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4919938 |
Sustained release pharmaceutical compositions in oral dosage form
Oral dosage forms for neutral, zwitterions or slats of acidic or basic drugs with approximate zero order release kinetics comprise a core matrix of the drug, and a gelling polymer, the matrix being...
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4917899 |
Controlled absorption diltiazem formulation
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and a...
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4917900 |
Controlled release formulations containing zidovudine
The invention relates to pharmaceutical formulations comprising discrete units of zidovudine provided with a controlled release coating in which the said units are preferably in the form of spheroids.
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4906474 |
Bioerodible polyanhydrides for controlled drug delivery
A composition of matter suitable for implantation in the body to effect zero order drug release comprising a drug and a polymer of the formula: ##STR1## wherein R and R' can be the same or...
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4904479 |
Drug delivery system
Particles of a drug are directed away from the reticuloendothelial system by the use of surface coating and surface grafting techniques which substantially prevent the take up of the composite...
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4904477 |
Spray dried ibuprofen compositions
A spray dried ibuprofen composition suitable for direct compression into tablets comprising a spray dried dispersion in water of ibuprofen, pregalatinized starch, a disintegrant and a wetting agent...
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4902516 |
Binder-free granules with delayed release of the active compound
Binder-free granules for oral and parenteral administration with delayed release of the active compound, consisting of a pharmaceutical active compound or granules thereof and a coating of 1 to 20%...
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4900558 |
Sustained release ibuprofen formulation including a core of ibuprofen and a microcrystalline cellulose and a covering of acrylic polymer and hydroxylated cellulose derivative
The present invention provides a sustained release αmethyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) formulation comprising sufficient granules to provide a predetermined dose or number of...
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4898737 |
Controlled absorption pharmaceutical composition
A sustained absorption propranolol-containing pellet for oral administration comprises a core of propranolol or a pharmaceutically acceptable salt thereof and an organic acid embedded in a...
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4894239 |
Sustained-release preparation and production thereof
The present invention concerns a sustained-release microcapsule preparation comprising an ion exchange resin with 6 to 16% crosslinking, containing a drug adsorbed in an amount not less than 80% of...
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4892740 |
Orally administrable pharmaceutical preparation of improved flavoring characteristics
An orally administrable pharmaceutical preparation of improved flavoring characteristics composed of a core material containing a drug and a coated layer applied to its surface, said coated layer...
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4891230 |
Diltiazem formulation
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
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4888177 |
Pharamaceutical preparations in the form of instant granules or tablets and process for their manufacture
The invention relates to a pharmaceutical preparation that contains at least one pharmaceutically active substance at least one granular carrier material and a layer enveloping the carrier material...
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4886669 |
Galenical formulation
A water-dispersible tablet essentially consisting of (a) microparticles which contain at least one pharmaceutically active substance (b) a least one disintegrant and (c) a swellable...
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4882166 |
Compositions comprising encapsulated particles and their preparation
A composition which comprises at least one solid or liquid particle comprising at least one active substance, the or a plurality of such particles being encapsulated by the in situ cationic...
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4882169 |
Swellable pellets
Pellets which can be used in liquid oral formulations of drugs are presented. They comprise (a) a core, containing microparticles of at least one pharmaceutically active substance, (b) optionally...
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4876290 |
Microencapsulation by interfacial polyaddition
Microcapsules, and especially suspensions of microencapsulated colorants well adapted for the manufacture of carbonless papers, are produced by emulsifying a hydrophobic organic fluid which...
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4876039 |
Process for preparing silicone microparticles cured by a Michael addition reaction
Microparticles, such as microspheres and microcapsules, comprising a solid organopolysiloxane are prepared by curing a dispersion of discrete entities by means of a Michael-type addition reaction....
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4876086 |
Injectable compositions of amoxycillin trihydrate
Injectable pharmaceutical compositions are provided which comprise fine particles of amoxycillin trihydrate coated with a dispersing agent, the ratio of amoxycillin trihydrate to dispersing agent...
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4874613 |
Taste concealing pharmaceutical dosage unit
A pharmaceutical dosage unit suitable for masking the unpleasant taste of orally administered pharmaceutical agents and which facilitates swallowing comprises a plurality of subdosage units...
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4871716 |
Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof
Novel magnetically responsive hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide and particulate magnetically...
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4871549 |
Time-controlled explosion systems and processes for preparing the same
The invention relates to a Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form...
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4867984 |
Drug in bead form and process for preparing same
A bead of a drug such as aspirin or acetaminophen formed from a small spheriodal seed particle of the drug or of an inert material coated with an adhesive and layers of drug particles likewise...
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4865851 |
Pharmaceutical composition comprising cefuroxime axetil
Cefuroxime axetil in particulate form is coated with an integral coating of a lipid or mixture of lipids which serves to mask the bitter taste of cefuroxime axetil but disperses or dissolves on...
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4863743 |
Controlled release potassium chloride
A controlled release potassium chloride tablet is disclosed which is comprised of potassium chloride crystals having a mesh size of about 30 to about 50 mesh which are coated with a coating...
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4861627 |
Preparation of multiwall polymeric microcapsules
A single step method for preparation of multi-layer polymeric delivery systems. Any two or three different degradable or non-degradable polymers which are not soluble in each other at a particular...
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4861599 |
Galenic formulations for oral use of rhein derivatives with delayed release for therapeutical use
Several methods are disclosed for the preparation of oral pharmaceutical forms with delayed release of rhein and its derivatives. The pharmaceutically active ingredient is provided in the form of...
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4859469 |
Novel galenic forms of verapamil, their preparation and medicines containing said novel galenic forms
The invention relates to a novel galenic form of verapamil which show an excellent bioavailability. The novel galenic form comprises microgranules containing a verapamil addition salt with an acid,...
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4857406 |
Microcapsules with polysalt capsule walls and their formation
The present invention provides a process for forming microcapsules having discrete capsule walls. An emulsion of an oily core material in a continuous aqueous phase containing a polymeric anionic...
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4851228 |
Multiparticulate controlled porosity osmotic
The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of a pharmaceutically active agent to an environment of use, said pump comprising: (I) a carrier...
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4847077 |
Controlled release pharmaceutical preparations
Controlled release pharmaceutical preparations containing coated sulfonic acid cationic exchange resin drug complex particles, the resin particles having been treated, prior to coating, with about...
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4844910 |
Spheroids
A controlled release pharmaceutical composition comprising a plurality of film coated spheroids, the film coated spheroids comprising a 3-alkylxanthine, a non-water soluble spheronising agent and...
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4844905 |
Granule remaining in stomach
A granule of drug to remain in the stomach comprises a core comprising a pharmaceutically effective ingredient, a foaming layer coated on said core and an expansive film coated on said layer.
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4844908 |
Method of preparing tablets with clovoxamine fumarate and tablets thus prepared
Clovoxamine, i.e., 4'-chloro-5-methoxyvalerophenone-O-(2-aminoethyl)oxime is a known compound having antidepressive activity. The fumarate (1:1) of clovoxamine may be administered orally in the...
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4840799 |
Process for preparing rapidly disintegrating granulates
The present invention relates to a process for preparing a rapidly disintegrating core granulate containing a pharmaceutically active compound, which granulate is optionally intended to be coated...
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4839177 |
System for the controlled-rate release of active substances
A system for the controlled-rate release of active substances, consisting of: (a) a deposit-core comprising the active substance and having defined geometric form; (b) a support-platform...
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4837031 |
Compositions containing ibuprofen
A granular composition containing 2-(4-isobutylphenyl)propionic acid (ibuprofen) as an active anti-inflammatory pharmaceutical ingredient as a major component, together with carboxymethylcellulose,...
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4837255 |
Palatable hypocholesterolaemic gel formulation containing a pharmaceutically acceptable non-digestible anion exchange resin
A gel formation for oral administration having improved palatability comprising an effective hypocholesterolaemic amount of a uniform gelled dispersion of (a) between about 8 and about 20...
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4837032 |
Theophylline sustained release tablet
Compressed tablets from which theophylline is released at a steady rate with twelve hour dosing intervals are disclosed. The tablets contain 43 to 50 weight percent theophylline; 10 to 20 weight...
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4837030 |
Novel controlled release formulations of tetracycline compounds
Pharmaceutical compositions comprising spherical granules including thereon or therein a 7- or 9-akylamino-6-deoxy-6-demethyltetracycline or an acid-addition salt thereof blended with at least one...
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4834982 |
Potassium-neutral salureticum with anti-hypertensive effect
A diuretically active combination comprising furosemide and triamterene in a ratio of 1:1 to 1:2, in which furosemide is in the form of controlled release so as to facilitate solubilization of the...
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4826945 |
Biodegradable polymeric materials based on polyether glycols, processes for the preparation thereof and surgical articles made therefrom
The invention provides poly(α-hydroxy-carboxylic acid)/poly(oxyalkylene) polymers selected from multiblock polymers of the following repeating unit I ##STR1## wherein R is an alkylene group, R 1 ...
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4818542 |
Porous microspheres for drug delivery and methods for making same
Controlled release drug delivery systems comprised of spherical microporous polymeric network of interconnecting channels containing pore incorporated drugs or other agents wherein the drugs or...
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4816264 |
Sustained release formulations
Drug delivery systems which exhibit sustained release properties when administered are produced using a "dual control" system which employs polymeric agents in core and membrane portions.
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4808411 |
Antibiotic-polymer compositions
Compositions which comprise a complex of carbomer (acrylic acid polymers) and erythromycin or a derivative thereof such as 6-O-methylerythromycin, are disclosed. The compositions provide nontoxic,...
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4808416 |
Preparation of a slow-release drug
The invention concerns the preparation of a slow-release drug characterized by the coating of a core comprising a therapeutically active principle by means of a substance which retards its release...
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4800084 |
Pharmaceutical product in the form of a pellet with continuous, delayed medicament substance emission
The discovery presented herewith concerns a pharmaceutical product in the form of a pellet with improved continous, delayed medicament substance emission through a coating, which is made of a...
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4795745 |
Macrophage-activating composition and a process for its manufacture
Macrophage-stimulatory composition containing a water-soluble β-1.3-bound glucan and a water-insoluble carrier to which the glucan has been immobilized; its use; and a process for its manufacture.
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4792450 |
Device for controlled release drug delivery
A device for the controlled release and delivery of a pharmacologically active agent, comprising a vinyl gel layer and a pharmacologically active agent uniformly dispersed in the layer in a...
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4789516 |
Production of sustained released system
Permeable capsules are loaded with a reservoir of the substance to be dispensed at a concentration sufficient to provide an osmotic pressure above threshold level, and the pore size of the capsule...
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