations and methods for providing prolonged local anesthesia
A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible,...
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6881421 |
Nanoparticles comprising at least one polymer and at least one compound able to complex one or more active ingredients
Nanoparticles containing at least one active ingredient including at least one polymer, preferably a poly(alkylcyanoacrylate), in which the alkyl group, linear or branched, contains from 1 to 12...
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6808720 |
Charged lipids and uses for the same
The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and...
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6793938 |
Biodegradable compositions for the controlled release of encapsulated substances
Pharmaceutical compositions that enable the release of a physiologically active substance over a prolonged period of time following administration to a patient are described. The pharmaceutical...
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6746685 |
Bioabsorbable, biocompatible polymers for tissue engineering
Bioabsorbable biocompatible polymers which provide a good match between their properties and those of certain tissue structures are provided. The bioabsorbable biocompatible polymers can be...
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6743438 |
Colored contact lenses and method of making same
Optical lenses and methods of preparing the same, in which an active material encapsulated in resin capsules is impregnated in said lens, adjacent an optical surface thereof. The active material...
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6730319 |
Pharmaceutical compositions having depressed melting points
The present invention relates to pharmaceutical compositions that contain a solid pharmaceutically active compound having a melting point ≧37° C. and a fatty acid or a fatty acid salt or a...
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6726932 |
Fatty acid-containing composition
The present invention provides a composition for enhancing the pharmacological activity of a water-soluble silicate polymer which comprises the water-soluble silicate polymer and a saturated fatty...
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6706289 |
Methods and compositions for enhanced delivery of bioactive molecules
Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid...
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