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8182867 |
Producing composite nanoparticles containing organic ions
A method for producing a composite nanoparticle, including the steps of, collapsing at least a portion of a polyelectrolyte polymer in solution about one or more precursor moieties to form a...
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8182791 |
Formulations for use in inhaler devices
A formulation for an inhaler device comprises carrier particles having a diameter of at least 50 μm and a mass median diameter of at least 175 μm; active particles; and additive material to which i...
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8178129 |
Formulations of water insoluble or poorly water soluble drugs in lipidated glycosaminoglycan particles and their use for diagnostic and therapy
The invention provides a formulation of water insoluble or poorly water soluble drugs encapsulated in lipidated glycosaminoglycan particles for targeted drug delivery.
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8173173 |
Anhdyrous lactose agglomerates and the preparation thereof
The invention relates to a process for the preparation of anhydrous lactose agglomerates, said process comprising (i) subjecting essentially anhydrous lactose primary particles comprising at least...
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8173168 |
Dispersible macromolecule compositions and methods for their preparation and use
A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting...
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8173107 |
Delivery of antipsychotics through an inhalation route
The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a...
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8173165 |
Water-dispersible pellets
A water-dispersible particle for delivery of nitrogen to a plant is disclosed. The water-dispersible particle also delivers an active ingredient such as a plant hormone to a desirable plant or a...
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8158827 |
Transfection reagents
Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with...
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8153161 |
Medicament-containing particle and a solid preparation containing the particle
The invention provides a medicament-containing particle wherein an unpleasant taste of the medicament is alleviated, which is obtainable by mixing and granulating the following ingredients: (1) the...
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8142814 |
Method and apparatus for supercritical fluid assisted particle production
The present invention provides an apparatus and methods of producing particles that include a polymer, a wax and/or lipid and, optionally, a biologically active substance. In accordance with the...
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8138229 |
Compositions and methods of delivery of pharmacological agents
The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human...
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8128958 |
Sustained release pharmaceutical composition
The present invention provides a sustained-release pharmaceutical composition, characterized in that, there are contained tamsulosin or a pharmaceutically acceptable salt thereof and a carrier for...
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8114841 |
Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
The present invention provides effective new methods and materials for maxillofacial bone augmentation, particularly alveolar ridge augmentation, that are free of problems associated with prior art...
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8097277 |
Charge-dynamic polymers and delivery of anionic compounds
The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic...
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8092820 |
Dry hemostatic compositions and methods for their preparation
Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain...
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8092833 |
Compositions containing inclusion complexes
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
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8088388 |
Stabilized synthetic immunogen delivery system
The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG...
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8088095 |
Polymeric sealant for medical use
The invention provides a polymeric film-forming medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the...
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8080236 |
Particulate materials
Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing the particles...
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8066904 |
Controlled generation of nitric oxide
Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of...
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8063243 |
Stable active compound complex of salts of o-acetylsalicylic acid with basic amino acids and glycine
The present invention relates to stable active compound complexes of salts of o-acetylsalicylic acid with basic amino acids and glycine, to a process for their preparation and to their use as...
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8063005 |
Personal care formulations with simultaneous exfoliant, cleansing and moisturizing properties
A non-aqueous cleansing formulation having cleansing, moisturizing and/or exfoliating properties includes an oil phase and a natural surfactant derived from legumes and/or grains. The oil phase can...
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8052998 |
Particulate vectors for improving oral absorption of active principles
The invention concerns particulate vectors designed to improve oral absorption of active principles, characterized in that they consist of a polymeric matrix comprising at least a biodegradable...
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8025892 |
Cosmetic particulate gel carriers for topically applied active agents
Gel particles or beads can be prepared by forming a hot aqueous solution of a gelling agent, and discharging the hot gelling agent solution through a discharge orifice into a cold moving stream of...
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8021684 |
Haemostatic composition comprising hyaluronic acid
The present invention relates to a haemostatic composition comprising a biologically absorbable material and hyaluronic acid or a derivative thereof, methods of producing such compositions and the...
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8017154 |
Polyamino acid for use as adjuvant
Use of a polyamino acid as an adjuvant; an application of a polyamino acid as an adjuvant in the production of a vaccine; a vaccine comprising a polyamino acid as an adjuvant; a biodegradable...
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8017156 |
Long-acting colloidal insulin formulation and its preparation
The invention relates to injectable long-acting insulin formulations for the treatment of types I and II diabetes in humans and animals. The essential object of the invention is to provide an...
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8012507 |
Preservation of bioactive materials by spray drying
This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of...
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8003080 |
Delivery of drug amines through an inhalation route
The present invention relates to the delivery of drug amines through an inhalation route. Specifically, it relates to aerosols containing drug amines that are used in inhalation therapy. In one...
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7998505 |
Dry granulation binders, products, and use thereof
A method for the preparation of microcrystalline cellulose containing tablets by roller compaction followed by tabletting is disclosed. A tablet formulation is converted to a dry granulate by...
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7993679 |
Flowable wound matrix and its preparation and use
This invention relates to a flowable collagen/glycosaminoglycan (GAG) material including particles of collagen/GAG matrix that, when hydrated, can be effectively delivered to wounds having varying...
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7993678 |
Hyaluronic acid derivatives
The present invention relates to the modification of hyaluronic acid (HA) with aryl/alkyl succinic anhydrides (ASA) to produce aryl/alkyl succinic anhydride HA derivatives, to the derivatives as...
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7988952 |
Delivery of drug esters through an inhalation route
The present invention relates to the delivery of drug esters through an inhalation route. Specifically, it relates to aerosols containing drug esters that are used in inhalation therapy. In a...
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7981871 |
Modified macromolescules and associated methods of synthesis and use
Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive...
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7981447 |
Particulate-soluble glucan preparation
Particulate β-glucan is solubilized at elevated pressure and temperature to form particulate-soluble β-glucan. The particulate-soluble β-glucan is capable of being dried to a powder form and su...
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7976825 |
Cancer cell diagnosis by targeting delivery of nanodevices
Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular...
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7972628 |
Porous biomaterials
The invention provides porous biomaterials and methods for forming porous biomaterials. The porous biomaterials of the invention comprise a biocompatible polymer scaffold defining an array of...
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7968123 |
Complexing agents for compositions containing inclusion complexes
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
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7964277 |
Composite nanoparticles, nanoparticles and methods for producing same
In various aspects provided are methods for producing a nanoparticle within a cross-linked, collapsed polymeric material, said method including (a) providing a polymeric solution comprising a...
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7956160 |
Concentrated protein lyophilates, methods, and uses
The invention provides, among other things, lyophilized compositions of high surface area that comprise a protein and that reconstitute quickly and efficiently to solution of high protein...
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7951402 |
Drug delivery particle
A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.
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7931918 |
Collagen-based microspheres and methods of preparation and uses thereof
A method of manufacture of ECM microparticles incorporating bioactive molecules for drug delivery has been developed, using a modified emulsification method or a water-in-oil-phase-separation...
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7927629 |
Method and compositions for polymer nanocarriers containing therapeutic molecules
A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a...
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7923031 |
Haemostatic sprays and compositions
The present invention is directed to a powder delivery system containing a composition comprising gelatin or collagen powder having a mean particle size of at least 10 μm. The gelatin or collagen ...
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7923029 |
Spray freeze dry of compositions for pulmonary administration
This invention provides methods and compositions to preserve bioactive materials, such as viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for pulmonary administration....
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7906144 |
Solubilizing aids in powder form for solid pharmaceutical presentation forms
The invention relates to excipients in powder form for use in solid pharmaceutical presentations, comprising a pharmaceutically acceptable polymer and a liquid or semisolid solubilizing...
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7893037 |
Pharmaceutical composition and process
The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,
4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate;...
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7883720 |
Charge-dynamic polymers and delivery of anionic compounds
The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic...
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7879818 |
Hyaluronic acid-based cross-linked nanoparticles
Methods are disclosed for preparing novel biodegradable cross-linked nanoparticles based on covalently cross-linking modifications of hyaluronic acid. The final products of the present invention...
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7846480 |
Manufacture of strong, lightweight carrier granules
Method for manufacturing carrier granules. The method forms a mixture comprising fibers, mineral filler, and binder. The mixture contains 32-48 weight-% wood fibers having a bulk density of less...
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