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Document Title |
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7611542 |
Tissue treatment
A method of treating tissue includes placing substantially spherical polymer particles in the tissue. The particles include an interior region having relatively large pores and a first region...
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7588780 |
Embolization
Embolic polymer particles are described. For example, the particles include pores such that the predominant size of pores near the center of the particles is greater than the predominant size of...
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7585521 |
Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic...
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7531334 |
Polymeric microcarriers for cell culture functions
Polymeric microcarriers suitable for use in cell culture processes and the methods of making such polymeric microcarriers by emulsion/aggregation polymerization processes.
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7473433 |
Pulmonary delivery of polyene antifungal agents
The present invention provides spray-dried polyene compositions for oral inhalation to the lung. The polyene antifungal compositions demonstrate superior aerosol properties, do not exhibit...
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7462366 |
Drug delivery particle
A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.
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7449236 |
Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
Embolic particles, as well as their methods of use and manufacture, are described.
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7442385 |
Chemoembolisation
A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer...
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7419685 |
Process for producing solid dosage forms
Solid dosage forms containing at least one polymer binder, at least one active ingredient and, where appropriate, conventional additives, wherein a physiologically tolerated, water-swellable graft...
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7413752 |
Composite hydrogel drug delivery systems
Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species...
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7374778 |
Enhanced transport using membrane disruptive agents
Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are...
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7371738 |
Method of transdermal drug delivery using hyaluronic acid nanoparticles
The present invention relates to the development of a hyaluronic acid and hyaluronic acid hybrid nanoparticle systems for the administration of active molecules, peptides, DNA and/or other...
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7357948 |
Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic...
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7351798 |
Stabilized protein crystals, formulations comprising them and methods of making them
This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention...
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7351430 |
Shape-retentive hydrogel particle aggregates and their uses
The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes...
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7348031 |
Method for preparing colloidal particles in the form of nanocapsules
The invention relates to a process for the preparation of dispersible colloidal systems in the form of nanocapsules whose wall consists of a polymer obtained by the polycondensation of two...
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7344705 |
Composition comprising low density microspheres
Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected...
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7291348 |
Compositions and methods for biodegradable microspheres as carriers of bioactive substances
A cost-effective, scalable technique for producing microspheres loaded with biologically active solid proteins is provided. The microspheres degrade over time and release biologically active VEGF,...
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7282220 |
Genipin-crosslinked gelatin microspheres as drug carrier
A pharmaceutical microsphere comprises a bioactive agent and a biological carrier that encapsulates the bioactive agent, wherein the biological carrier is crosslinked with a crosslinking agent.
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7282195 |
Flavored sealants
A single-component composition for repairing, protecting or sealing teeth comprising a polymerizable resin, a flavoring agent, wherein the flavoring agent is a non-oil containing natural flavoring...
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7258874 |
Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic...
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7255877 |
Fenofibrate microparticles
Fenofibrate microparticles are prepared using a combination of surface modifiers with a phospholipid. Particle size growth and stability are controlled while significantly smaller sized fenofibrate...
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7247319 |
Preparation of microparticles having improved flowability
Methods for preparing microparticles having improved flowability to facilitate processing in automated equipment. Microparticles are conditioned so that a flowability index of the microparticles is...
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7241813 |
End-capped polymers and compositions containing such compounds
End-capped polymers, methods for making those end-capped polymers and compositions containing those end-capped polymers are disclosed. One of the disclosed end-capped copolymers has the formula:
...
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7226617 |
Thermosensitive and biodegradable microgel and a method for the preparation thereof
The present invention provides a thermosensitive and biodegradable microgel and a method of synthesizing such microgels. The thermosensitive and biodegradable microgel is synthesized from a...
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7223419 |
Production process for polymeric micelle charged therein with drug and polymeric micelle composition
Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a...
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7220434 |
Dual-release compositions of a cyclooxygenase-2 inhibitor
Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility, for example...
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7205343 |
Stabilized bioactive preparations and method of use
Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that...
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7195780 |
Nanoparticle delivery system
The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials. The invention also describes the use of such nanotubes for the...
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7189417 |
Nanometer-sized carrier medium
The present invention relates to a colloidal dispersion of amine-terminated silica particles having a narrowly controlled size range in an aqueous phase for use in diagnostic imaging, drug delivery...
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7182957 |
Polymer blends that swell in an acidic environment and deswell in a basic environment
A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said...
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7172769 |
Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect
Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility in a...
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7169318 |
Imbibed organic liquids, especially halogenated organics
Solid composition has an organic spill absorbing material in which is absorbed certain of a liquid organic compound or composition. The organic spill absorbing material can be water insoluble,...
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7163698 |
Controlled drug delivery system using the conjugation of drug to biodegradable polyester
The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond...
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7163697 |
Biodegradable polymer compositions, compositions and uses related thereto
The present application is directed to biodegradable polymers, compositions, including microspheres and nanospheres, formed of such polymers, and methods of using such polymers and compositions. In...
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7160559 |
Controlled release galantamine composition
The present invention is concerned with controlled release compositions for oral administration comprising galantamine; and with processes of preparing such controlled release compositions.
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7160557 |
Matrices formed of polymer and hydrophobic compounds for use in drug delivery
A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release...
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7131997 |
Tissue treatment
A method of treating tissue includes placing substantially spherical polymer particles in the tissue. The particles include an interior region having relatively large pores and a first region...
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7101568 |
Methods and compositions for treating solid tumors
A biodegradable polymer composition comprising:
(a) a poly(phosphoester) biodegradable polymer and (b) at least one antineoplastic agent in an amount effective to inhibit the growth of a...
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7081450 |
Water soluble nanoparticles of hydrophilic and hydrophobic active materials and an apparatus and method for their production
This invention provides a soluble nano-sized particles formed of a core (water-insoluble lipophilic compound or hydrophilic compound) and an amphiphilic polymer and which demonstrated improved...
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7074432 |
Method of modifying the release profile of sustained release compositions
The present invention relates to a method for the sustained release in vivo of a biologically active agent comprising administering to a subject in need of treatment an effective amount of a...
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7070809 |
Hydrogel biomedical articles
Hydrogel biomedical articles formed from macromers having a polymeric backbone comprising 1,2-diol and/or 1,3-diol units, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups...
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7067154 |
Pharmaceutical compositions containing Vitamin D and calcium, their preparation and therapeutic use
Described herein is a pharmaceutical composition containing Vitamin D and calcium, comprising a binding agent chosen from among the group consisting of: propylene glycol, a polyethylene glycol...
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7052719 |
Matrices formed of polymer and hydrophobic compounds for use in drug delivery
A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release...
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7048946 |
Formulation for controlled release of drugs by combining hyrophilic and hydrophobic agents
Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent...
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7041320 |
High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence
Methods and compositions to induce opioid drug independence in opioid drug dependent individuals comprising administering opioid agonists and/or antagonists encapsulated in biodegradable polymer...
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7033608 |
“Burst-free” sustained release poly-(lactide/glycolide) microspheres
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous...
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7025991 |
Drug targeting system, method of its preparation and its use
A composition and method of fabrication are presented with which nanoparticles may be used as a tool to deliver drugs to a specific target within or on a mammalian body. Specifically, by using...
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7022347 |
Restorative and grafting material for hard tissue defects prepared from animal teeth
The restorative and grafting material for reconstruction of hard tissue defects and the fabrication method of the same are provided. In particular, the restorative and grafting material of this...
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7022313 |
Hydrogel particle formulation
New compositions formed from the combination of an active substance with a hydrogel carrier moiety are provided. The compositions are suitable for use in high-velocity transdermal particle...
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