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6827947 |
Film coating
A film coating composition suitable for use in coating pharmaceutical formulations to provide modified release comprising a dispersion which includes: a) an acrylic polymer, b) a vinyl acetate...
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6824793 |
Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants
Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the...
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6814980 |
Microspheres containing condensed polyanionic bioactive agents and methods for their production
The present invention relates to novel compositions comprising microspheres and/or nanospheres containing condensed polyanionic bioactive agents, such as DNA. The polyanionic bioactive agent in the...
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6809082 |
Synthetic transfection vectors
An inorganic particle, to which is bonded a cell binding component and a nucleic acid, is provided for delivery of a nucleic acid to a cell. The disclosed particle acts as a synthetic vector for...
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6805879 |
Stable polymer aqueous/aqueous emulsion system and uses thereof
This invention provides a stable aqueous/aqueous emulsion system which is prepared with a hydrophilic polymer. This invention also provides the method of preparing a stable aqueous/aqueous...
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6794367 |
Solid preparations for oral administration of drugs relating to genes
The invention provides solid preparations for oral administration of gene-related drugs comprising a core containing the gene-related drug with a coating which does not disintegrated in small...
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6780435 |
Omeprazole formulation
A pharmaceutical composition of omeprazole for oral administration is described which consists essentially of: (a) a pellet comprising an inert core component, a therapeutically effective amount...
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6776996 |
Pesticidal matrices
The present invention provides improved coated pesticidal matrices and a process for their preparation. The present invention also provides a wettable powder pesticidal composition containing the...
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6770695 |
Time release calcium sulfate matrix for bone augmentation
An implant composition having controlled resorption rate in vivo for stimulating bone growth, a method of making the implant composition, and a kit of implant materials are disclosed. The implant...
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6767557 |
Taste masked pharmaceutical compositions
A taste masked pharmaceutical composition comprising a microcapsule, wherein the microcapsule comprises a pharmaceutically active agent core coated with a taste masking effective amount of a...
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6764698 |
Controlled drug release system of retinoic acid
The present invention relates to a controlled drug release system in which a certain ratio or retinoic acid is incorporated into a microsphere comprising biodegradable polymer and amphoteric block...
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6761910 |
Pharmaceutical composition for the treatment of acute disorders
A pharmaceutical composition for the treatment of acute disorders is described. The composition comprises an essentially water-free, ordered mixture of at least one pharmaceutically active agent in...
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6759058 |
Enteric-coated proliposomal formulations for poorly water soluble drugs
This invention relates to enteric-coated proliposomal formulations for oral medicaments. In particular, it relates to an enteric-coated proliposomal oral drug delivery system for poorly water...
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6759059 |
Fentanyl composition for the treatment of acute pain
A pharmaceutical composition for the treatment of acute pain by sublingual administration is described. The composition comprises an essentially water-free, ordered mixture of fentanyl or a...
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6756062 |
Preparation of drug particles using evaporation precipitation into aqueous solutions
A method for preparing poorly water soluble drug particles is disclosed. The method comprises dissolving a drug in at least one organic solvent to form a drug/organic mixture, spraying the...
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6750249 |
Controlled release oral preparations of esculetin and its derivatives
The present invention relates to an oral preparation of esculetin with controlled release. The oral preparation of esculetin with controlled release of the present invention comprises a gel-forming...
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6749867 |
Delivery system for omeprazole and its salts
The present invention provides a time-release dosage form for delivering an acid-labile pharmaceutical, such as omeprazole, into the upper portion of the gastrointestinal tract downstream of the...
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6743444 |
Method of making microencapsulated DNA for vaccination and gene therapy
A method of making a microparticle that contains DNA coding for a polypeptide is described in which a solvent extraction method is used and solvent extraction takes place at elevated temperature....
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6740341 |
Taste masking rapid release coating system
The present invention relates to a core containing a drug encased in a spacing layer and a taste masking layer which provides effective taste masking for in-mouth disintegrable dosage forms...
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6737082 |
Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
It comprises a compound having antifungal activity as active principle, an inert core and a coating including said active principle, and is characterized in that said inert core has a particle size...
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6733790 |
Microcapsules and processes for making the same using various polymers and chitosans
A microcapsule having a mean diameter of from about 0.1 to about 5 mm, a membrane and a matrix containing at least one active principle wherein the microcapsule is the product of the process...
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6730324 |
Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation
This invention relates to novel room-temperature process for obtaining calcium phosphate, in particular hydroxyapatite, coatings and microspheres that encapsulate drugs, proteins, genes, DNA for...
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6730331 |
Topically applied creatine containing composition
The present invention is a stable topical creatine application suitable for absorption directly through the skin into the underlying muscle without traveling through the blood system for the...
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6723348 |
Orodispersible tablets containing fexofenadine
The present invention concerns orodispersible tablets, which are able to disintegrate in the buccal cavity upon contact with saliva by formation of an easy-to-swallow suspension, in less than 60...
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6720007 |
Polymeric microspheres
The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell...
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6716456 |
Method for production of microcapsules
The invention provides a process for microencapsulating a pharmaceutical substrate comprising the steps of: a) adding insoluble or sparingly soluble particles of the substrate to be...
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6713509 |
Controlled release formulation for treating COPD
This invention relates to a controlled or sustained release formulation designed to deliver a PDE4 inhibitor for treating an inflammatory disease such as asthma or COPD and the like.
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6713088 |
Low viscosity filler composition of boron nitride particles of spherical geometry and process
A low viscosity filler boron nitride agglomerate particles having a generally spherical shape bound together by an organic binder and to a process for producing a BN powder composition of...
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6709678 |
Easy to swallow oral medicament composition
An oral composition which is adapted to be dispersed in an aqueous carrier substantially immediately prior to administration comprises a multiplicity of particles comprising an active substance,...
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6706288 |
Microparticles
A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared,...
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6706778 |
Process for the production of molded particles for microbial cell-immobilization
This invention provides a process for the production of molded particles for microbial cell-immobilization which is characterized in that: an aqueous liquid composition which comprises: (a) an...
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6703047 |
Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize...
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6699508 |
Sustained release oral preparations of fasudil hydrochloride
An oral sustained-release preparation which contains at least one active ingredient selected from the group consisting of fasudil hydrochloride and a hydrate thereof is disclosed. A method for...
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6699501 |
Polyelectrolyte coverings on biological templates
The invention relates to a method for producing capsules provided with a polyelectrolyte covering, and to the capsules obtained using this method.
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6699506 |
Pharmaceutical composition with extended release of Milnacipran
The invention concerns a pharmaceutical composition with prolonged release, for oral administration of a single daily dose of 60 to 140 mg of Milnacipran, having a multi-particulate form containing...
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6696090 |
Electro-powder
A method and a process are disclosed for preparation of medical electro-powders. The electro-powder results from preparations of chemical and biological substances to form electro-powders suitable...
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6692728 |
Polyesters based on hydroxy fatty acids and lower hydroxy alkyl acids and uses thereof
The present invention provides biodegradable polyesters based on lower hydroxy acids and hydroxy fatty acids. The resulting polyesters are useful as cosmetic vehicles for sunscreens, skin lotions...
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6692769 |
Sustained-release particles
The present invention discloses sustained release particles having a mean particle size of 300 μm, or less, comprising a drug-containing core substance coated with a mixed coating of a hydrophobic...
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6685964 |
Opioid analgesics with controlled active substance release
An orally administered preparation with controlled lease of an opioid analgesic in the form of crystals having particle size of 10 μm to 3 mm, preferably of 50 μm to 1 mm, which have at least one...
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6685966 |
Composite particles containing an active substance
Composite particles are provided comprising at least one core including at least one organic polymer in which is dispersed at least one hydrophobic active material. The hydrophobic active material...
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6680067 |
Controlled-release pharmaceutical preparation containing nalbuphine and a process for preparing the same
A controlled-release pharmaceutical preparation containing an oil suspension which comprises an analgesic and an injectable oil. The analgesic is either a nalbuphine free base or a pharmaceutical...
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6677313 |
Method for gene therapy using nucleic acid loaded polymeric microparticles
The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form,...
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6663897 |
Oral itraconazole formulations and methods of making the same
A method of manufacturing an itraconazole oral dosage form that is substantially free of residual methylene chloride comprises the steps of: (a) providing a working solution comprising an alcohol,...
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6663896 |
Delayed release aspirin for vascular obstruction prophylaxis
A method and controlled release oral unit dosage form of acetylsalicylic acid (aspirin) delays the release of the drug until a predetermined time interval after ingestion. This enables the drug to...
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6660296 |
Sustained-release microgranules containing diltiazem as active principle
Novel forms of sustained-release microgranules (LP) containing diltiazem are disclosed. The microgranules consist of a neutral granular carrier coated with an active layer including diltiazem or a...
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6656506 |
Microparticle coated medical device
A drug-loaded microparticle is applied to a medical device for subsequent application to biological tissues. A method of formulating a drug-loaded microparticle and applying it to the surface of a...
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6652865 |
Method and formulation for decreasing statin metabolism
A pharmaceutical composition for oral use is disclosed. It includes, as active principle, a drug liable to undergo a strong first intestinal passage effect and a carrier which is...
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6645529 |
Instant granules and process for their formulation
The pharmaceutical formulation according to the invention is in the form of instant granules, in which the surface of the particles of at least two different soluble carrier materials is covered or...
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6645523 |
Paroxetine compositions and processes for making the same
Paroxetine salt compositions having improved stability are formed by controlling the pH to 6.5 or less. The compositions can be made with the aide of water without significant coloration problems....
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6645524 |
Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent
Novel pharmaceutical dosage forms provide for pulsatile delivery of an antiarrhythmic agent that releases the drug in spaced apart “pulses.” The dosage forms are comprised of first, second and...
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